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1. 发明授权

US06485796B1 Method of making metal matrix composites 有权
标题翻译：制备金属基复合材料的方法
公开(公告)号：US06485796B1
公开(公告)日：2002-11-26
申请号：US09616589
申请日：2000-07-14
申请人： Michael W. Carpenter , John L. Sinz , Paul S. Werner , Lawrence A. Crum , Herve E. Deve
发明人： Michael W. Carpenter , John L. Sinz , Paul S. Werner , Lawrence A. Crum , Herve E. Deve
IPC分类号： B05D300
CPC分类号： C22C47/064 , B22F2999/00 , C22C47/08 , H01B1/023 , B22F2201/20 , B22F2202/01
摘要： Methods for making metal matrix composite articles such as wires and tapes. The metal matrix composites include a plurality of substantially continuous, longitudinally positioned fibers in a metal matrix. The fibers are selected from the group of ceramic fibers, boron, carbon fibers, and mixtures thereof.
摘要翻译：制造金属基复合制品如电线和胶带的方法。金属基质复合材料包括在金属基质中的多个基本上连续的纵向定位的纤维。纤维选自陶瓷纤维，硼，碳纤维及其混合物。

2. 发明申请

US20120302927A1 METHODS FOR CHARACTERIZING NONLINEAR FIELDS OF A HIGH-INTENSITY FOCUSED ULTRASOUND SOURCE AND ASSOCIATED SYSTEMS AND DEVICES 审中-公开
标题翻译：用于表征高强度聚焦超声波源和相关系统和器件的非线性场的方法
公开(公告)号：US20120302927A1
公开(公告)日：2012-11-29
申请号：US13479067
申请日：2012-05-23
申请人： Vera A. Khokhlova , Petr Yuldashev , Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum
发明人： Vera A. Khokhlova , Petr Yuldashev , Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61N2007/0065 , A61N2007/0095
摘要： The present technology is directed to methods for characterizing nonlinear ultrasound fields and associated systems and devices. In several embodiments, for example, a method of calculating output of a high intensity focused ultrasound (HIFU) device comprises treating a target site with a multi-element HIFU array. In some embodiments, the array comprises a generally spherical segment. The method can further include simulating a field of the array by setting a boundary condition for the array. The boundary condition can be set by simplifying at least one geometrical aspect of the generally spherical segment.
摘要翻译：本技术涉及用于表征非线性超声场和相关系统和装置的方法。在几个实施例中，例如，计算高强度聚焦超声（HIFU）装置的输出的方法包括用多元素HIFU阵列处理靶位点。在一些实施例中，阵列包括大致球形的段。该方法还可以包括通过设置数组的边界条件来模拟阵列的一个字段。可以通过简化大致球形段的至少一个几何方面来设定边界条件。

3. 发明申请

US20100226555A1 COUNTERTOP ULTRASOUND IMAGING DEVICE AND METHOD OF USING THE SAME FOR PATHOLOGY SPECIMEN EVALUATION 审中-公开
标题翻译：计数器超声成像装置及其用于病理学样本评估的方法
公开(公告)号：US20100226555A1
公开(公告)日：2010-09-09
申请号：US12716991
申请日：2010-03-03
申请人： Robert E. Sandstrom , Lawrence A. Crum
发明人： Robert E. Sandstrom , Lawrence A. Crum
IPC分类号： G06K9/00 , G01N29/06 , G01N29/04
CPC分类号： G01N29/0672 , A61B8/08 , A61B2017/3409 , A61B2017/3413 , A61B2090/367 , A61B2090/3987 , G01N29/225 , G01N2291/02475 , G01N2291/106 , G01S15/8918 , G01S15/8938
摘要： A tissue specimen imaging device, comprising: a container having an upwardly facing surface, adapted to receive a tissue specimen and a liquid, an ultrasound imaging assembly, adapted to automatically form a three dimensional image of the tissue specimen interior. In one preferred embodiment the device includes a transducer head that is automatically moved relative to the specimen.
摘要翻译：一种组织标本成像装置，包括：适于接收组织样本和液体的向上表面的容器，适于自动形成组织样本内部的三维图像的超声成像组件。在一个优选实施例中，该装置包括相对于试样自动移动的换能器头。

