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1. 发明申请

US20060199265A1 Seeding implantable medical devices with cells 审中-公开
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060199265A1
公开(公告)日：2006-09-07
申请号：US11071597
申请日：2005-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.
摘要翻译：本发明涉及用于将可植入医疗装置（例如血管假体）与细胞如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞以悬浮液的形式引入装置的内腔，并且将该装置围绕由内腔限定的纵向轴线进行离心。轴向离心导致细胞集中到腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。

2. 发明申请

US20070059335A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20070059335A1
公开(公告)日：2007-03-15
申请号：US11515344
申请日：2006-09-01
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： A61F2/062 , A61L27/16 , A61L27/3616 , A61L27/38 , A61L27/3808 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

3. 发明申请

US20060210596A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060210596A1
公开(公告)日：2006-09-21
申请号：US11367006
申请日：2006-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/08 , C12M3/00 , A61F13/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

4. 发明申请

US20080103352A1 Implantable Medical Devices Having Recesses 审中-公开
标题翻译：具有凹槽的植入式医疗器械
公开(公告)号：US20080103352A1
公开(公告)日：2008-05-01
申请号：US11971534
申请日：2008-01-09
申请人： Nicolas Rivron , Paul Trescony , Michael Wolf
发明人： Nicolas Rivron , Paul Trescony , Michael Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2310/00389
摘要： In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.
摘要翻译：通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过材料的微观结构的物理加工来产生凹陷。物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

5. 发明申请

US20060184235A1 Implantable medical devices having recesses 审中-公开
标题翻译：具有凹槽的可植入医疗器械
公开(公告)号：US20060184235A1
公开(公告)日：2006-08-17
申请号：US11402509
申请日：2006-04-12
申请人： Nicolas Rivron , Paul Trescony , Michael Wolf
发明人： Nicolas Rivron , Paul Trescony , Michael Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2310/00389
摘要： In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.
摘要翻译：通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过对材料的微观结构的物理加工来产生凹陷。物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

6. 发明申请

US20050055085A1 Implantable medical devices having recesses 审中-公开
标题翻译：具有凹槽的可植入医疗器械
公开(公告)号：US20050055085A1
公开(公告)日：2005-03-10
申请号：US10656855
申请日：2003-09-04
申请人： Nicolas Rivron , Paul Trescony , Michael Wolf
发明人： Nicolas Rivron , Paul Trescony , Michael Wolf
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2310/00389
摘要： In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.
摘要翻译：通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过对材料的微观结构的物理加工来产生凹陷。物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

7. 发明公开

US20240120058A1 METHODS, SYSTEMS AND APPARATUSES FOR MANAGEMENT AND STORAGE 审中-公开
公开(公告)号：US20240120058A1
公开(公告)日：2024-04-11
申请号：US18233808
申请日：2023-08-14
申请人： Deborah Adler , Duane Sawyer , Michael Wolf , Joshua Stewart , Yayun Huang
发明人： Deborah Adler , Duane Sawyer , Michael Wolf , Joshua Stewart , Yayun Huang
IPC分类号： G16H20/13 , A61J1/03 , A61J7/04 , G09F3/00 , G09F3/02 , G09F3/10 , G16Z99/00
CPC分类号： G16H20/13 , A61J1/03 , A61J7/04 , G09F3/02 , G09F3/0289 , G09F3/10 , G16Z99/00 , A61J2205/30 , G09F2003/0252 , G09F2003/0272 , G09F2003/0273
摘要： The present invention relates to systems, methods, and apparatuses for the management, distribution, dispensing, and administration of consumer products, including over-the-counter and prescription medications through use of a product container labeling system and an optional integrated computer-based or online management system. In certain aspects, the invention relates to a product container comprising a hollow body, a child-resistant cap, and a specialized information label affixed to the hollow body.

