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1. 发明授权

US09371330B2 Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells 有权
标题翻译：可用作CBP /连环蛋白拮抗剂的取代的吡嗪并[1,2-a]嘧啶，用于增强体细胞干细胞的不对称分裂
公开(公告)号：US09371330B2
公开(公告)日：2016-06-21
申请号：US14350342
申请日：2012-05-15
申请人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
发明人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
IPC分类号： A61K31/4985 , C07D241/38 , C07D487/04
CPC分类号： C07D487/04
摘要： Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing adenosine receptor expression in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrancy). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/(β-catenin) antagonist compositions, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/(β-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative of formula (I) as disclosed herein
摘要翻译：提供：用于治疗老化或年龄相关病症，症状或疾病的组合物和方法; 刺激头发生长，再生长或色素沉着（或防止脱发）; 用于增加真皮细胞中的腺苷受体表达（与头发生长结合）; 用于治疗皮肤或其至少一种症状的病症或疾病，包括美容治疗（例如皱纹，色素沉着过度，发红，红斑痤疮，干燥，开裂，硬度丧失，弹性丧失，变薄和活力丧失）。所述方法包括施用足量的所公开的CBP /连环蛋白（例如CBP /（＆bgr-连翘蛋白）拮抗剂组合物），特别是其中给药的量和方式足以提供增加不对称更新分隔数相对于在特定方面，CBP /连环蛋白（例如，CBP /（＆bgr-连环蛋白）拮抗剂）包含式（I）的烷基和/或脂肪酸酯衍生物，或者以相关体细胞干细胞群体的对称分裂为代价。如本文所公开的

2. 发明申请

US20150232468A1 CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS 有权
标题翻译： CBP / CATENIN ANTAGONISTS用于增强异位干细胞的不对称性
公开(公告)号：US20150232468A1
公开(公告)日：2015-08-20
申请号：US14350342
申请日：2012-05-15
申请人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
发明人： Michael Kahn , Jia-Ling Teo , Michael McMillan , Yi Zhao , Yongfeng Wu
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/B-catenin) antagonist compositions, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/B-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative thereof as disclosed herein.
摘要翻译：提供：用于治疗老化或年龄相关病症，症状或疾病的组合物和方法; 刺激头发生长，再生长或色素沉着（或防止脱发）; 用于增加真皮细胞中腺苷受体的表达（与头发生长相结合）; 用于治疗皮肤或其至少一种症状的病症或疾病，包括美容治疗（例如皱纹，色素沉着过度，发红，红斑痤疮，干燥，开裂，硬度损失，弹性丧失，变薄和活动丧失）。所述方法包括施用足量的所公开的CBP /连环素（例如，CBP / B-连环素）拮抗剂组合物，特别是其中给药的量和方式足以提供相对于或或不同于其的不对称更新分隔数量以相关体细胞干细胞群体的对称分裂为代价。在具体方面，CBP /连环蛋白（例如，CBP / B-连环蛋白）拮抗剂包含本文公开的烷基和/或脂肪酸酯衍生物。

3. 发明申请

US20110039333A1 DEFINED CONDITIONS FOR HUMAN EMBRYONIC STEM CELL CULTURE AND PASSAGE 审中-公开
标题翻译：人类胚胎干细胞培养和通气的定义条件
公开(公告)号：US20110039333A1
公开(公告)日：2011-02-17
申请号：US12855578
申请日：2010-08-12
申请人： Michael Kahn , Kouichi Hasegawa , Jia-Ling Teo , Michael McMillan
发明人： Michael Kahn , Kouichi Hasegawa , Jia-Ling Teo , Michael McMillan
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2500/25 , C12N2500/90 , C12N2500/98 , C12N2501/115 , C12N2501/415 , C12N2533/52
摘要： The invention relates to human pluripotent cells. More specifically, the invention provides a chemically defined xeno-free culture system that allows for long term expansion of human pluripotent cells. This culture system allows for human pluripotent cell lines to be maintained in the pluripotent state for an extended time while maintaining a normal karyotype and the ability to differentiate into all three germ layers.
摘要翻译：本发明涉及人多能细胞。更具体地，本发明提供了一种化学上定义的不含异种植物的培养系统，其允许人类多能细胞的长期扩增。该培养系统允许人类多能细胞系在多能状态下保持延长的时间，同时保持正常的核型和分化成所有三个胚层的能力。

4. 发明申请

US20060293372A1 Beta-sheet mimetics and methods relating to the use thereof 审中-公开
公开(公告)号：US20060293372A1
公开(公告)日：2006-12-28
申请号：US10774043
申请日：2004-02-05
申请人： Maher Qabar , Michael McMillan , Michael Kahn , John Tulinsky , Cyprian Ogbu , Jessymol Mathew
发明人： Maher Qabar , Michael McMillan , Michael Kahn , John Tulinsky , Cyprian Ogbu , Jessymol Mathew
IPC分类号： A61K31/43 , A61K31/424 , A61K31/4196
CPC分类号： A61K31/4035 , A61K31/407 , A61K31/4152 , A61K31/4196 , A61K31/424 , A61K31/428 , A61K31/43 , A61K31/437 , A61K31/5025 , C07K1/047 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024 , C07K7/06
摘要： β-sheet mimetics and methods relating to the same are disclosed. The β-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a β-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.

