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1. 发明申请

US20070042347A1 High throughput biological heart rate monitor that is molecularly determined 审中-公开
标题翻译：分子确定的高通量生物心率监测仪
公开(公告)号：US20070042347A1
公开(公告)日：2007-02-22
申请号：US11520527
申请日：2006-09-12
申请人： Michael Rosen , Richard Robinson , Ira Cohen , Han-Gang Yu
发明人： Michael Rosen , Richard Robinson , Ira Cohen , Han-Gang Yu
IPC分类号： C12Q1/00
CPC分类号： G01N33/6872 , A61K38/1709 , A61K48/00 , G01N33/5008 , G01N33/502 , G01N33/5061
摘要： This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. The chamber holds from 24-96 such wells. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. Drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm. Further provided for by this invention is a A vector which comprises a compound which encode an ion channel.
摘要翻译：本发明提供了一种设计用于测定药物对心率的影响的室和系统。该室由一系列的孔组成，内径为3 mm×3 mm。将从新生儿动物分解的心肌细胞接种在每个孔的底部并在标准组织培养条件下生长。该厅拥有24-96个这样的井。当要测定药物时，每个孔中的细胞装载有钙敏感染料，并且用光电二极管监测每个孔中的搏动速率。将药物以分级浓度加入每个孔中，并平衡并观察其对速率的影响。该构建允许使用基于细胞的生物测定法来研究可能改变心率的药物或药剂。本发明可用于药物的高通量筛选以评估/预测其对心率和节律的影响。本发明进一步提供的是包含编码离子通道的化合物的A载体。

2. 发明申请

US20060234375A1 Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division 审中-公开
标题翻译：使用人类干细胞和/或其产生的因子通过心肌细胞分裂促进成年哺乳动物心脏修复
公开(公告)号：US20060234375A1
公开(公告)日：2006-10-19
申请号：US11240948
申请日：2005-09-29
申请人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
发明人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
IPC分类号： C12N5/08 , C12N5/00 , A01N63/00
CPC分类号： C12N5/0663 , A61K35/28 , A61K35/44 , A61K35/545
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
摘要翻译：一种用于在体内治疗患有心脏病症的受试者的方法，包括（i）在体外产生包含从细胞培养物调节的培养基的溶液，和（ii）向受试者施用步骤（i）的溶液，从而治疗受试者的心脏病。确定药物是否刺激或抑制肌细胞增殖的方法。

3. 发明申请

US20060198829A1 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair 有权
公开(公告)号：US20060198829A1
公开(公告)日：2006-09-07
申请号：US11227533
申请日：2005-09-14
申请人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
发明人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
IPC分类号： A61K48/00 , C12N5/08 , C12N15/87
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.

4. 发明申请

US20110275156A2 Delivery of DNA or RNA Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRNA 有权
标题翻译：通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统
公开(公告)号：US20110275156A2
公开(公告)日：2011-11-10
申请号：US12910346
申请日：2010-10-22
申请人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
发明人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
IPC分类号： C12N15/87 , C12N5/071
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译：将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。

5. 发明申请

US20070099268A1 Chimeric HCN channels 审中-公开
标题翻译：嵌合HCN通道
公开(公告)号：US20070099268A1
公开(公告)日：2007-05-03
申请号：US11519399
申请日：2006-09-11
申请人： Ira Cohen , Michael Rosen , Peter Brink , Richard Robinson
发明人： Ira Cohen , Michael Rosen , Peter Brink , Richard Robinson
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705
摘要： This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.
摘要翻译：本发明提供包含多于一种类型的HCN通道的嵌合超极化激活的环核苷酸门控（HCN）多肽。本发明还提供了治疗患有心律紊乱的受试者的方法，包括在心脏的选定区域中嵌合HCN多肽的表达，以便诱发心脏起搏器电流，从而治疗受试者。

6. 发明申请

US20070053886A1 Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart 有权
标题翻译：具有钠通道，钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞
公开(公告)号：US20070053886A1
公开(公告)日：2007-03-08
申请号：US11490760
申请日：2006-07-21
申请人： Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
发明人： Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
IPC分类号： A61K35/12 , C12N5/08 , A61K9/70
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译：本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。

7. 发明申请

US20120028241A2 Assay System for Monitoring the Effects of Genetically Engineered Cells to Alter Function of a Synctium 有权
标题翻译：用于监测遗传工程细胞对改变神经功能的影响的测定系统
公开(公告)号：US20120028241A2
公开(公告)日：2012-02-02
申请号：US11792426
申请日：2005-07-19
申请人： Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
发明人： Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
IPC分类号： C12Q1/68 , C12Q1/00
CPC分类号： G01N33/5061
摘要： This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for constructing a gene construct capable of coupling to a syncytial cell.
摘要翻译：本发明提供了确定基因构建体改变合胞体细胞的节律和收缩能力的方法。此外，本发明提供构建能够改变合胞体的节律或收缩性的基因构建体的方法。最后，本发明提供了构建能够与合胞体偶联的基因构建体的方法。

