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1. 发明申请

US20110243883A1 POLYMERIC BIOLUBRICANTS FOR MEDICAL USE 审中-公开
标题翻译：用于医疗用途的聚合物生物降解剂
公开(公告)号：US20110243883A1
公开(公告)日：2011-10-06
申请号：US13119526
申请日：2008-10-31
申请人： Mark W. Grinstaff , Michel Wathier , Neel Joshi , Stephanie Stoddart
发明人： Mark W. Grinstaff , Michel Wathier , Neel Joshi , Stephanie Stoddart
IPC分类号： A61K47/34 , C08G69/48 , A61K38/18 , A61K38/39 , A61K31/22 , A61K31/80 , A61K31/755 , A61K33/42 , A61K31/728 , A61P19/02
CPC分类号： A61K47/34 , A61K8/84 , A61K9/0019 , A61K2800/91 , A61L27/14 , A61L27/50 , A61Q19/00 , C08G83/003
摘要： The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供可在体内用作润滑剂或减震剂的支链聚合物。例如，本发明的聚合物可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

2. 发明授权

US08378064B2 Hydrophilic polymers as medical lubricants and gels 有权
标题翻译：亲水聚合物作为医用润滑剂和凝胶
公开(公告)号：US08378064B2
公开(公告)日：2013-02-19
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： A61K38/00 , A61K47/00 , A61K31/715 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H1/00 , A01N25/00 , A01N43/04
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

3. 发明申请

US20140058047A1 Ionic Viscoelastics and Viscoelastic Salts 审中-公开
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US20140058047A1
公开(公告)日：2014-02-27
申请号：US14065817
申请日：2013-10-29
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07C229/24 , C07C59/305 , C08F120/06 , C08G65/00 , C08F236/12 , C07F9/54 , C07D403/12 , C07C211/14
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

4. 发明授权

US08367845B2 Ionic viscoelastics and viscoelastic salts 有权
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US08367845B2
公开(公告)日：2013-02-05
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07D403/02
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

5. 发明申请

US20090208589A1 NOVEL HYDROPHILIC POLYMERS AS MEDICAL LUBRICANTS AND GELS 有权
标题翻译：新型水解聚合物作为医用润滑剂和凝胶
公开(公告)号：US20090208589A1
公开(公告)日：2009-08-20
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： A61K47/42 , C07K2/00 , C08B37/00 , A61K47/36 , A61K38/18 , A61K38/39 , A61K31/728
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。

6. 发明申请

US20090176956A1 Ionic Viscoelastics and Viscoelastic Salts 有权
标题翻译：离子粘弹性和粘弹性盐
公开(公告)号：US20090176956A1
公开(公告)日：2009-07-09
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C08F20/44 , C07C55/02 , C07F9/28
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

7. 发明授权

US08334324B2 Films and particles 有权
公开(公告)号：US08334324B2
公开(公告)日：2012-12-18
申请号：US12690607
申请日：2010-01-20
申请人： Yolonda L. Colson , Solomon Azouz , Mark W. Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda L. Colson , Solomon Azouz , Mark W. Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K47/06
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

8. 发明授权

US5512268A Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof 失效
标题翻译：由合成聚合物制备的用于医学成像的聚合物壳及其使用方法
公开(公告)号：US5512268A
公开(公告)日：1996-04-30
申请号：US486268
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译：根据本发明，提供了包含聚合物壳内的成像剂的组合物。本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。聚合物外壳直径通常为约2微米。因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。考虑用于本发明实践的示例性造影剂包括氟化合物。氟化合物通常是疏水性的，因此具有有限的水溶性。本发明方法允许以适于准备输送的生物相容形式制备这些化合物。

9. 发明授权

US08338492B2 Films and particles 有权
标题翻译：薄膜和颗粒
公开(公告)号：US08338492B2
公开(公告)日：2012-12-25
申请号：US12818693
申请日：2010-06-18
申请人： Yolonda L. Colson , Solomon Azouz , Mark W. Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda L. Colson , Solomon Azouz , Mark W. Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K47/06
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译：本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。

10. 发明授权

US06288221B1 Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction 失效
标题翻译：合成卤素碱基修饰寡核苷酸的方法，随后用金属催化反应进行标记
公开(公告)号：US06288221B1
公开(公告)日：2001-09-11
申请号：US09377612
申请日：1999-08-19
申请人： Mark W. Grinstaff , Amy E. Beilstein , Shoeb I. Khan
发明人： Mark W. Grinstaff , Amy E. Beilstein , Shoeb I. Khan
IPC分类号： C07H2100
CPC分类号： C07H19/06 , C07H19/10 , C07H21/00
摘要： The present invention provides metal-containing purines, pyrimidines, nucleosides, nucleotides and oligonucleotides; including phosphoramidite and photolabile derivatives thereof, including methods of making and method of using same. The present invention provides a method for detection of nucleic acid sequences via electrochemical or photochemical means.
摘要翻译：本发明提供含金属嘌呤，嘧啶，核苷，核苷酸和寡核苷酸; 包括亚磷酰胺及其不透光衍生物，包括制备方法及其使用方法。本发明提供了通过电化学或光化学方法检测核酸序列的方法。

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