8. 发明授权

US09079077B2 Adjustable putter head assembly 有权
标题翻译：可调式推杆头总成
公开(公告)号：US09079077B2
公开(公告)日：2015-07-14
申请号：US14088927
申请日：2013-11-25
申请人： Michael Wolf
发明人： Michael Wolf
IPC分类号： A63B53/02 , A63B53/16 , A63B53/04
CPC分类号： A63B53/0487 , A63B53/02 , A63B53/04 , A63B2053/025 , A63B2053/028
摘要： An adjustable putter head assembly having a hosel attachment member that includes a hosel for receipt of a golf club shaft, a striking face, a bottom surface, and an adjustment surface that is generally parallel to the striking face and opposite the striking face. The hosel attachment member further includes an extension member that includes an aperture for mating with a threaded opening of the adjustment surface, and a plurality of receptacles that vertically extend the length of the extension member and correspond with a plurality of settings disposed on the adjustment surface. The adjustment surface defines multiple hosel position points for selectively attaching the hosel along the length of the putter head, and, adjusting the angular orientation between the golf club shaft and bottom surface in the plane in which the shaft lies.
摘要翻译：一种可调节推杆头组件，其具有插鞘连接构件，所述插鞘连接构件包括用于接收高尔夫球杆杆杆，击打面，底面以及大致平行于击打面并与击打面相对的调节面的插鞘。插鞘连接构件还包括延伸构件，该延伸构件包括用于与调节表面的螺纹开口配合的孔，以及多个插座，其垂直延伸延伸构件的长度并对应于设置在调节表面上的多个设置。调节表面限定多个插鞘位置点，用于沿着推杆头的长度选择性地附接插鞘，并且调节高尔夫球杆杆杆与轴所在平面中的底表面之间的角度定向。

9. 发明申请

US20150148146A1 Adjustable Putter Head Assembly 有权
标题翻译：可调式推杆组件
公开(公告)号：US20150148146A1
公开(公告)日：2015-05-28
申请号：US14088927
申请日：2013-11-25
申请人： Michael Wolf
发明人： Michael Wolf
IPC分类号： A63B53/02 , A63B53/04
CPC分类号： A63B53/0487 , A63B53/02 , A63B53/04 , A63B2053/025 , A63B2053/028
摘要： An adjustable putter head assembly having a hosel attachment member that includes a hosel for receipt of a golf club shaft, a striking face, a bottom surface, and an adjustment surface that is generally parallel to the striking face and opposite the striking face. The hosel attachment member further includes an extension member that includes an aperture for mating with a threaded opening of the adjustment surface, and a plurality of receptacles that vertically extend the length of the extension member and correspond with a plurality of settings disposed on the adjustment surface. The adjustment surface defines multiple hosel position points for selectively attaching the hosel along the length of the putter head, and, adjusting the angular orientation between the golf club shaft and bottom surface in the plane in which the shaft lies.
摘要翻译：一种可调节推杆头组件，其具有插鞘连接构件，所述插鞘连接构件包括用于接收高尔夫球杆杆杆，击打面，底面以及大致平行于击打面并与击打面相对的调节面的插鞘。插鞘连接构件还包括延伸构件，该延伸构件包括用于与调节表面的螺纹开口配合的孔，以及多个插座，其垂直延伸延伸构件的长度并对应于设置在调节表面上的多个设置。调节表面限定多个插鞘位置点，用于沿着推杆头的长度选择性地附接插鞘，并且调节高尔夫球杆杆杆与轴所在平面中的底表面之间的角度定向。

10. 发明申请

US20140054108A1 Sheet-Like Finishing Element 有权
标题翻译：片状整理元件
公开(公告)号：US20140054108A1
公开(公告)日：2014-02-27
申请号：US13992352
申请日：2011-12-07
申请人： Richard Wolf , Michael Wolf
发明人： Richard Wolf , Michael Wolf
IPC分类号： E04B1/84
CPC分类号： E04B1/8409 , B32B3/12 , B32B2307/102 , B32B2307/304 , B32B2607/00 , B32B2607/02 , E04B1/90 , E04B2001/747 , E04C2/3405 , E04C2002/345 , E04C2002/3466 , E04F15/203
摘要： A panel-like/sheet-like finishing element (11) for covering floors and walls, for example in the renovation of old buildings, is provided with heat-insulating and sound-absorbing properties if its interior (15) is provided, between outer covering layers (12, 13), with channel-forming undulating supporting structures (16) filled with high-density coarse granules (21). The supporting structures (16) are connected to the covering layers (12, 13) along the vertex lines (17) so as to provide wet-strength action, and the interior (15), between these covering layers, is sealed by enclosing edging strips (19) to provide wet-strength action, with the simultaneous inclusion of moisture-tight, but vapour-permeable, supporting layers (20) on covering layers (12, 13). If this finishing element (11) is mounted vertically, the granule-filled channels (14) run horizontally.
摘要翻译：例如在旧建筑物的翻新中，用于覆盖地板和墙壁的板状/片状整理元件（11）如果在内部（15）之间设置有绝热和吸声性能覆盖层（12,13），其中填充有高密度粗颗粒（21）的通道形成波状支撑结构（16）。支撑结构（16）沿着顶点线（17）连接到覆盖层（12,13）以提供湿强度作用，并且在这些覆盖层之间的内部（15）通过包围边缘条带（19）以提供湿强度作用，同时在覆盖层（12,13）上包含防潮透气的支撑层（20）。如果该精加工元件（11）垂直安装，则颗粒填充通道（14）水平延伸。

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