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1. 发明授权

US5916213A Systems and methods for tissue mapping and ablation 失效
标题翻译：用于组织测绘和消融的系统和方法
公开(公告)号：US5916213A
公开(公告)日：1999-06-29
申请号：US794804
申请日：1997-02-04
申请人： Michel Haissaguerre , Walter Bruszewski , Le Le , Mark Maguire , John Gaiser , Huu Nguyen
发明人： Michel Haissaguerre , Walter Bruszewski , Le Le , Mark Maguire , John Gaiser , Huu Nguyen
IPC分类号： A61B5/0402 , A61B18/08 , A61B18/12 , A61B18/14 , A61M25/00 , A61B17/39
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/003 , A61B2017/2945 , A61B2018/00011 , A61B2018/00029 , A61B2018/0016 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2018/00898 , A61B2018/0091 , A61B2018/1432 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A steerable electrophysiology catheter includes a shaft having a distal ablation segment with one or more electrodes coupled to a source of electrical energy by a connector extending through the shaft. The distal ablation segment of the shaft is movable between a collapsed configuration sized for percutaneous introduction into the patient and/or endoluminal delivery to the target site and an expanded configuration, in which the distal ablation segment forms a substantially continuous surface transverse to the shaft axis for engaging the heart tissue and creating a linear lesion thereon. The catheter includes one or more force element(s) positioned to apply an axial force between the distal and proximal ends of the ablation segment. The force element(s) provide a sufficiently uniform force against the distal ablation segment to establish continuous contact pressure between the electrodes and the patient's heart tissue. This contact pressure allows the surgeon to engage the entire length of the distal ablation segment against the heart tissue to provide a relatively long linear lesion on this tissue.
摘要翻译：可引导的电生理导管包括具有远端消融段的轴，其具有通过延伸穿过轴的连接器而与电源耦合的一个或多个电极。轴的远端消融段可在被定形成经皮引入患者体内和/或腔内递送到目标部位的膨胀构型和扩张构型之间移动，其中远侧消融段形成横向于轴线的基本上连续的表面用于接合心脏组织并在其上产生线性损伤。导管包括定位成在消融段的远端和近端之间施加轴向力的一个或多个力元件。力元件提供足够均匀的力抵抗远端消融段，以在电极和患者的心脏组织之间建立连续的接触压力。该接触压力允许外科医生将远端消融段的整个长度接合心脏组织以在该组织上提供相对较长的线性损伤。

2. 发明授权

US6068629A System and methods for tissue mapping and ablation 有权
标题翻译：用于组织测绘和消融的系统和方法
公开(公告)号：US6068629A
公开(公告)日：2000-05-30
申请号：US213332
申请日：1998-12-15
申请人： Michel Haissaguerre , Walter Bruszewski , Le Le , Mark Maguire , John Gaiser , Huu Nguyen
发明人： Michel Haissaguerre , Walter Bruszewski , Le Le , Mark Maguire , John Gaiser , Huu Nguyen
IPC分类号： A61B5/0402 , A61B18/08 , A61B18/12 , A61B18/14 , A61M25/00 , A61B17/39
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/003 , A61B2017/2945 , A61B2018/00011 , A61B2018/00029 , A61B2018/0016 , A61B2018/00214 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2018/00898 , A61B2018/0091 , A61B2018/1432 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A steerable electrophysiology catheter includes a shaft having a distal ablation segment with one or more electrodes coupled to a source of electrical energy by a connector extending through the shaft. The distal ablation segment of the shaft is movable between a collapsed configuration sized for percutaneous introduction into the patient and/or endoluminal delivery to the target site and an expanded configuration, in which the distal ablation segment forms a substantially continuous surface transverse to the shaft axis for engaging the heart tissue and creating a linear lesion thereon. The catheter includes one or more force element(s) positioned to apply an axial force between the distal and proximal ends of the ablation segment. The force element(s) provide a sufficiently uniform force against the distal ablation segment to establish continuous contact pressure between the electrodes and the patient's heart tissue. This contact pressure allows the surgeon to engage the entire length of the distal ablation segment against the heart tissue to provide a relatively long linear lesion on this tissue.
摘要翻译：可引导的电生理导管包括具有远端消融段的轴，其具有通过延伸穿过轴的连接器而与电源耦合的一个或多个电极。轴的远端消融段可在被定形成经皮引入患者体内和/或腔内递送到目标部位的膨胀构型和扩张构型之间移动，其中远侧消融段形成横向于轴线的基本上连续的表面用于接合心脏组织并在其上产生线性损伤。导管包括定位成在消融段的远端和近端之间施加轴向力的一个或多个力元件。力元件提供足够均匀的力抵抗远端消融段，以在电极和患者的心脏组织之间建立连续的接触压力。该接触压力允许外科医生将远端消融段的整个长度接合心脏组织以在该组织上提供相对较长的线性损伤。

