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1. 发明授权

US07598363B2 Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion 有权
标题翻译：多核酸多交叉分子的多边形纳米结构和基于双交叉内聚的晶格组装
公开(公告)号：US07598363B2
公开(公告)日：2009-10-06
申请号：US11148423
申请日：2005-06-09
申请人： Nadrian C. Seeman , Baoquan Ding , Pamela E. Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
发明人： Nadrian C. Seeman , Baoquan Ding , Pamela E. Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
IPC分类号： C07H21/00
CPC分类号： C12N15/1031 , B82Y5/00 , B82Y40/00 , C07H21/02 , C12N15/10 , C12N15/1027
摘要： Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains.
摘要翻译：基于多边形单元的双交叉内聚力来组装稳健的核酸阵列和晶格，其边缘由核酸多交换结构域组成。

2. 发明申请

US20060078910A1 Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion 有权
公开(公告)号：US20060078910A1
公开(公告)日：2006-04-13
申请号：US11148423
申请日：2005-06-09
申请人： Nadrian Seeman , Baoquan Ding , Pamela Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
发明人： Nadrian Seeman , Baoquan Ding , Pamela Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1031 , B82Y5/00 , B82Y40/00 , C07H21/02 , C12N15/10 , C12N15/1027
摘要： Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains.

3. 发明申请

US20120315010A1 SYSTEM AND METHOD FOR VIDEO SUMMARIZATION AND NAVIGATION BASED ON STATISTICAL MODELS 有权
标题翻译：基于统计模型的视频总结和导航系统与方法
公开(公告)号：US20120315010A1
公开(公告)日：2012-12-13
申请号：US13492510
申请日：2012-06-08
申请人： Xiaoping Zhang , Junfeng Jiang
发明人： Xiaoping Zhang , Junfeng Jiang
IPC分类号： H04N9/80 , H04N5/775
CPC分类号： G11B27/005 , G06F17/30846 , H04N5/147 , H04N5/783 , H04N5/93 , H04N9/8227 , H04N21/44008 , H04N21/47217 , H04N21/8456
摘要： The disclosed method calculates video time density functions based on inter-frame mutual information or other similarity measures. The method includes acquiring a video sequence from memory, computing mutual information or other similarity measures between two consecutive frames of the video sequence, and constructing a video temporal density function based on the mutual information or similarity measures. The method enables fast navigation of the video sequence by performing a temporal quantization of the video time density function to determine a set of quanta. The video sequence can be navigated using the nearest neighbor video frames to the set of quanta. The method enables thumbnail extraction of a video sequence using statistical modeling by performing a temporal quantization of the video time density function to segment video sequence in time domain and using mixture (such as Gaussian mixture and ICA mixture) vector quantization to find the sample frames for each temporal segment.
摘要翻译：所公开的方法基于帧间相互信息或其他相似性度量来计算视频时间密度函数。该方法包括从存储器获取视频序列，计算视频序列的两个连续帧之间的相互信息或其他相似性度量，以及基于相互信息或相似性度量构建视频时间密度函数。该方法通过执行视频时间密度函数的时间量化来确定一组量子，从而能够快速导航视频序列。视频序列可以使用最近邻视频帧导航到量子集。该方法通过使用视频时间密度函数的时间量化来在时域中分割视频序列并使用混合（诸如高斯混合和ICA混合）矢量量化来使用统计建模缩略图提取视频序列，以找到用于每个时间段。

4. 发明申请

US20120183578A1 POLYETHYLENE GLYCOL-BASED DENDRONS 有权
标题翻译：聚乙烯甘油为基础的DENDRONS
公开(公告)号：US20120183578A1
公开(公告)日：2012-07-19
申请号：US13296213
申请日：2011-11-14
申请人： Patrick J. Sinko , Jieming Gao , Yashveer Singh , Xiaoping Zhang , Matthew S. Palombo , Stanley Stein
发明人： Patrick J. Sinko , Jieming Gao , Yashveer Singh , Xiaoping Zhang , Matthew S. Palombo , Stanley Stein
IPC分类号： A61K39/00 , A61K47/06 , A61P35/00 , A61P31/12 , A61P37/02 , C12Q1/02 , C07K4/00
CPC分类号： A61K47/48215 , A61K47/34 , A61K47/60 , A61K2039/6093 , A61K2039/645
摘要： The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.
摘要翻译：本发明涉及基于聚乙二醇的树枝状突变体，也称为PEGTIDE树突，其组合物和使用方法。

