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1. 发明授权

US11504712B2 Fluid device and fluid control system 有权
公开(公告)号：US11504712B2
公开(公告)日：2022-11-22
申请号：US16772093
申请日：2017-12-28
申请人： NIKON CORPORATION
发明人： Naoya Ishizawa , Taro Ueno , Ryo Kobayashi , Tetsuomi Takasaki
IPC分类号： B01L3/00
摘要： A fluid device includes a substrate and a gas-liquid separating filter, the substrate has a flow path through which a solution flows, a reservoir, in which the solution is accommodated, connected to the flow path, an injection hole configured to connect the reservoir to the outside, and an air introduction hole branched off from the injection hole and connected to the outside, and the gas-liquid separating filter is disposed in a path of the air introduction hole, allows passage of a gas flowing through the air introduction hole, and prevents passage of a liquid flowing through the air introduction hole.

2. 发明授权

US10301682B2 Fluidic device, exosome analysis method, biomolecule analysis method, and biomolecule detection method 有权
公开(公告)号：US10301682B2
公开(公告)日：2019-05-28
申请号：US15080266
申请日：2016-03-24
申请人： The University of Tokyo , Nikon Corporation
发明人： Takanori Ichiki , Masashi Kobayashi , Ayako Hayashi , Shoichi Tsuchiya , Takanori Akagi , Taro Ueno , Takashi Funatsu , Kenji Miyamoto
IPC分类号： C12Q1/6886 , G01N33/53 , B01L3/00 , C12Q1/6806
摘要： The present invention provides a fluidic device, an exosome analysis method, a biomolecule analysis method, and a biomolecule detection method, which can analyze even the content of an exosome in a series of flows by introducing a sample into the device. A fluidic device of the present invention is a fluidic device which detects a biomolecule contained in an exosome in a sample, and includes: an exosome purification unit which has a layer modified with a compound having a hydrophobic chain and a hydrophilic chain; a biomolecule purification unit; a biomolecule detection unit; a first flow path which connects the exosome purification unit to the biomolecule purification unit; and a second flow path which connects the biomolecule purification unit to the biomolecule detection unit.

3. 发明申请

US20190134860A1 FLUIDIC DEVICE, METHOD OF MANUFACTURING FLUIDIC DEVICE, AND VALVE FOR FLUIDIC DEVICE 审中-公开
公开(公告)号：US20190134860A1
公开(公告)日：2019-05-09
申请号：US16241684
申请日：2019-01-07
申请人： NIKON CORPORATION
发明人： Naoya ISHIZAWA , Taro Ueno , Masaaki Tanabe
IPC分类号： B29C39/04 , B29C39/26
摘要： A method of manufacturing a fluidic device includes molding either one of the base member and the valve part with a first mold; and molding the other one of the base member and the valve part with a second mold with respect to the molded base member or the molded valve part.