3. 发明授权

US07610073B2 Method for mapping a tubular region near the heart 有权
标题翻译：用于映射心脏附近的管状区域的方法
公开(公告)号：US07610073B2
公开(公告)日：2009-10-27
申请号：US11706601
申请日：2007-02-13
申请人： Kristine B. Fuimaono , Michel Haissaguerre
发明人： Kristine B. Fuimaono , Michel Haissaguerre
IPC分类号： A61B5/042
CPC分类号： A61B5/6857 , A61B5/0422 , A61B5/6856 , A61M25/0147 , A61M25/0152 , A61M2025/0161
摘要： A method is provided for mapping electrical activity within a tubular region of or near the heart having a inner circumference, such as a pulmonary vein. The method comprises inserting into the heart a distal end of a mapping catheter. The mapping catheter comprises an elongated tubular catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. The catheter includes a mapping assembly comprising a tubular structure comprising a pre-formed generally circular main region generally transverse and distal to the catheter body and having an outer circumference. The tubular structure comprises a non-conductive cover over at least the main region of the mapping assembly. A plurality of electrode pairs, each comprising two ring electrodes, are carried by the generally circular main region of the mapping assembly. The method further comprises contacting the outer circumference of the generally circular main region with the inner circumference of the tubular region and mapping the electrical activity within the tubular region with the electrodes along the generally circular main region.
摘要翻译：提供了一种用于映射具有内周（例如肺静脉）的心脏或附近的管状区域内的电活动的方法。该方法包括将映射导管的远端插入心脏。映射导管包括细长的管状导管本体，其具有外壁，近端和远端以及延伸穿过其中的至少一个内腔。导管包括映射组件，其包括管状结构，该管状结构包括通常横向和远离导管主体并且具有外周的预先形成的大致圆形的主要区域。管状结构包括至少在映射组件的主要区域上的非导电盖。每个包括两个环形电极的多个电极对由映射组件的大致圆形的主要区域承载。该方法还包括使大致圆形的主区域的外圆周与管状区域的内周接触，并且将管状区域内的电活动映射到沿着大致圆形主区域的电极。

