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1. 发明授权

US07056471B1 Ternary and quarternary nanocrystals, processes for their production and uses thereof 有权
标题翻译：三元和三元纳米晶体，其生产和使用的过程
公开(公告)号：US07056471B1
公开(公告)日：2006-06-06
申请号：US10321278
申请日：2002-12-16
申请人： Mingyong Han , Xinhua Zhong , Wolfgang Knoll
发明人： Mingyong Han , Xinhua Zhong , Wolfgang Knoll
IPC分类号： C22C18/00
CPC分类号： C30B7/00 , C30B29/48 , C30B29/605
摘要： The present invention relates to nanocrystals consisting of a homogeneous ternary or quaternary alloy having the composition M11-xM2xA and M11-xM2xAyB1-y, respectively, a process for its production, as well as to uses of such nanocrystals such as as short wavelength light-emitting devices, and in the detection of analytes, in particular biomolecules.
摘要翻译：本发明涉及由均匀的三元或四元合金组成的纳米晶体，其具有组成M1×1-x×M2×A和M1×1-x < 分别为其制备方法，以及这种纳米晶体的使用，例如短的波长发光器件，以及检测分析物，特别是生物分子。

2. 发明申请

US20060110279A1 TERNARY AND QUARTERNARY NANOCRYSTALS, PROCESSES FOR THEIR PRODUCTION AND USES THEREOF 有权
标题翻译：第三季度和第四季度纳米晶体，其生产工艺及其用途
公开(公告)号：US20060110279A1
公开(公告)日：2006-05-25
申请号：US10321278
申请日：2002-12-16
申请人： Mingyong Han , Xinhua Zhong , Wolfgang Knoll
发明人： Mingyong Han , Xinhua Zhong , Wolfgang Knoll
IPC分类号： C22C18/00
CPC分类号： C30B7/00 , C30B29/48 , C30B29/605
摘要： The present invention relates to nanocrystals consisting of a homogeneous ternary or quaternary alloy having the composition M11-xM2xA and M11-xM2xAyB1-y, respectively, a process for its production, as well as to uses of such nanocrystals such as as short wavelength light-emitting devices, and in the detection of analytes, in particular biomolecules.
摘要翻译：本发明涉及由均匀的三元或四元合金组成的纳米晶体，其具有组成M1×1-x×M2×A和M1×1-x < 分别为其制备方法，以及这种纳米晶体的使用，例如短的波长发光器件，以及检测分析物，特别是生物分子。

3. 发明申请

US20120032122A1 METHOD FOR FORMING A CADMIUM CONTAINING NANOCRYSTAL 审中-公开
标题翻译：形成含铌的纳米晶的方法
公开(公告)号：US20120032122A1
公开(公告)日：2012-02-09
申请号：US12672270
申请日：2007-08-06
申请人： Yun Zong , Mingyong Han , Wolfgang Knoll
发明人： Yun Zong , Mingyong Han , Wolfgang Knoll
IPC分类号： H01B1/06 , C01G11/02 , C01B19/04 , B82Y40/00 , B82Y30/00
CPC分类号： C30B29/60 , C30B7/00 , C30B29/48 , C30B29/50
摘要： The present invention provides a method of forming a nanocrystal of the composition CdA, with A being S or Se. The method includes forming in a suitable solvent a solution of cadmium, or a compound thereof, in a form suitable for the generation of a nanocrystal. The solvent includes a compound selected from an ether and an amine. The method further includes bringing the solution to a temperature selected in the range from about 20° C. to about 200° C. The method also includes adding at the temperature selected in the range from about 20° C. to about 200° C. the element A in a form suitable for the generation of a nanocrystal. Thereby the forming of a nanocrystal of the composition CdA is allowed.
摘要翻译：本发明提供一种形成组合物CdA的纳米晶体的方法，其中A为S或Se。该方法包括在合适的溶剂中形成适于产生纳米晶体的形式的镉或其化合物的溶液。溶剂包括选自醚和胺的化合物。该方法还包括使溶液达到在约20℃至约200℃范围内选择的温度。该方法还包括在约20℃至约200℃范围内加入的温度。元素A以适于产生纳米晶体的形式。从而允许形成组合物CdA的纳米晶体。

