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1. 发明申请

US20110045466A1 Field-effect transistor type biosensor and bio-signal amplification method thereof 审中-公开
标题翻译：场效应晶体管型生物传感器及其生物信号放大方法
公开(公告)号：US20110045466A1
公开(公告)日：2011-02-24
申请号：US12572555
申请日：2009-10-02
申请人： Ming-Yu Lin , Yuh-Shyong Yang , Hsin Chen
发明人： Ming-Yu Lin , Yuh-Shyong Yang , Hsin Chen
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/682 , C12Q1/6804 , C12Q1/6825 , G01N27/4145 , C12Q2565/607 , C12Q2531/125 , C12Q2527/101 , C12Q2521/101
摘要： The present invention discloses a field-effect transistor (FET) type biosensor and a bio-signal amplification method. The biosensor comprises a field-effect transistor chip, a biomolecular immobilization layer and at least one primer. The biomolecular immobilization layer is formed on a gate surface of the FET chip or a surface of an external device connected to a gate. The primer used for performing a nucleic acid amplification is immobilized onto the gate surface or the external device surface by binding with the biomolecular immobilization layer, such that an analyte can have a nucleic acid amplification reaction with the primer at room temperature or a constant temperature environment. With an extension of a nucleic acid sequence, the inducing electricity of the FET gate surface can be increased so as to amplify an inspection signal, thereby enhancing the sensitivity of the FET type biosensor effectively.
摘要翻译：本发明公开了一种场效应晶体管（FET）型生物传感器和生物信号放大方法。生物传感器包括场效应晶体管芯片，生物分子固定化层和至少一个引物。生物分子固定化层形成在FET芯片的栅极表面或连接到栅极的外部器件的表面上。用于进行核酸扩增的引物通过与生物分子固定化酶结合而固定在栅极表面或外部器件表面上，使得分析物可以在室温或恒温环境下与引物进行核酸扩增反应。通过核酸序列的延伸，可以增加FET栅极表面的感应电力，从而放大检查信号，从而有效提高FET型生物传感器的灵敏度。

2. 发明授权

US08921075B2 Method of manufacturing nanoparticle chain 有权
标题翻译：制造纳米颗粒链的方法
公开(公告)号：US08921075B2
公开(公告)日：2014-12-30
申请号：US13488748
申请日：2012-06-05
申请人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
发明人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12P19/34 , C12Q1/6834 , C12Q2525/151 , C12Q2525/307 , C12Q2563/155
摘要： A method of manufacturing a nanoparticle chain is disclosed. The method comprises the steps of: providing a single-stranded circular primer with a determined length, and amplifying the single-stranded circular primer into single-stranded DNA nanotemplate by an isothermal nucleotide amplification reaction such that an end of the single-stranded DNA nanotemplate is fixed to a surface of a substrate; and adding a single-stranded DNA probe conjugated with nanoparticle at one end of which, and attaching the single-stranded DNA probe to the corresponding sequence on the single-stranded DNA nanotemplate to form a nanoparticles chain. The method of manufacturing a nanoparticle chain further comprises providing a fluid, and the flowing direction of the fluid controls the aligning direction of the nanoparticle chain. Wherein, the inter-nanoparticle distance of the nanoparticle chain can be adjusted by adjusting a reaction temperature or adding the single-stranded DNA probe without conjugating with nanoparticles.
摘要翻译：公开了一种制造纳米颗粒链的方法。该方法包括以下步骤：提供具有确定长度的单链环状引物，并通过等温核苷酸扩增反应将单链环状引物扩增成单链DNA纳米模板，使得单链DNA纳米模板的末端固定在基板的表面上; 并在其一端加入与纳米颗粒缀合的单链DNA探针，并将单链DNA探针连接到单链DNA纳米模板上的相应序列上以形成纳米颗粒链。制造纳米颗粒链的方法还包括提供流体，流体的流动方向控制纳米颗粒链的排列方向。其中，可以通过调节反应温度或加入单链DNA探针而不与纳米颗粒共轭来调节纳米颗粒链的纳米颗粒间距离。

