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1. 发明申请

US20120015404A1 GENE CLUSTER FOR THURINGIENSIN SYNTHESIS 审中-公开
标题翻译：神经元合成基因簇
公开(公告)号：US20120015404A1
公开(公告)日：2012-01-19
申请号：US13145071
申请日：2009-12-15
申请人： Ming Sun , Ziniu Yu , Lifang Ruan , Shouwen Chen , Xiaoyan Liu , Donghai Peng
发明人： Ming Sun , Ziniu Yu , Lifang Ruan , Shouwen Chen , Xiaoyan Liu , Donghai Peng
IPC分类号： C12P19/44 , C12N1/20 , C12N15/61
CPC分类号： C12N15/52 , C07K14/32
摘要： The invention belongs to the technical field of genetic engineering of agricultural microorganisms. Specifically, the invention relates to producing and using gene cluster for thuringiensin synthesis from Bacillus thuringiensis. The gene cluster includes 11 genes of thuA, thuB, thuC, thuD, thuE, thuF, thuG, thu1, thu2, thu3 and thu4. These genes have the nucleotide sequence as shown in SEQ ID NO: 1. And the thuringiensin biosynthetase encoded by these genes have the amino acid sequences as shown in SEQ ID NO: 2-12. The genes according to the invention and the proteins encoded by those genes can be used as new nucleosides lead compound of pesticide library and provide new target for developing insecticides. In practical use, a series of new, efficient and low toxic insecticide can be obtained by structure modification.
摘要翻译：本发明属于农业微生物遗传工程技术领域。具体地说，本发明涉及生产和使用苏云金芽孢杆菌的苏氨酸素合成基因簇。基因簇包含thuA，thuB，thuC，thuD，thuE，thuF，thuG，thu1，thu2，thu3和thu4等11个基因。这些基因具有如SEQ ID NO：1所示的核苷酸序列。由这些基因编码的苏云金素生物合成酶具有如SEQ ID NO：2-12所示的氨基酸序列。根据本发明的基因和由这些基因编码的蛋白质可以用作农药图谱的新核苷酸铅化合物，并提供开发杀虫剂的新靶标。在实际应用中，通过结构修饰可以获得一系列新型，高效，低毒的杀虫剂。

2. 外观设计

USD974052S1 Mirror 有权
公开(公告)号：USD974052S1
公开(公告)日：2023-01-03
申请号：US29808127
申请日：2021-09-17
申请人： Xiaoyan Liu
设计人： Xiaoyan Liu

3. 发明申请

US20120141388A1 ANTIBACTERIAL DENTIFRICE EXHIBITING ENHANCED ANTIPLAQUE AND BREATH FRESHENING PROPERTIES 审中-公开
标题翻译：抗菌素抗生素和抗生素的抗菌性能
公开(公告)号：US20120141388A1
公开(公告)日：2012-06-07
申请号：US13372871
申请日：2012-02-14
申请人： Lori H. Szeles , Xiaoyan Liu , Malcolm Williams , M. Teresa R. Carale , Michael Prencipe , James G. Masters
发明人： Lori H. Szeles , Xiaoyan Liu , Malcolm Williams , M. Teresa R. Carale , Michael Prencipe , James G. Masters
IPC分类号： A61K8/66 , A61Q11/00
CPC分类号： A61K8/25 , A61K8/24 , A61K8/411 , A61K8/4926 , A61K8/66 , A61Q11/00
摘要： An abrasive dentifrice composition which effects enhanced antiplaque and breath freshening properties which comprises an orally acceptable vehicle containing a combination of a safe and effective amount of an antibacterial agent and at least two enzyme ingredients.
摘要翻译：一种具有增强的抗牙斑和呼吸清新性能的研磨性洁齿剂组合物，其包含含有安全有效量的抗菌剂和至少两种酶成分的组合的口服可接受的载体。

