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1. 发明授权

US06285775B1 Watermarking scheme for image authentication 失效
标题翻译：图像认证的水印方案
公开(公告)号：US06285775B1
公开(公告)日：2001-09-04
申请号：US09164474
申请日：1998-10-01
申请人： Min Wu , Bede Liu
发明人： Min Wu , Bede Liu
IPC分类号： G06K900
CPC分类号： G06T1/0042 , G06T2201/0052
摘要： A digital watermarking process whereby an invisible watermark inserted into a host image is utilized to determine whether or not the image has been altered and, if so, where in the image such alteration occurred. The watermarking method includes the steps of providing a look-up table containing a plurality of coefficients and corresponding values; transforming the image into a plurality of blocks, wherein each block contains coefficients matching coefficients in the look-up table; and embedding the watermark in the image by performing the following substeps for at least some of the blocks: First, a coefficient is selected for insertion of a marking value representative of a corresponding portion of the watermark. Next, the value of the selected coefficient to used to identify a corresponding value in the look-up table. Finally, the identified coefficient is left unchanged if the corresponding value is the same as the marking value, and is changed if the corresponding value is different from the marking value. After the insertion of the watermark, the image may be stored in a lossy-compression form, thus permitting efficient storage and distribution. Moreover, the method may be used to produce two output signals for authentication: (1) a meaningful pattern to facilitate a quick visual check, and (2) an additional signal to detect unauthorized alteration. The method can be applied to an image compressed using JPEG or other techniques, such as Wavelet compression, and the marked image can be kept in the compressed format. Any alteration made on the marked image can be localized, making the method suitable for use in a “trustworthy” digital camera or camcorder.
摘要翻译：使用数字水印处理，由此使用插入到主机图像中的不可见水印来确定图像是否已被改变，如果是，则在图像中发生这种改变。该水印方法包括以下步骤：提供包含多个系数和对应值的查找表; 将图像变换成多个块，其中每个块包含在查找表中匹配系数的系数; 以及通过对于至少一些块执行以下子步骤来将图像嵌入图像中：首先，选择用于插入表示水印的相应部分的标记值的系数。接下来，选择的系数的值用于识别查找表中的相应值。最后，如果相应的值与标记值相同，则识别的系数保持不变，如果相应值与标记值不同，则该变化将被改变。在插入水印之后，可以以有损压缩形式存储图像，从而允许有效的存储和分发。此外，该方法可以用于产生用于认证的两个输出信号：（1）有意义的模式以便于快速视觉检查，以及（2）附加信号以检测未经授权的改变。该方法可以应用于使用JPEG或其他技术（例如小波压缩）压缩的图像，并且标记的图像可以保持为压缩格式。对标记图像进行的任何更改均可进行本地化，使该方法适用于“值得信赖”的数码相机或摄像机。

2. 发明授权

US11592913B2 Method, apparatus, and system for wireless writing tracking 有权
公开(公告)号：US11592913B2
公开(公告)日：2023-02-28
申请号：US17180763
申请日：2021-02-20
申请人： Sai Deepika Regani , Chenshu Wu , Beibei Wang , Min Wu , K. J. Ray Liu , Oscar Chi-Lim Au
发明人： Sai Deepika Regani , Chenshu Wu , Beibei Wang , Min Wu , K. J. Ray Liu , Oscar Chi-Lim Au
IPC分类号： G06F3/038 , G06F3/0354 , H04W4/029
摘要： Methods, apparatus and systems for wireless writing tracking are described. In one example, a described system comprises: a transmitter configured for transmitting a first wireless signal through a wireless multipath channel of a venue; a receiver configured for receiving a second wireless signal through the wireless multipath channel; and a processor. The second wireless signal comprises a reflection of the first wireless signal by a tip of a writing instrument in the venue. The processor is configured for: obtaining a time series of channel information (CI) of the wireless multipath channel based on the second wireless signal, wherein each CI comprises at least one of: a channel state information (CSI), channel impulse response (CIR), channel frequency response (CFR), or received signal strength index (RSSI); and tracking a movement of the tip of the writing instrument based on the time series of CI (TSCI).

3. 发明授权

US09345788B2 Reconstituted human breast tumor model 有权
公开(公告)号：US09345788B2
公开(公告)日：2016-05-24
申请号：US11170338
申请日：2005-06-28
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.

4. 发明授权

US08269008B2 Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions 有权
标题翻译：恶唑吡啶和异恶唑吡啶衍生物，用于治疗HIF介导的病症
公开(公告)号：US08269008B2
公开(公告)日：2012-09-18
申请号：US12734895
申请日：2008-12-02
申请人： Michael P. Arend , Heng Cheng , Lee A. Flippin , Danny Ng , Eric D. Turtle , Min Wu
发明人： Michael P. Arend , Heng Cheng , Lee A. Flippin , Danny Ng , Eric D. Turtle , Min Wu
IPC分类号： C07D221/18 , C07D221/02 , C07D221/22 , A01N43/42 , A01N43/40 , A61K31/44 , A61K31/435 , A61P25/00 , A61P3/04 , C07C63/00 , C07C65/00 , C12N9/99 , C12N9/14
CPC分类号： C07D498/04
摘要： The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
摘要翻译：本发明涉及能够通过抑制至少一种HIF羟化酶的活性来调节缺氧诱导因子（HIF）的稳定性和/或活性的新型化合物。