3. 发明授权

US08808229B2 System and method of wireless physiological signal integration 有权
标题翻译：无线生理信号整合的系统与方法
公开(公告)号：US08808229B2
公开(公告)日：2014-08-19
申请号：US12291876
申请日：2008-11-14
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
IPC分类号： A61M31/00 , A61B5/00 , G06F19/00 , A61B5/021 , A61B5/145 , A61B5/024 , A61B5/1486 , A61B5/0476
CPC分类号： A61B5/4839 , A61B5/0002 , A61B5/0006 , A61B5/021 , A61B5/02438 , A61B5/0476 , A61B5/145 , A61B5/14532 , A61B5/1486 , A61B5/14865 , G06F19/00 , G06F19/3468
摘要： A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.
摘要翻译：提供无线生理信号整合的系统。该系统包括无线传输传感器芯片和药物递送系统，其中无线传输传感器芯片包括感测患者的生理信号的传感器，将生理信号转换为转换信号的信号转换模块以及无线传输模块发送转换的信号，并且药物递送系统根据转换的信号确定药物的剂量和提供药物的定时。

4. 发明申请

US20130273610A1 Method of Manufacturing Nanoparticle Chain 有权
标题翻译：制造纳米粒子链的方法
公开(公告)号：US20130273610A1
公开(公告)日：2013-10-17
申请号：US13488748
申请日：2012-06-05
申请人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
发明人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C12Q1/6834 , C12Q2525/151 , C12Q2525/307 , C12Q2563/155
摘要： A method of manufacturing a nanoparticle chain is disclosed. The method comprises the steps of: providing a single-stranded circular primer with a determined length, and amplifying the single-stranded circular primer into single-stranded DNA nanotemplate by an isothermal nucleotide amplification reaction such that an end of the single-stranded DNA nanotemplate is fixed to a surface of a substrate; and adding a single-stranded DNA probe conjugated with nanoparticle at one end of which, and attaching the single-stranded DNA probe to the corresponding sequence on the single-stranded DNA nanotemplate to form a nanoparticles chain. The method of manufacturing a nanoparticle chain further comprises providing a fluid, and the flowing direction of the fluid controls the aligning direction of the nanoparticle chain. Wherein, the inter-nanoparticle distance of the nanoparticle chain can be adjusted by adjusting a reaction temperature or adding the single-stranded DNA probe without conjugating with nanoparticles.
摘要翻译：公开了一种制造纳米颗粒链的方法。该方法包括以下步骤：提供具有确定长度的单链环状引物，并通过等温核苷酸扩增反应将单链环状引物扩增成单链DNA纳米模板，使得单链DNA纳米模板的末端固定在基板的表面上; 并在其一端加入与纳米颗粒缀合的单链DNA探针，并将单链DNA探针连接到单链DNA纳米模板上的相应序列上以形成纳米颗粒链。制造纳米颗粒链的方法还包括提供流体，流体的流动方向控制纳米颗粒链的排列方向。其中，可以通过调节反应温度或加入单链DNA探针而不与纳米颗粒共轭来调节纳米颗粒链的纳米颗粒间距离。

5. 发明申请

US20130210110A1 Method for Changing Surface Properties of a Substrate from Immobilized Biomolecules 有权
标题翻译：从固定化生物分子改变底物表面性质的方法
公开(公告)号：US20130210110A1
公开(公告)日：2013-08-15
申请号：US13437340
申请日：2012-04-02
申请人： Ming-Yu Lin , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
发明人： Ming-Yu Lin , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
IPC分类号： C12N11/16 , C07K14/195 , C07K14/00
CPC分类号： C12N11/14
摘要： A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle.
摘要翻译：通过在温和的生物学条件下操纵固定化的生物分子来修饰底物的表面性质的方法。操作包括以下步骤：通过亲和结合标签提供与至少一种与第一蛋白质组合的ssDNA组合的生物分子; 加入与第二种蛋白质缀合的第二种ssDNA，其浓度大于第一种蛋白质的浓度; 并通过化学竞争原理用ssDNA替代第二个蛋白质上的第一个蛋白质。本发明可以包括具有适当设计生物素化DNA探针的步骤，功能化的ssDNA纳米模板可以通过热力学原理回收到其未结合状态。