5. 发明申请

US20080270512A1 Virtual network projection system supporting multiple projection sources and method thereof 审中-公开
标题翻译：支持多种投影源的虚拟网络投影系统及其方法
公开(公告)号：US20080270512A1
公开(公告)日：2008-10-30
申请号：US12077249
申请日：2008-03-18
申请人： Xiaobing Guo , Dekui Zhang , Xiaoping Zhang , Xiaoyu Zhou , Shaowei Chen , Yiqiang Yan
发明人： Xiaobing Guo , Dekui Zhang , Xiaoping Zhang , Xiaoyu Zhou , Shaowei Chen , Yiqiang Yan
IPC分类号： G06F15/16
CPC分类号： G09G3/002 , G06F3/1423 , G06F3/1454
摘要： A network projection system and method are disclosed, the system comprises announcement means for announcing virtual network projection device information over a network and receiving a projection request from at least one network projection source, projection data receiving means for receiving data used in projection from the at least one network projection source, processing means for processing the data received from the at least one network projection source to meet a user's requirement, and projection data displaying means for displaying the processed projection data on a connected display device or transmitting the processed projection data to another network projection device over the network. With the structure of the present invention, a common display device can be virtualized as a network projection device to facilitate simultaneous display of projection contents from multiple projection sources on the same screen or switching of display via the network.
摘要翻译：公开了一种网络投影系统和方法，所述系统包括用于通过网络通知虚拟网络投影设备信息并从至少一个网络投影源接收投影请求的通知装置，用于接收来自at的投影使用的投影数据接收装置的投影数据接收装置至少一个网络投影源，用于处理从所述至少一个网络投影源接收的数据以满足用户需求的处理装置;以及投影数据显示装置，用于在所连接的显示装置上显示经处理的投影数据或将所处理的投影数据发送到网络上的另一个网络投影设备。利用本发明的结构，可以将公共显示装置虚拟化为网络投影装置，以便同时从同一屏幕上的多个投影源投影内容或通过网络切换显示。

6. 发明授权

US06727562B2 Basic common optical cell configuration of dual cavities for optical tunable devices 失效
公开(公告)号：US06727562B2
公开(公告)日：2004-04-27
申请号：US10165490
申请日：2002-06-07
申请人： Naiqian Han , Jidong Hou , Xiaoping Zhang , Liji Huang , Gaofeng Wang
发明人： Naiqian Han , Jidong Hou , Xiaoping Zhang , Liji Huang , Gaofeng Wang
IPC分类号： H01L2982
CPC分类号： H01S5/18366 , H01S5/0207
摘要： The present invention discloses a tunable optical device. The tunable optical device includes a tuning cavity having a tuning means provided for alternately bonding to at least two different tunable optical cells each comprising a tuning membrane wherein the tuning cavity disposed near the tuning membrane for moving the tuning membrane for tuning one of the at least two tunable optical cells bonded thereon. In a preferred embodiment, the tuning cavity further includes a first electrode disposed on the tuning membrane and a second electrode disposed on a substrate supporting the tuning cavity for applying a voltage to move the tuning membrane. In a preferred embodiment, the optical device further includes an optical device control circuit connected to the tuning means for controlling and moving the tuning membrane. In a preferred embodiment, the tuning cavity further includes through hole along an optical path for an optical transmission passing through the tunable membrane for providing an interface-free and ripple-free optical path for the optical transmission. In a preferred embodiment, the tunable optical cells constitute an optical filter for bonding to the tuning cavity and tunable by moving the tunable membrane. In a preferred embodiment, the tunable optical cells constitute an optical attenuator for bonding to the tuning cavity and tunable by moving the tunable membrane. In a preferred embodiment, the tunable optical cells constitute an optical switch for bonding to the tuning cavity and tunable by moving the tunable membrane. In a preferred embodiment, the tunable optical cells constitute an optical dispersion compensator for bonding to the tuning cavity and tunable by moving the tunable membrane. In a preferred embodiment, the optical device constitutes a micro-electro-mechanical system (MEMS) optical device manufactured by applying a micro-electro-mechanical system (MEMS) technology.

7. 发明申请

US20140165099A1 INPUT METHOD, SMART TV AND SMART INTERACTION SYSTEM 有权
标题翻译：输入法，智能电视和智能互动系统
公开(公告)号：US20140165099A1
公开(公告)日：2014-06-12
申请号：US14233443
申请日：2012-06-29
申请人： Xiaoping Zhang , Zhepeng Wang
发明人： Xiaoping Zhang , Zhepeng Wang
IPC分类号： H04N21/422
CPC分类号： H04N21/42218 , G06F3/04886 , H04N5/4403 , H04N5/44591
摘要： The present invention provides an input method, a smart TV and a smart interaction system. The input method comprises: displaying a virtual keyboard having a key layout corresponding to that of a physical keyboard used for inputting to a smart TV; obtaining from the physical keyboard a first signal that is generated in response to an operator selecting a physical key on the physical keyboard and indicates information on position of the operator on the physical keyboard; and displaying on the virtual keyboard the position of the operator based on the first signal. The physical keyboard is consistent with the virtual keyboard displayed on the smart TV. Thus, each physical key on the physical keyboard can be found in the virtual keyboard. When a physical key on the physical keyboard is selected or triggered, the input process can be viewed visually on the smart TV. In this way, the input speed can be increased and the user experience can be improved.
摘要翻译：本发明提供一种输入方法，智能电视和智能交互系统。输入方法包括：将具有与用于输入的物理键盘的键布局相对应的键布局的虚拟键盘显示到智能电视机; 从物理键盘获得响应于操作者选择物理键盘上的物理键而产生的第一信号，并且指示操作者在物理键盘上的位置的信息; 以及基于所述第一信号在所述虚拟键盘上显示所述操作者的位置。物理键盘与智能电视机上显示的虚拟键盘一致。因此，可以在虚拟键盘中找到物理键盘上的每个物理键。当选择或触发物理键盘上的物理键时，可以在智能电视机上视觉上观看输入过程。以这种方式，可以提高输入速度并提高用户体验。

