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1. 发明申请

US20120172800A1 INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS 失效
标题翻译：空调泵送空气管理系统及方法
公开(公告)号：US20120172800A1
公开(公告)日：2012-07-05
申请号：US12981152
申请日：2010-12-29
申请人： Thomas Dudar , Ross Krogh , James Martucci , Shmuel Sternberg
发明人： Thomas Dudar , Ross Krogh , James Martucci , Shmuel Sternberg
IPC分类号： A61M5/36 , A61M5/38
CPC分类号： A61M5/172 , A61M5/36 , A61M5/365 , A61M5/38 , A61M5/385 , A61M2205/60
摘要： An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).
摘要翻译：静脉内（“IV”）液体输送系统包括：IV泵管组; 一个穿梭泵或膜泵驱动器，可与IV泵管组一起操作; 上游和下游阀致动器可与IV泵管组一起操作; 所述IV泵管组包括排气装置; 空气检测器，被配置为感测IV泵管组中的空气; 控制单元，其配置和布置成（i）打开上游阀致动器并关闭下游阀致动器以允许泵致动器将液体引入IV泵管组的泵致动部分，以及（ii）关闭上游阀致动器并且打开下游阀致动器以允许泵致动器将液体推出泵致动部分，该系统构造成在根据（i）和（i）和（i））操作上游和下游阀致动器期间尝试经由除气装置去除空气， ii）。

2. 发明申请

US20100063445A1 Device to Indicate Priming of an Infusion Line 有权
标题翻译：指示灌注线灌注的装置
公开(公告)号：US20100063445A1
公开(公告)日：2010-03-11
申请号：US12555606
申请日：2009-09-08
申请人： Shmuel Sternberg , Siddharth B. Desai , Larry Black , Robin G. Pauley
发明人： Shmuel Sternberg , Siddharth B. Desai , Larry Black , Robin G. Pauley
IPC分类号： A61J1/18 , A61M39/00 , G08B21/00
CPC分类号： G01D7/005 , A61M5/141 , A61M5/3146 , A61M5/385 , A61M39/10 , A61M39/20 , A61M2005/1402 , A61M2005/3125 , A61M2039/205 , A61M2205/331 , A61M2205/7536
摘要： A priming indicator for a fluid infusion system includes a luer cap or other component of the infusion system having an indicator surface covered by a membrane. The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.
摘要翻译：用于流体输注系统的起动指示器包括输注系统的路厄帽或其他组件，其具有由膜覆盖的指示器表面。当膜干燥时，膜呈现第一视觉特征，例如不透明的，并且当湿时呈现第二特性，例如变得不透明。一旦膜变湿，可以设置在至少部分地被膜覆盖的杆上的表面上的标记变得可见，从而指示固定有鲁尔帽的静脉内管已经被引发或几乎被引发。可以在输液器的上游端（例如在提供流体供应的医疗袋的端口处）使用指示器，以指示医疗袋中的低水平的流体。

3. 发明授权

US06824688B2 Blood collection systems and methods using a porous membrane element 有权
标题翻译：使用多孔膜元件的采血系统和方法
公开(公告)号：US06824688B2
公开(公告)日：2004-11-30
申请号：US10606589
申请日：2003-06-26
申请人： Julian P. Breillatt, Jr. , Shmuel Sternberg
发明人： Julian P. Breillatt, Jr. , Shmuel Sternberg
IPC分类号： B01D3700
CPC分类号： B01D69/12 , A61M1/3633 , A61M1/3636 , B01D61/18 , B01D63/081 , B01D65/00
摘要： A filter for removing leukocytes from blood comprises a filter media enclosed in a housing. The filter media includes a main filter region comprising a porous membrane structure extending between first and second skin surfaces. The porous membrane structure is formed by intersecting cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores, which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 &mgr;m and 28 &mgr;m.
摘要翻译：用于从血液中除去白细胞的过滤器包括封装在壳体中的过滤介质。过滤介质包括主过滤器区域，其包括在第一和第二表皮之间延伸的多孔膜结构。多孔膜结构由具有一定范围的直径的细胞相交形成。与第一皮肤表面相邻的细胞的直径通常小于与第二皮肤表面相邻的细胞的直径。第一皮肤表面包括由细胞与第一皮肤表面相交形成的由孔限定的开放区域。开放区域的大部分由具有约12μm和28μm之间的直径的孔限定。

