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1. 发明申请

US20130344023A1 POLYMER-ACTIVE AGENT CONJUGATES 审中-公开
标题翻译：聚合物活性剂共混物
公开(公告)号：US20130344023A1
公开(公告)日：2013-12-26
申请号：US13981235
申请日：2012-01-11
申请人： Michel Wathier , Hideki Suzuki
发明人： Michel Wathier , Hideki Suzuki
IPC分类号： A61K47/48
CPC分类号： A61K47/48176 , A61K47/58
摘要： A polymer includes at least one monomeric unit represented by Formula I, II, or III: where X is CH2 or O; R1 is H, COOR2, COCH3, CONHR2, OR2 or SR2; L is a bond or a linker group; AA is a group derived from an active agent; each R2 is independently H, a cation, an alkyl, an alkenyl, an alkynyl, COCH3, CH2CH2OH, CH2CH2OR3, an amino acid, a small peptide, a large peptide, enzyme, protein, growth factor, cytokine, antibody, single chain antibody, antibody fragment, COCCH3═CH2, COCH═CH2, CH2CO2H, CH2CH2CO2H, CH2CH2SH, CH2CH2SR3 or (CH2CH2O)n′R4; n′ is an integer from 1 to 2000; each R3 is independently trityl, 4-methyltrityl or 2 pyridyl; each R4 is independently H, an alkyl, an alkenyl, an alkynyl, COCCH3═CH2, COCH═CH2, CH2CHO, CH2CH2CHO, CO2H, CO2R5, CH2CO2H, CH2CH2CO2H, CH2NH2, CH2NHR5, CH2N(R5)2, CH2CH2NH2, CH2CH2NHR, CH2CH2N(R5)2, SH, CH2CO2R5, or CH2CH2CO2R5; and each R5 is independently maleimide, a cation, an amino acid, a small peptide, a large peptide, protein, enzyme, growth factor, cytokine, antibody, single chain antibody, phosphate, sulfate, choline, or an activated ester.
摘要翻译：聚合物包括由式I，II或III表示的至少一个单体单元：其中X是CH 2或O; R1是H，COOR2，COCH3，CONHR2，OR2或SR2; L是键或连接基; AA是一种衍生自活性剂的基团; 每个R 2独立地是H，阳离子，烷基，烯基，炔基，COCH 3，CH 2 CH 2 OH，CH 2 CH 2OR 3，氨基酸，小肽，大肽，酶，蛋白质，生长因子，细胞因子，抗体，单链抗体，抗体片段，COCCH3 = CH2，COCH = CH2，CH2CO2H，CH2CH2CO2H，CH2CH2SH，CH2CH2SR3或（CH2CH2O）n'R4; n'是从1到2000的整数; 每个R 3独立地是三苯甲基，4-甲基三苯甲基或2-吡啶基; 每个R 4独立地是H，烷基，烯基，炔基，COCCH 3 = CH 2，COCH = CH 2，CH 2 CHO，CH 2 CH 2 CHO，CO 2 H，CO 2 R 5，CH 2 CO 2 H，CH 2 CH 2 CO 2 H，CH 2 NH 2，CH 2 NHR 5，CH 2 N（R 5）2，CH 2 CH 2 NH 2，CH 2 CH 2 NHR，CH 2 CH 2 N （R5）2，SH，CH2CO2R5或CH2CH2CO2R5; 每个R 5独立地为马来酰亚胺，阳离子，氨基酸，小肽，大肽，蛋白质，酶，生长因子，细胞因子，抗体，单链抗体，磷酸盐，硫酸盐，胆碱或活化酯。

