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1. 发明授权

US5453099A Catheter tubing of controlled in vivo softening 失效
标题翻译：导管可控制体内软化
公开(公告)号：US5453099A
公开(公告)日：1995-09-26
申请号：US245883
申请日：1994-05-18
申请人： Min-Shiu Lee , Mutlu Karakelle , David E. Spielvogel , Robert A. Taller
发明人： Min-Shiu Lee , Mutlu Karakelle , David E. Spielvogel , Robert A. Taller
IPC分类号： A61L29/08 , A61L29/14 , A61M25/00
CPC分类号： A61M25/0054 , A61L29/085 , A61L29/14 , A61M2025/0064
摘要： A catheter tubing has a layer of a hydrophobic stiffening polymer encapsulated by a layer of hydrophilic thermoplastic base polymer. Preferred stiffening polymers are polyesterpolyether block copolymers. Preferred base polymers are thermoplastic polyetherurethanes. The encapsulated layer may be a stripe or an annular layer having base polymer layers laminated on both surfaces thereof.
摘要翻译：导管管具有由一层亲水性热塑性基础聚合物包封的疏水硬化聚合物层。优选的加强聚合物是聚酯聚醚嵌段共聚物。优选的基础聚合物是热塑性聚醚氨基甲酸酯。封装层可以是带状或具有层压在其两个表面上的基础聚合物层的环形层。

2. 发明授权

US5226899A Catheter tubing of controlled in vivo softening 失效
标题翻译：导管可控制体内软化
公开(公告)号：US5226899A
公开(公告)日：1993-07-13
申请号：US746813
申请日：1991-08-15
申请人： Min-Shiu Lee , Mutlu Karakelle , David E. Spielvogel , Robert A. Taller
发明人： Min-Shiu Lee , Mutlu Karakelle , David E. Spielvogel , Robert A. Taller
IPC分类号： A61L29/08 , A61L29/14 , A61M25/00
CPC分类号： A61M25/0054 , A61L29/085 , A61L29/14 , B29C47/0023 , B29C47/065 , A61M2025/0064 , B29L2031/7542
摘要： A catheter tubing has a layer of a hydrophobic stiffening polymer encapsulated by a layer of hydrophilic thermoplastic base polymer. Preferred stiffening polymers are polyesterpolyether block copolymers. Preferred base polymers are thermoplastic polyetherurethanes. The encapsulated layer may be a stripe or an annular layer having base polymer layers laminated on both surfaces thereof.
摘要翻译：导管管具有由一层亲水性热塑性基础聚合物包封的疏水硬化聚合物层。优选的加强聚合物是聚酯聚醚嵌段共聚物。优选的基础聚合物是热塑性聚醚氨基甲酸酯。封装层可以是带状或具有层压在其两个表面上的基础聚合物层的环形层。

3. 发明授权

US5302385A Polyurethane-polyvinylpyrrolidone block copolymer and iodine carrier therefrom 失效
标题翻译：聚氨酯 - 聚乙烯吡咯烷酮嵌段共聚物和碘载体
公开(公告)号：US5302385A
公开(公告)日：1994-04-12
申请号：US569804
申请日：1990-08-20
申请人： Mohammad A. Khan , Mutlu Karakelle , Min-Shiu Lee , Robert A. Taller
发明人： Mohammad A. Khan , Mutlu Karakelle , Min-Shiu Lee , Robert A. Taller
IPC分类号： A61L15/26 , A61L15/42 , A61L15/46 , A61L27/34 , A61L29/08 , C08G18/40 , C08G18/62 , C08G18/65 , A61L15/00 , A61L29/00
CPC分类号： C08G18/65 , A61L15/26 , A61L15/425 , A61L15/46 , A61L27/34 , A61L29/085 , C08G18/4063 , C08G18/6283 , A61L2300/202 , A61L2300/404
摘要： A copolymer having free hydroxyl groups is formed from N-vinyl pyrrolidone and allyl alcohol. A polyurethane is formed from a reaction mixture which includes the copolymer, a diisocyanate, a chain extender and a polyglycol. The polyurethane takes up iodine to give a complex useful as an antimicrobial coating on a medical article or as an antimicrobial foam sponge or wound dressing.
摘要翻译：具有游离羟基的共聚物由N-乙烯基吡咯烷酮和烯丙醇形成。由包括共聚物，二异氰酸酯，扩链剂和聚二醇的反应混合物形成聚氨酯。聚氨酯吸收碘以产生用作医疗制品上的抗微生物涂层的复合物或作为抗微生物泡沫海绵或伤口敷料的复合物。

