会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • Method for Identifying Within a Mammal a DNA Encoding A Physiologically Active Polypeptide
    • 用于在哺乳动物中识别编码生理活性多肽的DNA的方法
    • US20100329988A1
    • 2010-12-30
    • US12858960
    • 2010-08-18
    • Kiyoshi HabuKou-ichi JishageHiroshi Suzuki
    • Kiyoshi HabuKou-ichi JishageHiroshi Suzuki
    • A61K49/00A61P43/00
    • A01K67/0275A01K67/0271A01K2217/05A61K38/00A61K48/00A61K2039/53C12N15/1034G01N33/5088
    • The present inventors found that a physiological effect of a particular DNA can be detected independently within mice into which a pool of various DNAs in various quantities has been introduced. This finding suggests that it is possible to identify a DNA having a particular physiological effect by successively fractionating a pool of various DNAs in various quantities using the particular physiological effect seen within a mammal as an index. Such a method of screening will have the advantage of saving much time and effort as required in conventional screenings such as those utilizing transgenic and knockout mice. Furthermore, the method of screening has the additional advantage of enabling the identification of a DNA having a physiological activity, for example, even when the cells producing a physiologically active substance cannot be maintained in vitro or in immunodeficient animals, or when the cells change their characteristics during passage and stop producing the physiologically active substance.
    • 本发明人发现,在引入了各种量的各种DNA的小鼠中,可以独立地检测特定DNA的生理作用。 该发现表明,可以通过使用哺乳动物中看到的特定生理效应作为指标,以各种量依次分级各种DNA的池来鉴定具有特定生理效应的DNA。 这种筛选方法将具有如常规筛选(例如使用转基因和敲除小鼠的筛选)所需的大量时间和精力的优点。 此外,筛选方法具有能够鉴定具有生理活性的DNA的额外优点,例如即使当生产生理活性物质的细胞不能在体外或免疫缺陷动物中维持时,或者当细胞改变其 特性在通过和停止生产生理活性物质。
    • 4. 发明申请
    • Method for Identifying Within a Mammal a DNA encoding a Physiologically Active Polypeptide
    • 用于在哺乳动物体内鉴定编码生理活性多肽的DNA的方法
    • US20090092995A1
    • 2009-04-09
    • US12327770
    • 2008-12-03
    • Kiyoshi HabuKou-Ichi JishageHiroshi Suzuki
    • Kiyoshi HabuKou-Ichi JishageHiroshi Suzuki
    • C12Q1/68
    • A01K67/0275A01K67/0271A01K2217/05A61K38/00A61K48/00A61K2039/53C12N15/1034G01N33/5088
    • The present inventors found that a physiological effect of a particular DNA can be detected independently within mice into which a pool of various DNAs in various quantities has been introduced. This finding suggests that it is possible to identify a DNA having a particular physiological effect by successively fractionating a pool of various DNAs in various quantities using the particular physiological effect seen within a mammal as an index. Such a method of screening will have the advantage of saving much time and effort as required in conventional screenings such as those utilizing transgenic and knockout mice. Furthermore, the method of screening has the additional advantage of enabling the identification of a DNA having a physiological activity, for example, even when the cells producing a physiologically active substance cannot be maintained in vitro or in immunodeficient animals, or when the cells change their characteristics during passage and stop producing the physiologically active substance.
    • 本发明人发现,在引入了各种量的各种DNA的小鼠中,可以独立地检测特定DNA的生理作用。 该发现表明,可以通过使用哺乳动物中看到的特定生理效应作为指标,以各种量依次分级各种DNA的池来鉴定具有特定生理效应的DNA。 这种筛选方法将具有如常规筛选(例如使用转基因和敲除小鼠的筛选)所需的大量时间和精力的优点。 此外,筛选方法具有能够鉴定具有生理活性的DNA的额外优点,例如即使当生产生理活性物质的细胞不能在体外或免疫缺陷动物中维持时,或者当细胞改变其 特性在通过和停止生产生理活性物质。