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1. 发明申请

US20050271725A1 Adhesive gel composition for iontophoresis preparation and process for producing the same 审中-公开
标题翻译：用于离子电渗疗法制备的粘合剂凝胶组合物及其制备方法
公开(公告)号：US20050271725A1
公开(公告)日：2005-12-08
申请号：US10525531
申请日：2003-08-30
申请人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
发明人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
IPC分类号： A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/04 , A61N1/30 , A61P5/44 , A61K9/14
CPC分类号： A61N1/0428 , A61K9/0009 , A61K9/0014 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/0444 , A61N1/0496
摘要： The present invention provides an adhesive gel composition for iontophoretic formulations which is useful for the application through the skin or the mucosa, which excels in all of drug absorption, drug stability, gel shape retention and gel adhesion, which is easy to prepare and fill at the time of production, and which can be produced at low costs and a method for producing the same. The adhesive gel composition for iontophoretic formulations is produced by mixing an ionic synthetic polymer(s), a nonionic synthetic polymer(s), a naturally-occurring polymer(s), a polyhydric alcohol(s), a crosslinking agent(s) and a drug(s). In the production of the adhesive gel composition for iontophoretic formulations, oxygen dissolved in the gel is positively removed by carrying out replacement with nitrogen and/or vacuum kneading at the time of the ingredients are mixed and kneaded.
摘要翻译：本发明提供了一种用于离子电渗疗法制剂的粘合性凝胶组合物，其可用于通过皮肤或粘膜的应用，其在药物吸收，药物稳定性，凝胶形状保留和凝胶粘附方面均优异，易于制备和填充生产时间，可以以低成本制造的方法及其制造方法。用于离子电渗疗法制剂的粘合凝胶组合物通过将离子合成聚合物，非离子合成聚合物，天然存在的聚合物，多元醇，交联剂和一种药物。在用于离子电渗疗法制剂的粘合剂凝胶组合物的制备中，通过在混合和捏合成分时，用氮气和/或真空捏合进行置换，可以有效地去除溶解在凝胶中的氧气。

2. 发明申请

US20050085860A1 Transdermal/transmucosal preparations for electroporation 审中-公开
标题翻译：用于电穿孔的透皮/透粘膜制剂
公开(公告)号：US20050085860A1
公开(公告)日：2005-04-21
申请号：US10501946
申请日：2003-01-20
申请人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/70 , A61K31/05 , A61K31/155 , A61K31/192 , A61K31/196 , A61K31/375 , A61K47/36 , A61N1/30 , A61P25/04 , A61P39/06 , A61P43/00
CPC分类号： A61N1/30
摘要： A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).
摘要翻译：提供了用于电穿孔的经皮或经粘膜给药的制剂，其能够有效施用待给药的化合物例如药物。透皮或经粘膜给药用于电穿孔的制剂包括其中分散有固体或半固体形式的基质中的待给药化合物（生理活性物质）如药物的药物储存器（11），背衬（12）保持药物储存器和设置在药物储存器（11）上的一对用于电穿孔的电极（13）。粘合剂层（14）设置在背衬（12）的凸缘部分上。绝缘层（15）设置在用于电穿孔（13）的电极的至少一部分上，接触除了药物储存器（11）上的部分之外的施用部位。

3. 发明申请

US20050169976A1 Insulin administration apparatus 审中-公开
标题翻译：胰岛素给药装置
公开(公告)号：US20050169976A1
公开(公告)日：2005-08-04
申请号：US10510694
申请日：2003-03-28
申请人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/08 , A61K9/10 , A61K38/28 , A61K47/32 , A61K47/36 , A61M1/36 , A61N1/30 , A61N1/32 , A61P3/10
CPC分类号： A61N1/0416 , A61K38/28 , A61N1/0424 , A61N1/0432 , A61N1/044 , A61N1/30 , A61N1/327
摘要： The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.
摘要翻译：本发明提供了能够通过经皮或粘膜下给药途径有效施用胰岛素的胰岛素给药装置。本发明的装置用于使用离子电渗疗法和电穿孔来经皮或经粘膜内施用由下述结构式表示的赖脯胰岛素或其药学上可接受的盐。

4. 发明申请

US20070123837A1 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US20070123837A1
公开(公告)日：2007-05-31
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8。平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够输送药物的多个开口7，该开口分别与突起相对应地布置。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

5. 发明授权

US08275454B2 Iontophoresis device activated in use 有权
标题翻译：离子渗透装置在使用中激活
公开(公告)号：US08275454B2
公开(公告)日：2012-09-25
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

6. 发明申请

US20110152743A1 IONTOPHORESIS DEVICE ACTIVATED IN USE 有权
标题翻译：使用激活的IOPOPHORESIS设备
公开(公告)号：US20110152743A1
公开(公告)日：2011-06-23
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

7. 发明授权

US07914813B2 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US07914813B2
公开(公告)日：2011-03-29
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8.平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够递送分别布置的药物的多个开口7 与预测对应。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

