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1. 发明授权

US08412307B2 System and method for marking an anatomical structure in three-dimensional coordinate system 有权
标题翻译：用于在三维坐标系中标记解剖结构的系统和方法
公开(公告)号：US08412307B2
公开(公告)日：2013-04-02
申请号：US11223513
申请日：2005-09-09
申请人： N. Parker Willis , Alex Brisken , Jinglin Zeng , Marsha Hurd
发明人： N. Parker Willis , Alex Brisken , Jinglin Zeng , Marsha Hurd
IPC分类号： A61B5/04
CPC分类号： A61B5/06 , A61B5/0422 , A61B5/6855 , A61B5/6856 , A61B5/6858 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/543 , A61B18/1492 , A61B2017/00106 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61N2007/0078
摘要： The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
摘要翻译：本发明是使用一个或多个超声参考导管使用三角测量原理在患者心脏内建立固定的三维坐标系的装置定位系统。坐标系在视频监视器上以三维图形化地表示，并且帮助临床医生引导其他具有超声波换能器的医疗设备，通过身体到需要进行临床程序的位置。在根据本发明的系统的一个实施例中，该系统用于心脏中，以帮助医师将用于测量电活动的导管和用于将心脏组织的选定区域烧蚀的消融导管映射到心脏内的所需位置。

2. 发明授权

US06970733B2 System and method for electrode localization using ultrasound 失效
标题翻译：使用超声波电极定位的系统和方法
公开(公告)号：US06970733B2
公开(公告)日：2005-11-29
申请号：US10273468
申请日：2002-10-21
申请人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
发明人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
IPC分类号： A61B5/042 , A61B5/06 , A61B8/08 , A61B8/12 , A61B18/14 , A61B5/04
CPC分类号： A61B5/06 , A61B5/0422 , A61B5/6855 , A61B5/6856 , A61B5/6858 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/543 , A61B18/1492 , A61B2017/00106 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61N2007/0078
摘要： The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
摘要翻译：本发明是使用一个或多个超声参考导管使用三角测量原理在患者心脏内建立固定的三维坐标系的装置定位系统。坐标系在视频监视器上以三维图形化地表示，并且帮助临床医生引导其他具有超声波换能器的医疗设备，通过身体到需要进行临床程序的位置。在根据本发明的系统的一个实施例中，该系统用于心脏中，以帮助医师将用于测量电活动的导管和用于将心脏组织的选定区域烧蚀的消融导管映射到心脏内的所需位置。

3. 发明授权

US06216027B1 System for electrode localization using ultrasound 失效
标题翻译：超声波电极定位系统
公开(公告)号：US06216027B1
公开(公告)日：2001-04-10
申请号：US08991556
申请日：1997-12-16
申请人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
发明人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
IPC分类号： A61B800
CPC分类号： A61B5/06 , A61B5/0422 , A61B5/6855 , A61B5/6856 , A61B5/6858 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/543 , A61B18/1492 , A61B2017/00106 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61N2007/0078
摘要： The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
摘要翻译：本发明是使用一个或多个超声参考导管使用三角测量原理在患者心脏内建立固定的三维坐标系的装置定位系统。坐标系在视频监视器上以三维图形化地表示，并且帮助临床医生引导其他具有超声波换能器的医疗设备，通过身体到需要进行临床程序的位置。在根据本发明的系统的一个实施例中，该系统用于心脏中，以帮助医师将用于测量电活动的导管和用于将心脏组织的选定区域烧蚀的消融导管映射到心脏内的所需位置。

4. 发明授权

US06490474B1 System and method for electrode localization using ultrasound 失效
标题翻译：使用超声波电极定位的系统和方法
公开(公告)号：US06490474B1
公开(公告)日：2002-12-03
申请号：US08905090
申请日：1997-08-01
申请人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
发明人： N. Parker Willis , Axel Brisken , Jinglin Zeng , Marsha Hurd
IPC分类号： A61B504
CPC分类号： A61B5/06 , A61B5/0422 , A61B5/6855 , A61B5/6856 , A61B5/6858 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/543 , A61B18/1492 , A61B2017/00106 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61N2007/0078
摘要： The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
摘要翻译：本发明是使用一个或多个超声参考导管使用三角测量原理在患者心脏内建立固定的三维坐标系的装置定位系统。坐标系在视频监视器上以三维图形化地表示，并且帮助临床医生引导其他具有超声波换能器的医疗设备，通过身体到需要进行临床程序的位置。在根据本发明的系统的一个实施例中，该系统用于心脏中，以帮助医师将用于测量电活动的导管和用于将心脏组织的选定区域烧蚀的消融导管映射到心脏内的所需位置。

