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1. 发明申请

US20060253088A1 Dual needle delivery system 有权
公开(公告)号：US20060253088A1
公开(公告)日：2006-11-09
申请号：US11112546
申请日：2005-04-22
申请人： Mina Chow , Dwight Ambat , Jin Cheng , Eugene Michal
发明人： Mina Chow , Dwight Ambat , Jin Cheng , Eugene Michal
IPC分类号： A61M25/00
CPC分类号： A61M25/06 , A61M25/003 , A61M25/0071 , A61M2025/0034 , A61M2025/0037
摘要： An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.

2. 发明授权

US09149602B2 Dual needle delivery system 有权
标题翻译：双针输送系统
公开(公告)号：US09149602B2
公开(公告)日：2015-10-06
申请号：US11112546
申请日：2005-04-22
申请人： Mina Chow , Dwight A. Ambat , Jin Cheng , Eugene Michal
发明人： Mina Chow , Dwight A. Ambat , Jin Cheng , Eugene Michal
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/06 , A61M25/003 , A61M25/0071 , A61M2025/0034 , A61M2025/0037
摘要： An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.
摘要翻译：一种用于传送设备的设备。该装置包括具有细长轴的导管，该细长轴具有第一内腔和延伸穿过其中的第二腔。该装置还包括远端部分，其具有与导管的远端中的端口以及与第一管腔和第二管腔连通的内腔。第一管腔被配置为用于第一装置，并且第二管腔被配置为用于设置在其中的第二装置。所述装置还包括：与所述细长轴相连的近端适配器，其具有与所述第一管腔连通的第一端口和与所述第二管腔连通的第二端口。

3. 发明申请

US20060265043A1 Method and apparatus for treating vulnerable plaque 审中-公开
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US20060265043A1
公开(公告)日：2006-11-23
申请号：US11388355
申请日：2006-03-24
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译：描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

4. 发明授权

US08303509B2 Echogenic needle catheter configured to produce an improved ultrasound image 有权
标题翻译：构造为产生改善的超声图像的生殖针导管
公开(公告)号：US08303509B2
公开(公告)日：2012-11-06
申请号：US12882156
申请日：2010-09-14
申请人： William E. Webler , Mina Chow
发明人： William E. Webler , Mina Chow
IPC分类号： A61B8/14
CPC分类号： A61M25/0068 , A61B8/0841 , A61B90/36 , A61B2090/3782 , A61M25/0009 , A61M25/0045 , A61M25/0052 , A61M25/0069 , A61M25/0084 , A61M25/0108 , A61M25/0147 , A61M2025/0089
摘要： An echogenic medical device, such as a needle catheter, which produces an improved ultrasonic image of the device, and a method of performing a medical procedure using a device of the invention. One aspect is directed to a catheter which reduces artifacts in the ultrasound image of the catheter. In one embodiment, the catheter has a spherical distal tip. Another aspect of the invention is directed to an echogenic catheter with echogenic portions arranged in an array to facilitate determination by ultrasonic imaging of the rotational orientation of the catheter relative to a desired location within the patient.
摘要翻译：产生设备的改进的超声波图像的回声医疗装置，例如针导管，以及使用本发明的装置执行医疗程序的方法。一个方面涉及导管，其减少导管的超声图像中的伪像。在一个实施例中，导管具有球形远端尖端。本发明的另一方面涉及一种具有排列成阵列的回声部分的回声导管，以有助于通过超声波成像来确定导管相对于患者内的期望位置的旋转取向。

5. 发明授权

US07267650B2 Ultrasound directed guiding catheter system and method 失效
标题翻译：超声导向导管系统及方法
公开(公告)号：US07267650B2
公开(公告)日：2007-09-11
申请号：US10320728
申请日：2002-12-16
申请人： Mina Chow , William E. Webler
发明人： Mina Chow , William E. Webler
IPC分类号： A61B8/12
CPC分类号： A61B8/12
摘要： A guiding catheter system employs a flexible shaft having a preformed bend at a distal end. An ultrasound transducer is mounted proximal to the pre-formed bend. The ultrasound transducer has a field of view directed to a distal tip of the guiding catheter. The guiding catheter includes an open lumen adapted for the introduction of payloads through the catheter system. The guiding catheter system can be used to direct a smaller guiding catheter or guide wire into a destination vessel from a heart chamber. In one application, the guiding catheter system is used to introduce a guiding catheter into the coronary sinus ostium from the right atrium.
摘要翻译：引导导管系统采用在远端具有预成形弯曲部的柔性轴。超声换能器安装在预成形弯曲部的近侧。超声换能器具有指向导向导管的远端的视野。引导导管包括适于通过导管系统引入有效载荷的开口腔。引导导管系统可用于将较小的引导导管或导丝从心室引导到目的血管中。在一个应用中，引导导管系统用于将导向导管从右心房引入冠状窦口。