4. 发明申请

US20150051105A1 NUCLEIC ACID DETECTION METHOD, DETECTION PROBE, DETECTION PROBE SET, AND NUCLEIC ACID QUANTIFICATION METHOD 有权
标题翻译：核酸检测方法，检测探针，检测探针组和核酸定量方法
公开(公告)号：US20150051105A1
公开(公告)日：2015-02-19
申请号：US14510282
申请日：2014-10-09
申请人： The University of Tokyo , Nikon Corporation
发明人： Taro Ueno , Takashi Funatsu , Takanori Ichiki , Hirofumi Shiono
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6834 , C12Q1/6837 , C12Q2600/178 , C12Q2521/501 , C12Q2525/301 , C12Q2565/519
摘要： A method for detecting a target nucleic acid, comprising: (a) contacting a nucleic acid sample comprising a target nucleic acid, comprising a first portion and a second portion, with: (i) a detection probe, wherein the detection probe is labeled with a labeling substance and comprises a nucleic acid sequence that forms a stem-loop structure and having a 5′ protruding end or a 3′ protruding end that is capable of hybridizing to the second portion, and (ii) a capture probe comprising a nucleic acid sequence capable of hybridizing to the first portion, wherein the capture probe is immobilized to a substrate, under conditions to form a target nucleic acid-detection probe-capture probe complex by hybridizing the second portion to the detection probe and hybridizing the first portion to the capture probe; (b) ligating a first end of the detection probe with an end of the target nucleic acid and ligating a second end of the detection probe with an end of the capture probe; and (c) detecting the labeling substance of the nucleic acid-detection probe-capture probe complex formed on the substrate.
摘要翻译：一种检测靶核酸的方法，包括：（a）将包含第一部分和第二部分的靶核酸的核酸样品与以下物质接触：（i）检测探针，其中所述检测探针用标记物质，并且包含形成茎 - 环结构并具有能够与第二部分杂交的5'突出端或3'突出端的核酸序列，和（ii）包含核酸的捕获探针能够与第一部分杂交的序列，其中捕获探针固定在底物上，条件是通过将第二部分与检测探针杂交形成靶核酸检测探针 - 捕获探针复合体，并将第一部分与捕获探针（b）将检测探针的第一端与靶核酸的末端连接，并将检测探针的第二末端与捕获探针的末端连接; 和（c）检测形成在基板上的核酸检测探针 - 捕获探针复合体的标记物质。

5. 发明授权

US11642818B2 Fluidic device, method of manufacturing fluidic device, and valve for fluidic device 有权
公开(公告)号：US11642818B2
公开(公告)日：2023-05-09
申请号：US16241684
申请日：2019-01-07
申请人： NIKON CORPORATION
发明人： Naoya Ishizawa , Taro Ueno , Masaaki Tanabe
IPC分类号： B29C39/04 , B29C39/26 , B01J19/00 , G01N37/00 , B01L3/00 , B81C99/00
CPC分类号： B29C39/04 , B01J19/00 , B01L3/502738 , B29C39/26 , B81C99/0085 , G01N37/00 , B01L3/502707 , B01L2200/0689 , B01L2300/0887 , B01L2400/049 , B01L2400/0481 , B01L2400/0487 , B01L2400/0672 , B81B2201/054 , B81C2201/034
摘要： A method of manufacturing a fluidic device includes molding either one of the base member and the valve part with a first mold; and molding the other one of the base member and the valve part with a second mold with respect to the molded base member or the molded valve part.

6. 发明授权

US11642636B2 Solution mixer, fluidic device, and solution mixing method 有权
公开(公告)号：US11642636B2
公开(公告)日：2023-05-09
申请号：US16216299
申请日：2018-12-11
申请人： The University of Tokyo , Nikon Corporation
发明人： Takanori Ichiki , Taro Ueno , Shoichi Tsuchiya , Masashi Kobayashi , Kenji Miyamoto
IPC分类号： B01F25/54 , B01F23/451 , B01F25/51 , B01F33/30 , B01F35/75 , G01N1/38 , G01N35/00 , B01L3/00
CPC分类号： B01F25/54 , B01F23/451 , B01F25/51 , B01F33/30 , B01F35/7547 , B01L3/5027 , B01L2300/0867 , G01N2001/386 , G01N2035/00158
摘要： A solution mixer comprising: a main flow path in which a solution circulates; at least one solution introduction flow path connected to the main flow path; and at least one solution discharge flow path connected to the main flow path, wherein the solution discharge flow path has at least one solution discharge flow path valve, and wherein the main flow path has at least one main flow path valve.

7. 发明授权

US11192106B2 Fluidic device, system, method of detecting sample material and method of purifying sample material 有权
公开(公告)号：US11192106B2
公开(公告)日：2021-12-07
申请号：US16209857
申请日：2018-12-04
申请人： Nikon Corporation
发明人： Ryo Kobayashi , Keiji Mitsui , Taro Ueno , Hirofumi Shiono
IPC分类号： B01L3/00 , G01N1/34 , C12Q1/68 , B01J19/00 , G01N35/08 , B81B7/02 , C12M1/00 , G01N37/00 , B81B1/00 , G01N1/10 , B03C1/00 , B03C1/28 , C12N15/09 , B03C1/01
摘要： A fluidic device includes a first circulation flow path and a second circulation flow path which circulate a solution containing a sample material, the first circulation flow path and the second circulation flow path share at least a part of the flow path, and at least one selected from the group consisting of a capture unit which captures the sample material, a detection unit which detects the sample material, a valve, and a pump is provided on the shared flow path.