4. 发明授权

US07228164B2 Catheter and method for mapping Purkinje fibers 有权
标题翻译：导管和Purkinje纤维的方法
公开(公告)号：US07228164B2
公开(公告)日：2007-06-05
申请号：US11025448
申请日：2004-12-29
申请人： Kristine B. Fuimaono , Bart-Jan Korteling , Michel Haissaguerre
发明人： Kristine B. Fuimaono , Bart-Jan Korteling , Michel Haissaguerre
IPC分类号： A61B5/0402
CPC分类号： A61B5/6859 , A61B5/0422 , A61B5/06 , A61B5/062 , G01S5/02
摘要： An improved catheter is provided that is particularly useful for mapping the Purkinje fibers for potential diagnosis of ventricular fibrillation. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen extending longitudinally therethrough. Mounted at the distal end of the catheter body is a mapping assembly having at least two spines, each having a proximal end attached at the distal end of the catheter body and a free distal end. Each spine comprises at least one electrode, preferably a tip electrode and at least one ring electrode. An irrigation tube extends through the catheter body and has an open distal end that is in communication with the outside of the distal end of the catheter body. The spines may be arranged in an expanded arrangement wherein each spine extends radially outwardly from the catheter body or in a collapsed arrangement wherein each spine is disposed generally along the longitudinal axis of the catheter body. In use, at least one electrode from each spine is positioned in contact with heart tissue to map the electrical activity of the heart. The location sensors are used to determine the location of each point where the electrical activity is monitored.
摘要翻译：提供了一种改进的导管，其特别可用于映射浦肯野纤维以用于心室颤动的潜在诊断。导管包括细长的导管主体，其具有近端和远端以及纵向延伸穿过其中的至少一个内腔。安装在导管主体的远端处的是具有至少两个脊的映射组件，每个脊具有附接在导管主体的远端处的近端和自由远端。每个脊柱包括至少一个电极，优选地是尖端电极和至少一个环形电极。冲洗管延伸穿过导管主体并且具有与导管主体的远端的外侧连通的开口远端。脊柱可以以扩展布置布置，其中每个脊柱从导管主体径向向外延伸，或者以折叠布置方式延伸，其中每个脊部大致沿着导管主体的纵向轴线设置。在使用中，来自每个脊柱的至少一个电极定位成与心脏组织接触以映射心脏的电活动。位置传感器用于确定监测电活动的每个点的位置。

5. 发明授权

US06315778B1 Apparatus for creating a continuous annular lesion 有权
标题翻译：用于产生连续环形损伤的装置
公开(公告)号：US06315778B1
公开(公告)日：2001-11-13
申请号：US09396502
申请日：1999-09-10
申请人： Richard Gambale , Gary S. Falwell , Donald Patterson , Michel Haissaguerre , Sean Forde
发明人： Richard Gambale , Gary S. Falwell , Donald Patterson , Michel Haissaguerre , Sean Forde
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2017/22068 , A61B2018/00214 , A61B2018/00261 , A61B2018/00285 , A61B2018/00375 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821
摘要： A medical device is disclosed which includes a deformable electrode device. In one illustrative embodiment, the deformable electrode is in the form of a braided member, at least a portion of which is electrically conductive. The braided member is extended over an elongated inner member, such as a guide wire, catheter shaft, or the like. A proximal sheath is slidably extended over the inner member and is connected to the braided, electrically conductive member. The proximal sheath may be advanced distally to deform the braided member so that it defines a distally facing, ablative ring, and is operative to form an annular lesion.
摘要翻译：公开了一种包括可变形电极装置的医疗装置。在一个说明性实施例中，可变形电极是编织构件的形式，其至少一部分是导电的。编织构件在诸如导丝，导管轴等的细长内部构件上延伸。近侧护套可滑动地延伸到内部构件上并连接到编织的导电构件。近端护套可以向远侧推进以使编织构件变形，使得其限定朝向远侧的消融环，并且可操作以形成环形损伤。

6. 发明授权

US06628976B1 Catheter having mapping assembly 有权
公开(公告)号：US06628976B1
公开(公告)日：2003-09-30
申请号：US09551467
申请日：2000-04-17
申请人： Kristine B. Fuimaono , Michel Haissaguerre
发明人： Kristine B. Fuimaono , Michel Haissaguerre
IPC分类号： A61B504
CPC分类号： A61B5/042 , A61B5/0422 , A61B5/6856 , A61B5/6857 , A61B18/1402 , A61B2018/0016 , A61B2018/00839 , A61M25/0147 , A61M25/0152 , A61M2025/0161
摘要： A mapping catheter comprises a catheter body and a mapping assembly. The catheter body has an outer wall, proximal and distal ends, and at least one lumen extending therethrough. The mapping assembly comprises a generally straight proximal region attached to the catheter body, a generally circular main region distal the proximal region having an outer circumference, and a generally straight distal region distal the main region. The mapping assembly also comprises a support member having shape-memory, a non-conductive covering over the support member, and a plurality of electrodes on the non-conductive covering along the generally circular main region.