4. 发明授权

US5084315A Lubricious coatings, medical articles containing same and method for their preparation 失效
标题翻译：润滑涂料，含有其的医药制品及其制备方法
公开(公告)号：US5084315A
公开(公告)日：1992-01-28
申请号：US473506
申请日：1990-02-01
申请人： Houshang Karimi , Stanley C. Wells , David E. Spielvogel , Mutlu Karakelle , Robert A. Taller
发明人： Houshang Karimi , Stanley C. Wells , David E. Spielvogel , Mutlu Karakelle , Robert A. Taller
IPC分类号： A61L29/00 , A61L29/08 , A61L29/14 , A61L31/00 , A61L33/06
CPC分类号： A61L29/14 , A61L29/085 , A61L33/068 , A61L2400/10
摘要： An article which becomes lubricious when wet includes a base polymer and a coating composition thereon. The composition includes a lubricating polymer and a matrix polymer which adheres to the base polymer and serves as a carrier for the lubricating polymer. The composition may also include a homogenizing polymer to enhance the compatibility of the matrix and lubricating polymer. The invention includes a method to make the article of the invention by coextruding the base polymer and the coating composition.

5. 发明授权

US5302392A Polyurethane sponge having rapid iodine release 失效
标题翻译：聚氨酯海绵具有快速的碘释放
公开(公告)号：US5302392A
公开(公告)日：1994-04-12
申请号：US570656
申请日：1990-08-20
申请人： Mutlu Karakelle , C. David Benson , Robert A. Taller , Min-Shiu Lee , Mohammad A. Khan
发明人： Mutlu Karakelle , C. David Benson , Robert A. Taller , Min-Shiu Lee , Mohammad A. Khan
IPC分类号： A01N25/16 , A01N25/34 , A01N59/12 , C08G18/10 , A61M31/00
CPC分类号： A01N25/34 , A01N25/16 , A01N59/12
摘要： A polyurethane composition has particles of solid polyvinylpyrrolidone-iodine complex evenly distributed throughout the polyurethane matrix so that the complex does not associate with the polyurethane to any appreciable extent. In one embodiment of the composition, the polyurethane is thermoplastic for coating or molding applications. In another embodiment, the composition is a polyurethane foam particularly useful as a sponge for scrubbing which provides almost instantaneous release of the complex. The sponge may be provided in a package which includes other items useful for scrubbing.
摘要翻译：聚氨酯组合物具有均匀分布在整个聚氨酯基质中的固体聚乙烯吡咯烷酮 - 碘络合物的颗粒，使得络合物不会与聚氨酯发生任何明显的相关性。在组合物的一个实施方案中，聚氨酯是用于涂布或模塑应用的热塑性塑料。在另一个实施方案中，组合物是特别用作擦洗海绵的聚氨酯泡沫，其提供了复合物的几乎瞬时释放。海绵可以设置在包括用于洗涤的其它物品的包装中。

6. 发明授权

US5091443A Composition for gelling liquids 失效
标题翻译：凝胶液组合物
公开(公告)号：US5091443A
公开(公告)日：1992-02-25
申请号：US476869
申请日：1990-02-07
申请人： Mutlu Karakelle , Carl D. Benson , Robert A. Taller , David E. Spielvogel
发明人： Mutlu Karakelle , Carl D. Benson , Robert A. Taller , David E. Spielvogel
IPC分类号： A61L15/00 , C02F1/00 , C08B31/00 , C08L1/00 , C08L1/08 , C08L3/00 , C08L3/04 , C08L33/02 , C08L51/02 , C09K3/00
CPC分类号： C08L33/02 , C08L51/02
摘要： A gelling composition for an aqueous liquid includes ungellated starch which has been reacted with a silane coupling agent. In preferred compositions, the starch is a starch-polyacrylate graft copolymer and the composition includes a polyacrylate gelling agent. A disinfectant may be added to the composition for compositions intended for use with medical waste.

