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1. 发明授权

US07550185B2 Port tube and closure composition, structure and assembly for a flowable material container 有权
标题翻译：端口管和封闭组件，可流动材料容器的结构和组装
公开(公告)号：US07550185B2
公开(公告)日：2009-06-23
申请号：US11042651
申请日：2005-01-24
申请人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
发明人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
IPC分类号： F16L11/04 , F16L9/14 , A61M5/00
CPC分类号： C08L23/12 , A61L29/126 , B29C65/04 , B29C66/1122 , B29C66/53262 , B29C66/71 , B29C66/7234 , B29C2035/0861 , B32B1/08 , B32B27/08 , B32B27/32 , C08L23/0815 , C08L23/0869 , C08L23/142 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L2314/06 , Y10T428/1352 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/31746 , Y10T428/31913 , Y10T428/31924 , Y10T428/31931 , C08L2666/24 , C08L2666/04 , B29C65/00 , B29K2079/08 , B29K2077/00 , B29K2075/02 , B29K2075/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2023/18 , B29K2023/14 , B29K2023/12 , B29K2023/086 , B29K2023/083 , B29K2023/08 , B29K2021/003 , B29K2009/00
摘要： The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.
摘要翻译：本发明提供了一种可流动的材料容器组件，其具有同轴地设置在端口管内的膜管。膜管具有外层，芯层和内层。外层是聚烯烃和热塑性弹性体的共混物。芯层是聚烯烃和热塑性弹性体的共混物。内层是聚烯烃，射频敏感聚合物和热塑性弹性体的混合物。

2. 发明授权

US06869653B2 Port tube closure assembly 有权
标题翻译：端口管封闭组件
公开(公告)号：US06869653B2
公开(公告)日：2005-03-22
申请号：US09756490
申请日：2001-01-08
申请人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
发明人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
IPC分类号： F16L11/04 , A61J1/10 , A61J1/14 , A61L29/12 , A61L31/00 , B29C35/08 , B29C65/04 , B32B1/08 , B32B25/08 , B32B27/08 , B32B27/32 , C08L23/08 , C08L23/12 , C08L23/14 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L47/00
CPC分类号： C08L23/12 , A61L29/126 , B29C65/04 , B29C66/1122 , B29C66/53262 , B29C66/71 , B29C66/7234 , B29C2035/0861 , B32B1/08 , B32B27/08 , B32B27/32 , C08L23/0815 , C08L23/0869 , C08L23/142 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L2314/06 , Y10T428/1352 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/31746 , Y10T428/31913 , Y10T428/31924 , Y10T428/31931 , C08L2666/24 , C08L2666/04 , B29C65/00 , B29K2079/08 , B29K2077/00 , B29K2075/02 , B29K2075/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2023/18 , B29K2023/14 , B29K2023/12 , B29K2023/086 , B29K2023/083 , B29K2023/08 , B29K2021/003 , B29K2009/00
摘要： The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend and (B) the second layer is disposed coaxially within the first layer; and the membrane tube (II) is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.
摘要翻译：本发明提供一种具有端口管和膜管的可流动材料容器封闭组件。端口管（I）具有第一层和第二层，（A）第一层是聚合物共混物，（B）第二层同轴地设置在第一层内; 并且膜管（II）同轴地设置在端口管内，膜管具有外层，芯层和内层。

3. 发明授权

US6060640A Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译：用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构
公开(公告)号：US6060640A
公开(公告)日：2000-05-09
申请号：US446210
申请日：1995-05-19
申请人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
发明人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
IPC分类号： A61F2/02 , A61K9/00 , A61L27/38 , C12N5/08 , A61D7/00 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38
摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.
摘要翻译：可渗透结构形成容纳活细胞的室。所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。第三可渗透区域位于第一和第二可渗透区域之间。第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。第三可渗透区域将第一和第二可渗透区域结合在一起。第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。第三个就地区域也可以具有提供免疫隔离作用的构象。此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

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