2. 发明申请

US20100304357A1 UNIVERSAL DRINKING ADAPTER FOR BEVERAGE BOTTLES, AND DEVICES AND KITS FOR DETERMINING SMALL MOLECULES, METAL IONS, ENDOTOXINS, AND BACTERIA, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于饮料瓶的通用饮用适配器，以及用于确定小分子，金属离子，内毒素和细菌的装置和试剂盒及其使用方法
公开(公告)号：US20100304357A1
公开(公告)日：2010-12-02
申请号：US12718604
申请日：2010-03-05
申请人： Steven Meyers , Michel Wathier , Mark Grinstaff
发明人： Steven Meyers , Michel Wathier , Mark Grinstaff
IPC分类号： G01N33/04 , A61J9/04 , A47G19/22 , B65D69/00 , G01N33/06 , C12M1/00 , G01N21/00 , C12Q1/00
CPC分类号： A61J11/04 , G01N33/52
摘要： Certain features, aspects, examples and embodiments described herein relate to adapters for securing drinking apparatuses for individuals of all ages (infants, children, adults, and seniors) such as nipples, sippers, and straws, to commercially available beverage containers to aid in the consumption of the contained liquid. Other features, aspects, examples and embodiments relate to devices and kits useful for the detection of analytes in milk samples such as small molecules, metal ions, endotoxins, and bacteria.
摘要翻译：本文所述的某些特征，方面，示例和实施例涉及用于将所有年龄的个体（婴儿，儿童，成年人和老年人）的饮用设备（例如乳头，拖鞋和吸管）固定到商业上可获得的饮料容器的适配器，以帮助所含液体的消耗。其他特征，方面，实施例和实施方案涉及可用于检测牛奶样品（例如小分子，金属离子，内毒素和细菌）中的分析物的装置和试剂盒。

3. 发明申请

US20110243883A1 POLYMERIC BIOLUBRICANTS FOR MEDICAL USE 审中-公开
标题翻译：用于医疗用途的聚合物生物降解剂
公开(公告)号：US20110243883A1
公开(公告)日：2011-10-06
申请号：US13119526
申请日：2008-10-31
申请人： Mark W. Grinstaff , Michel Wathier , Neel Joshi , Stephanie Stoddart
发明人： Mark W. Grinstaff , Michel Wathier , Neel Joshi , Stephanie Stoddart
IPC分类号： A61K47/34 , C08G69/48 , A61K38/18 , A61K38/39 , A61K31/22 , A61K31/80 , A61K31/755 , A61K33/42 , A61K31/728 , A61P19/02
CPC分类号： A61K47/34 , A61K8/84 , A61K9/0019 , A61K2800/91 , A61L27/14 , A61L27/50 , A61Q19/00 , C08G83/003
摘要： The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供可在体内用作润滑剂或减震剂的支链聚合物。例如，本发明的聚合物可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

4. 发明授权

US08378064B2 Hydrophilic polymers as medical lubricants and gels 有权
标题翻译：亲水聚合物作为医用润滑剂和凝胶
公开(公告)号：US08378064B2
公开(公告)日：2013-02-19
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： A61K38/00 , A61K47/00 , A61K31/715 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H1/00 , A01N25/00 , A01N43/04
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

5. 发明申请

US20140058047A1 Ionic Viscoelastics and Viscoelastic Salts 审中-公开
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US20140058047A1
公开(公告)日：2014-02-27
申请号：US14065817
申请日：2013-10-29
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07C229/24 , C07C59/305 , C08F120/06 , C08G65/00 , C08F236/12 , C07F9/54 , C07D403/12 , C07C211/14
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

6. 发明授权

US08367845B2 Ionic viscoelastics and viscoelastic salts 有权
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US08367845B2
公开(公告)日：2013-02-05
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07D403/02
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

7. 发明申请

US20090208589A1 NOVEL HYDROPHILIC POLYMERS AS MEDICAL LUBRICANTS AND GELS 有权
标题翻译：新型水解聚合物作为医用润滑剂和凝胶
公开(公告)号：US20090208589A1
公开(公告)日：2009-08-20
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： A61K47/42 , C07K2/00 , C08B37/00 , A61K47/36 , A61K38/18 , A61K38/39 , A61K31/728
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

8. 发明申请

US20090176956A1 Ionic Viscoelastics and Viscoelastic Salts 有权
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US20090176956A1
公开(公告)日：2009-07-09
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C08F20/44 , C07C55/02 , C07F9/28
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

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