6. 发明申请

US20090272180A1 CONTINUOUS TESTING DEVICE AND CONTINUOUS TESTING SYSTEM 审中-公开
标题翻译：连续测试设备和连续测试系统
公开(公告)号：US20090272180A1
公开(公告)日：2009-11-05
申请号：US12272872
申请日：2008-11-18
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kun-Hsi Tsai , William Wang , Long Hsu , Cheng-Hsien Liu , Chung-Cheng Chou
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kun-Hsi Tsai , William Wang , Long Hsu , Cheng-Hsien Liu , Chung-Cheng Chou
IPC分类号： G01N33/49
CPC分类号： G01N21/31 , B01L3/502761 , B01L3/502792 , B01L9/527 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0427 , B01L2400/0454 , B03C5/005 , B03C5/026 , G01N21/05 , G01N33/491 , G01N2021/0325 , G01N2021/0346 , G01N2021/058 , G01N2201/062
摘要： A continuous testing device for testing the concentration of a target object in a fluid is provided. The continuous testing device includes a first chip, a signal source and a second chip. The first chip includes a separating unit and a reacting unit. The separating unit separates the target object from a non-target object in the fluid. The reacting unit enables the fluid having separated out the non-target object to react with a reagent. The signal source provides a signal passing through the fluid having reacted with the reagent. The second chip disposed at one side of the first chip includes a signal transducing element and a processing unit. The signal transducing element receives the signal passing through the fluid and outputs an electronic signal corresponding to the input signal. The processing unit acquires the concentration of the target object according to the electronic signal.
摘要翻译：提供了用于测试流体中目标物体的浓度的连续测试装置。连续测试装置包括第一芯片，信号源和第二芯片。第一芯片包括分离单元和反应单元。分离单元将目标物体与流体中的非目标物体分离。反应单元使得分离出非目标物体的流体能够与试剂反应。信号源提供通过与试剂反应的流体的信号。布置在第一芯片的一侧的第二芯片包括信号转换元件和处理单元。信号转换元件接收通过流体的信号并输出与输入信号相对应的电子信号。处理单元根据电子信号获取目标物体的浓度。

7. 发明申请

US20090137947A1 System and method of wireless physiological signal integration 有权
标题翻译：无线生理信号整合的系统与方法
公开(公告)号：US20090137947A1
公开(公告)日：2009-05-28
申请号：US12291876
申请日：2008-11-14
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
IPC分类号： A61M5/00
CPC分类号： A61B5/4839 , A61B5/0002 , A61B5/0006 , A61B5/021 , A61B5/02438 , A61B5/0476 , A61B5/145 , A61B5/14532 , A61B5/1486 , A61B5/14865 , G06F19/00 , G06F19/3468
摘要： A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.
摘要翻译：提供无线生理信号整合的系统。该系统包括无线传输传感器芯片和药物递送系统，其中无线传输传感器芯片包括感测患者的生理信号的传感器，将生理信号转换为转换信号的信号转换模块以及无线传输模块发送转换的信号，并且药物递送系统根据转换的信号确定药物的剂量和提供药物的定时。