4. 发明申请

US20110233468A1 PROCESS OF FORMING A CADMIUM AND SELENIUM CONTAINING NANOCRYSTALLINE COMPOSITE AND NANOCRYSTALLINE COMPOSITE OBTAINED THEREFROM 审中-公开
标题翻译：形成包含纳米复合材料的纳米复合材料和纳米复合材料的方法
公开(公告)号：US20110233468A1
公开(公告)日：2011-09-29
申请号：US12672269
申请日：2008-08-06
申请人： Yun Zong , Mingyong Han , Wolfgang Knoll
发明人： Yun Zong , Mingyong Han , Wolfgang Knoll
IPC分类号： C09K11/54 , B82Y20/00
CPC分类号： C09K11/565 , C09K11/883
摘要： Provided is a process of forming a Cd and Se containing nanocrystalline composite. The nanocrystalline composite has a composition of one of (a) Cd, M, Se, (b) Cd, Se, A, and (c) Cd, M, Se, A, with M being an element of group (12) of the PSE other than Cd and A being an element of group (16) of the PSE other than O and Se. In one embodiment in a suitable solvent a solution of the element Cd, or a precursor thereof, and, where applicable, of M, or a precursor thereof is formed. To the solution the element Se and, where applicable, A is added and thereby a reaction mixture formed. The reaction mixture is heated for a sufficient period of time at a temperature suitable for forming the Cd and Se containing nanocrystalline composite and then the reaction mixture is allowed to cool. Finally the Cd and Se containing nanocrystalline composite isolated. In another embodiment the reaction mixture is formed by adding into a suitable solvent the element Cd, or a precursor thereof, Se, where applicable M and where applicable A. In this embodiment the reaction mixture is heated and water formed during the process is being removed.
摘要翻译：提供了形成含Cd和Se的纳米晶复合材料的方法。纳米晶复合物具有（a）Cd，M，Se，（b）Cd，Se，A和（c）Cd，M，Se，A中的一种的组成，M是组（12）的元素除了Cd和A之外的PSE是除了O和Se之外的PSE的组（16）的元素。在一个实施方案中，在合适的溶剂中，形成元素Cd或其前体，以及适用的M或其前体的溶液。向溶液中加入元素Se和（如适用）A，形成反应混合物。将反应混合物在适于形成含Cd和Se的纳米晶复合材料的温度下加热足够的时间，然后使反应混合物冷却。最后分离Cd和Se纳米晶复合物。在另一个实施方案中，反应混合物通过在合适的溶剂中加入元素Cd或其前体Se，在适用的情况下加入，并且在适用的情况下，在适用的情况下，A形成。在该实施方案中，将反应混合物加热并在该过程中形成水。

5. 发明申请

US20050255629A1 Biomimetic approach to low-cost fabrication of complex nanostructures of metal oxides by natural oxidation at low-temperature 失效
标题翻译：在低温下通过自然氧化低成本地制造金属氧化物的复杂纳米结构的生物模拟方法
公开(公告)号：US20050255629A1
公开(公告)日：2005-11-17
申请号：US11104581
申请日：2005-04-13
申请人： Mingyong Han , Zhongping Zhang
发明人： Mingyong Han , Zhongping Zhang
IPC分类号： C30B7/00 , C30B29/16 , C30B29/60 , H01L21/00
CPC分类号： B82Y30/00 , C30B7/00 , C30B7/005 , C30B29/16 , C30B29/605 , Y10S977/762 , Y10S977/811 , Y10S977/892
摘要： A metal oxide nanostructure is formed by oxidizing metallic metal in the presence of a solution containing a liquid ligand to form a metal-ligand complex, and decomposing the metal-ligand complex to form the metal oxide nanostructure. The metal-ligand complex can be a complex of zinc or copper with formamide. In one form, the nanostructure forms ZnO nanorods having a diameter of 10 to 1000 nm, where the nanorods having a hexagonal crystallographic morphology, and the nanorods are oriented perpendicular to a substrate.
摘要翻译：通过在含有液体配体的溶液存在下，使金属金属氧化形成金属 - 配体络合物，并分解金属 - 配体络合物以形成金属氧化物纳米结构，形成金属氧化物纳米结构。金属 - 配体络合物可以是锌或铜与甲酰胺的络合物。在一种形式中，纳米结构形成直径为10至1000nm的ZnO纳米棒，其中纳米棒具有六方晶系的形态，纳米棒垂直于基底取向。

