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1. 发明授权

US09314790B1 System for separation of a sample 有权
标题翻译：样品分离系统
公开(公告)号：US09314790B1
公开(公告)日：2016-04-19
申请号：US12796385
申请日：2010-06-08
申请人： Naida M. Loskutoff
发明人： Naida M. Loskutoff
IPC分类号： C12M1/00 , C12M3/00 , B01L3/00 , C12M1/32 , G01N21/07
CPC分类号： C12M33/10 , A61L2/0082 , C12M23/08 , C12M33/14
摘要： A centrifuge layering insert configured for insertion into a centrifuge tube includes a tube having a first open end and a second open end. The centrifuge layering insert also includes a casing having an outer wall, an inner wall, a first open end, and a second substantially closed end. The casing forms an annular space around the tube between the tube first end and the tube second end. The tube has at least a portion of the length extending beyond the first open end of the casing in a direction opposite the second open end of the tube.
摘要翻译：构造成用于插入到离心管中的离心机分层插入件包括具有第一开口端和第二开口端的管。离心机分层插入件还包括具有外壁，内壁，第一开口端和第二基本封闭端的壳体。套管在管的第一端和管的第二端之间形成围绕管的环形空间。管具有至少一部分长度在与管的第二开口端相反的方向上延伸超过壳体的第一开口端。

2. 发明申请

US20100196872A1 Semen extender composition and methods for manufacturing and using 失效
标题翻译：精液增量剂的制备和使用方法
公开(公告)号：US20100196872A1
公开(公告)日：2010-08-05
申请号：US12660978
申请日：2010-03-08
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A01P1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.
摘要翻译：提供精液延长剂组合物。精液延长剂组合物包括精子细胞保护量的磷脂，有效量的表面活性剂以减少组合物冷冻期间的冰晶形成; 碳水化合物和生物缓冲液，以提供pH为约6.9至约7.5的精液增量剂使用溶液，并且其中所述使用溶液的重量克分子渗透浓度为约250mOsM至约350mOsM。提供了制造和使用精液延伸剂组合物的方法。

3. 发明授权

US07405036B2 Process for reducing pathogens in a biological sample and removing a sample pellet from a sample tube 有权
标题翻译：用于减少生物样品中的病原体并从样品管中除去样品颗粒的方法
公开(公告)号：US07405036B2
公开(公告)日：2008-07-29
申请号：US10900061
申请日：2004-07-26
申请人： Naida M. Loskutoff , Kari Morfeld , James Dow
发明人： Naida M. Loskutoff , Kari Morfeld , James Dow
IPC分类号： A01N1/02 , C12N5/00 , C07G15/00
CPC分类号： A61L2/0011 , Y10T436/25125 , Y10T436/25375
摘要： The present invention is directed towards an apparatus and method for disinfecting biological samples, including semen and the like, and for removing a biological sample pellet from surrounding media while reducing the risk of recontamination of the pellet with said media. An insert receptacle includes a receiving cylinder having a drain in a floor which allows the fluids to decant slowly down the side of a tube. The insert receptacle further includes an aspiration channel which allows an aspiration device, such as a modified micro-pipette, to be utilized for extracting a sample pellet from the bottom of the tube. Utilizing the novel apparatus, a method for reducing pathogens in a biological sample includes decanting the biological sample through the receiving cylinder and into a tube where it passes through a multi-layer gradient including an enzyme suitable for removal of at least one pathogen from the biological sample. Centrifuging of the insert receptacle, tube, and sample, isolates a sample pellet of the biological sample from the surrounding at least one pathogen. After the sample pellet is isolated it is aspirated via the aspiration device without re-contaminating the sample pellet through contact with the surrounding at least one pathogen.
摘要翻译：本发明涉及用于消毒生物样品（包括精液等）的装置和方法，以及用于从周围介质中除去生物样品沉淀物，同时降低与所述培养基重新沉淀的风险。插入容器包括容纳圆筒，底座中有排水管，允许流体沿管的侧面缓慢倾斜。插入容器还包括抽吸通道，其允许诸如改进的微量移液管的抽吸装置用于从管的底部提取样品颗粒。利用该新颖的装置，用于减少生物样品中的病原体的方法包括将生物样品通过接收圆筒倾倒并进入其中通过多层梯度的管中，所述多层梯度包括适于从生物中去除至少一种病原体的酶样品。插入容器，管和样品的离心分离生物样品的样品颗粒与周围的至少一种病原体。在分离样品颗粒后，通过抽吸装置吸出样品沉淀，而不会通过与周围的至少一种病原体接触而再次污染样品颗粒。

