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1. 发明申请

US20060198829A1 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair 有权
公开(公告)号：US20060198829A1
公开(公告)日：2006-09-07
申请号：US11227533
申请日：2005-09-14
申请人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
发明人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
IPC分类号： A61K48/00 , C12N5/08 , C12N15/87
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.

2. 发明申请

US20060234375A1 Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division 审中-公开
标题翻译：使用人类干细胞和/或其产生的因子通过心肌细胞分裂促进成年哺乳动物心脏修复
公开(公告)号：US20060234375A1
公开(公告)日：2006-10-19
申请号：US11240948
申请日：2005-09-29
申请人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
发明人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
IPC分类号： C12N5/08 , C12N5/00 , A01N63/00
CPC分类号： C12N5/0663 , A61K35/28 , A61K35/44 , A61K35/545
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
摘要翻译：一种用于在体内治疗患有心脏病症的受试者的方法，包括（i）在体外产生包含从细胞培养物调节的培养基的溶液，和（ii）向受试者施用步骤（i）的溶液，从而治疗受试者的心脏病。确定药物是否刺激或抑制肌细胞增殖的方法。

3. 发明申请

US20070072294A1 Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division 审中-公开
标题翻译：使用人类干细胞和/或其产生的因子通过心肌细胞分裂促进成年哺乳动物心脏修复
公开(公告)号：US20070072294A1
公开(公告)日：2007-03-29
申请号：US11296018
申请日：2005-12-06
申请人： Sergey Doronin , Glenn Gaudette , Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
发明人： Sergey Doronin , Glenn Gaudette , Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： A61L27/367 , A61K35/28 , A61K35/44 , A61K35/545 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/3843 , A61L27/3873 , A61L2430/20 , C12N5/0657 , C12N2501/33 , C12N2501/415 , C12N2502/1358 , C12N2510/00 , C12N2533/32 , C12N2533/52 , G01N33/5061 , G01N33/5073
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
摘要翻译：一种用于在体内治疗患有心脏病症的受试者的方法，包括（i）在体外产生包含从细胞培养物调节的培养基的溶液，和（ii）向受试者施用步骤（i）的溶液，从而治疗受试者的心脏病。确定药物是否刺激或抑制肌细胞增殖的方法。

4. 发明授权

US08431397B2 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair 有权
标题翻译：将人间充质干细胞分化为促进心脏修复的心脏祖细胞
公开(公告)号：US08431397B2
公开(公告)日：2013-04-30
申请号：US11227533
申请日：2005-09-14
申请人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
发明人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
IPC分类号： C12N5/00 , A01N63/00
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
摘要翻译：在体内治疗患有心脏病症的受试者的方法包括（i）诱导祖细胞在体外对心源性细胞的分化; 和（ii）向受试者施用治疗有效量的步骤（i）的心源性细胞，从而治疗受试者的心脏疾病。本发明还提供了相关的制造和方法。

5. 发明申请

US20100158805A1 QUANTUM DOT LABELED STEM CELLS FOR USE IN CARDIAC REPAIR 审中-公开
标题翻译：量子标签干细胞用于心脏修复
公开(公告)号：US20100158805A1
公开(公告)日：2010-06-24
申请号：US12532780
申请日：2008-03-21
申请人： Ira S. Cohen , Amy Rosen Kontorovich , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy Rosen Kontorovich , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61K49/10 , C12N5/071 , A61K35/12 , A61K9/14 , C12N5/077 , A61P9/00
CPC分类号： A61K35/28 , A61K49/0067 , A61K49/0097 , A61K49/0409 , A61K49/0423 , B82Y5/00
摘要： The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译：本发明提供了关于用量子点（QD）标记靶细胞的方法和组合物。具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。这些标记的MSC提供了跟踪已经施用于受试者以促进心脏修复的MSC的分布和命运的手段。本发明基于这样的发现，MSC可以在体外追踪长达至少6周。另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。

6. 发明申请

US20090062876A1 Quantum dot labeled stem cells for use in providing pacemaker function 有权
标题翻译：用于提供起搏器功能的量子点标记的干细胞
公开(公告)号：US20090062876A1
公开(公告)日：2009-03-05
申请号：US12077970
申请日：2008-03-21
申请人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61N1/362 , C12N5/06 , A61K49/00 , A61P9/00
CPC分类号： G01N33/588 , A61K35/12 , A61N1/372 , B82Y15/00 , C12N5/0663 , C12N2510/00 , G01N33/6872 , G01N2333/705
摘要： The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been genetically engineered to express, for example, a hyperpolarization-activated cyclic nucleotide-gated (“HCN”) channel and administered to a subject to create a biological pacemaker. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译：本发明提供了与称为量子点（QD）的纳米尺度荧光半导体标记靶细胞有关的方法和组合物。具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。这种标记的MSC提供了用于跟踪已经被遗传工程化以表达例如超极化激活的环核苷酸门控（“HCN”）信道并且施用于受试者以创建生物起搏器的MSC的分布和命运的手段。本发明基于这样的发现，MSC可以在体外追踪长达至少6周。另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。