6. 发明申请

US20110033368A1 METHODS OF FORMING A NANOCRYSTAL 审中-公开
标题翻译：形成纳米晶的方法
公开(公告)号：US20110033368A1
公开(公告)日：2011-02-10
申请号：US12681771
申请日：2008-10-03
申请人： Enyi Ye , Yin Win Khin , Mingyong Han
发明人： Enyi Ye , Yin Win Khin , Mingyong Han
IPC分类号： C01B19/04 , C01B19/00 , C01G49/02 , C01G45/02 , C01G9/02 , C01G51/04 , B82Y99/00
CPC分类号： C30B7/00 , B82Y30/00 , C09K11/54 , C09K11/602 , C09K11/605 , C09K11/883 , C30B29/40 , C30B29/48 , C30B29/60
摘要： Methods of forming a nanocrystal are provided. The nanocrystal may be a binary nanocrystal of general formula M1A or of general formula M1O, a ternary nanocrystal of general formula M1M2A, of general formula M1AB or of general formula M1M2O or a quaternary nanocrystal of general formula M1M2AB. M1 is a metal of Groups II-IV, Group VII or Group VIII of the PSE. A is an element of Group VI or Group V of the PSE. O is oxygen. A homogenous reaction mixture in a non-polar solvent of low boiling point is formed, that includes a metal precursor containing the metal M1 and, where applicable M2. For an oxygen containing nanocrystal the metal precursor contains an oxygen donor. Where applicable, A is also included in the homogenous reaction mixture. The homogenous reaction mixture is under elevated pressure brought to an elevated temperature that is suitable for forming a nanocrystal.
摘要翻译：提供了形成纳米晶体的方法。纳米晶体可以是通式M1A或通式M1O的二元纳米晶体，通式M1M2A的三元纳米晶体，通式M1AB或通式M1M2O或通式M1M2AB的季纳米晶体。 M1是PSE的II-IV族，VII族或VIII族的金属。 A是PSE的第VI组或第V组的要素。 O是氧气。在低沸点的非极性溶剂中形成均匀的反应混合物，其包括含有金属M1的金属前体，以及适用的M2。对于含氧纳米晶体，金属前体含有氧供体。在适用的情况下，A也包含在均匀的反应混合物中。均匀的反应混合物在升高的压力下达到适于形成纳米晶体的升高的温度。

7. 发明申请

US20070161043A1 Methods of Preparing Multicolor Quantum Dot Tagged Beads and Conjugates Thereof 审中-公开
标题翻译：制备多色量子点标记珠及其结合体的方法
公开(公告)号：US20070161043A1
公开(公告)日：2007-07-12
申请号：US11566601
申请日：2006-12-04
申请人： Shuming Nie , Xiaohu Gao , Mingyong Han
发明人： Shuming Nie , Xiaohu Gao , Mingyong Han
IPC分类号： G01N33/53 , B05D3/00
CPC分类号： B82Y15/00 , G01N33/54393 , G01N33/544 , G01N33/588
摘要： The present invention provides a method of preparing a multicolor quantum dot-tagged bead, a multicolor quantum dot-tagged bead, a conjugate thereof, and a composition comprising such a bead or conjugate. Additionally, the present invention provides a method of making a conjugate thereof and methods of using a conjugate for multiplexed analysis of target molecules.
摘要翻译：本发明提供了制备多色量子点标记珠，多色量子点标记珠，其缀合物以及包含这种珠或缀合物的组合物的方法。此外，本发明提供了制备其共轭物的方法和使用缀合物用于靶分子多重分析的方法。

8. 发明申请

US20120045514A1 ANTI-CANCER MICROPARTICLE 审中-公开
标题翻译：抗癌微生物
公开(公告)号：US20120045514A1
公开(公告)日：2012-02-23
申请号：US13130957
申请日：2009-11-24
申请人： Yin Win Khin , Enyi Ye , Mingyong Han
发明人： Yin Win Khin , Enyi Ye , Mingyong Han
IPC分类号： A61K9/14 , C12Q1/02 , A61P35/00 , C12N5/09 , B82Y15/00 , B82Y5/00
CPC分类号： A61K31/00 , A61K9/1647 , A61K9/5031
摘要： The present invention relates to a microparticle and its use. The microparticle has a width of at least about 1 micron. The microparticle includes a biocompatible polymer, a nanoparticle, and an anti-cancer agent.
摘要翻译：本发明涉及一种微粒及其用途。微粒具有至少约1微米的宽度。微粒包括生物相容性聚合物，纳米颗粒和抗癌剂。