6. 发明授权

US07179249B2 Directional needle injection drug delivery device and method of use 有权
标题翻译：定向注射药物输送装置及其使用方法
公开(公告)号：US07179249B2
公开(公告)日：2007-02-20
申请号：US10390942
申请日：2003-03-17
申请人： Jeffrey Steward , Mina Chow
发明人： Jeffrey Steward , Mina Chow
IPC分类号： A61M31/00
CPC分类号： A61B8/12 , A61B5/4839 , A61B8/445 , A61M25/0084 , A61M25/104 , A61M37/0092 , A61M2025/009 , A61M2025/0096
摘要： The invention relates to an apparatus and method for imaging and mapping various structures located at a target area within a patient's lumen using conventional IVUS technology. The mapped images are used to accurately determine and control the location of the device within the lumen relative to the target area and/or target site. Once the drug delivery device is properly positioned within the lumen, additional ultrasonic images are generated and used to control the position and depth of penetration of a retractable needle of the device. Needle position can be precisely determined, both in relationship to the device as well as the target site for drug delivery. This allows accurate delivery of drug to the target site and, thus, enhanced treatment capabilities.
摘要翻译：本发明涉及一种用于使用常规IVUS技术对位于患者管腔内的目标区域的各种结构进行成像和映射的装置和方法。映射的图像用于相对于目标区域和/或目标位置精确地确定和控制流明内的装置的位置。一旦药物输送装置适当地定位在内腔内，则产生附加的超声波图像并用于控制装置的可伸缩针的穿透位置和深度。可以精确地确定针位置，无论是与装置以及药物递送的目标部位有关。这允许将药物准确地递送到目标部位，从而提高治疗能力。

7. 发明授权

US07867169B2 Echogenic needle catheter configured to produce an improved ultrasound image 有权
标题翻译：构造为产生改善的超声图像的生殖针导管
公开(公告)号：US07867169B2
公开(公告)日：2011-01-11
申请号：US11293420
申请日：2005-12-02
申请人： William E. Webler , Mina Chow
发明人： William E. Webler , Mina Chow
IPC分类号： A61B8/14
CPC分类号： A61M25/0068 , A61B8/0841 , A61B90/36 , A61B2090/3782 , A61M25/0009 , A61M25/0045 , A61M25/0052 , A61M25/0069 , A61M25/0084 , A61M25/0108 , A61M25/0147 , A61M2025/0089
摘要： An echogenic medical device, such as a needle catheter, which produces an improved ultrasonic image of the device, and a method of performing a medical procedure using a device of the invention. One aspect is directed to a catheter which reduces artifacts in the ultrasound image of the catheter. In one embodiment, the catheter has a spherical distal tip. Another aspect of the invention is directed to an echogenic catheter with echogenic portions arranged in an array to facilitate determination by ultrasonic imaging of the rotational orientation of the catheter relative to a desired location within the patient.
摘要翻译：产生设备的改进的超声波图像的回声医疗装置，例如针导管，以及使用本发明的装置执行医疗程序的方法。一个方面涉及导管，其减少导管的超声图像中的伪像。在一个实施例中，导管具有球形远端尖端。本发明的另一方面涉及一种具有排列成阵列的回声部分的回声导管，以有助于通过超声波成像来确定导管相对于患者内的期望位置的旋转取向。

8. 发明申请

US20080041516A1 INFUSION TREATMENT AGENTS, CATHETERS, FILTER DEVICES, AND OCCLUSION DEVICES, AND USE THEREOF 有权
标题翻译：输液治疗剂，过滤器，过滤器和消毒装置及其用途
公开(公告)号：US20080041516A1
公开(公告)日：2008-02-21
申请号：US11923258
申请日：2007-10-24
申请人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
发明人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
IPC分类号： B29C53/60
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.
摘要翻译：实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置限制流体，如血液。可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

9. 发明申请

US20050015048A1 Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof 审中-公开
标题翻译：输液治疗剂，导管，过滤装置和闭塞装置及其用途
公开(公告)号：US20050015048A1
公开(公告)日：2005-01-20
申请号：US10800323
申请日：2004-03-11
申请人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
发明人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial and/or co-linear lumen, a supporting mandrel, and/or an occlusion device at its distal end. Moreover, according to embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, and/or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.
摘要翻译：实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。输送导管可以在其远端具有附属腔，同轴和/或共线的腔，支撑心轴和/或闭塞装置。此外，根据实施例，闭塞装置可以是具有不同材料的内衬和外层的单一材料或复合球囊，高顺应性低压气球和/或限制颗粒通过而过滤装置不限制流体，如血液。可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

10. 发明授权

US06692466B1 Drug delivery catheter with retractable needle 有权
标题翻译：药物输送导管带伸缩针
公开(公告)号：US06692466B1
公开(公告)日：2004-02-17
申请号：US09746498
申请日：2000-12-21
申请人： Mina Chow , Paul John Kawula , Jeffrey Steward
发明人： Mina Chow , Paul John Kawula , Jeffrey Steward
IPC分类号： A61M5178
CPC分类号： A61M25/0084 , A61M25/10 , A61M2025/0086 , A61M2025/0087 , A61M2025/009
摘要： A catheter assembly having a balloon disposed at the distal end thereof and a therapeutic substance delivery assembly, including a needle in fluid communication with a therapeutic substance delivery lumen for allowing a therapeutic substance to be injected into a diseased physiological lumen. A deflector is positioned along an inside wall of the delivery lumen, positioned, such that as a bend region forms caused by the movement of the delivery lumen, the deflector bends to rest on the outside curvature of the bend. As the needle is made to travel through the bend, the ribbon helps to bounce the needle tip off the wall of the delivery lumen, allowing the needle to travel through the bend without digging into and/or gouging the delivery lumen wall.
摘要翻译：一种具有设置在其远端处的气囊的导管组件和包括与治疗物质输送腔流体连通的针的治疗物质输送组件，用于允许将治疗物质注射到患病的生理管腔中。偏转器沿着输送腔的内壁定位，定位成使得由于由输送腔的运动引起的弯曲区域形成，偏转器弯曲以弯曲的外侧曲率。当针被制造成穿过弯曲部时，带状物有助于使针尖从输送腔的壁反弹，从而允许针穿过弯曲部而不会进入和/或凿出输送腔壁。

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