4. 发明授权

US06596230B1 Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
标题翻译：用灭菌辐射使病原体灭活治疗液的装置和方法
公开(公告)号：US06596230B1
公开(公告)日：2003-07-22
申请号：US09494338
申请日：2000-01-28
申请人： Lecon Woo , Daniel R. Boggs , Shmuel Sternberg , Craig Sandford , Atul Khare , Julian Breillatt
发明人： Lecon Woo , Daniel R. Boggs , Shmuel Sternberg , Craig Sandford , Atul Khare , Julian Breillatt
IPC分类号： A61L208
CPC分类号： A61M1/3681 , A61L2/0011 , A61L2/10 , A61M1/0281 , A61M2202/0415 , A61M2205/053
摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a “carrying” mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
摘要翻译：一种在具有对具有高光密度的流体显示辐射剂量均匀性的连续薄流体流动布置中灭菌治疗性流体中的灭菌辐射的装置和方法。辐射剂量均匀性部分地通过移动或携带流体的“携带”机构实现，从而消除了通道流速分布，其中通道壁附近的流量具有过度暴露于辐射的风险，这是由于内部的非常大的停留时间渠道。该装置包括连接到通过入口（24）的流体流和带室（22）上的出口（26）的相对平坦的带室（22）。带室（22）具有顶表面（28）和底表面（30）。辐射透射板（32）邻近带室（22）的顶表面（28）设置并与带室（22）接触。辐射源（42）邻近于与带室（22）相对的一侧邻近板（32）设置。具有多个柔性叶片（36）的带（34）邻近带室（22）的底表面（30）设置，使得叶片（36）与带室（22）接触。皮带由辊机构（38）沿着流体流动的方向驱动。当流体流过皮带室（22）时，柔性叶片（36）提供刮板状机构，以使流体通过一对叶片（36）限定的离散的分组（40）移动通过皮带室（22）。当流体包装移动通过皮带室时，它们暴露于穿过板（32）的灭菌辐射。

5. 发明授权

US6060640A Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译：用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构
公开(公告)号：US6060640A
公开(公告)日：2000-05-09
申请号：US446210
申请日：1995-05-19
申请人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
发明人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
IPC分类号： A61F2/02 , A61K9/00 , A61L27/38 , C12N5/08 , A61D7/00 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38
摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.
摘要翻译：可渗透结构形成容纳活细胞的室。所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。第三可渗透区域位于第一和第二可渗透区域之间。第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。第三可渗透区域将第一和第二可渗透区域结合在一起。第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。第三个就地区域也可以具有提供免疫隔离作用的构象。此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

6. 发明申请

US20080021381A1 MEDICAL FLUID ACCESS DEVICE WITH ANTISEPTIC INDICATOR 有权
标题翻译：具有抗菌指示器的医用流体访问装置
公开(公告)号：US20080021381A1
公开(公告)日：2008-01-24
申请号：US11780917
申请日：2007-07-20
申请人： Kent L. LURVEY , Shmuel STERNBERG , Vadim V. KRONGAUZ , Rosa H. YEH , Robin G. PAULEY , Dustin C. CAWTHON , Ton That HAI , Lecon L. WOO , Ashok K. KHANNA , Birendra K. LAL , Michael Tung-Kiung LING , William S. HOERLE , Craig L. SANDFORD , Mark A. NORDHAUS , Alexander SAVITSKI , Nicklaus J. KIRICHKOW , Kenneth Glen SUH , Sivaramakrishnan KRISHNAMOORTHY , Hsinjin E. YANG , Robert A. CLARKE
发明人： Kent L. LURVEY , Shmuel STERNBERG , Vadim V. KRONGAUZ , Rosa H. YEH , Robin G. PAULEY , Dustin C. CAWTHON , Ton That HAI , Lecon L. WOO , Ashok K. KHANNA , Birendra K. LAL , Michael Tung-Kiung LING , William S. HOERLE , Craig L. SANDFORD , Mark A. NORDHAUS , Alexander SAVITSKI , Nicklaus J. KIRICHKOW , Kenneth Glen SUH , Sivaramakrishnan KRISHNAMOORTHY , Hsinjin E. YANG , Robert A. CLARKE
IPC分类号： A61M37/00
CPC分类号： G01N21/78 , A61M39/02 , A61M39/045 , A61M39/16 , A61M39/26 , A61M2039/1033 , A61M2039/1072 , A61M2205/583 , A61M2205/584 , G01N31/22
摘要： A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.
摘要翻译：公开了一种医疗装置，例如血管通路装置，用于提供对医用流体流路的通路，用于将医用流体引入或取出流路。访问装置包括用于当访问装置已经暴露于防腐剂时提供视觉指示的指示器。

7. 发明授权

US06908553B1 Composite membrane with particulate matter substantially immobilized therein 失效
标题翻译：复合膜，其中颗粒物质基本上固定在其中
公开(公告)号：US06908553B1
公开(公告)日：2005-06-21
申请号：US09111915
申请日：1998-07-08
申请人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
发明人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
IPC分类号： B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D39/00
CPC分类号： B01J20/28033 , A61M1/3686 , B01D69/141 , B01J20/28004 , B01J20/28026 , B01J20/28035
摘要： Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
摘要翻译：公开了膜和膜的制造方法。膜包括聚合物基质和固定在基质内的颗粒物质。作为病原体灭活处理的一部分，膜可以特别适用于从生物液体中除去有机化合物的方法和装置。