8. 发明申请

US20070129664A1 Electrode chip for biological application and its using method 有权
标题翻译：用于生物应用的电极芯片及其使用方法
公开(公告)号：US20070129664A1
公开(公告)日：2007-06-07
申请号：US10579287
申请日：2004-10-22
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Mitsuru Kuribayashi , Naruhito Higo
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Mitsuru Kuribayashi , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： This invention relates to a technology for preventing leakage of liquid from gel (70). The electrode chip (10) comprises a cup-like support (20) including a cup part (210), and a sheet-like support (30) attached with an electrode layer (40). The gel (70) in the cup part (210) delivers liquid (700) containing water confined at the time of crosslinking. The liquid (700) moves by capillarity from the gel (70) side through a narrow gap between the outer flange (220) of the cup-like support (20) and the outside part (310o) of the sheet-like support (30) in a direction away from the gel (70). Since a groove (80) exists in the vicinity of the cup part (210) and the gap is large at that part, capillarity is broken thereat.
摘要翻译：本发明涉及防止液体从凝胶（70）泄漏的技术。电极芯片（10）包括一个包括一个杯形部分（210）的杯状支撑件（20）和一个安装有电极层（40）的片状支撑件（30）。杯部（210）中的凝胶（70）输送含有交联时限制的水的液体（700）。液体（700）通过毛细管作用从凝胶（70）侧通过杯形支撑件（20）的外凸缘（220）与片状支撑件（310）的外部（310o）之间的窄间隙移动 30）沿远离凝胶（70）的方向。由于在杯部（210）附近存在凹槽（80），并且在该部分处间隙大，所以毛细管损坏。

9. 发明授权

US06654635B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06654635B1
公开(公告)日：2003-11-25
申请号：US09622050
申请日：2000-08-24
申请人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
发明人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/303
摘要： An iontophoresis device, which can ensure the long-term stability of drugs and which can be easily assembled when used, is provided. A donor electrode-printed portion (6) is placed on one side of a backing layer (4), and a reference electrode-printed portion (7) is placed on the other side. Both printed parts are connected to a current generating part (Ia) through a connector (Id). A drug support film (14) is joined to a drug-dissolving portion (11), and a cup-like shaped protective cover (12), which covers the drug support film (14), is removed before the device is used. The exposed drug support film (14) is attached to the skin of a user, and the device is driven by turning on a power supply of the current-generating portion (Ia).
摘要翻译：一种离子电渗疗法装置，其可以确保药物的长期稳定性，并且在使用时可以容易地组装。供体电极印刷部分（6）放置在背衬层（4）的一侧上，另一侧放置参考电极印刷部分（7）。两个印刷部分通过连接器（Id）连接到电流产生部分（Ia）。将药物保护膜（14）与药物溶解部（11）接合，在使用该装置之前，除去覆盖药物保护膜（14）的杯状保护罩（12）。暴露的药物支撑膜（14）附接到使用者的皮肤，并且通过接通电流产生部分（1a）的电源来驱动该装置。

10. 发明申请

US20070264316A1 Patch Activated In Use 审中-公开
标题翻译：补丁激活使用
公开(公告)号：US20070264316A1
公开(公告)日：2007-11-15
申请号：US10584172
申请日：2004-12-27
申请人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
发明人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
IPC分类号： A61F13/02
CPC分类号： A61K9/703 , A61F13/0203 , A61K9/7084
摘要： Provided a patch activated in use capable of uniformly activating a drug by supplying a solution when used. The patch activated in use comprises an absorber 11 containing a dry drug 10 and formed of a material capable of absorbing a liquid, a wall material 13 arranged around the absorber 11 and having an adhesive layer 12 on the lower surface thereof, a support 15 arranged on the absorber 11 and the wall material 13 and having an opening 14 at the center, a diaphragm 20 arranged on the support 15, and a dissolution liquid reservoir 18 arranged on the diaphragm 20, holding a dissolution liquid dissolving the drug in a space with the diaphragm 20 and having a protruding portion 17 which breaks the diaphragm 20 by pressure. The protruding portion 17 has a liner top end portion and arranged in contact or in the proximity with the diaphragm 20. A liner 19 is detachably provided on the lower surface of the absorber 11 and adhesive layer 12.
摘要翻译：提供使用时能够通过在使用时提供溶液来均匀地活化药物的活化片。在使用中活化的贴片包括含有干药10并由能够吸收液体的材料形成的吸收体11，围绕吸收体11排列并且在其下表面上具有粘合层12的壁材13，在吸收器11和壁材料13上，中心具有开口14，设置在支撑体15上的隔膜20和布置在隔膜20上的溶解液储存器18，将溶解药物的溶解液保持在空间中，隔膜20具有突出部分17，其通过压力破坏隔膜20。突出部分17具有衬里顶端部分并且与隔膜20接触或邻近设置。衬垫19可拆卸地设置在吸收体11和粘合剂层12的下表面上。

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