5. 发明授权

US08257971B2 In vitro tumor angiogenesis model 失效
标题翻译：体外肿瘤血管生成模型
公开(公告)号：US08257971B2
公开(公告)日：2012-09-04
申请号：US12697700
申请日：2010-02-01
申请人： Min Wu
发明人： Min Wu
IPC分类号： C12N5/00
CPC分类号： G01N33/5064 , C12N5/069 , C12N2502/30
摘要： Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells.
摘要翻译：提供了在正常内皮细胞中诱导管形成的方法，包括将正常内皮细胞与肿瘤细胞共培养并从正常内皮细胞形成小管。

6. 发明申请

US20120178755A1 CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：氰基喹啉化合物及其使用方法
公开(公告)号：US20120178755A1
公开(公告)日：2012-07-12
申请号：US13430568
申请日：2012-03-26
申请人： Michael Arend , Lee A. Flippin , Min Wu , Eric D. Turtle , Wen-Bin Ho , Shaojiang Deng
发明人： Michael Arend , Lee A. Flippin , Min Wu , Eric D. Turtle , Wen-Bin Ho , Shaojiang Deng
IPC分类号： A61K31/47 , A61K31/5377 , A61P7/06 , A61K31/4709
CPC分类号： C07D217/26 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:
摘要翻译：本发明涉及适合用于治疗缺氧诱导因子介导和/或促红细胞生成素相关病症的氰基异喹啉化合物。本发明的氰基异喹啉化合物具有以下结构：

7. 发明申请

US20110296078A1 MEMORY POOL INTERFACE METHODS AND APPARATUSES 审中-公开
标题翻译：记忆体接口方法和装置
公开(公告)号：US20110296078A1
公开(公告)日：2011-12-01
申请号：US12896646
申请日：2010-10-01
申请人： Raheel Khan , Min Wu
发明人： Raheel Khan , Min Wu
IPC分类号： G06F12/06 , G06F13/372
CPC分类号： G06F12/0207 , G06F9/54 , G06F12/0607
摘要： Techniques are provided which may be implemented in various methods and/or apparatuses that to provide a memory pool interface capability to interface with a plurality of shared processes/engines and/or a virtual buffer interface associated there with.
摘要翻译：提供了技术，其可以在提供与多个共享进程/引擎和/或与之相关联的虚拟缓冲区接口的存储器池接口能力的各种方法和/或装置中实现。

8. 发明申请

US20100330199A1 ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY 有权
标题翻译：作为HIF（HYPOXIA诱导因子）活性的调节剂的异噻唑衍生物
公开(公告)号：US20100330199A1
公开(公告)日：2010-12-30
申请号：US12811821
申请日：2009-01-12
申请人： Xiaoti Zhou , Michael P. Arend , Min Wu , Lee A. Flippin
发明人： Xiaoti Zhou , Michael P. Arend , Min Wu , Lee A. Flippin
IPC分类号： A61K33/26 , C07D513/04 , A61K31/437 , A61K31/70 , A61K38/18
CPC分类号： A61K31/437 , A61K31/497 , A61K45/06 , C07D513/04
摘要： The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).
摘要翻译：本发明涉及式I或II的新化合物，方法和能够降低HIF羟化酶活性的组合物，从而增加缺氧诱导因子（HIF）的稳定性和/或活性。式（I）或（II）。

9. 发明申请

US20100303928A1 ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS 有权
标题翻译：用于治疗HIF介导的病症的异丙嗪吡啶衍生物
公开(公告)号：US20100303928A1
公开(公告)日：2010-12-02
申请号：US12734895
申请日：2008-12-02
申请人： Michael P. Arend , Heng Cheng , Lee A. Flippin , Danny Ng , Eric D. Turtle , Min Wu
发明人： Michael P. Arend , Heng Cheng , Lee A. Flippin , Danny Ng , Eric D. Turtle , Min Wu
IPC分类号： A61K31/437 , C07D498/04 , A61K31/714 , A61K31/519 , A61K33/26 , A61K38/18 , A61P9/10 , C12N9/99
CPC分类号： C07D498/04
摘要： The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
摘要翻译：本发明涉及能够通过抑制至少一种HIF羟化酶的活性来调节缺氧诱导因子（HIF）的稳定性和/或活性的新型化合物。

10. 发明申请

US20100221751A1 METHOD OF SCREENING ENDOTHELIAL CELLS FOR ANGIOGENIC CAPABILITY 失效
标题翻译：筛选内源性细胞的抗原能力的方法
公开(公告)号：US20100221751A1
公开(公告)日：2010-09-02
申请号：US12463010
申请日：2009-05-08
申请人： Min Wu
发明人： Min Wu
IPC分类号： G01N33/567 , C12N5/07
CPC分类号： G01N33/74 , G01N33/5064 , G01N33/56966 , G01N2333/515 , G01N2333/70596 , G01N2333/71
摘要： Provided is a method of screening a primary endothelial cell population for angiogenesis capability comprising: (a) measuring the percentage of cells that are positive for VEGF R2 and CD34, the level of VEGF R2, or measuring the VEGF R2 to VEGF R1 ratio in the population; and (b) selecting those populations where the measured percentage or the measured ratio is over a threshold value.
摘要翻译：本发明提供一种筛选血管发生能力的主要内皮细胞群体的方法，包括：（a）测量VEGF R2和CD34阳性的细胞百分比，VEGF R2的水平或测量VEGF R2与VEGF的比例人口; 和（b）选择测量百分比或测量比超过阈值的那些群体。

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