7. 发明申请

US20110142804A1 NANOFIBER SCAFFOLD 有权
公开(公告)号：US20110142804A1
公开(公告)日：2011-06-16
申请号：US12954829
申请日：2010-11-26
申请人： Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
发明人： Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
IPC分类号： A61K35/12 , C12N11/00 , C12N11/02 , C12N11/08 , A61P9/00
CPC分类号： C12N11/08 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L2400/12 , C12N5/0068 , C12N2533/30 , C08L75/04
摘要： The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
摘要翻译：本发明涉及一种阻止人间充质干细胞（hMSCs）从递送部位迁移的装置和方法，同时允许干细胞和天然心肌细胞之间的通信。该装置的特征在于支架孔径，纤维直径和生物材料选择。本发明包括防止干细胞迁移的两部分聚氨酯支架，允许通过孔形成间隙连接并被包装以进行微创递送。

8. 发明申请

US20110041857A1 FIBROBLAST DERIVED STEM CELLS 审中-公开
标题翻译： FIBROBLAST衍生干细胞
公开(公告)号：US20110041857A1
公开(公告)日：2011-02-24
申请号：US12744568
申请日：2008-11-26
申请人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
发明人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
IPC分类号： A61B19/00 , C12N5/02 , C12N5/074 , C12N5/10 , A61K35/12 , A61P9/10
CPC分类号： C12N5/0662 , C12N5/0657 , C12N2506/1307 , C12N2533/32
摘要： The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions.
摘要翻译：本发明提供了与衍生于去分化成纤维细胞的干细胞的生产有关的方法和组合物，以及这些干细胞用于治疗各种不同疾病和病症的用途。本发明基于令人惊奇的发现，即可以通过在选择性培养条件下培养成纤维细胞来产生能够分化成多种不同细胞类型的干细胞群体。

9. 发明申请

US20080292052A1 Methods for Assisting Recovery of Damaged Brain and Spinal Cord and Treating Various Diseases Using Arrays of X-Ray Microplanar Beams 有权
标题翻译：使用X射线微平面光束阵列辅助损伤脑脊髓的恢复和治疗各种疾病的方法
公开(公告)号：US20080292052A1
公开(公告)日：2008-11-27
申请号：US11884158
申请日：2006-02-10
申请人： F. Avraham Dilmanian , David J. Anchel , Glenn Gaudette , Pantaleo Romanelli , James Hainfeld
发明人： F. Avraham Dilmanian , David J. Anchel , Glenn Gaudette , Pantaleo Romanelli , James Hainfeld
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/1064 , A61N2005/1091
摘要： A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.
摘要翻译：辅助恢复中枢神经系统（CNS）的损伤部位或治疗疾病的方法包括通过平行微平面光束阵列向目标体积提供治疗剂量的X射线辐射。治疗CNS损伤的剂量暂时从照射部位移除再生抑制剂。在梁之间存活的基本未照射的细胞迁移到入射梁部分并辅助恢复。剂量可以使用角度可变的相交微束阵列（AVIMA）在会话上以分数交错。通过改变梁的取向来施加额外的剂量。通过将干细胞注射到损伤部位来增强该方法。应用一个阵列或AVIMA方法来消融与疾病相关的目标体内的选择的细胞用于姑息治疗或治疗效果。通过照射心房壁来破坏心肌细胞，同时持续旋转受试者来治疗房颤。

10. 发明授权

US08691543B2 Nanofibrous scaffold comprising immobilized cells 有权
标题翻译：包含固定化细胞的纳米纤维支架
公开(公告)号：US08691543B2
公开(公告)日：2014-04-08
申请号：US12954829
申请日：2010-11-26
申请人： Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
发明人： Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
IPC分类号： C12N11/08 , A61F2/00 , C12N11/04 , C12N5/07
CPC分类号： C12N11/08 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L2400/12 , C12N5/0068 , C12N2533/30 , C08L75/04
摘要： The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
摘要翻译：本发明涉及一种阻止人间充质干细胞（hMSCs）从递送部位迁移的装置和方法，同时允许干细胞和天然心肌细胞之间的通信。该装置的特征在于支架孔径，纤维直径和生物材料选择。本发明包括防止干细胞迁移的两部分聚氨酯支架，允许通过孔形成间隙连接并被包装以进行微创递送。

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