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    • 3. 发明申请
    • Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
    • 间充质干细胞作为合胞体结构中离子通道转移的载体
    • US20050002914A1
    • 2005-01-06
    • US10757827
    • 2004-01-15
    • Michael RosenRichard RobinsonIra CohenPeter Brink
    • Michael RosenRichard RobinsonIra CohenPeter Brink
    • A61K35/12C07K14/705C12N5/08A61K48/00
    • C07K14/705A61K2035/124
    • This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel transfer which comprises stem cells incorporated with a compound in an amount sufficient to create ion channels. This invention also provides for a method of expressing a functional gene product in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a gene, to the syncytial structure. This invention further provides a method of expressing a functional ion channel in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a compound in an amount sufficient to create ion channels, to the syncytial structure. This invention also provides a composition for delivery of small molecules comprising stem cells incorporated with the small molecules or genes encoding the small molecules.
    • 本发明提供了用于将基因递送至合成结构的组合物,其包括掺入该基因的干细胞。 本发明还提供了用于离子通道转移的组合物,其包含与足以产生离子通道的量的化合物结合的干细胞。 本发明还提供了一种在合胞体结构中表达功能基因产物的方法,其包括将包含基因的干细胞组合物施用于合胞体结构。 本发明进一步提供一种在合胞体结构中表达功能性离子通道的方法,其包括向合成结构施用包含与足以产生离子通道的化合物结合的干细胞的组合物。 本发明还提供了用于递送小分子的组合物,其包括与小分子结合的干细胞或编码小分子的基因。