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1. 发明授权

US11723992B2 Method for extraction and purification of 68GA 有权
公开(公告)号：US11723992B2
公开(公告)日：2023-08-15
申请号：US17265138
申请日：2019-08-02
申请人： Board of Regents, The University of Texas System
发明人： Mai Lin , Carlos E. Gonzalez-Lepera
IPC分类号： A61K51/04 , B01J41/12 , B01J47/02 , C01G15/00 , G21G1/00 , A61K51/08 , G21G1/10
CPC分类号： A61K51/088 , A61K51/0402 , A61K51/048 , A61K51/0482 , A61K51/08 , A61K51/082 , A61K51/083 , B01J41/12 , B01J47/02 , C01G15/003 , G21G1/001 , G21G1/10 , C01P2006/88 , G21G2001/0021
摘要： Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.

2. 发明授权

US08937166B2 68Ga generator 有权
标题翻译： 68Ga发电机
公开(公告)号：US08937166B2
公开(公告)日：2015-01-20
申请号：US13929374
申请日：2013-06-27
申请人： ITM Isotopen Technologien Munchen AG
发明人： Konstantin Zhernosekov , Tuomo Nikula
IPC分类号： G21G1/00 , G01N21/01
CPC分类号： G21G1/0005 , G21G1/001 , G21G2001/0021
摘要： The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
摘要翻译：本发明涉及一种68Ga发生器，其中68Ge母体核素通过三乙氧基苯基特异性地连接到载体上，并连续分解成68Ga，三乙氧基苯基通过连接体与载体材料共价结合。

3. 发明申请

US20130084220A1 Ga-68 radionuclide generator structure 有权
标题翻译： Ga-68放射性核素发生器结构
公开(公告)号：US20130084220A1
公开(公告)日：2013-04-04
申请号：US13252195
申请日：2011-10-03
申请人： MING-HSIN LI , JIN-JENN LIN , THER-JEN TING , I-LEA DAI
发明人： MING-HSIN LI , JIN-JENN LIN , THER-JEN TING , I-LEA DAI
IPC分类号： B01J19/00
CPC分类号： G21G4/08 , A61K51/02 , G21G1/0005 , G21G2001/0021 , Y10S422/903
摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
摘要翻译：本发明涉及Ga-68放射性核素发生器的新型结构。它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

4. 发明申请

US20160358683A1 PROCESS FOR PRODUCING GALLIUM-68 THROUGH THE IRRADIATION OF A SOLUTION TARGET 审中-公开
标题翻译：通过解决方案目标的辐射生产GALLIUM-68的方法
公开(公告)号：US20160358683A1
公开(公告)日：2016-12-08
申请号：US15172905
申请日：2016-06-03
申请人： Ion Beam Applications
发明人： Antero ABRUNHOSA , Vítor ALVES , Francisco ALVES
IPC分类号： G21G1/00 , B01J39/18 , C07B59/00 , B01J41/12 , B01J47/00 , A61K51/08 , B01J39/04 , B01J41/04
CPC分类号： G21G1/001 , A61K51/088 , B01J39/05 , B01J39/18 , B01J41/05 , B01J41/12 , B01J47/00 , C07B59/008 , C07B2200/05 , C22B58/00 , G21G1/10 , G21G2001/0021
摘要： The present invention relates to a process for purifying and concentrating 68Ga isotope produced by the irradiation with an accelerated particle beam of a 68Zn target in solution. The process according to the invention allows for the production of pure and concentrated 68Ga isotope in hydrochloric acid solution. The present invention also relates to a disposable cassette suitable to perform the steps of purification and concentration of the process.
摘要翻译：本发明涉及通过在溶液中用68Zn靶的加速粒子束照射产生的68Ga同位素的纯化和浓缩方法。根据本发明的方法允许在盐酸溶液中生产纯的和浓缩的68Ga同位素。本发明还涉及一种适用于执行该方法的纯化和浓缩步骤的一次性盒。