7. 发明授权

US5061424A Method for applying a lubricious coating to an article 失效
标题翻译：将润滑涂层施用于制品的方法
公开(公告)号：US5061424A
公开(公告)日：1991-10-29
申请号：US643639
申请日：1991-01-22
申请人： Houshang Karimi , Mutlu Karakelle , Robert A. Taller
发明人： Houshang Karimi , Mutlu Karakelle , Robert A. Taller
IPC分类号： B29C47/04 , A61L29/00 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10 , B29C47/06 , B29K55/00 , B29K75/00 , B29L31/06 , B29L31/40 , B32B27/00 , C08J5/16 , C08L39/00 , C08L39/06 , C08L75/00 , C08L75/08 , C09D175/00 , C09D175/04
CPC分类号： B29C47/0023 , A61L29/049 , A61L29/085 , A61L31/041 , A61L31/10 , B29C47/065 , B29C47/128 , B29C47/26 , B29K2039/06 , B29K2075/00 , B29L2031/753
摘要： A composition which includes polyvinylpyrrolidone and a polyurethane is melt processed to give a shaped article. The melt processing may be a coextrusion with a substrate polymer to give a shaped article having the composition coated on the surface thereof. The article surface is lubricious when contacted with water.

8. 发明授权

US4990357A Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings 失效
标题翻译：弹性分段亲水聚醚聚氨酯基润滑涂料
公开(公告)号：US4990357A
公开(公告)日：1991-02-05
申请号：US347133
申请日：1989-05-04
申请人： Mutlu Karakelle , Houshang Karimi , Min-Shui Lee , Robert A. Taller
发明人： Mutlu Karakelle , Houshang Karimi , Min-Shui Lee , Robert A. Taller
IPC分类号： C08L29/10 , A61L29/08 , C08L71/02 , C08L75/00 , C08L75/08 , C08L101/00 , C08L101/02 , C09D129/00 , C09D129/10 , C09D175/00 , C09D175/08
CPC分类号： C09D175/08 , A61L29/085 , A61L2400/10
摘要： A coating composition for an article surface includes a uniform blend of an elastomeric segmented hydrophilic polyetherurethane and a hydrophilic polymer, such as polyvinylpyrrolidone. The invention includes a method for rendering an article surface lubricious which includes coating the composition onto the article surface and contacting the coated surface with an aqueous liquid.

9. 发明授权

US5092858A Liquid gelling agent distributor device 失效
标题翻译：液体胶凝剂分配器
公开(公告)号：US5092858A
公开(公告)日：1992-03-03
申请号：US496475
申请日：1990-03-20
申请人： C. David Benson , Mutlu Karakelle , Robert A. Taller
发明人： C. David Benson , Mutlu Karakelle , Robert A. Taller
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0096
摘要： A device is provided for deliberately distributing simultaneously over the entire vertical and/or longitudinal extend of a body of aqueous containing liquid a gelation agent for the rapid containment of contaminated aqueous liquids. The device is an elongated rigid or semi-rigid body for containing an envelope or package of material immediately dissolvable in the aqueous liquids, and which contains the gelling agent prior to liquid exposure. The device includes means for exposure of its content to the liquid, once the device is positioned in or is surrounded by the liquid. The invention contemplates a conventional suction canister having the device positioned therein for receiving contaminated body fluids.
摘要翻译：提供一种装置，用于同时在水性含水液体的整个垂直和/或纵向延伸处同时分布凝胶剂，用于快速容纳受污染的含水液体。该装置是细长的刚性或半刚性体，用于容纳立即可溶于含水液体中的材料的包封或包装物，并且在液体暴露之前含有胶凝剂。该装置包括用于将其内容物暴露于液体的装置，一旦装置定位在液体中或被液体包围。本发明设想一种传统的吸力罐，其中装置定位在其中以便接收被污染的体液。

10. 发明授权

US08241354B2 Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics 有权
标题翻译：扩展焦距（EDOF）镜头，通过利用瞳孔动力学增加伪适应度
公开(公告)号：US08241354B2
公开(公告)日：2012-08-14
申请号：US12503267
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

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