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1. 发明申请

US20120220495A1 ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF 审中-公开
标题翻译：微阵列阵列及其制备方法
公开(公告)号：US20120220495A1
公开(公告)日：2012-08-30
申请号：US13465618
申请日：2012-05-07
申请人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： C40B40/06 , C40B40/10 , C40B40/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在芯片上，芯片可以根据本文所述的方法组合以形成多芯片阵列。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

2. 发明申请

US20110098201A1 Arrays of microparticles and methods of preparation thereof 审中-公开
标题翻译：微粒阵列及其制备方法
公开(公告)号：US20110098201A1
公开(公告)日：2011-04-28
申请号：US12910468
申请日：2010-10-22
申请人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： C40B50/18
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在芯片上，芯片可以根据本文所述的方法组合以形成多芯片阵列。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

3. 发明授权

US07057704B2 System and method for programmable illumination pattern generation 有权
标题翻译：用于可编程照明图案生成的系统和方法
公开(公告)号：US07057704B2
公开(公告)日：2006-06-06
申请号：US10098604
申请日：2002-03-16
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G03B27/42 , G03B27/72
CPC分类号： G01N21/6456 , B01L3/502761 , B01L2200/0668 , B01L2300/089 , B01L2400/0415 , G01N21/6428 , G01N21/6452 , G01N2021/6463 , G01N2021/6478
摘要： An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles: the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects them on to planar surfaces. i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.
摘要翻译：公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。该装置实现LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装：电解质/氧化硅/硅界面的图案化以对组装过程施加空间控制; 并通过外部照明实现对装配过程的实时控制。该设备产生照明模式并将它们投影到平面上。即LEAPS电极。这使得能够使用个人计算机上的图形设计或绘图软件来创建图案，并且使用液晶显示器（LCD）面板将所述图案或图案序列（“时变图案”）投影到界面上将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

4. 发明授权

US08615367B2 Number coding for identification of subtypes of coded types of solid phase carriers 失效
标题翻译：用于识别编码类型的固相载体亚型的编号
公开(公告)号：US08615367B2
公开(公告)日：2013-12-24
申请号：US13071055
申请日：2011-03-24
申请人： Michael Seul , Chiu Wo Chau , Enqing Tan
发明人： Michael Seul , Chiu Wo Chau , Enqing Tan
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： G01N33/6845 , G01N33/543 , G01N33/54313 , G01N33/564
摘要： Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.
摘要翻译：公开了固态载波的对（“双”）或小集（“多重”）的数字编码，其提供给定类型的这种载波的可区分的子类型，其中每个载波类型基于不同的码可区分。这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因通过知道多少载体与检测每个不同等位基因的分子相关联来区分颜色代码。

5. 发明授权

US08084274B2 Programmable illumination pattern for transporting microparticles 有权
标题翻译：用于运输微粒的可编程照明图案
公开(公告)号：US08084274B2
公开(公告)日：2011-12-27
申请号：US12029189
申请日：2008-02-11
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G01N33/543 , G01N33/553
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0454 , C12Q1/6837 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , C12Q2565/607 , C12Q2563/155
摘要： An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes is disclosed. The apparatus implements LEAPS (light-controlled electrokinetic assembly of particles near surfaces), which relies on AC electric field-induced assembly of particles, patterning of an electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process, and real-time control of assembly via external illumination. The apparatus generates patterns of illumination and projects them onto planar surfaces, i.e., LEAPS electrodes. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns or sequences of patterns (“time-varying patterns”) onto the interface using a liquid crystal display (LCD) panel and an optical design that images the LCD panel onto the surface of interest to provide for the assembly of particles within such patterns.
摘要翻译：公开了提供用于在电极之间的悬浮液中的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。该装置实现LEAPS（靠近表面的颗粒的光控电动组装），其依赖于AC电场引起的颗粒组装，图案化电解质/氧化硅/硅界面以对组装过程进行空间控制，通过外部照明组装的时间控制。该装置产生照明模式并将它们投射到平面表面即LEAPS电极上。这使得能够使用个人计算机上的图形设计或绘图软件创建图案，并且使用液晶显示器（LCD）面板和光学设计将所述图案或图案序列（“时变图案”）投影到界面上将LCD面板图像到感兴趣的表面上，以提供在这种图案内的颗粒的组装。

6. 发明授权

US07144119B2 System and method for programmable illumination pattern generation 有权
标题翻译：用于可编程照明图案生成的系统和方法
公开(公告)号：US07144119B2
公开(公告)日：2006-12-05
申请号：US09768413
申请日：2001-01-24
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G03B21/00 , G03B21/26 , G01N33/543 , G01N33/546
CPC分类号： H05H3/04 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01L3/502761 , B01L3/502792 , B01L2200/0663 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2400/0415 , B01L2400/0454 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , G01N33/54313 , G01N2015/149 , G02B3/0012 , G02B3/0043 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects then onto planar surfaces, i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection or said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.
摘要翻译：公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。该装置实现了LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装，电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。该装置产生照明模式，然后投射到平面表面即LEAPS电极上。这使得能够使用液晶显示器（LCD）面板和使用液晶显示器（LCD）面板在个人计算机上使用图形设计或绘图软件创建图案，并且使用投影或所述图案或图案序列（“时变图案”）到界面上将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

7. 发明授权

US08999731B2 Programmable illumination pattern for transporting microparticles 有权
标题翻译：用于运输微粒的可编程照明图案
公开(公告)号：US08999731B2
公开(公告)日：2015-04-07
申请号：US13332715
申请日：2011-12-21
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G01N33/543 , B01L3/00 , C12Q1/68 , G01N15/02 , G01N30/00 , G01N15/14
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0454 , C12Q1/6837 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , C12Q2565/607 , C12Q2563/155
摘要： The present application provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
摘要翻译：本申请提供了一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

8. 发明申请

US20080123089A1 Quality control method for making a biochip displaying an encoded bead array 有权
标题翻译：用于制造显示编码珠阵列的生物芯片的质量控制方法
公开(公告)号：US20080123089A1
公开(公告)日：2008-05-29
申请号：US11874355
申请日：2007-10-18
申请人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： G01N21/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在芯片上，芯片可以根据本文所述的方法组合以形成多芯片阵列。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

9. 发明授权

US07041510B2 System and method for programmable illumination pattern generation 失效
公开(公告)号：US07041510B2
公开(公告)日：2006-05-09
申请号：US09768414
申请日：2001-01-24
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G01N33/543
CPC分类号： H05H3/04 , B01J19/0046 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502792 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0454 , B01L2400/086 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B60/10 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , G01N2030/0035 , G02B3/0012 , G02B3/0056 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (“gray scales”) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles.

10. 发明授权

US07842649B2 Quality control method for making a biochip displaying an encoded bead array 有权
标题翻译：用于制造显示编码珠阵列的生物芯片的质量控制方法
公开(公告)号：US07842649B2
公开(公告)日：2010-11-30
申请号：US11874355
申请日：2007-10-18
申请人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： C40B50/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在芯片上，芯片可以根据本文所述的方法组合以形成多芯片阵列。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

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