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1. 发明授权

US08241354B2 Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics 有权
标题翻译：扩展焦距（EDOF）镜头，通过利用瞳孔动力学增加伪适应度
公开(公告)号：US08241354B2
公开(公告)日：2012-08-14
申请号：US12503267
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

2. 发明授权

US08562675B2 Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics 有权
标题翻译：扩展焦距（EDOF）镜头，通过利用瞳孔动力学增加伪适应度
公开(公告)号：US08562675B2
公开(公告)日：2013-10-22
申请号：US13562143
申请日：2012-07-30
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

3. 发明申请

US20120290085A1 EXTENDED DEPTH OF FOCUS (EDOF) LENS TO INCREASE PSEUDO-ACCOMMODATION BY UTILIZING PUPIL DYNAMICS 有权
标题翻译：聚焦深度（EDOF）镜头通过利用PUPIL动态增加PSEUDO-ACCOMMODATION
公开(公告)号：US20120290085A1
公开(公告)日：2012-11-15
申请号：US13562143
申请日：2012-07-30
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

4. 发明申请

US20100016961A1 Extended Depth of Focus (EDOF) Lens to Increase Pseudo-Accommodation by Utilizing Pupil Dynamics 有权
标题翻译：扩展焦点（EDOF）镜头通过利用瞳孔动力学增加伪住宿
公开(公告)号：US20100016961A1
公开(公告)日：2010-01-21
申请号：US12503267
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16 , G02C7/06
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

5. 发明申请

US20100016965A1 Accommodative IOL with Toric Optic and Extended Depth of Focus 审中-公开
标题翻译：适应性IOL与Toric Optic和扩展的焦点深度
公开(公告)号：US20100016965A1
公开(公告)日：2010-01-21
申请号：US12503307
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Myoung-Taek Choi , Yan Zhang , Son Tran
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Myoung-Taek Choi , Yan Zhang , Son Tran
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1629 , A61F2/1645 , A61F2/1648 , G02C7/088
摘要： In one aspect, the present invention provides an intraocular lens (IOL), which comprises at least two optics disposed in tandem along an optical axis, and an accommodative mechanism that is coupled to at least one of the optics and is adapted to adjust a combined optical power of the optics in response to natural accommodative forces of an eye in which the optics are implanted so as to provide accommodation. At least one of the optics has a surface characterized by a first refractive region, a second refractive region and transition region therebetween, where an optical phase shift of incident light having a design wavelength (e.g., 550 nm) across the transition region corresponds to a non-integer fraction of that wavelength.
摘要翻译：在一个方面，本发明提供了一种眼内透镜（IOL），其包括沿着光轴串联设置的至少两个光学器件，以及调节机构，其耦合到所述光学器件中的至少一个并且适于调整组合响应于眼睛的自然调节力，光学器件的光学功率，其中植入光学器件以提供适应。至少一个光学元件具有由第一折射区域，第二折射区域和它们之间的过渡区域表征的表面，其中穿过过渡区域的具有设计波长（例如，550nm）的入射光的光学相移对应于该波长的非整数分数。

6. 发明申请

US20070171362A1 Truncated diffractive intraocular lenses 审中-公开
$Truncated diffractive intraocular lenses$
标题翻译：截断的衍射眼内透镜
公开(公告)号：US20070171362A1
公开(公告)日：2007-07-26
申请号：US11444112
申请日：2006-08-23
申请人： Michael Simpson , Mutlu Karakelle , Steve Vannoy , Xiaoxiao Zhang , Xin Hong , Jihong Xie
发明人： Michael Simpson , Mutlu Karakelle , Steve Vannoy , Xiaoxiao Zhang , Xin Hong , Jihong Xie
IPC分类号： G02C7/02
CPC分类号： A61F2/1654 , A61F2/1618 , G02C7/042 , G02C7/044 , G02C2202/20
摘要： In one aspect, the present invention provides a method of designing a diffractive ophthalmic lens (e.g., an intraocular lens (IOL)) that includes providing an optic having an anterior refractive surface and a posterior refractive surface, wherein the optic provides a far-focus power (e.g., in a range of about 18 to about 26 Diopters (D)). A truncated diffractive structure can be disposed on at least one of the surfaces for generating a near-focus add power (e.g., in a range of about 3 D to about 4 D). And the diffractive structure can be adjusted so as to obtain a desired distribution of optical energy between the near and far foci for a range of pupil sizes.
摘要翻译：一方面，本发明提供了一种设计衍射眼用透镜（例如，眼内透镜（IOL））的方法，其包括提供具有前折射表面和后折射表面的光学元件，其中所述光学元件提供远焦点功率（例如，在约18至约26屈光度（D）的范围内）。截面的衍射结构可以设置在至少一个表面上，用于产生近焦点添加功率（例如，在约3D至约4D的范围内）。并且可以调整衍射结构，以便在一定范围的瞳孔尺寸之间获得近焦点和远焦点之间期望的光能分布。