4. 发明申请

US20090231703A1 Method of Fixing Polarization-Reversed Region Formed in Ferroelectric Single Crystal and Optical Element Using the Same 有权
标题翻译：固定在铁电单晶中形成的极化反转区域的方法及使用其的光学元件
公开(公告)号：US20090231703A1
公开(公告)日：2009-09-17
申请号：US12225162
申请日：2007-03-05
申请人： Xiaoyan Liu , Shunji Takekawa , Kazuya Terabe , Shunichi Hishita , Kenji Kitamura
发明人： Xiaoyan Liu , Shunji Takekawa , Kazuya Terabe , Shunichi Hishita , Kenji Kitamura
IPC分类号： G02B5/30 , C01D15/00
CPC分类号： G02F1/3558 , G02F2202/20
摘要： A method of fixing polarization-reversed regions formed in a ferroelectric single crystal with ease and an optical element containing such a ferroelectric single crystal are provided. The method of fixing the polarization-reversed regions formed in a ferroelectric single crystal is characterized by including a step of irradiating an ion beam or a neutral beam on the ferroelectric single crystal where polarization-reversed regions are formed. An optical element containing such a ferroelectric single crystal is characterized by being manufactured by a method including such a step.
摘要翻译：提供了容易地形成在铁电单晶中形成的偏振反转区域的方法和包含这种铁电单晶的光学元件。固定形成在铁电单晶中的偏振反转区域的方法的特征在于包括在形成极化反转区域的铁电单晶上照射离子束或中性光束的步骤。含有这种铁电单晶的光学元件的特征在于通过包括这种步骤的方法制造。

5. 发明申请

US20060210981A1 Method for detecting the mutant genes of the major gene cacna1h relating to the childhood absence epilepsy and the cacna1h mutant genes 审中-公开
标题翻译：检测与儿童期无癫痫和cacna1h突变基因有关的主要基因cacna1h突变基因的方法
公开(公告)号：US20060210981A1
公开(公告)日：2006-09-21
申请号：US10543503
申请日：2003-01-27
申请人： Xiru Wu , Yan Shen , Yucai Chen , Husheng Wu , Keming Xu , Hong Pan , Yuehua Zhang , Xiaoyan Liu , Jianjun Lv , Yuwu Jiang
发明人： Xiru Wu , Yan Shen , Yucai Chen , Husheng Wu , Keming Xu , Hong Pan , Yuehua Zhang , Xiaoyan Liu , Jianjun Lv , Yuwu Jiang
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method of detecting the CACNA1H mutant gene of childhood absence epilepsy-the main function gene, the said method is directly sequencing or restriction analysis. The present invention relates to CACNA1H mutant gene. The present invention further relates to the use of the said detection and mutant gene. The present invention connects the CACNA1H gene with medicine for treating childhood absence epilepsy, proving new target site for medicine for treating the same. The present invention establishes the foundation for developing new medicines for treating childhood absence epilepsy and other type of idiopathic system epilepsy as well as other system diseases associated with CACNA1H gene.
摘要翻译：本发明涉及检测儿童无症状癫痫的主要功能基因CACNA1H突变基因的方法，所述方法为直接测序或限制性分析。本发明涉及CACNA1H突变基因。本发明还涉及所述检测和突变基因的用途。本发明将CACNA1H基因与用于治疗儿童期不存在癫痫的药物连接，证明了用于治疗儿童的药物的新靶点。本发明为开发用于治疗儿童期癫痫和其他类型特发性系统癫痫以及与CACNA1H基因相关的其他系统疾病的新药物奠定基础。

6. 发明申请

US20050163807A1 Anticancer agents using vero toxin variants 审中-公开
标题翻译：使用vero毒素变体的抗癌剂
公开(公告)号：US20050163807A1
公开(公告)日：2005-07-28
申请号：US10503415
申请日：2003-02-03
申请人： Xiaoyan Liu
发明人： Xiaoyan Liu
IPC分类号： A61K48/00 , A61P35/00 , A61P43/00 , C07K14/245 , C07K14/195 , A61K39/02
CPC分类号： C07K14/245 , A61K48/00
摘要： An attenuated verotoxin comprising a verotoxin A subunit amino acid sequence in which at least one of the amino acids at positions 167 to 172 and positions 202 to 207 from the N terminus is mutated; an attenuated verotoxin A subunit thereof; a complex of the A subunit with a ligand; an anticancer agent using the verotoxin, A subunit or ligand; a method for treating cancer; a gene that encodes the attenuated verotoxin or its A subunit; a gene therapy agent using the gene; and a gene therapy method.
摘要翻译：一种减毒的毒素，其包含其中来自N末端的167至172位和202至207位的至少一个氨基酸被突变的藜芦毒素A亚基氨基酸序列; 其减毒的毒素A亚基; A亚基与配体的复合物; 使用该毒素，A亚基或配体的抗癌剂; 一种治疗癌症的方法; 编码减毒的毒素或其A亚基的基因; 使用该基因的基因治疗剂; 和基因治疗方法。