5. 发明授权

US07633502B2 System and method for graphically representing anatomical orifices and vessels 有权
标题翻译：用于图形化地表示解剖孔和血管的系统和方法
公开(公告)号：US07633502B2
公开(公告)日：2009-12-15
申请号：US10850357
申请日：2004-05-19
申请人： N. Parker Willis , Ren-Her Hwang , Jinglin Zeng
发明人： N. Parker Willis , Ren-Her Hwang , Jinglin Zeng
IPC分类号： G06T17/00
CPC分类号： A61B5/0422 , A61B5/06 , A61B5/064 , A61B8/0833 , A61B8/0883 , A61B8/0891 , A61B18/1492 , A61B34/20 , A61B90/36 , A61B2017/00053 , A61B2018/00839 , A61B2034/102 , A61B2034/105 , A61B2034/2063 , G06T17/00 , G06T2210/41
摘要： Methods and systems are provided for generating graphical representations of orifices and vessels. One method comprises generating a representation of the surface (e.g., an endocardial surface) within a coordinate system, and laterally moving the distal end of an elongated probe within an orifice (e.g., a valve or a vessel ostium) associated with the surface. The method further comprises defining line segments within the coordinate system while the probe distal end is moved within the orifice, wherein each of the line segments represents the probe distal end. The method further comprises defining intersection points within the coordinate system, wherein each of the points represents an intersection of one of the line segments and the surface representation. Lastly, the method comprises graphically generating a representation of the orifice based on the intersection points, e.g., by forming the orifice representation around the intersection points. Another method comprises moving the distal end of an elongated probe within the vessel, defining line segments within a coordinate system while the probe distal end is moved within the vessel, wherein each of the line segments represents the probe distal end, and graphically generating a representation of the vessel based on the line segments.
摘要翻译：提供了用于产生孔和容器的图形表示的方法和系统。一种方法包括产生坐标系统内的表面（例如，心内膜表面）的表示，以及在与表面相关联的孔口（例如，阀或血管口）内横向移动细长探针的远端。所述方法还包括在所述探针远端在所述孔口内移动的同时在所述坐标系统内限定线段，其中所述线段中的每一个代表所述探针远端。该方法还包括定义坐标系内的交点，其中每个点表示线段和表面表示之一的交点。最后，该方法包括基于交点图形地生成孔口的表示，例如通过在交点附近形成孔口表示。另一种方法包括在血管内移动细长探针的远端，在探针远端在血管内移动时在坐标系内限定线段，其中每个线段表示探针远端，并以图形方式产生表示基于线段的船舶。

6. 发明授权

US5813991A Endocardial mapping system and method 失效
标题翻译：心内膜测绘系统及方法
公开(公告)号：US5813991A
公开(公告)日：1998-09-29
申请号：US842942
申请日：1997-04-25
申请人： N. Parker Willis , Marsha Hurd , Donald Chin
发明人： N. Parker Willis , Marsha Hurd , Donald Chin
IPC分类号： A61N1/37 , A61B55/04
CPC分类号： A61N1/37
摘要： Endocardial system and method in which noise and artifacts introduced by a simulator are decoupled from a recorder by connecting the stimulator to the electrodes used for pacing and recording only when it is necessary to do so. At other times, the stimulator is disconnected, and low level signals are recorded without interference from the stimulator. In one embodiment, the stimulator is connected only during the time the pacing pulse is being delivered. In another, a stimulator which delivers pacing pulses in response to intrinsic activation of tissue at the pacing site is connected during delivery of a pacing pulse, disconnected during the measurement period which follows, and then reconnected so that it can sense further intrinsic activity and deliver another pacing pulse.
摘要翻译：通过将刺激器连接到仅用于起搏和记录的电极的情况下，通过将仿真器引入的噪声和伪像与记录器分离的心内膜系统和方法，仅在需要时才进行。在其他时间，刺激器断开，低电平信号被记录而不受刺激器的干扰。在一个实施例中，刺激器仅在起搏脉冲被输送的时间期间连接。另一方面，响应于起搏部位的组织的内在活化而产生起搏脉冲的刺激器在递送起搏脉冲期间连接，在随后的测量期间断开连接，然后重新连接，使得其可以感测到进一步的内在活动和递送另一个起搏脉冲。