8. 发明申请

US20090010569A1 IMAGE DATA PROCESSING METHOD AND IMAGE DISPLAY APPARATUS 有权
标题翻译：图像数据处理方法和图像显示装置
公开(公告)号：US20090010569A1
公开(公告)日：2009-01-08
申请号：US11867696
申请日：2007-10-05
申请人： Po-Chin Hu , Ming-Yu Lin , Wei-Chen Tsai
发明人： Po-Chin Hu , Ming-Yu Lin , Wei-Chen Tsai
IPC分类号： G06K9/32
CPC分类号： G06T3/0056
摘要： An image data processing method is provided. In this method, a plurality of original pixel values of an image is input. An interpolation position of a target pixel in the image is determined. Whether the interpolation position is in a central region of an object or in a marginal region of an object is determined. A pixel value interpolation with respect to the interpolation position is performed. When the interpolation position is in the central region of an object, the pixel value interpolation is performed in a first calculation mode, and when the interpolation position is in the marginal region of an object, the pixel value interpolation is performed in a second calculation mode, wherein the first calculation mode may be a low pass filtering interpolation mode, and the second calculation mode may be a linear interpolation mode.
摘要翻译：提供了图像数据处理方法。在该方法中，输入图像的多个原始像素值。确定图像中的目标像素的内插位置。确定内插位置是否在物体的中心区域或物体的边缘区域中。执行相对于插补位置的像素值插值。当内插位置在对象的中心区域时，以第一计算模式执行像素值内插，并且当内插位置在对象的边缘区域中时，以第二计算模式执行像素值内插其中，所述第一计算模式可以是低通滤波插值模式，并且所述第二计算模式可以是线性插值模式。

9. 发明申请

US20070069916A1 METHOD AND APPARATUS FOR PERFORMING AUTOMATIC IDENTITY CODE LEARNING AND IDENTITY CODE VERIFICATION IN A WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：在无线通信系统中执行自动身份识别代码学习和身份识别代码验证的方法和设备
公开(公告)号：US20070069916A1
公开(公告)日：2007-03-29
申请号：US11535493
申请日：2006-09-27
申请人： Ming-Yu Lin , Jui-Jung HUANG
发明人： Ming-Yu Lin , Jui-Jung HUANG
IPC分类号： G05B19/02 , H02J13/00
CPC分类号： H04M1/7253 , H04W56/00
摘要： A data processing method of a wireless communication system includes generating an identity code corresponding to a receiver, storing the identity code in a receiver, exclusive-oring output data with the identity code corresponding to the receiver, outputting the exclusive-ored data, receiving data at a receiver, and exclusive-oring the received data with an identity code stored in the receiver. The data processing method performs automatic identity code learning and identity code verification with exclusive-or operations in the wireless communication system.
摘要翻译：一种无线通信系统的数据处理方法，包括生成与接收机相对应的身份码，将身份码存储在接收机中，对具有对应于接收者的身份码进行排他性输出数据，输出独占数据，接收数据在接收器处，并且使用存储在接收器中的身份码对所接收的数据进行异或。数据处理方法通过在无线通信系统中的排除或操作执行自动识别码学习和身份码验证。

10. 发明授权

US06489196B1 Method of forming a capacitor with high capacitance and low voltage coefficient 有权
标题翻译：形成具有高电容和低电压系数的电容器的方法
公开(公告)号：US06489196B1
公开(公告)日：2002-12-03
申请号：US10055943
申请日：2002-01-28
申请人： Ming-Yu Lin , Hsueh-Wen Wang
发明人： Ming-Yu Lin , Hsueh-Wen Wang
IPC分类号： H01L218242
CPC分类号： H01L28/55
摘要： The present invention provides a method of forming a capacitor in an integrated circuit. The method comprises providing a semiconductor substrate having a conductive layer thereon. The partial conductive layer is removed to form an electrode. A plurality of first dopants are implanted on a surface of the electrode to form a first doped region. Then a plurality of second dopants are implanted into the electrode to form a second doped region below the first doped region. Then the capacitor is formed comprising the electrode. The first doped region and the second region can reduce voltage coefficient as well as increase capacitance of the capacitor.
摘要翻译：本发明提供一种在集成电路中形成电容器的方法。该方法包括提供其上具有导电层的半导体衬底。去除部分导电层以形成电极。多个第一掺杂剂注入电极的表面以形成第一掺杂区域。然后将多个第二掺杂剂注入到电极中以在第一掺杂区域下方形成第二掺杂区域。然后形成包括电极的电容器。第一掺杂区域和第二区域可以降低电压系数以及增加电容器的电容。

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