4. 发明授权

US07674576B2 Semen extender composition and methods for manufacturing and using 有权
公开(公告)号：US07674576B2
公开(公告)日：2010-03-09
申请号：US10044796
申请日：2002-01-11
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A61B17/43
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.

5. 发明授权

US07273694B2 Method and apparatus for reducing pathogens in a biological sample 有权
标题翻译：用于减少生物样品中病原体的方法和装置
公开(公告)号：US07273694B2
公开(公告)日：2007-09-25
申请号：US10478917
申请日：2002-05-21
申请人： Naida M. Loskutoff
发明人： Naida M. Loskutoff
IPC分类号： A01N1/02 , C12N5/00 , C07G15/00
CPC分类号： A61K35/52 , A61L2/0082
摘要： The present invention is directed to a method and apparatus for disinfection of biological samples, including semen and the like. In a first aspect of the present invention, a method for reducing pathogens in a biological sample includes passing the biological sample through a gradient including an enzyme suitable for removal of at least one pathogen from the sample. In an additional aspect of the present invention, an apparatus for removing pathogens from a biological sample includes a container including a gradient having at least one layer that is suitable for having the biological sample pass through the layer, the at least one layer including an enzyme suitable for removing at least one pathogen from the biological sample.
摘要翻译：本发明涉及一种用于消毒生物样品的方法和装置，包括精液等。在本发明的第一方面，一种用于减少生物样品中的病原体的方法包括使生物样品通过包含适于从样品中除去至少一种病原体的酶的梯度。在本发明的另一方面，用于从生物样品中除去病原体的装置包括容器，其包括具有至少一层适于使生物样品通过层的梯度的梯度，所述至少一层包含酶适于从生物样品中除去至少一种病原体。

6. 发明申请

US20170015970A1 System for Separation of a Sample 审中-公开
标题翻译：样品分离系统
公开(公告)号：US20170015970A1
公开(公告)日：2017-01-19
申请号：US15131951
申请日：2016-04-18
申请人： Naida M. Loskutoff
发明人： Naida M. Loskutoff
IPC分类号： C12M1/26 , C12M1/24
CPC分类号： C12M33/10 , A61L2/0082 , C12M23/08 , C12M33/14
摘要： A centrifuge layering insert configured for insertion into a centrifuge tube includes a tube having a first open end and a second open end. The centrifuge layering insert also includes a casing having an outer wall, an inner wall, a first open end, and a second substantially closed end. The casing forms an annular space around the tube between the tube first end and the tube second end. The tube has at least a portion of the length extending beyond the first open end of the casing in a direction opposite the second open end of the tube.
摘要翻译：构造成用于插入到离心管中的离心机分层插入件包括具有第一开口端和第二开口端的管。离心机分层插入件还包括具有外壁，内壁，第一开口端和第二基本封闭端的壳体。套管在管的第一端和管的第二端之间形成围绕管的环形空间。管具有至少一部分长度在与管的第二开口端相反的方向上延伸超过壳体的第一开口端。

7. 发明授权

US08435730B2 Semen extender composition and methods for manufacturing and using 失效
公开(公告)号：US08435730B2
公开(公告)日：2013-05-07
申请号：US12660978
申请日：2010-03-08
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A61B17/43
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.

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