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1. 发明授权

US06525775B1 Method for updating software in a digital television receiver using recorded data 有权
标题翻译：使用记录数据更新数字电视接收机中的软件的方法
公开(公告)号：US06525775B1
公开(公告)日：2003-02-25
申请号：US09169645
申请日：1998-10-09
申请人： Michael Kahn , David Goodwin
发明人： Michael Kahn , David Goodwin
IPC分类号： H04N700
CPC分类号： H04N5/775 , G06F8/65 , H04N5/4401 , H04N21/4348 , H04N21/435 , H04N21/8166
摘要： A television receiver which is coupled to a digital VCR to receive an ATSC-encoded multi-program stream containing video, audio and data programs. The receiver recognizes one of the data programs as containing computer software for the digital television receiver, extracts the data program from the multi-program stream into a memory area which is separate from the memory areas used to decode the audio and video programs and then uses data in the extracted data program to update information which controls the operation of the television receiver. The television receiver includes a microprocessor which is coupled to a video processor via an IC bus. The video processor includes registers which are coupled to the IC bus. The microprocessor updates these values from the information in the extracted data program. The extracted data program may include a program image for the operational software for the microprocessor and may replace the operational software to update the operation of the television receiver. Alternatively, the extracted data program may include programming which applies to video and audio data that is recorded on the video tape and allows a user to interact with the presentation of the video and audio data.
摘要翻译：一种电视接收机，其耦合到数字VCR以接收包含视频，音频和数据节目的ATSC编码的多节目流。该接收器将数据程序中的一个识别为包含用于数字电视接收机的计算机软件，从多节目流中提取数据程序到与用于解码音频和视频节目的存储区域分离的存储区域，然后使用提取的数据程序中的数据以更新控制电视接收机的操作的信息。电视接收机包括经由IC总线耦合到视频处理器的微处理器。视频处理器包括耦合到IC总线的寄存器。微处理器从提取的数据程序中的信息更新这些值。所提取的数据程序可以包括用于微处理器的操作软件的程序图像，并且可以替换操作软件来更新电视接收机的操作。或者，所提取的数据程序可以包括适用于记录在录像带上并允许用户与视频和音频数据的呈现相互作用的视频和音频数据的编程。

2. 发明授权

US06137539A Digital television status display 有权
标题翻译：数字电视状态显示
公开(公告)号：US06137539A
公开(公告)日：2000-10-24
申请号：US169295
申请日：1998-10-09
申请人： George Lownes , Perry Dunn , David Goodwin , Michael Kahn , Matthew Curreri , Sergei Danilchuk
发明人： George Lownes , Perry Dunn , David Goodwin , Michael Kahn , Matthew Curreri , Sergei Danilchuk
IPC分类号： G09G5/00 , H04N5/445 , H04N5/775 , H04N21/41 , H04N21/485 , H04N21/488 , H04N5/44
CPC分类号： H04N7/0122 , H04N21/4135 , H04N21/4312 , H04N5/44513 , H04N5/775 , H04N21/43632
摘要： A television receiver which receives an ATSC multi-program stream for a single major channel and generates a status display which displays the major channel identifier and a plurality of indicators, each corresponding to a respective one of the minor channels associated with the major channel. The indicator corresponding to the minor channel that is currently selected is highlighted with respect to the other indicators. The television receiver includes an image format converter and the status display also includes information concerning the format of the received signal and any format conversion that is currently being performed. The television receiver is also coupled to a digital VCR via a digital communications link. The digital television receiver generates a control panel for the digital VCR on the display device of the television receiver, and includes a facility for receiving commands for the digital VCR, sending the commands to the digital VCR via the digital communications link displaying the current status of the digital VCR. The television receiver maintains the status display for the digital VCR, by sending a status change request to the digital VCR immediately after receiving any status change information, whereby the VCR responds to the status change request only on a subsequent change in its operational status.
摘要翻译：一种电视接收机，其接收用于单个主要频道的ATSC多节目流，并且生成显示主要频道标识符和多个指示符的状态显示，每个指示符对应于与主频道相关联的次要频道中的相应一个。对应于当前选择的次要通道的指示器相对于其他指示灯突出显示。电视接收机包括图像格式转换器，并且状态显示还包括关于接收信号的格式和当前正在执行的任何格式转换的信息。电视接收机还经由数字通信链路耦合到数字VCR。数字电视接收机在电视接收机的显示装置上产生用于数字VCR的控制面板，并且包括用于接收数字VCR的命令的设备，经由显示当前状态的数字通信链路向数字VCR发送命令数字录像机。电视接收机通过在接收到任何状态改变信息之后立即向数字VCR发送状态改变请求来维持数字VCR的状态显示，由此VCR仅在其操作状态的随后改变时响应状态改变请求。