7. 发明授权

US06371955B1 Atrial branding iron catheter and a method for treating atrial fibrillation 有权
标题翻译：心房品牌铁导管和一种治疗房颤的方法
公开(公告)号：US06371955B1
公开(公告)日：2002-04-16
申请号：US09370605
申请日：1999-08-10
申请人： Kristine B. Fuimaono , Michel Haissaguerre
发明人： Kristine B. Fuimaono , Michel Haissaguerre
IPC分类号： A61B1818
CPC分类号： A61B18/1492
摘要： A catheter for ablating tissue comprises a catheter body, a tip section, a branding iron assembly and an infusion tube. The catheter body has an outer wall, proximal and distal ends, and at least one lumen extending therethrough. The tip section comprises a segment of flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The branding iron assembly has proximal and distal ends and is fixedly attached at its proximal end to the distal end of the tubing of the tip section. The branding iron assembly is bent relative to the tubing and comprises a non-retractable tubular electrode formed of a material having shape-memory. The tubular electrode has proximal and distal ends and at least one irrigation port through which fluid can pass from the inside to the outside of the electrode. The infusion tube extends through a lumen in the tip section, with its distal end in fluid communication with the proximal end of the tubular electrode.
摘要翻译：用于消融组织的导管包括导管主体，尖端部分，品牌铁组件和输注管。导管主体具有外壁，近端和远端以及延伸穿过其中的至少一个内腔。尖端部分包括具有近端和远端以及穿过其中的至少一个内腔的柔性管段。尖端部分的近端固定地附接到导管主体的远端。品牌铁组件具有近端和远端，并且其近端固定地附接到尖端部分的管道的远端。品牌铁组件相对于管弯曲并且包括由具有形状记忆的材料形成的不可缩回的管状电极。管状电极具有近端和远端以及至少一个冲洗口，流体可从该冲洗口从电极的内部向外部通过。输注管延伸穿过末端部分中的内腔，其远端与管状电极的近端流体连通。

8. 发明授权

US08571626B2 Mono-phasic action potential electrogram recording catheter, and method 有权
标题翻译：单相动作电位记录导管及方法
公开(公告)号：US08571626B2
公开(公告)日：2013-10-29
申请号：US13604139
申请日：2012-09-05
申请人： Michael Lau , Randell L. Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haissaguerre , Meleze Hocini
发明人： Michael Lau , Randell L. Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haissaguerre , Meleze Hocini
IPC分类号： A61B5/042 , A61B18/14 , A61N1/05
CPC分类号： A61B5/042 , A61B5/6858 , A61B18/1492 , A61B2018/00214 , A61B2018/00839 , A61B2018/00898 , A61N1/06
摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.
摘要翻译：用于获得单相动作电位（“MAP”）电描记图的导管和方法包括限定纵向轴线的柔性导管主体，以及固定到导管主体远端的远端组件，其限定远端尖端。远端组件具有至少三个MAP记录电极和用于确定参考电位的至少一个参考电极。记录电极各自在至少三个不同的径向方向上与纵向轴线径向距离，限定基本上具有径向对称性的记录几何形状。参考电极是与记录几何形状的纵向距离。可选功能包括可导向的导管轴，一个或多个射频消融电极和专用起搏电极。不同的可能实施例包括具有固定空间布置的记录电极的圆顶壳体和在至少三个柔性环形元件上具有电极阵列的远端环组件。

