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1. 发明授权

US5629340A Angiogenesis inhibitor and novel compound 失效
标题翻译：血管生成抑制剂和新型化合物
公开(公告)号：US5629340A
公开(公告)日：1997-05-13
申请号：US481465
申请日：1995-07-10
申请人： Michihiko Kuwano , Mayumi Ono , Mika Kusano , Junko Watanabe , Masakazu Takeda
发明人： Michihiko Kuwano , Mayumi Ono , Mika Kusano , Junko Watanabe , Masakazu Takeda
IPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/341 , A61K31/34 , A61K31/075
CPC分类号： A61K31/09 , A61K31/05 , A61K31/085 , A61K31/341
摘要： An angiogenesis inhibitor comprising, as an active agent, Compound (I) represented by the formula below: ##STR1## where R.sub.1 is a lower alkyl group, an alkoxycarbonyl group or a carboxyl group; andR.sub.2, R.sub.3 and R.sub.4 maybe the same or different and represent a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group.This compound has a remarkable angiogenesis inhibition activity, and an angiogenesis inhibitor useful for treatment of various diseases are provided.
摘要翻译： PCT No.PCT / JP93 / 01893 Sec。 371日期：1995年7月10日 102（e）日期1995年7月10日PCT提交1993年12月27日PCT公布。公开号WO94 / 15594 日本时间1994年7月21日一种血管生成抑制剂，其包含作为活性剂的由下式表示的化合物（I）：其中R 1为低级烷基，烷氧基羰基或羧基; R2，R3和R4可以相同或不同，表示氢原子，羟基，甲氧基或乙酰氧基。该化合物具有显着的血管生成抑制活性，并且提供了可用于治疗各种疾病的血管生成抑制剂。

2. 发明授权

US07947707B2 Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same 有权
标题翻译：氮化杂环化合物和包含其的药物组合物
公开(公告)号：US07947707B2
公开(公告)日：2011-05-24
申请号：US12089518
申请日：2006-10-03
申请人： Takahiro Toyoshima , Toshinobu Sasaki , Chikara Hoshino , Masakazu Takeda
发明人： Takahiro Toyoshima , Toshinobu Sasaki , Chikara Hoshino , Masakazu Takeda
IPC分类号： A61K31/437 , A61K31/4155 , A61K31/4162 , A61K31/4192 , C07D221/00 , C07D231/56 , C07D207/00 , C07D209/04 , C07D231/10 , C07D403/00
CPC分类号： C07D207/416 , C07D209/42 , C07D231/14 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/056
摘要： The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): wherein Y1 represents N or C(R4); Y2 represents N or C(R5); R4 and R5 independently represent an alkyl group, a hydrogen atom etc.; one of R1 and R2 represents an optionally substituted aryl group, an alkoxy group or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyano group, a halogen atom etc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.
摘要翻译：本发明涉及具有黄嘌呤氧化酶抑制作用和尿酸排泄作用的新化合物以及包含其作为活性成分的药物组合物。也就是说，本发明涉及由以下通式（I）表示的含氮杂环化合物：其中Y1表示N或C（R4）; Y2表示N或C（R5）; R4和R5独立地表示烷基，氢原子等; R1和R2之一表示任选取代的芳基，烷氧基或任选取代的杂环基; R1和R2中的另一个表示卤代烷基，氰基，卤素原子等; 并且R 3表示5-四唑基或羧基，及其药学上可接受的盐，以及包含其作为活性成分的药物组合物。

3. 发明授权

US07907489B2 Optical-disc discrimination method and optical disc apparatus 失效
标题翻译：光盘鉴别方法和光盘装置
公开(公告)号：US07907489B2
公开(公告)日：2011-03-15
申请号：US11905337
申请日：2007-09-28
申请人： Masakazu Takeda
发明人： Masakazu Takeda
IPC分类号： G11B7/00
CPC分类号： G11B19/12 , G11B2007/0006
摘要： In an HD-DVD, record densities are different between in a lead-in area and in a data area. On the other hand, in a DVD, the record densities of a lead-in area and a data area are equal. In discriminating an optical disc between the HD-DVD and the DVD, a light beam having a wavelength for the HD-DVD or for the DVD is projected onto the respective areas of the lead-in area and the data area, and a comparison is made between the amplitude of a tracking error (TE) signal obtained on the basis of reflected light from the lead-in area and that of a TE signal obtained on the basis of reflected light from the data area. When the difference between both the amplitudes is within a predetermined range, the optical disc is discriminated as the DVD, and when the difference between both the amplitudes is larger than the predetermined range, the optical disc is discriminated as the HD-DVD.
摘要翻译：在HD-DVD中，导入区和数据区之间的记录密度不同。另一方面，在DVD中，导入区域和数据区域的记录密度相等。在识别HD-DVD和DVD之间的光盘时，具有用于HD-DVD或DVD的波长的光束被投影到导入区域和数据区域的各个区域上，并且比较在基于来自导入区域的反射光获得的跟踪误差（TE）信号的幅度与基于来自数据区域的反射光获得的TE信号的幅度之间。当两个幅度之间的差异在预定范围内时，光盘被鉴别为DVD，并且当两个幅度之间的差异大于预定范围时，该光盘被鉴别为HD-DVD。