4. 发明授权

US07686763B2 Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy 失效
标题翻译：使用造影剂增加高强度聚焦超声治疗的有效性
公开(公告)号：US07686763B2
公开(公告)日：2010-03-30
申请号：US10770350
申请日：2004-02-02
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , Lawrence A. Crum
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61B8/12 , A61B8/06 , A61B8/0833 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Ultrasound contrast agents are used to enhance imaging and facilitate HIFU therapy in four different ways. A contrast agent is used: (1) before therapy to locate specific vascular structures for treatment; (2) to determine the focal point of a HIFU therapy transducer while the HIFU therapy transducer is operated at a relatively low power level, so that non-target tissue is not damaged as the HIFU is transducer is properly focused at the target location; (3) to provide a positive feedback mechanism by causing cavitation that generates heat, reducing the level of HIFU energy administered for therapy compared to that required when a contrast agent is not used; and, (4) to shield non-target tissue from damage, by blocking the HIFU energy. Various combinations of these techniques can also be employed in a single therapeutic implementation.
摘要翻译：超声造影剂用于增强成像，并以四种不同的方式促进HIFU治疗。使用造影剂：（1）治疗前定位特异性血管结构进行治疗; （2）确定HIFU治疗传感器的焦点，同时HIFU治疗传感器在相对较低的功率水平下运行，使得非靶组织不被损坏，因为HIFU换能器被适当地聚焦在目标位置; （3）通过引起产生热量的空化来提供正反馈机制，与不使用造影剂时所需的HIFU能量相比，降低施用的HIFU能量水平; 和（4）通过阻止HIFU能量来屏蔽非靶组织免受损伤。这些技术的各种组合也可以在单一治疗实施中使用。

5. 发明授权

US5882302A Methods and devices for providing acoustic hemostasis 失效
标题翻译：提供声学止血的方法和装置
公开(公告)号：US5882302A
公开(公告)日：1999-03-16
申请号：US669601
申请日：1996-06-24
申请人： Edward C. Driscoll, Jr. , Lawrence A. Crum , Wing K. Law , Stan DeMarta
发明人： Edward C. Driscoll, Jr. , Lawrence A. Crum , Wing K. Law , Stan DeMarta
IPC分类号： A61B5/00 , A61B8/00 , A61B8/06 , A61B8/08 , A61B17/00 , A61B17/12 , A61B19/00 , A61N7/02
CPC分类号： A61B8/06 , A61B5/416 , A61B8/08 , A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/461 , A61B8/467 , A61B8/483 , A61B8/485 , A61N7/022 , A61B2017/00274 , A61B2017/12004 , A61B2018/00547 , A61B2090/378 , A61B8/4281 , A61B8/4405 , A61N2007/0065 , A61N2007/0078
摘要： Methods and apparatus for the remote coagulation of blood using high-intensity focused ultrasound (HIFU) are provided. A remote hemostasis method comprises identifying a site of internal bleeding and focusing therapeutic ultrasound energy on the site, the energy being focused through an intervening tissue. An apparatus for producing remote hemostasis comprises a focused therapeutic ultrasound radiating surface and a sensor for identifying a site of internal bleeding, with a registration means coupled to the radiating surface and the sensor top bring a focal target and the bleeding site into alignment. The sensor generally comprises a Doppler imaging display. Hemostasis enhancing agents may be introduced to the site for actuation by the ultrasound energy.
摘要翻译：提供了使用高强度聚焦超声（HIFU）进行血液远程凝血的方法和装置。远程止血方法包括识别内部出血部位并将治疗超声能量聚焦在部位上，能量通过中间组织聚焦。用于产生远端止血的装置包括聚焦的治疗超声辐射表面和用于识别内部出血部位的传感器，其中联接到辐射表面的对准装置和传感器顶部使焦点瞄准器和出血部位对准。传感器通常包括多普勒成像显示器。可以将止血增强剂引入该部位以通过超声能量致动。

6. 发明授权

US08668658B2 Derating method for therapeutic applications of high intensity focused ultrasound 有权
标题翻译：高强度聚焦超声治疗应用降容方法
公开(公告)号：US08668658B2
公开(公告)日：2014-03-11
申请号：US13236531
申请日：2011-09-19
申请人： Vera A. Khokhlova , Olga V. Bessonova , Michael S. Canney , Michael R. Bailey , Oleg A. Sapozhnikov , Lawrence A. Crum
发明人： Vera A. Khokhlova , Olga V. Bessonova , Michael S. Canney , Michael R. Bailey , Oleg A. Sapozhnikov , Lawrence A. Crum
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61B2034/104
摘要： Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.
摘要翻译：本文公开了降低非线性超声场和相关系统的方法。根据本技术的实施例的降低非线性超声场的方法可以包括例如将超声源校准为第一源极电压（Vw）并且从超声源产生非线性声波到水中。该方法还可以包括测量非线性声波的聚焦波形并确定在组织中产生相同焦点波形的超声源的第二源电压（Vt）。