8. 发明授权

US10775368B2 Fluidic device, system, and method 有权
公开(公告)号：US10775368B2
公开(公告)日：2020-09-15
申请号：US15679816
申请日：2017-08-17
申请人： The University of Tokyo , NIKON CORPORATION
发明人： Takanori Ichiki , Taro Ueno , Ryo Kobayashi , Hirofumi Shiono
IPC分类号： G01N33/543 , B01F5/10 , B01F13/00 , B01L3/00 , C12Q1/6834
摘要： A fluidic device includes: a circulation flow path; and a capture part arranged on the circulation flow path and configured to capture a sample substance in a solution and/or a detection part arranged on the circulation flow path and configured to detect a sample substance in a solution. A method of capturing a sample substance that is bound to a carrier particle, using a fluidic device which includes a circulation flow path and a capture part arranged on the circulation flow path and configured to capture the carrier particle and in which the circulation flow path has two or more circulation flow path valves, includes: an introduction step of, in a state where the circulation flow path valve is closed, introducing a solution that includes a sample substance to at least one of partitions partitioned by the circulation flow path valve and introducing a solution that includes a carrier particle which is bound to the sample substance to at least another of the partitions; a mix step of opening all of the circulation flow path valves and circulating and mixing a solution in the circulation flow path; and a capture step of capturing the carrier particle by the capture part.

9. 发明申请

US20190111429A1 FLUIDIC DEVICE, SYSTEM, METHOD OF DETECTING SAMPLE MATERIAL AND METHOD OF PURIFYING SAMPLE MATERIAL 审中-公开
公开(公告)号：US20190111429A1
公开(公告)日：2019-04-18
申请号：US16209857
申请日：2018-12-04
申请人： Nikon Corporation
发明人： Ryo KOBAYASHI , Keiji Mitsui , Taro Ueno , Hirofumi Shiono
IPC分类号： B01L3/00 , G01N1/34 , B03C1/01 , B03C1/28 , B81B1/00
摘要： A fluidic device includes a first circulation flow path and a second circulation flow path which circulate a solution containing a sample material, the first circulation flow path and the second circulation flow path share at least a part of the flow path, and at least one selected from the group consisting of a capture unit which captures the sample material, a detection unit which detects the sample material, a valve, and a pump is provided on the shared flow path.

10. 发明授权

US11369959B2 Fluidic device 有权
公开(公告)号：US11369959B2
公开(公告)日：2022-06-28
申请号：US16771174
申请日：2017-12-13
申请人： NIKON CORPORATION
发明人： Ryo Kobayashi , Naoya Ishizawa , Taro Ueno
IPC分类号： B01L3/00 , G01N35/08
摘要： The present invention aims at providing a fluidic device that can hold a large amount of solutions in a reservoir without depending on an attitude. The reservoir includes a meandering flow path including: a plurality of first flow paths that extend linearly along a first direction and that are arranged to be spaced in a second direction crossing the first direction; and a second flow path that extends linearly along the second direction such that a connection between first end sides of the adjacent first flow paths and a connection between second end sides of the adjacent first flow paths are alternately switched along the second direction for each first flow path, wherein the meandering flow path meanders along the second direction. When the length of each of the first flow path and the second flow path is L, a surface tension is γ, the density of the solution is ρ, the acceleration which includes a gravity and which is applied to the solution is G, the wetted perimeter length of the first flow path and the second flow path is Wp, a cross-sectional area of the first flow path and the second flow path is A, a receding contact angle is α, and an advancing contact angle is β, a relationship L≤(γ×Wp×(cos α−cos β))/(ρ×A×G) is satisfied.

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