9. 发明申请

US20110129944A1 WATER-SOLUBLE NANOCRYSTALS AND METHODS OF PREPARING THEM 审中-公开
标题翻译：水溶性纳米晶体及其制备方法
公开(公告)号：US20110129944A1
公开(公告)日：2011-06-02
申请号：US11813906
申请日：2005-01-17
申请人： Fuke Wang , Mingyong Han
发明人： Fuke Wang , Mingyong Han
IPC分类号： G01N33/544 , C07F9/28 , C08B37/16
CPC分类号： C09K11/025 , B82Y15/00 , C08B37/0012 , C08B37/0015 , C09K11/565 , C09K11/883 , G01N33/588
摘要： Disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup IIb, subgroup VIIa, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup I1b, subgroup VI1a, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), and at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent is covalently linked to a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup I1b, subgroup VI1a, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Finally, compositions and uses of such nanocrystals are disclosed.
摘要翻译：公开了一种水溶性纳米晶体，其具有包含至少一种金属M1的核心，所述金属M1选自元素周期系统的亚组IIb，亚组VIIa，亚组VI11a，亚组1b，亚组IV，主要组II或主要组III的元素（ PSE），至少一种元素A，其选自元素周期系统的主族V或VI的元素，其中封端剂附着到纳米晶体的芯的表面，并且其中封端剂形成主要客体复合物与水溶性主体分子。还公开了一种水溶性纳米晶体，其具有包含至少一种金属M1的核心，所述金属M1选自元素周期系统的亚组I1b，亚组VI1a，亚组VI11a，亚组1b，亚组IV，主组II或主组III的元素（PSE）和选自元素周期性系统的主族V或VI的元素中的至少一种元素A，其中封端剂附着到纳米晶体的芯的表面，并且其中封端剂与水溶性主体分子共价连接。还公开了一种水溶性纳米晶体，其具有包含至少一种金属M1的核心，所述金属M1选自元素周期系统的亚组I1b，亚组VI1a，亚组VI11a，亚组1b，亚组IV，主组II或主组III的元素（PSE），其中封端剂附着在纳米晶体的芯的表面上，并且其中封端剂与水溶性主体分子形成宿主客体络合物。最后，公开了这种纳米晶体的组成和用途。

10. 发明申请

US20090042032A1 NOVEL WATER-SOLUBLE NANOCRYSTALS COMPRISING A LOW MOLECULAR WEIGHT COATING REAGENT, AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：包含低分子量涂层试剂的新型水溶性纳米晶体及其制备方法
公开(公告)号：US20090042032A1
公开(公告)日：2009-02-12
申请号：US11913671
申请日：2005-05-04
申请人： Mingyong Han , Fuke Wang
发明人： Mingyong Han , Fuke Wang
IPC分类号： B32B1/00
CPC分类号： G01N33/588 , B82Y15/00 , B82Y30/00 , C01B19/007 , C01P2004/64 , C01P2004/80 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/883 , Y10T428/2982
摘要： The invention relates to a water soluble nanocrystal with a nanocrystal core comprising at least one metal M1 selected form an element of main group II, VIIA, subgroup VIIA, subgroup IB, subgroup IIB, main group III or main group IV of the periodic system of the elements (PSE), at least one element A selected from main group V or main group VI of the PSE, a capping reagent attached to the surface of the core of the nanocrystal, said capping reagent having at least two coupling groups, and a second layer comprising a low molecular weight coating reagent having at least two coupling moieties covalently coupled with the coating reagent, and at least one water soluble group for conferring water solubility to the second layer.
摘要翻译：本发明涉及具有纳米晶核的水溶性纳米晶体，其包含至少一种金属M1，其选自主要组II，VIIA，亚组VIIA，亚组IB，亚组IIB，主要组III或主要IV族的元素元素（PSE），选自主要组V或PSE主组VI中的至少一种元素A，附着在纳米晶体核心表面的封端剂，所述封端剂具有至少两个偶联基团，和第二层包含具有与涂层试剂共价偶联的至少两个偶联部分的低分子量涂覆试剂和用于赋予第二层水溶性的至少一个水溶性基团。

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