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    • 8. 发明授权
    • Process for the manufacture of 2-phenyl-4,5-oxazoledione
4-phenylhydrazone derivatives
    • 2-苯基-4,5-恶唑二酮4-苯腙衍生物的制备方法
    • US5646291A
    • 1997-07-08
    • US431573
    • 1995-05-01
    • Hajime HoshiKazuhiko SunagawaTakeo Watanabe
    • Hajime HoshiKazuhiko SunagawaTakeo Watanabe
    • C09B26/02C07D263/18
    • C09B26/02
    • A process for manufacturing derivatives of 2-phenyl-4,5-oxazoledione 4-phenylhyrazone is disclosed. The process comprises reacting a derivative of a benezenediazonium salt, a hippuric acid derivative, and acetic anhydride in the presence of a neutralizing agent to effect the cyclization reaction for the formation of the oxazolone ring and the succeeding diazo-coupling reaction. The process does not require the conventional separate, independent step for the preparation of a solution of a hippuric acid derivative and acetic anhydride, thus eliminating the quick heating and quenching procedures and further avoiding the loss of the hippuric acid derivative due to decomposition of the oxazolone derivative. There is thus obtained a high yield of the desired product in a short period of time.
    • 公开了一种制备2-苯基-4,5-恶唑二酮4-苯基腙的衍生物的方法。 该方法包括在中和剂存在下使衍生重氮盐,马尿酸衍生物和乙酸酐的衍生物进行反应,以进行恶唑酮环的形成和后续的重氮偶合反应的环化反应。 该方法不需要用于制备马尿酸衍生物和乙酸酐的常规独立的独立步骤,因此消除了快速加热和淬灭程序,并进一步避免了由于恶唑酮分解导致的马尿酸衍生物的损失 衍生物。 因此在短时间内获得了高产率的所需产物。