7. 发明授权

US06749019B2 Automatic paraffin removal unit 失效
标题翻译：自动除蜡装置
公开(公告)号：US06749019B2
公开(公告)日：2004-06-15
申请号：US10042824
申请日：2002-01-07
申请人： Xiaoyan Liu
发明人： Xiaoyan Liu
IPC分类号： E21B3702
CPC分类号： E21B37/02
摘要： An automatic paraffin removal unit, including a scraper body, a tumbler, an arc spring leaf and a return torque spring, and the upper and lower commutators having a sleeve, an open spacing ring and a tower spring. In operation, the scraper is clamped on a pumping rod, while the upper, lower commutators are respectively connected to the upper, lower ends of the tubing section from the well head to the section having toe temperature lower than paraffin deposition temperature requiring paraffin removal. The scraper moves up and down following the pumping rod via unidirectional upward or downward movement, paraffin removal being performed to the inner wall of tubing and pumping rod unceasingly, and variations in direction being performed in the upper, lower commutators.
摘要翻译：一种自动除石装置，包括刮刀体，翻转开关，弧形弹簧叶片和返回扭矩弹簧，上下换向器具有套筒，开口间隔环和塔架弹簧。在操作中，刮刀被夹紧在泵杆上，而上，下换向器分别从井口连接到管段的上下端，其具有低于石蜡沉积温度的部分，其需要石蜡去除。刮刀通过单向向上或向下运动沿着泵杆上下移动，不断地对管道和泵杆的内壁进行石蜡去除，并且在上，下换向器中执行方向的变化。

8. 发明授权

US08962839B2 Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof 有权
标题翻译：手性螺吡啶基氨基膦配体化合物，其合成方法及其应用
公开(公告)号：US08962839B2
公开(公告)日：2015-02-24
申请号：US13885051
申请日：2011-11-18
申请人： Qilin Zhou , Jianhua Xie , Xiaoyan Liu , Jianbo Xie , Lixin Wang
发明人： Qilin Zhou , Jianhua Xie , Xiaoyan Liu , Jianbo Xie , Lixin Wang
IPC分类号： C07F9/06 , B01J31/24 , B01J31/18 , C07B53/00 , C07C29/145 , C07C41/26 , C07C67/31 , C07D307/83 , C07F9/58 , C07F9/60 , C07B41/02 , C07F15/00
CPC分类号： B01J31/249 , B01J31/189 , B01J2231/643 , B01J2531/827 , C07B41/02 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C41/26 , C07C67/31 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D307/83 , C07F9/58 , C07F9/60 , C07F15/004 , C07C33/18 , C07C33/28 , C07C69/732 , C07C69/675 , C07C69/734 , C07C31/1355 , C07C33/20 , C07C35/32 , C07C35/36 , C07C69/76 , C07C33/46 , C07C43/23 , C07C33/22 , C07C33/26
摘要： The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.
摘要翻译：本发明涉及手性螺 - 吡啶基氨基膦配体化合物，其合成方法及其应用。手性螺 - 吡啶基氨基膦化合物是具有式（I）结构的化合物，其外消旋物或其旋光异构体或其催化可接受的盐，其主要特征在于在其结构中具有手性螺二氢 - 茚骨架。手性螺 - 吡啶基氨基膦化合物可以用光学活性7-二芳基/烷基膦基-7'-氨基-1,1'-螺二氢 - 茚或取代的7-二芳基/烷基膦基-7'-氨基-1,1' - 螺 - 二氢 - 茚作为手性起始原料。手性螺吡啶基氨基膦化合物可以用作由铱催化的羰基化合物的不对称氢化中的手性配体，其中反应活性非常高，催化剂的量可以为0.0001mol％，反应的对映选择性高达99.9％ee。