7. 发明申请

US20060244904A1 Intraocular lens 有权
标题翻译：人工晶状体
公开(公告)号：US20060244904A1
公开(公告)日：2006-11-02
申请号：US11397332
申请日：2006-04-04
申请人： Xin Hong , Jihong Xie , Stephen Van Noy , Dan Stanley , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson
发明人： Xin Hong , Jihong Xie , Stephen Van Noy , Dan Stanley , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson
IPC分类号： G02C7/04
CPC分类号： A61F2/1613 , A61F2/1637 , G02C7/02
摘要： In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about −0.202 microns to about −0.190 microns across the power range.
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有前光学表面和后光学表面的光学元件，其中所述光学元件提供在约16D至约25D的范围内的光焦度如在具有基本上类似于眼睛房水的折射率的介质中测量的（例如，约1.336）。至少一个光学表面的特征在于非球面基部轮廓，使得光学器件在功率范围内在约-0.202微米至约-0.190微米的范围内呈现负球面像差。

8. 发明申请

US20060227286A1 Optimal IOL shape factors for human eyes 审中-公开
标题翻译：人眼的最佳IOL形状因子
公开(公告)号：US20060227286A1
公开(公告)日：2006-10-12
申请号：US11397305
申请日：2006-04-04
申请人： Xin Hong , Stephen Van Noy , Jihong Xie , Dan Stanley , Mutlu Karakelle , Michael Simpson , Xiaoxiao Zhang
发明人： Xin Hong , Stephen Van Noy , Jihong Xie , Dan Stanley , Mutlu Karakelle , Michael Simpson , Xiaoxiao Zhang
IPC分类号： G02C7/02
CPC分类号： A61F2/1613 , A61F2/1637 , G02C7/02
摘要： The present invention provides an ophthalmic lens (e.g., an intraocular lens) having an optic with an anterior surface and a posterior surface, which exhibits a shape factor (defined as a ratio of the sum of the anterior and posterior curvatures to the difference of such curvatures) in a range of about −0.5 to about 4. In a related aspect, the shape factor of the optic lies in a range of about 0 to about 2. The above shape factors give rise to a plurality of different lens shapes, such as concave-convex, plano-convex and plano-concave.
摘要翻译：本发明提供了具有前表面和后表面的光学元件的眼用透镜（例如，眼内透镜），其呈现形状因子（定义为前曲率和后曲率之和与其之间的差的比值曲率）在约-0.5至约4的范围内。在相关方面，光学元件的形状因子在约0至约2的范围内。上述形状因子产生多个不同的透镜形状，例如作为凹凸，平凸和平凹。

9. 发明授权

US08100527B2 Intermediate vision with phakic multifocal optics utilizing residual accommodations 有权
标题翻译：中间视觉与复式多焦点光学利用残留住宿
公开(公告)号：US08100527B2
公开(公告)日：2012-01-24
申请号：US12522949
申请日：2008-01-11
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
IPC分类号： G02C7/02 , A61F2/16
CPC分类号： A61F2/1602 , A61F2/1618 , A61F2/1654
摘要： In one aspect, the present invention provides a method of correcting vision, which comprises determining a residual accommodation exhibited by a natural, crystalline lens of an eye, and selecting a multifocal intraocular lens (IOL), which exhibits a far-focus optical power (e.g., in a range of about −15 to about +50 Diopters (D)) and an add power (e.g., in a range of about 1 D to about 4 D), for implantation in the eye while retaining the natural lens. The add power of the IOL is selected as a function of the residual accommodation such that a combination of the IOL and the natural lens provides a visual contrast greater than about 10% at a spatial frequency of about 20 cycles/degree for viewing objects at a distance greater than about 30 cm from the eye.
摘要翻译：一方面，本发明提供了一种矫正视力的方法，其包括确定由天然眼晶体显示的残留调节物，以及选择呈现远焦光功率的多焦点眼内透镜（IOL）例如，在约-15至约+50屈光度（D）的范围内）和附加功率（例如，在约1至约4D的范围内），用于植入眼睛同时保持天然晶状体。选择IOL的附加功率作为残余调节的函数，使得IOL和自然透镜的组合在大约20个循环/度的空间频率处提供大于约10％的视觉对比度，以便在距离距离眼睛约30厘米。

10. 发明申请

US20110238174A1 ACCOMMODATING INTRAOCULAR LENS USING TRAPEZOIDAL PHASE SHIFT 有权
标题翻译：使用TRAPEZOIDAL相位移位调节内窥镜
公开(公告)号：US20110238174A1
公开(公告)日：2011-09-29
申请号：US13042688
申请日：2011-03-08
申请人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
发明人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
IPC分类号： A61F2/16
CPC分类号： A61F2/1629 , A61F2/1648 , A61F2/1694 , A61F2002/1683 , A61F2002/1699
摘要： An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.
摘要翻译：适应性眼内透镜（AIOL）包括适于产生梯形相移和多个触觉的光学元件。每个触觉件从触觉 - 视觉连接处延伸到至少一个与眼睛囊袋接触的横向臂，并且每个触觉具有足够的长度和刚度，以拉伸眼睛的囊袋以接触眼睛的睫状肌。触觉视觉交叉点相对于触觉件向前保持视线，并且由睫状肌压迫襻部，使前视镜向前移动。通过前视镜和梯形相移的运动产生的组合调节力至少为0.5屈光度。

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