4. 发明申请

US20090306396A1 NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：氮杂杂环化合物和包含其的药物组合物
公开(公告)号：US20090306396A1
公开(公告)日：2009-12-10
申请号：US12089518
申请日：2006-10-03
申请人： Takahiro Toyoshima , Toshinobu Sasaki , Chikara Hoshino , Masakazu Takeda
发明人： Takahiro Toyoshima , Toshinobu Sasaki , Chikara Hoshino , Masakazu Takeda
IPC分类号： C07D231/14 , C07D417/04 , C07D409/04 , C07D491/056 , C07D209/42 , C07D403/04 , C07D207/34
CPC分类号： C07D207/416 , C07D209/42 , C07D231/14 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/056
摘要： The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): wherein Y1 represents N or C(R4); Y2 represents N or C(R5); R4 and R5 independently represent an alkyl group, a hydrogen atom etc.; one of R1 and R2 represents an optionally substituted aryl group, an alkoxy group or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyano group, a halogen atom etc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.
摘要翻译：本发明涉及具有黄嘌呤氧化酶抑制作用和尿酸排泄作用的新化合物以及包含其作为活性成分的药物组合物。也就是说，本发明涉及由以下通式（I）表示的含氮杂环化合物：其中Y1表示N或C（R4）; Y2表示N或C（R5）; R4和R5独立地表示烷基，氢原子等; R1和R2之一表示任选取代的芳基，烷氧基或任选取代的杂环基; R1和R2中的另一个表示卤代烷基，氰基，卤素原子等; 并且R 3表示5-四唑基或羧基，及其药学上可接受的盐，以及包含其作为活性成分的药物组合物。

5. 发明申请

US20080080349A1 Optical-disc discrimination method and optical disc apparatus 失效
标题翻译：光盘鉴别方法和光盘装置
公开(公告)号：US20080080349A1
公开(公告)日：2008-04-03
申请号：US11905337
申请日：2007-09-28
申请人： Masakazu Takeda
发明人： Masakazu Takeda
IPC分类号： G11B7/00 , G11B11/00 , G11B27/36
CPC分类号： G11B19/12 , G11B2007/0006
摘要： In an HD-DVD, record densities are different between in a lead-in area and in a data area. On the other hand, in a DVD, the record densities of a lead-in area and a data area are equal. In discriminating an optical disc between the HD-DVD and the DVD, a light beam having a wavelength for the HD-DVD or for the DVD is projected onto the respective areas of the lead-in area and the data area, and a comparison is made between the amplitude of a tracking error (TE) signal obtained on the basis of reflected light from the lead-in area and that of a TE signal obtained on the basis of reflected light from the data area. When the difference between both the amplitudes is within a predetermined range, the optical disc is discriminated as the DVD, and when the difference between both the amplitudes is larger than the predetermined range, the optical disc is discriminated as the HD-DVD.
摘要翻译：在HD-DVD中，导入区和数据区之间的记录密度不同。另一方面，在DVD中，导入区域和数据区域的记录密度相等。在识别HD-DVD和DVD之间的光盘时，具有用于HD-DVD或DVD的波长的光束被投影到导入区域和数据区域的各个区域上，并且比较在基于来自导入区域的反射光获得的跟踪误差（TE）信号的幅度与基于来自数据区域的反射光获得的TE信号的幅度之间。当两个幅度之间的差异在预定范围内时，光盘被鉴别为DVD，并且当两个幅度之间的差异大于预定范围时，该光盘被鉴别为HD-DVD。

6. 发明授权

US4578043A Method and apparatus for manufacturing light bulb with bead sealing gas 失效
标题翻译：用珠密封气体制造灯泡的方法和装置
公开(公告)号：US4578043A
公开(公告)日：1986-03-25
申请号：US705747
申请日：1985-02-26
申请人： Toru Teshima , Masanobu Aizawa , Mitsunari Yoshida , Toshiyuki Shima , Masakazu Takeda
发明人： Toru Teshima , Masanobu Aizawa , Mitsunari Yoshida , Toshiyuki Shima , Masakazu Takeda
IPC分类号： H01K3/26 , H01J9/24 , H01J9/38 , H01K3/22 , H01K3/24 , H01J9/18
CPC分类号： H01J9/38 , H01J9/247 , H01K3/22
摘要： A method and apparatus for manufacturing a bulb wherein a bead mount and a glass bulb are set in a recess in an upper surface of a heater arranged inside a hermetically sealed chamber, a first gas comprised of one component of a composition of a sealing gas in the glass bulb or an inert gas excluding the sealing gas is supplied to the chamber at a predetermined pressure after the chamber is evacuated, a second gas comprised of a remaining component of the sealing gas or all of the components thereof is sprayed in a space between the glass bulb and the bead mount at a pressure higher than that of the first gas to exhaust the first gas from the space within the glass bulb. The heater is energized after the substitution of the gas within the space of the bulb is performed, or while the gas substitution in the space is being performed, in order to heat and melt an edge portion of the bead mount and glass bulb to seal the glass bulb to the bead mount with the second gas sealed within the glass bulb.
摘要翻译：一种用于制造灯泡的方法和装置，其中珠子安装件和玻璃灯泡设置在布置在气密密封室内的加热器的上表面的凹部中，第一气体由包含密封气体的组合物的一种组分除了密封气体之外的玻璃灯泡或惰性气体在腔室被抽真空之后以预定的压力供应到腔室，由密封气体的剩余组分或其所有组分组成的第二气体被喷射在所述玻璃灯泡和所述珠子安装座的压力高于所述第一气体的压力，以从所述玻璃灯泡内的空间排出所述第一气体。在执行灯泡空间内的气体的取代之前，或者在执行空间中的气体替换的同时，加热器被通电，以加热和熔化胎圈安装件和玻璃灯泡的边缘部分以密封玻璃灯泡到珠子安装，第二个气体密封在玻璃灯泡内。

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