7. 发明授权

US06950689B1 Dynamically alterable three-dimensional graphical model of a body region 有权
标题翻译：身体区域的动态变化三维图形模型
公开(公告)号：US06950689B1
公开(公告)日：2005-09-27
申请号：US09128304
申请日：1998-08-03
申请人： N. Parker Willis , Jinglin Zeng , James A. Quarato
发明人： N. Parker Willis , Jinglin Zeng , James A. Quarato
IPC分类号： A61B19/00 , A61B5/042 , A61B5/107 , A61B8/00 , A61B8/12 , A61B17/00 , A61B18/12 , A61B5/00
CPC分类号： A61B5/0422 , A61B6/541 , A61B8/12 , A61B8/4245 , A61B8/445 , A61B34/10 , A61B2017/00053 , A61B2017/00243 , Y10S128/92 , Y10S128/922
摘要： The present invention is a system and method for graphically displaying a three-dimensional model of a region located within a living body. A three-dimensional model of a region of interest is displayed on a graphical display. The location in three-dimensional space of a physical characteristic (e.g. a structure, wall or space) in the region of interest is determined using at least one probe positioned within the living body. The graphical display of the model is deformed to approximately reflect the determined three-dimensional location of the physical characteristic. Preferably, the probe or probes are moved throughout the region of interest so as to gather multiple data points that can be used to increase the conformity between the graphical display and the actual region of interest within the patient.
摘要翻译：本发明是用于图形显示位于生物体内的区域的三维模型的系统和方法。感兴趣区域的三维模型显示在图形显示器上。使用定位在生物体内的至少一个探针来确定感兴趣区域中的物理特性（例如，结构，壁或空间）的三维空间中的位置。模型的图形显示被变形以近似地反映所确定的物理特征的三维位置。优选地，探针或探针在整个感兴趣区域移动，以便收集可用于增加图形显示和患者内感兴趣的实际感兴趣区域之间的一致性的多个数据点。

8. 发明授权

US08718773B2 Optimizing energy transmission in a leadless tissue stimulation system 有权
标题翻译：优化无铅组织刺激系统中的能量传递
公开(公告)号：US08718773B2
公开(公告)日：2014-05-06
申请号：US11752775
申请日：2007-05-23
申请人： N. Parker Willis , Axel F. Brisken , Mark W. Cowan , Michael Pare , Robert Fowler , James Brennan
发明人： N. Parker Willis , Axel F. Brisken , Mark W. Cowan , Michael Pare , Robert Fowler , James Brennan
IPC分类号： A61N1/18 , A61N1/378
CPC分类号： A61N1/3787 , A61N1/37217 , A61N1/37235 , A61N1/3756
摘要： Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.
摘要翻译：公开了用于优化可植入装置中的声能传输的方法和系统。传感器元件将声学定位器信号传送到接收器组件，并且接收器用位置信号进行响应。位置信号可以显示与接收机的位置有关的信息和由接收机接收的所发送的声波的效率。该信息使发射机能够瞄准接收机并优化发射机和接收机之间的声能传输。能量可用于治疗目的，例如刺激组织或用于诊断目的。

9. 发明授权

US08588926B2 Implantable wireless accoustic stimulators with high energy conversion efficiencies 有权
公开(公告)号：US08588926B2
公开(公告)日：2013-11-19
申请号：US13734680
申请日：2013-01-04
申请人： David F. Moore , Paul Mohr , N. Parker Willis , Axel F. Brisken
发明人： David F. Moore , Paul Mohr , N. Parker Willis , Axel F. Brisken
IPC分类号： A61N1/375
CPC分类号： A61N1/3787 , A61B2560/0214 , A61N1/02 , A61N1/05 , A61N1/362 , A61N1/37205 , A61N1/3756 , A61N1/3758 , H01L41/113 , H01L41/25 , H02N2/181 , H02N2/186 , H02N2/188 , Y10T29/42
摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

10. 发明授权

US07720520B2 Method and system for registering an image with a navigation reference catheter 有权
标题翻译：用于使用导航参考导管注册图像的方法和系统
公开(公告)号：US07720520B2
公开(公告)日：2010-05-18
申请号：US11002399
申请日：2004-12-01
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61B5/05 , A61B8/14 , A61B5/04 , A61B6/00
CPC分类号： A61B8/0833 , A61B5/0422 , A61B5/743 , A61B6/12 , A61B6/503 , A61B6/5247 , A61B8/0841 , A61B8/0883 , A61B8/463 , A61B8/5238 , A61B90/36 , A61B2090/364 , A61B2090/3929 , G06F19/00
摘要： Methods and systems for processing and/or superimposing a medical image of an anatomical body (e.g., a heart) with graphical information are provided. Reference elements and/or reference catheter are placed in contact with the anatomical body. A physical structure within a navigational coordinate system is located using the reference elements and/or reference catheter. An image reference within an image coordinate corresponding to the physical structure is located. Location of the image reference can be accomplished, e.g., by displaying the medical image and electronically marking the displayed image reference, or by automatically locating image data corresponding to the image reference. The navigational and image coordinate systems are then registered based on the location of the physical structure within the navigational coordinate system and the location of the image reference within the image coordinate system, which allows graphical information to be accurately merged with the medical image data.
摘要翻译：提供了用于利用图形信息处理和/或叠加解剖体（例如，心脏）的医学图像的方法和系统。参考元件和/或参考导管被放置成与解剖体接触。使用参考元件和/或参考导管定位导航坐标系内的物理结构。位于与物理结构相对应的图像坐标内的图像参考。图像参考的位置可以例如通过显示医学图像和电子地标记所显示的图像参考，或者通过自动定位对应于图像参考的图像数据来实现。然后基于导航坐标系中的物理结构的位置和图像坐标系中的图像参考的位置来登记导航和图像坐标系，其允许图形信息与医学图像数据精确地合并。

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