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1. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

2. 发明授权

US07072700B2 Biological photometric device 失效
公开(公告)号：US07072700B2
公开(公告)日：2006-07-04
申请号：US10148991
申请日：2000-11-29
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

3. 发明授权

US08229531B2 Optical bioinstrumentation devices 有权
标题翻译：光学生物仪器
公开(公告)号：US08229531B2
公开(公告)日：2012-07-24
申请号：US11914701
申请日：2006-02-13
申请人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
发明人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.
摘要翻译：提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上，固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

4. 发明申请

US20090088616A1 Ultrasonic Diagnostic Apparatus 有权
标题翻译：超声诊断仪
公开(公告)号：US20090088616A1
公开(公告)日：2009-04-02
申请号：US11914701
申请日：2006-02-13
申请人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
发明人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.
摘要翻译：提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上，固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

5. 发明申请

US20070083097A1 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US20070083097A1
公开(公告)日：2007-04-12
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Fumio Kawaguchi , Shingo Kawasaki
发明人： Michiyuki Fujiwara , Fumio Kawaguchi , Shingo Kawasaki
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

6. 发明授权

US09198624B2 Biological photometric device and biological photometry method using same 有权
标题翻译：生物光度测定装置及其生物测光方法
公开(公告)号：US09198624B2
公开(公告)日：2015-12-01
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00 , A61B5/00 , G01N21/359 , G01N21/49
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

7. 发明申请

US20130102907A1 BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME 有权
标题翻译：生物光学设备和使用相同的生物光度测定方法
公开(公告)号：US20130102907A1
公开(公告)日：2013-04-25
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

8. 发明申请

US20120209105A1 MAGNETIC-FIELD MEASUREMENT JIG, MAGNETIC-FIELD MEASUREMENT PROGRAM, AND INSPECTION DEVICE PROVIDED WITH MAGNETIC POSITION DETECTOR 有权
标题翻译：磁场测量仪，磁场测量程序和检测装置，带有磁性位置检测器
公开(公告)号：US20120209105A1
公开(公告)日：2012-08-16
申请号：US13503956
申请日：2010-10-15
申请人： Michiyo Tanii , Shingo Kawasaki , Michiyuki Fujiwara , Takashi Ishizuka
发明人： Michiyo Tanii , Shingo Kawasaki , Michiyuki Fujiwara , Takashi Ishizuka
IPC分类号： A61B5/05 , G01B7/14
CPC分类号： G01R33/1269
摘要： In order to provide a highly reliable inspection device that prevents a loss in reliability of inspection that uses information from a position detector as a result of the influence of magnetic bodies or the like that are present in the environment, the inspection device is characterized by being provided with biological information measurement units (10, 12) that measure biological information of an inspected target and form an image containing said biological information, a magnetic position detector (50) that detects the position of at least one of the aforementioned biological information measurement units and the inspection target, and a control unit (14) that controls the aforementioned biological information measurement units and the aforementioned magnetic position detector (50); and is further characterized by the aforementioned control unit (14) being provided with an environmental magnetic field measurement unit (301) that uses the output of the aforementioned magnetic position detector (50) to measure distortion of the magnetic field in the measured space in which the aforementioned biological information measurement units are placed.
摘要翻译：为了提供高度可靠的检查装置，其防止由于环境中存在的磁体等的影响而使用来自位置检测器的信息的检查可靠性的损失，检查装置的特征在于：设置有测量检测对象的生物信息的生物信息测量单元（10,12），并形成包含所述生物信息的图像;磁位置检测器（50），其检测所述生物信息测量单元和检查对象，以及控制上述生物信息测量单元和上述磁性位置检测器（50）的控制单元（14）。并且其特征还在于上述控制单元（14）设置有环境磁场测量单元（301），该环境磁场测量单元使用上述磁位置检测器（50）的输出来测量测量空间中的磁场的失真，其中放置上述生物信息测量单元。

9. 发明申请

US20120203088A1 BIOLOGICAL OPTICAL MEASUREMENT INSTRUMENT AND REFERENCE IMAGE DISPLAY METHOD 有权
标题翻译：生物光学测量仪器和参考图像显示方法
公开(公告)号：US20120203088A1
公开(公告)日：2012-08-09
申请号：US13501815
申请日：2010-10-08
申请人： Michiyo Tanii , Shingo Kawasaki , Michiyuki Fujiwara , Joerg Schnackenberg , Akihiro Toda
发明人： Michiyo Tanii , Shingo Kawasaki , Michiyuki Fujiwara , Joerg Schnackenberg , Akihiro Toda
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/02028 , A61B5/14546 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： The biological optical measurement instrument is provided with a mobile position sensor that can move in a 3-dimensional space and that detects spatial position in the 3-dimensional space, a head-surface image creating unit that creates a head-surface image of an object and a head-surface point creating unit that creates, on the head-surface image, a head-surface point corresponding to the spatial position of the mobile position sensor.
摘要翻译：该生物光学测量仪器设置有能够在三维空间中移动并且检测三维空间中的空间位置的移动位置传感器，产生物体的头部表面图像的头表面图像生成单元以及头表面点生成单元，其在头表面图像上形成与移动位置传感器的空间位置对应的头表面点。

10. 发明授权

US07778694B2 Biological optical measurement instrument 有权
标题翻译：生物光学测量仪器
公开(公告)号：US07778694B2
公开(公告)日：2010-08-17
申请号：US11355017
申请日：2006-02-16
申请人： Mikihiro Kaga , Noriyoshi Ichikawa , Fumio Kawaguchi , Michiyuki Fujiwara
发明人： Mikihiro Kaga , Noriyoshi Ichikawa , Fumio Kawaguchi , Michiyuki Fujiwara
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/1455 , A61B2562/0233 , A61B2562/046 , G01N21/4795
摘要： A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light beams passed inside the subject from a plurality of positions to facilitate production of diagnostics from collected light beams of the subject, wherein the measurement probe is provided with probe casings which hold the optical fibers, fixing members where each respective fixing member is mateable with a respective probe casing to position the probe casings in a predetermined interval, and a support member which supports the fixing members, and wherein at least one of the respective probe casing or the respective fixing member is provided with a stopper claw to permit fixed engagement of the respective probe casing with the respective fixing member upon mating thereof.
摘要翻译：一种生物学光学测量仪器，包括：测量探针，其可定位到被检体的表面，其将来自光束源的多个波长的光束通过光纤照射到所述被检体上，并且从所述被检体的内部收集通过所述被检体内的光束多个位置以便于从被检体的收集的光束产生诊断，其中测量探针设置有保持光纤的探针壳体，固定构件，其中每个相应的固定构件可与相应的探针壳体配合，以将探针壳体以及支撑固定构件的支撑构件，并且其中各个探针壳体或相应的固定构件中的至少一个设置有止动爪，以允许各个探针壳体与相应的固定构件的固定接合在交配时。

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