3. 发明授权

US09371330B2 Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells 有权
标题翻译：可用作CBP /连环蛋白拮抗剂的取代的吡嗪并[1,2-a]嘧啶，用于增强体细胞干细胞的不对称分裂
公开(公告)号：US09371330B2
公开(公告)日：2016-06-21
申请号：US14350342
申请日：2012-05-15
申请人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
发明人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
IPC分类号： A61K31/4985 , C07D241/38 , C07D487/04
CPC分类号： C07D487/04
摘要： Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing adenosine receptor expression in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrancy). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/(β-catenin) antagonist compositions, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/(β-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative of formula (I) as disclosed herein
摘要翻译：提供：用于治疗老化或年龄相关病症，症状或疾病的组合物和方法; 刺激头发生长，再生长或色素沉着（或防止脱发）; 用于增加真皮细胞中的腺苷受体表达（与头发生长结合）; 用于治疗皮肤或其至少一种症状的病症或疾病，包括美容治疗（例如皱纹，色素沉着过度，发红，红斑痤疮，干燥，开裂，硬度丧失，弹性丧失，变薄和活力丧失）。所述方法包括施用足量的所公开的CBP /连环蛋白（例如CBP /（＆bgr-连翘蛋白）拮抗剂组合物），特别是其中给药的量和方式足以提供增加不对称更新分隔数相对于在特定方面，CBP /连环蛋白（例如，CBP /（＆bgr-连环蛋白）拮抗剂）包含式（I）的烷基和/或脂肪酸酯衍生物，或者以相关体细胞干细胞群体的对称分裂为代价。如本文所公开的

4. 发明申请

US20120059010A1 ALPHA-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROSIS 有权
标题翻译： ALPHA-HELIX纤维化和治疗纤维化的方法
公开(公告)号：US20120059010A1
公开(公告)日：2012-03-08
申请号：US13073176
申请日：2011-03-28
申请人： Michael Kahn , Masakatsu Eguchi
发明人： Michael Kahn , Masakatsu Eguchi
IPC分类号： A61K31/53 , C07D487/04 , A61P13/12 , A61P25/28 , A61P1/16 , A61P7/04 , A61P15/00 , A61P17/00 , A61K31/498 , A61P11/00
CPC分类号： C07K7/56
摘要： The invention provides α-helix mimetic structures and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.
摘要翻译：本发明提供α-螺旋模拟结构和与其相关的化学文献。包含该化合物的化合物，药物组合物和使用该化合物的本发明的方法涉及治疗包括纤维化在内的疾病，例如肺纤维化。

5. 发明授权

US08101751B2 Reverse-turn mimetics and method relating thereto 有权
公开(公告)号：US08101751B2
公开(公告)日：2012-01-24
申请号：US12541388
申请日：2009-08-14
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4985 , Y02A50/467
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

6. 发明申请

US20100081655A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
标题翻译：反向转换和相关的方法
公开(公告)号：US20100081655A1
公开(公告)日：2010-04-01
申请号：US12541388
申请日：2009-08-14
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
IPC分类号： A61K31/53 , C07D487/04 , A61K31/538 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/4985 , Y02A50/467
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

7. 发明申请

US20100029630A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
公开(公告)号：US20100029630A1
公开(公告)日：2010-02-04
申请号：US12510107
申请日：2009-07-27
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： A61K31/53 , C07D487/04 , A61K31/538 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/53 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

8. 发明授权

US07531320B2 Modulation of β-catenin/TCF-activated transcription 失效
标题翻译：调节β-连环蛋白/ TCF激活转录
公开(公告)号：US07531320B2
公开(公告)日：2009-05-12
申请号：US10928626
申请日：2004-08-27
申请人： Michael Kahn , SeWoong Oh , DaeHoon Kim , JongRyul Ha , Katayoon Hojjati-Emami
发明人： Michael Kahn , SeWoong Oh , DaeHoon Kim , JongRyul Ha , Katayoon Hojjati-Emami
IPC分类号： C12P21/06
CPC分类号： A61K31/00 , A61K31/4985 , A61K31/5025 , A61K31/53 , C07D487/04 , C07K14/47 , C12Q1/02 , C12Q1/18 , G01N2333/37
摘要： The present invention provides compounds and methods for modulating transcription activated by β-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/β-catenin pathway.
摘要翻译：本发明提供了调节由β-连环蛋白/ TCF激活的转录的化合物和方法，例如选择性抑制由Wnt /β-连环蛋白途径靶向的基因。

9. 发明申请

US20080279992A1 Holder for objects which melt, drip or leaves finger imprints 审中-公开
标题翻译：用于熔化，滴落或留下手指印记的物体的持有人
公开(公告)号：US20080279992A1
公开(公告)日：2008-11-13
申请号：US11800674
申请日：2007-05-07
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： A47J43/00 , A23G9/26
CPC分类号： A47G21/00 , A23G9/503
摘要： A holder for holding an object which melts or drips or leaves imprints on one's fingers comprising a handle and a protrusion section. The device can further comprise a slip prevention disk with is located between said handle and said protrusion section.
摘要翻译：用于保持物体的保持器，该物体在包括手柄和突出部分的手指上熔化或滴落或留下印记。该装置还可以包括位于所述手柄和所述突出部之间的防滑盘。

10. 发明申请

US20080153743A1 METHODS RELATING TO THE TREATMENT OF FIBROSIS 审中-公开
标题翻译：关于治疗纤维化的方法
公开(公告)号：US20080153743A1
公开(公告)日：2008-06-26
申请号：US11860933
申请日：2007-09-25
申请人： William R. HENDERSON , Emil Y. Chi , Michael Kahn
发明人： William R. HENDERSON , Emil Y. Chi , Michael Kahn
IPC分类号： A61K38/12 , A61P3/00 , A61P11/00 , A61P19/00 , A61P17/00
CPC分类号： C07K7/56
摘要： The invention provides α-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, R1 and R2 as set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the reversal of fibrotic conditions, such as pulmonary fibrosis.
摘要翻译：本发明提供式（I）的α-螺旋模拟结构，其具有设定的A，B，D，E，G，W，R 1和R 2 2的定义在描述中以及与之相关的化学图书馆。包含化合物的化合物，药物组合物和使用该化合物的本发明的方法涉及纤维化病症如肺纤维化的逆转。

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