8. 发明申请

US20050009006A1 High throughput monitoring chamber for testing drug effects on repolarization and conduction 审中-公开
标题翻译：高通量监测室，用于测试药物对复极和传导的影响
公开(公告)号：US20050009006A1
公开(公告)日：2005-01-13
申请号：US10841266
申请日：2004-05-07
申请人： Ofer Binah , Ira Cohen , Richard Robinson , Michael Rosen
发明人： Ofer Binah , Ira Cohen , Richard Robinson , Michael Rosen
IPC分类号： G01N33/50 , C12Q1/00 , C12N5/06
CPC分类号： G01N33/5061 , G01N33/5008 , G01N33/502 , G01N33/5073
摘要： The invention provides a method for determining the effects of an agent on repolarization of cells in vitro, comprising stimulating the cells with an energy source and under conditions sufficient and for a time sufficient to depolarize the cells, measuring the QT interval of the electrical signals output by the cells in response to the stimulating step, contacting the cells with an agent, re-stimulating the cells with the same energy source and under the same conditions as the first stimulating step and for a time sufficient to depolarize the cells, measuring the QT interval of the electrical signals output by the cells in response to the second stimulating step, and comparing the results of the measuring taken after the first and second stimulating steps to determine whether the agent affects repolarization of cells. The present invention also provides a method for determining the effects of an agent on conduction of cells in vitro.
摘要翻译：本发明提供了一种用于确定试剂对体外细胞复极化的影响的方法，包括用能量源刺激细胞并在足以使足以使细胞去极化的时间的条件下测量电信号输出的QT间隔通过响应于刺激步骤的细胞，使细胞与试剂接触，用与第一刺激步骤相同的能量源和相同的条件再刺激细胞并持续足以使细胞去极化的时间，测量QT 响应于第二刺激步骤由细胞输出的电信号的间隔，以及比较在第一和第二刺激步骤之后测量的结果以确定试剂是否影响细胞的复极化。本发明还提供了一种用于测定试剂对体外细胞传导的影响的方法。

9. 发明申请

US20050002914A1 Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures 审中-公开
标题翻译：间充质干细胞作为合胞体结构中离子通道转移的载体
公开(公告)号：US20050002914A1
公开(公告)日：2005-01-06
申请号：US10757827
申请日：2004-01-15
申请人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink
发明人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink
IPC分类号： A61K35/12 , C07K14/705 , C12N5/08 , A61K48/00
CPC分类号： C07K14/705 , A61K2035/124
摘要： This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel transfer which comprises stem cells incorporated with a compound in an amount sufficient to create ion channels. This invention also provides for a method of expressing a functional gene product in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a gene, to the syncytial structure. This invention further provides a method of expressing a functional ion channel in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a compound in an amount sufficient to create ion channels, to the syncytial structure. This invention also provides a composition for delivery of small molecules comprising stem cells incorporated with the small molecules or genes encoding the small molecules.
摘要翻译：本发明提供了用于将基因递送至合成结构的组合物，其包括掺入该基因的干细胞。本发明还提供了用于离子通道转移的组合物，其包含与足以产生离子通道的量的化合物结合的干细胞。本发明还提供了一种在合胞体结构中表达功能基因产物的方法，其包括将包含基因的干细胞组合物施用于合胞体结构。本发明进一步提供一种在合胞体结构中表达功能性离子通道的方法，其包括向合成结构施用包含与足以产生离子通道的化合物结合的干细胞的组合物。本发明还提供了用于递送小分子的组合物，其包括与小分子结合的干细胞或编码小分子的基因。

10. 发明申请

US20110256112A2 Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein 审中-公开
标题翻译：使用编码钠通道或间隙结蛋白的核酸补偿房室传导阻滞
公开(公告)号：US20110256112A2
公开(公告)日：2011-10-20
申请号：US12921395
申请日：2009-03-06
申请人： Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
发明人： Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
IPC分类号： A61K35/12 , A61P9/00 , A61K35/76 , C07H21/00 , A61K48/00 , C12N5/10
CPC分类号： A61K48/005 , A61K48/0075 , C07K14/705 , C12N2799/022 , C12N2799/04
摘要： A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node.
摘要翻译：通过在具有小于正常传导速度的AV结和/或His束中引起钠通道的表达或增加心脏阻塞或心脏阻塞风险的哺乳动物的AV传导速度的方法，间隙连接蛋白，如SkM-1通道，Cx43或Cx32，以增加AV节点的传导速度。

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