9. 发明申请

US20060111627A1 Catheter and method for mapping purkinje fibers 有权
标题翻译：导尿管和purkinje纤维的方法
公开(公告)号：US20060111627A1
公开(公告)日：2006-05-25
申请号：US11323056
申请日：2005-12-30
申请人： Kristine Fuimaono , Bart-Jan Korteling , Michel Haissaguerre
发明人： Kristine Fuimaono , Bart-Jan Korteling , Michel Haissaguerre
IPC分类号： A61B5/04
CPC分类号： A61B5/6859 , A61B5/0422 , A61B5/06 , A61B5/062 , G01S5/02
摘要： An improved catheter is provided that is particularly useful for mapping the Purkinje fibers for potential diagnosis of ventricular fibrillation. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen extending longitudinally therethrough. Mounted at the distal end of the catheter body is a mapping assembly having at least two spines, each having a proximal end attached at the distal end of the catheter body and a free distal end. Each spine comprises at least one electrode, preferably a tip electrode and at least one ring electrode. An irrigation tube extends through the catheter body and has an open distal end that is in communication with the outside of the distal end of the catheter body. The spines may be arranged in an expanded arrangement wherein each spine extends radially outwardly from the catheter body or in a collapsed arrangement wherein each spine is disposed generally along the longitudinal axis of the catheter body. In use, at least one electrode from each spine is positioned in contact with heart tissue to map the electrical activity of the heart. The location sensors are used to determine the location of each point where the electrical activity is monitored.
摘要翻译：提供了一种改进的导管，其特别可用于映射浦肯野纤维以用于心室颤动的潜在诊断。导管包括细长的导管主体，其具有近端和远端以及纵向延伸穿过其中的至少一个内腔。安装在导管主体的远端处的是具有至少两个脊的映射组件，每个脊具有附接在导管主体的远端处的近端和自由远端。每个脊柱包括至少一个电极，优选地是尖端电极和至少一个环形电极。冲洗管延伸穿过导管主体并且具有与导管主体的远端的外侧连通的开口远端。脊柱可以以扩展布置布置，其中每个脊柱从导管主体径向向外延伸，或者以折叠布置方式延伸，其中每个脊部大致沿着导管主体的纵向轴线设置。在使用中，来自每个脊柱的至少一个电极定位成与心脏组织接触以映射心脏的电活动。位置传感器用于确定监测电活动的每个点的位置。

10. 发明授权

US06711428B2 Catheter having mapping assembly 有权
标题翻译：导管具有地图组装
公开(公告)号：US06711428B2
公开(公告)日：2004-03-23
申请号：US09943546
申请日：2001-08-30
申请人： Kristine B. Fuimaono , Michel Haissaguerre
发明人： Kristine B. Fuimaono , Michel Haissaguerre
IPC分类号： A61B5042
CPC分类号： A61B5/6857 , A61B5/0422 , A61B5/6856 , A61M25/0147 , A61M25/0152 , A61M2025/0161
摘要： A catheter that is particularly useful for mapping tubular regions of the heart, such as the pulmonary vein, is provided. The catheter comprises an elongated tubular catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. The catheter further includes a mapping assembly, which comprises a tubular structure comprising a generally circular main region generally transverse and distal to the catheter body and having an outer circumference and a generally straight distal region distal to the main region, wherein the tubular structure comprises a non-conductive cover over at least the main region of the mapping assembly. A support member having shape-memory is disposed within at least the main region of the mapping assembly. A plurality of electrode pairs, each comprising two ring electrodes, are carried by the generally circular main region of the mapping assembly.
摘要翻译：提供了特别可用于映射心脏的管状区域（例如肺静脉）的导管。导管包括细长的管状导管本体，其具有外壁，近端和远端以及延伸穿过其中的至少一个内腔。该导管还包括一个映射组件，其包括管状结构，该管状结构包括大体上圆形的主要区域，大致横向和远离导管主体并且具有远离主区域的外圆周和大致直的远侧区域，其中管状结构包括至少在映射组件的主要区域上不导电覆盖。具有形状记忆体的支撑构件设置在至少映射组件的主要区域内。每个包括两个环形电极的多个电极对由映射组件的大致圆形的主要区域承载。

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