5. 发明授权

US09269467B2 General radioisotope production method employing PET-style target systems 有权
标题翻译：采用PET样式目标系统的一般放射性同位素生产方法
公开(公告)号：US09269467B2
公开(公告)日：2016-02-23
申请号：US13485885
申请日：2012-05-31
申请人： Nigel Raymond Stevenson
发明人： Nigel Raymond Stevenson
IPC分类号： G21G1/10 , G21G1/00
CPC分类号： G21G1/10 , G21G2001/0015 , G21G2001/0021 , G21G2001/0042 , G21G2001/0052 , G21G2001/0057 , G21G2001/0063 , G21G2001/0073 , G21G2001/0094
摘要： Methods for producing a radioisotope by a charged particle irradiation of a fluid target matrix are provided. A method of producing a radioisotope includes irradiating a fluid target matrix comprising a compound of a target isotope with a charged particle beam to transform at least a portion of the target isotope to the radioisotope, and isolating the radioisotope from the irradiated fluid target matrix. The target isotope may be an isotope of cadmium, an isotope of thallium, an isotope of zinc, an isotope of gallium, an isotope of tellurium, an isotope of molybdenum, an isotope of rhodium, an isotope of selenium, an isotope of nickel, an isotope of yttrium, an isotope of strontium, an isotope of bismuth, an isotope of tungsten, and an isotope of titanium, provided that the target isotope is not Mo-100.
摘要翻译：提供了通过流体靶矩阵的带电粒子照射来生产放射性同位素的方法。制备放射性同位素的方法包括：将含有目标同位素化合物的流体靶基质与带电粒子束照射，将目标同位素的至少一部分转化成放射性同位素，并将放射性同位素与被照射的流体靶基质分离。目标同位素可以是镉的同位素，铊的同位素，锌的同位素，镓的同位素，碲的同位素，钼的同位素，铑的同位素，硒的同位素，镍的同位素，钇的同位素，锶的同位素，铋的同位素，钨的同位素和钛的同位素，条件是目标同位素不是Mo-100。

6. 发明申请

US20140263074A1 GE ADSORBENT FOR 68Ge-68Ga GENERATOR 审中-公开
标题翻译： GE GeForce 68Ge-68Ga发生器
公开(公告)号：US20140263074A1
公开(公告)日：2014-09-18
申请号：US14353061
申请日：2012-10-19
申请人： NAGASAKI UNIVERSITY
发明人： Morio Nakayama , Mamoru Haratake , Takeshi Fuchigami , Mayumi Iwatake
IPC分类号： B01D15/42 , B01J20/26 , B01J20/24
CPC分类号： B01D15/424 , B01J20/24 , B01J20/267 , B01J20/285 , B01J20/3071 , B01J20/3425 , B01J20/3475 , C08B15/00 , C08B37/0021 , C08L1/08 , C08L5/02 , G21G1/0005 , G21G2001/0021
摘要： The present invention provides a Ge adsorbent for a 68Ge—68Ga generator, which is a polysaccharide polymer having a glucamine group represented by the formula (1) or the formula (2), wherein R1 is a hydrogen atom or an alkyl group, and * is a bonding position.
摘要翻译：本发明提供了一种用于68Ge-68Ga发生器的Ge吸附剂，其是具有由式（1）或式（2）表示的葡糖胺基团的多糖聚合物，其中R 1是氢原子或烷基，和* 是一个粘接位置。

7. 发明授权

US07728310B2 Method for the chemical separation of GE-68 from its daughter Ga-68 失效
标题翻译： GE-68与其女儿Ga-68化学分离的方法
公开(公告)号：US07728310B2
公开(公告)日：2010-06-01
申请号：US12151865
申请日：2008-05-08
申请人： Jonathan M. Fitzsimmons , Robert W. Atcher
发明人： Jonathan M. Fitzsimmons , Robert W. Atcher
IPC分类号： B01D59/44
CPC分类号： G21G1/001 , G21G2001/0021
摘要： The present invention is directed to a generator apparatus for separating a daughter gallium-68 radioisotope substantially free of impurities from a parent gernanium-68 radioisotope, including a first resin-containing column containing parent gernanium-68 radioisotope and daughter gallium-68 radioisotope, a source of first eluent connected to said first resin-containing column for separating daughter gallium-68 radioisotope from the first resin-containing column, said first eluent including citrate whereby the separated gallium is in the form of gallium citrate, a mixing space connected to said first resin-containing column for admixing a source of hydrochloric acid with said separated gallium citrate whereby gallium citrate is converted to gallium tetrachloride, a second resin-containing column for retention of gallium-68 tetrachloride, and, a source of second eluent connected to said second resin-containing column for eluting the daughter gallium-68 radioisotope from said second resin-containing column.
摘要翻译：本发明涉及一种用于将母体锗-68放射性同位素基本上不含杂质的子镓-68放射性同位素分离的发生器装置，包括含有母体锗-68放射性同位素和子镓68放射性同位素的第一含树脂柱，连接到所述第一含树脂柱的第一洗脱液源，用于从第一含树脂柱中分离子镓-68放射性同位素，所述第一洗脱液包括柠檬酸盐，由此分离的镓是柠檬酸镓的形式，与所述第一含树脂柱连接的混合空间第一含树脂柱，用于将盐酸源与所述分离的柠檬酸镓混合，由此将柠檬酸镓转化为四氯化镓，用于保留四氯化镓的第二含树脂的塔，以及连接到所述的四氯化镓的第二洗脱源第二树脂柱，用于从所述第二树脂洗脱子镓-68放射性同位素含n柱。