8. 发明授权

US4222870A Ultrafiltration apparatus and method 失效
标题翻译：超滤装置及方法
公开(公告)号：US4222870A
公开(公告)日：1980-09-16
申请号：US880950
申请日：1978-02-24
申请人： Shmuel Sternberg , Steven S. Emmer
发明人： Shmuel Sternberg , Steven S. Emmer
IPC分类号： B01D63/00 , B01D13/00
CPC分类号： B01D61/18 , B01D61/145 , B01D63/06 , B01D63/08
摘要： Method and apparatus for the constant volume solvent exchange or constant volume neutralization of a liquid solution or suspension of macromolecules. Liquid enters a bulk zone and passes into a thin layer filtration zone, in which the separation is effected through a semi-permeable membrane filter.
摘要翻译：用于恒定体积溶剂交换或恒定体积中和大分子液体溶液或悬浮液的方法和装置。液体进入散装区并进入薄层过滤区，其中通过半透膜过滤器进行分离。

9. 发明授权

US4184963A Immersible molecular filter unit and process of making it 失效
标题翻译：潜在的分子过滤器单元及其制作工艺
公开(公告)号：US4184963A
公开(公告)日：1980-01-22
申请号：US846330
申请日：1977-10-28
申请人： Shmuel Sternberg
发明人： Shmuel Sternberg
IPC分类号： B01D63/00 , B01D31/00 , B01D13/04
CPC分类号： B01D69/10 , B01D61/145
摘要： Covers an immersible molecular filter unit having a body that is formed from a porous polymeric material of generally cylindrical shape, preferably rounded at least at one of its ends. A tubular connector is mounted at one end of this body, with a bore that communicates with the porous network of the body. An anisotropic membrane encapsulates the body and is formed with an integral collar portion that engages about a portion of the connector, where it projects from the body, in substantially fluid-tight fashion. Preferably the membrane, which is formed in situ, is shrunk about the tube and the body, and is solvent welded to the connector.This unit is formed by dipping the body and the juxtaposed connector in a polymer casting solution, to encapsulate the porous body and a part of the connector. The dip-coating unit is then converted to an anisotropic membrane. The preferred way to do this is immersion in a liquid that is not a solvent for the cast polymer, but that is miscible with the solvent of the casting solution, to cause formation of a highly anisotropic structure. Preferably, this is accompanied by simultaneous shrinking of the applied coating and solvent welding of the collar portion of the coating to the tube. The viscosity of the casting solution and the porosity of the body are such that there is substantially no penetration of the casting solution into the porous structure of the body.
摘要翻译：覆盖一个浸入式分子过滤器单元，其具有由大致圆柱形形状的多孔聚合材料形成的主体，其优选至少在其一端至少圆形。管状连接器安装在本体的一端，具有与主体的多孔网络连通的孔。各向异性膜封装主体并且形成有整体的套环部分，该套环部分围绕连接器的一部分接合，其中，其基本上以流体密封的方式从身体突出。优选地，原位形成的膜围绕管和主体收缩，并且被溶剂焊接到连接器。该单元通过将主体和并置的连接器浸渍在聚合物浇注溶液中来形成，以封装多孔体和连接器的一部分。然后将浸涂单元转化成各向异性膜。优选的方法是浸入不是浇铸聚合物的溶剂的液体中，但是可以与浇铸溶液的溶剂混溶，从而形成高度各向异性的结构。优选地，这伴随着施加的涂层的同时收缩和涂层的套环部分的溶剂焊接到管。铸造溶液的粘度和主体的孔隙度使得铸造溶液基本上不渗透到主体的多孔结构中。

10. 发明申请

US20080107564A1 MEDICAL FLUID ACCESS SITE WITH ANTISEPTIC INDICATOR 审中-公开
公开(公告)号：US20080107564A1
公开(公告)日：2008-05-08
申请号：US11550643
申请日：2006-10-18
申请人： Shmuel Sternberg , Kent L. Lurvey , Robin G. Pauley , Dustin C. Cawthon , Ton That Hai , Lecon Woo , Ashok K. Khanna , Birendra K. Lal , Michael Tung-Kiung Ling , Vadim V. Krongauz , Rosa H. Yeh , William S. Hoerle , Craig L. Sandford
发明人： Shmuel Sternberg , Kent L. Lurvey , Robin G. Pauley , Dustin C. Cawthon , Ton That Hai , Lecon Woo , Ashok K. Khanna , Birendra K. Lal , Michael Tung-Kiung Ling , Vadim V. Krongauz , Rosa H. Yeh , William S. Hoerle , Craig L. Sandford
IPC分类号： G01N21/78 , A61M5/50
CPC分类号： G01N21/78 , A61M39/02 , A61M39/045 , A61M39/16 , A61M39/26 , A61M2039/1033 , A61M2039/1072 , A61M2205/583 , A61M2205/584 , G01N31/22
摘要： An access device including access site is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

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