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1. 发明申请

US20060199265A1 Seeding implantable medical devices with cells 审中-公开
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060199265A1
公开(公告)日：2006-09-07
申请号：US11071597
申请日：2005-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.
摘要翻译：本发明涉及用于将可植入医疗装置（例如血管假体）与细胞如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞以悬浮液的形式引入装置的内腔，并且将该装置围绕由内腔限定的纵向轴线进行离心。轴向离心导致细胞集中到腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。

2. 发明申请

US20070059335A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20070059335A1
公开(公告)日：2007-03-15
申请号：US11515344
申请日：2006-09-01
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： A61F2/062 , A61L27/16 , A61L27/3616 , A61L27/38 , A61L27/3808 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

3. 发明申请

US20060210596A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060210596A1
公开(公告)日：2006-09-21
申请号：US11367006
申请日：2006-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/08 , C12M3/00 , A61F13/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

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