8. 发明公开

US20240304352A1 System and Method For Fractional Elution of Mother-Daughter Radionuclides 审中-公开
公开(公告)号：US20240304352A1
公开(公告)日：2024-09-12
申请号：US18513220
申请日：2023-11-17
申请人： Northstar Medical Technologies, LLC
发明人： James T. HARVEY , Daniel DEVRIES , Glenn H. ISENSEE , Dorian LUST , Erik BLUEMNER
IPC分类号： G21G1/00
CPC分类号： G21G1/001 , G21G2001/0021 , G21G2001/0042 , G21G2001/0073 , G21G2001/0089
摘要： A method and a system for eluting a desired activity concentration of a daughter radionuclide-containing eluate obtained from a mixture of mother/daughter radionuclides is disclosed. The method comprises contacting separation particles with an aqueous solution containing a mixture of mother and daughter radionuclides wherein daughter radionuclides bind to separation particles and mother radionuclides does not. That contact is maintained for a time for unbound daughter radionuclide to bind to the separation particles. The unbound mother radionuclide is separated from the daughter radionuclide-bound separation particles using a washing solution. A first fractional amount of the bound daughter radionuclide is stripped from the separation particles using a volume of stripping solution so that an aqueous eluate solution having a desired daughter radionuclide activity is obtained. The remaining aqueous solution containing a second fractional amount of the desired daughter radionuclide still in the aqueous solution is retained.

9. 发明申请

US20180158559A1 METHOD AND SYSTEM FOR PRODUCING GALLIUM-68 RADIOISOTOPE BY SOLID TARGETING IN A CYCLOTRON 审中-公开
公开(公告)号：US20180158559A1
公开(公告)日：2018-06-07
申请号：US15579823
申请日：2016-06-06
申请人： NCM USA BRONX LLC
发明人： Ali A. Abbasi , Balu Easwaramoorthy
IPC分类号： G21G1/10 , G21G1/00 , A61K51/08
CPC分类号： G21G1/10 , A61K51/08 , C01G15/00 , C01P2002/87 , C01P2006/88 , G21G1/001 , G21G2001/0021
摘要： In a system and a method for making carrier-free radioactive isotopic Gallium-68, stable enriched Zinc-68 is formed into a solid target of very high purity. The solid target of enriched Zinc-68 is exposed to a proton beam provided by irradiation in a cyclotron to change the enriched Zinc-68 into Gallium-68. After irradiation, the solid target contains high concentrations of Gallium-68 with only trace amounts of enriched Zinc-68 and isotopic Gallium-67. Gallium-68 is then further purified to remove the impurities resulting in a Gallium-68 composition with high purity and specific activity and without Germanium-68, Also provided are radiopharmaceutical agents that are labeled with the Gallium-68 compositions made by solid targeting in a cyclotron.

10. 发明申请

US20180130567A1 TARGET ASSEMBLY AND ISOTOPE PRODUCTION SYSTEM 审中-公开
公开(公告)号：US20180130567A1
公开(公告)日：2018-05-10
申请号：US15348198
申请日：2016-11-10
申请人： General Electric Company
发明人： Tomas Eriksson , Martin Pärnaste , Jonas Norling
IPC分类号： G21G1/10 , G21G1/00
CPC分类号： G21G1/10 , G21G1/001 , G21G2001/0015 , G21G2001/0021 , H05H6/00
摘要： Target assembly for an isotope production system. The target assembly includes a target body having a production chamber and a beam cavity that is adjacent to the production chamber. The production chamber is configured to hold a target material. The beam cavity opens to an exterior of the target body and is configured to receive a particle beam that is incident on the production chamber. The target assembly also includes a target sheet positioned to separate the beam cavity and the production chamber. The target sheet has a side that is exposed to the production chamber such that the target sheet is in contact with the target material during isotope production. The target sheet includes graphene.

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