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1. 发明授权

US11202577B2 System for monitoring cardiovascular and brain function in combination with physiological detection device and method thereof 有权
公开(公告)号：US11202577B2
公开(公告)日：2021-12-21
申请号：US16664946
申请日：2019-10-28
申请人： Ming-Hsin Li , Kai-Hung Cheng , Shih-Wei Lo
发明人： Ming-Hsin Li , Kai-Hung Cheng , Shih-Wei Lo
IPC分类号： A61B5/0205 , A61B5/029 , A61B5/00 , A61B5/021 , A61B5/024 , A61B5/369
摘要： A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

2. 发明授权

US11850291B2 PSMA targeted radiotherapy medicine and preparation method thereof 有权
公开(公告)号：US11850291B2
公开(公告)日：2023-12-26
申请号：US16663387
申请日：2019-10-25
申请人： Ming-Hsin Li , Sheng-Nan Lo , Shih-Wei Lo , Shih-Ying Lee , Su-Jung Chen , Shih-Min Wang , Ming-Wei Chen , Wei-Lin Lo
发明人： Ming-Hsin Li , Sheng-Nan Lo , Shih-Wei Lo , Shih-Ying Lee , Su-Jung Chen , Shih-Min Wang , Ming-Wei Chen , Wei-Lin Lo
IPC分类号： A61K51/08
CPC分类号： A61K51/088
摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

3. 发明申请

US20200078478A1 Structural molecule of peptide derivative for PSMA-targeting radiotherapy diagnosis and treatment 审中-公开
公开(公告)号：US20200078478A1
公开(公告)日：2020-03-12
申请号：US16125787
申请日：2018-09-10
申请人： Ming-Hsin Li , Ming-Wei Chen , Shin-Min Wang , Shih-Wei Lo , Chun-Fang Feng , Cheng-Hui Chuang , Sheng-Nan Lo
发明人： Ming-Hsin Li , Ming-Wei Chen , Shin-Min Wang , Shih-Wei Lo , Chun-Fang Feng , Cheng-Hui Chuang , Sheng-Nan Lo
IPC分类号： A61K51/04
摘要： A PSMA targeting peptide derivative for radiotherapy, which is a structural molecule developed for diagnosis or treatment of prostate cancer, as prostate-specific membrane antigen (PSMA) is a protein present on the surface of healthy prostate cells, which is often at a high level of expression on the surface of prostate cancer cells, and the molecular composition of PSMA inhibitor is mainly composed of glutamic acid, urea and lysine, in addition to the linker of the present invention, PSMA inhibitor can be combined with a chelating agent and truncated Evans Blue, which can be labeled with radionuclides Ga-67, Ga-68, In-111, Lu-177, Cu-64 or Y-90, used for image analysis and analysis of human prostate cancer tumor pattern as a new PSMA targeting peptide receptor radionuclide therapy (PRRT), and which has a longer half-life in vivo and is featured by specific binding of PSMA for radiotherapy diagnosis or treatment.

4. 发明授权

US09707521B2 Automated test apparatus for testing risk and integrity of pharmaceutical filtration membranes and method thereof 有权
公开(公告)号：US09707521B2
公开(公告)日：2017-07-18
申请号：US13956375
申请日：2013-08-01
申请人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
发明人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
IPC分类号： B01D65/10 , G01M3/06
CPC分类号： B01D65/102 , B01D65/10 , G01M3/06
摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.

5. 发明申请

US20160113884A1 Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权
标题翻译：辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法
公开(公告)号：US20160113884A1
公开(公告)日：2016-04-28
申请号：US14522583
申请日：2014-10-24
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
IPC分类号： A61K9/51 , A61K31/704
CPC分类号： A61K9/5146 , A61K9/5192 , A61K31/704
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
摘要翻译：用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒，在质子治疗期间质子穿透组织。质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强杀死肿瘤的癌细胞。

6. 发明授权

US09277192B2 Monitoring system of real time image control for radiopharmaceutical automatic synthesizing apparatus in a micro hot cell 有权
公开(公告)号：US09277192B2
公开(公告)日：2016-03-01
申请号：US14049228
申请日：2013-10-09
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
IPC分类号： H04N7/18 , G01N23/00 , G01N21/84
CPC分类号： H04N7/188 , G01N21/84 , G01N23/00
摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.

7. 发明授权

US08802014B2 Ga-68 radionuclide generator structure 有权
标题翻译： Ga-68放射性核素发生器结构
公开(公告)号：US08802014B2
公开(公告)日：2014-08-12
申请号：US13252195
申请日：2011-10-03
申请人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
发明人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
IPC分类号： G21G4/08 , G21G1/00
CPC分类号： G21G4/08 , A61K51/02 , G21G1/0005 , G21G2001/0021 , Y10S422/903
摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
摘要翻译：本发明涉及Ga-68放射性核素发生器的新型结构。它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

8. 发明授权

US08007730B2 Synthetic method and automation device for fluorine-18-ACETATE 有权
标题翻译：氟-18-ACETATE的合成方法和自动化装置
公开(公告)号：US08007730B2
公开(公告)日：2011-08-30
申请号：US12478787
申请日：2009-06-05
申请人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
发明人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
IPC分类号： G21C1/00 , G05B1/00 , G05D16/00 , B01J19/00
CPC分类号： B01J19/004
摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
摘要翻译：用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。操作非常简单，可以有效提高生产效率。

9. 发明授权

US11077217B2 Radioactive labeling method for neuropeptide Y derivative compound and medicine for multi-type breast cancer therapy thereof 有权
公开(公告)号：US11077217B2
公开(公告)日：2021-08-03
申请号：US16215647
申请日：2018-12-11
申请人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
发明人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
IPC分类号： A61K51/08 , A61K51/04 , A61K51/06
摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

10. 发明申请

US20150010447A1 Method of purification for recycling of gallium-69 isotope 有权
公开(公告)号：US20150010447A1
公开(公告)日：2015-01-08
申请号：US13936219
申请日：2013-07-08
申请人： Ming-Hsin Li , Hsin-Han Hsieh
发明人： Ming-Hsin Li , Hsin-Han Hsieh
IPC分类号： C22B58/00
CPC分类号： C22B58/00 , C22B3/0004 , Y02P10/234
摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.

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