9. 发明授权

US08929123B2 Resistive-switching device capable of implementing multiary addition operation and method for multiary addition operation 有权
标题翻译：能够实现多重加法运算的电阻式开关装置及多次加法运算方法
公开(公告)号：US08929123B2
公开(公告)日：2015-01-06
申请号：US13641832
申请日：2011-11-18
申请人： Jinfeng Kang , Feifei Zhang , Bin Gao , Bing Chen , Lifeng Liu , Xiaoyan Liu
发明人： Jinfeng Kang , Feifei Zhang , Bin Gao , Bing Chen , Lifeng Liu , Xiaoyan Liu
IPC分类号： G11C11/00 , G11C13/00 , G11C11/56
CPC分类号： G11C13/0007 , G11C11/5685 , G11C13/0069 , G11C2013/0073 , G11C2013/0083
摘要： The present disclosure provides a resistive-switching device capable of implementing multiary addition operation and a method for implementing multiary addition operation using the resistive-switching device. The resistive-switching device has a plurality of resistance values each corresponding to a respective data value stored by the resistive-switching device and ranging from a high resistance value to a low resistance value. The data value stored by the resistive-switching device is increased by ‘1’ successively with a series of set pulses having a same pulse width and a same voltage amplitude being applied thereto. The data value stored by the resistive-switching device is set to ‘0’ with a reset pulse being applied thereto, and meanwhile a data value stored by a higher-bit resistive-switching device is increased by ‘1’ with a set pulse being applied thereto. In this way, multiary addition operation is implemented.
摘要翻译：本公开提供了一种能够实现多加法运算的电阻式开关装置和使用电阻式开关装置实现多重加法运算的方法。电阻开关器件具有多个电阻值，每个电阻值对应于由电阻开关器件存储的各个数据值，并且从高电阻值到低电阻值。由电阻式开关器件存储的数据值以相同的脉冲宽度和相同的电压幅度施加一系列设定脉冲连续增加“1”。由施加复位脉冲的电阻开关器件存储的数据值被设定为“0”，同时由高位电阻开关器件存储的数据值增加“1”，设定脉冲为应用于此。以这种方式，实现多重添加操作。

10. 发明授权

US08924321B2 Three-layered neuron devices for neural network with reset voltage pulse 有权
标题翻译：神经元设备和神经网络
公开(公告)号：US08924321B2
公开(公告)日：2014-12-30
申请号：US13502462
申请日：2011-11-03
申请人： Jinfeng Kang , Bin Gao , Feifei Zhang , Bing Chen , Lifeng Liu , Xiaoyan Liu
发明人： Jinfeng Kang , Bin Gao , Feifei Zhang , Bing Chen , Lifeng Liu , Xiaoyan Liu
IPC分类号： G06F15/18 , G06N3/00 , G06N3/063
CPC分类号： G06N3/063
摘要： A neuron device includes a bottom electrode, a top electrode, and a layer of metal oxide variable resistance material sandwiched between the bottom electrode and the top electrode, in which the neuron device is switched to a normal state upon application of reset pulse, and is switched to an excitation state upon application of stimulus pulses. The neuron device has a comprehensive response to different amplitude, different width of a stimulus voltage pulse and different number of a sequence of stimulus pulses, and provides functionalities of a weighting section and a computing section. The neuron device has a simple structure, excellent scalability, quick speed, low operation voltage, and is compatible with the conventional silicon-based CMOS fabrication process, and thus suitable for mass production. The neuron device is capable of performing many biological functions and complex logic operations.
摘要翻译：神经元装置包括底部电极，顶部电极和夹在底部电极和顶部电极之间的金属氧化物可变电阻材料层，其中神经元装置在施加复位脉冲时切换到正常状态，并且是在施加刺激脉冲时切换到激发状态。神经元装置对刺激电压脉冲的不同幅度，不同宽度和不同数量的刺激脉冲序列具有综合响应，并提供加权部分和计算部分的功能。神经元器件结构简单，可扩展性好，速度快，工作电压低，与传统的硅基CMOS制造工艺兼容，适合批量生产。神经元器件能够执行许多生物学功能和复杂的逻辑运算。

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