8. 发明申请

US20130302249A1 INTESTINAL PEPTIDE TARGETING LIGANDS 有权
公开(公告)号：US20130302249A1
公开(公告)日：2013-11-14
申请号：US13879205
申请日：2011-10-14
申请人： Patrick J. Sinko , Xiaoping Zhang , Zoltan Szekely
发明人： Patrick J. Sinko , Xiaoping Zhang , Zoltan Szekely
IPC分类号： C07K7/06 , A61K47/48 , A61K45/06 , C07K7/08
CPC分类号： C07K7/08 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/62 , A61K47/6925 , C07K7/06
摘要： Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed.

9. 发明申请

US20130072447A1 ENHANCED ORAL TRANSCOMPARTMENTAL DELIVERY OF THERAPEUTIC OR DIAGANOSTIC AGENTS 审中-公开
标题翻译：治疗或诊断药物的加强口服转运
公开(公告)号：US20130072447A1
公开(公告)日：2013-03-21
申请号：US13471083
申请日：2012-05-14
申请人： Srinivasan Ramanathan , Stanley Stein , Michael Leibowitz , Patrick J. Sinko , Tamara Minko , Gregory C. Williams , Goubao Zhang , Xiaoping Zhang , Shahrair Pooyan , Seong Hee Park , Bo Qiu , Pankaj Paranjpe
发明人： Srinivasan Ramanathan , Stanley Stein , Michael Leibowitz , Patrick J. Sinko , Tamara Minko , Gregory C. Williams , Goubao Zhang , Xiaoping Zhang , Shahrair Pooyan , Seong Hee Park , Bo Qiu , Pankaj Paranjpe
IPC分类号： A61K47/48 , A61K38/08 , A61K47/34
CPC分类号： A61K38/08 , A61K47/60 , A61K47/62 , A61K47/665 , B82Y5/00
摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
摘要翻译：本发明涉及通过施用以下缀合物之一将治疗剂或诊断剂从一个身体隔室递送至一个或多个其它身体隔室的药物组合物和方法：具有多个官能团的聚合物，其中至少一个共价结合至少一种与治疗剂或诊断剂共价结合的细胞摄取促进剂; 或与其结合的聚合物和至少一种细胞摄取促进剂; 所述聚合物还包含多个官能团，其中至少一个与治疗剂或诊断剂共价结合。

10. 发明申请

US20120301460A1 SUBCUTANEOUSLY ADMINISTERED ANTI-IL-6 RECEPTOR ANTIBODY 有权
标题翻译：免疫应答的抗IL-6受体抗体
公开(公告)号：US20120301460A1
公开(公告)日：2012-11-29
申请号：US13290366
申请日：2011-11-07
申请人： Min Bao , Olivier Alfred Harari , Angelika M. Jahreis , Johannes F. Schmidt , Xiaoping Zhang
发明人： Min Bao , Olivier Alfred Harari , Angelika M. Jahreis , Johannes F. Schmidt , Xiaoping Zhang
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00
CPC分类号： A61K31/573 , A61K9/0019 , A61K38/47 , A61K39/39533 , A61K39/3955 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2300/00 , C07K16/2866 , C07K2317/24 , C07K2317/76 , C07K2317/94 , C12Y302/01035
摘要： The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.
摘要翻译：本申请公开了用于治疗IL-6介导的病症的方法，例如类风湿性关节炎（RA），幼年特发性关节炎（JIA），系统性JIA（sJIA），多关节病JIA（pcJIA），系统性硬化症或巨细胞性动脉炎 GCA），其具有结合白细胞介素-6受体（抗IL-6R抗体）的皮下施用的抗体。特别地，其涉及固定剂量的抗IL-6R抗体的鉴定。托美珠单抗，其对于IL-6介导的病症患者的皮下给药是安全和有效的。此外，公开了可用于皮下施用抗IL-6R抗体的制剂和装置。

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