7. 发明授权

US08370996B2 Acoustical treatment of polymeric fibers and small particles and apparatus therefor 失效
标题翻译：聚合物纤维和小颗粒的声学处理及其设备
公开(公告)号：US08370996B2
公开(公告)日：2013-02-12
申请号：US12797362
申请日：2010-06-09
申请人： Dario Felipe Gaitan , Robert Hiller , Lawrence A. Crum
发明人： Dario Felipe Gaitan , Robert Hiller , Lawrence A. Crum
IPC分类号： D01G99/00
CPC分类号： D01G99/00
摘要： Systems and methods for treating small elongated fibrous and particles of certain materials, e.g., PTFE materials in a suspension are presented. In some instances, high-intensity ultrasound (or acoustical energy) is applied to a sample of the material, through a fluid coupling medium or suspension, to achieve a material transformation in the sample. In various embodiments, fibrillation of particles of PTFE or similar materials is accomplished, or the formation of extended structures of these materials is caused or enhanced. Also, the ability to separate long fiber samples by ultrasonic or acoustic cavitation action is provided.
摘要翻译：提出了用于处理某些材料的细长纤维和颗粒的系统和方法，例如悬浮液中的PTFE材料。在一些情况下，通过流体耦合介质或悬浮液将高强度超声（或声能）施加到材料的样品上，以实现样品中的材料转化。在各种实施方案中，完成了PTFE或类似材料的颗粒的原纤化，或者引起或增强了这些材料的延伸结构的形成。此外，提供了通过超声或声空化作用分离长纤维样品的能力。

8. 发明申请

US20110016671A1 Acoustical Treatment of Polymeric Fibers and Small Particles and Apparatus Therefor 失效
标题翻译：聚合物纤维和小颗粒的声学处理及其设备
公开(公告)号：US20110016671A1
公开(公告)日：2011-01-27
申请号：US12797362
申请日：2010-06-09
申请人： Dario Felipe GAITAN , Robert Hiller , Lawrence A. Crum
发明人： Dario Felipe GAITAN , Robert Hiller , Lawrence A. Crum
IPC分类号： D01G99/00
CPC分类号： D01G99/00
摘要： Systems and methods for treating small elongated fibrous and particles of certain materials, e.g., PTFE materials in a suspension are presented. In some instances, high-intensity ultrasound (or acoustical energy) is applied to a sample of the material, through a fluid coupling medium or suspension, to achieve a material transformation in the sample. In various embodiments, fibrillation of particles of PTFE or similar materials is accomplished, or the formation of extended structures of these materials is caused or enhanced. Also, the ability to separate long fiber samples by ultrasonic or acoustic cavitation action is provided.
摘要翻译：提出了用于处理某些材料的细长纤维和颗粒的系统和方法，例如悬浮液中的PTFE材料。在一些情况下，通过流体耦合介质或悬浮液将高强度超声（或声能）施加到材料的样品上，以实现样品中的材料转化。在各种实施方案中，完成了PTFE或类似材料的颗粒的原纤化，或者引起或增强了这些材料的延伸结构的形成。此外，提供了通过超声或声空化作用分离长纤维样品的能力。

9. 发明授权

US06835393B2 Enhanced transport using membrane disruptive agents 有权
标题翻译：增强运输使用膜破坏剂
公开(公告)号：US06835393B2
公开(公告)日：2004-12-28
申请号：US09226044
申请日：1999-01-05
申请人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , David Tirrell , Niren Murthy , Chantal Lackey , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter
发明人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , David Tirrell , Niren Murthy , Chantal Lackey , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter
IPC分类号： A61K9127
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

10. 发明授权

US06716184B2 Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound 有权
标题翻译：超声治疗头被配置为耦合到超声成像探针以促进使用低强度超声的同时成像和使用高强度聚焦超声
公开(公告)号：US06716184B2
公开(公告)日：2004-04-06
申请号：US10166795
申请日：2002-06-07
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61N700
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

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