5. 发明授权

US09074733B2 Single multi-chip lamp sources and related methods 有权
标题翻译：单芯片灯源及相关方法
公开(公告)号：US09074733B2
公开(公告)日：2015-07-07
申请号：US12887975
申请日：2010-09-22
申请人： Michael McMillan
发明人： Michael McMillan
IPC分类号： H01L33/08 , F21K99/00 , F21V29/00 , F21L4/02 , F21Y101/02 , H01L25/075
CPC分类号： F21K9/00 , F21L4/027 , F21V29/20 , F21V29/70 , F21Y2115/10 , H01L25/0753 , H01L2224/48471 , H01L2224/49175 , H01L2224/73265 , H01L2924/10253 , H01L2924/181 , H01L2924/00 , H01L2924/00012
摘要： Multi-chip sources and related methods are disclosed. A single multi-chip lamp source can include a substrate and at least three light emitting diode (LED) chips operably configured to the substrate to form a single LED package. The LED chips can include at least three different colored LED chips. The LED chips can be configured to be actuatable either individually or together to provide selectable colored light beams. The LED chips can be positioned on the substrate such that an emitted light beam remains concentric without shifting regardless of the chip or chips emitting the light beam.
摘要翻译：公开了多芯片源和相关方法。单个多芯片灯源可以包括衬底和至少三个可操作地配置到衬底以形成单个LED封装的发光二极管（LED）芯片。 LED芯片可以包括至少三种不同颜色的LED芯片。 LED芯片可以被配置为单独地或一起致动以提供可选择的彩色光束。 LED芯片可以定位在基板上，使得发射的光束保持同心而不移动，而不管发射光束的芯片或芯片如何。

6. 发明申请

US20110303711A1 LOAD CARRYING SYSTEM FOR MOTOR VEHICLES 审中-公开
标题翻译：车载车载系统
公开(公告)号：US20110303711A1
公开(公告)日：2011-12-15
申请号：US12962640
申请日：2010-12-07
申请人： Michael McMillan
发明人： Michael McMillan
IPC分类号： B60R9/055 , B60R9/042 , B60R9/08
CPC分类号： B60R9/055 , B60R9/10
摘要： Disclosed is a load carrier made up of a flat tray like body which attaches to a vehicle by load bars. A cargo container attaches to the flat tray-like load carrier body, and is locked in one of several possible positions on the flat tray-like body. The load container may also be removed and the load carrier used without the cargo container. Devices for holding objects such as bicycles, canoes, kayaks, may also be attached to the load carrier.
摘要翻译：公开了一种由平板托盘状体构成的负载托架，该承载托架通过加载杆附接到车辆。货物集装箱附接到平坦的托盘状承载体上，并且被锁定在平坦的托盘状主体上的几个可能位置之一上。装载容器也可以被卸下，载货架在没有货物集装箱的情况下使用。用于保持物体（例如自行车，独木舟，皮划艇）的装置也可以附接到负载架上。

7. 发明申请

US20110006317A1 SINGLE MULTI-CHIP LAMP SOURCES AND RELATED METHODS 审中-公开
标题翻译：单芯片灯源及相关方法
公开(公告)号：US20110006317A1
公开(公告)日：2011-01-13
申请号：US12887975
申请日：2010-09-22
申请人： Michael McMillan
发明人： Michael McMillan
IPC分类号： H01L33/08 , H01L33/58
CPC分类号： F21K9/00 , F21L4/027 , F21V29/20 , F21V29/70 , F21Y2115/10 , H01L25/0753 , H01L2224/48471 , H01L2224/49175 , H01L2224/73265 , H01L2924/10253 , H01L2924/181 , H01L2924/00 , H01L2924/00012
摘要： Multi-chip sources and related methods are disclosed. A single multi-chip lamp source can include a substrate and at least three light emitting diode (LED) chips operably configured to the substrate to form a single LED package. The LED chips can include at least three different colored LED chips. The LED chips can be configured to be actuatable either individually or together to provide selectable colored light beams. The LED chips can be positioned on the substrate such that an emitted light beam remains concentric without shifting regardless of the chip or chips emitting the light beam.
摘要翻译：公开了多芯片源和相关方法。单个多芯片灯源可以包括衬底和至少三个可操作地配置到衬底以形成单个LED封装的发光二极管（LED）芯片。 LED芯片可以包括至少三种不同颜色的LED芯片。 LED芯片可以被配置为单独地或一起致动以提供可选择的彩色光束。 LED芯片可以定位在基板上，使得发射的光束保持同心而不移动，而不管发射光束的芯片或芯片如何。

8. 发明申请

US20080272165A1 LOAD-CARRYING SYSTEM FOR OFF-ROAD VEHICLES 审中-公开
标题翻译：非道路车辆的装载系统
公开(公告)号：US20080272165A1
公开(公告)日：2008-11-06
申请号：US12174610
申请日：2008-07-16
申请人： Michael McMillan
发明人： Michael McMillan
IPC分类号： B60R9/02
CPC分类号： B60R9/00 , B60R9/12
摘要： A load carrier for an off-road vehicle, such as an ATV or snowmobile, includes a generally horizontal platform and moveable article-mounts that may be adjustably fixed in position underneath and/or on top of said platform to receive various pieces of cargo. The article-mounts may receive and anchor elongated objects such as snowboards, skis, and rifle cases, preferably in a horizontal orientation generally parallel to the length of the vehicle. Preferably, a substantial portion of the platform upper surface is on a single, substantially horizontal plane and is available for multiple of said article-mounts, while another portion is recessed for receiving smaller, shorter, or more regularly-shaped objects. In a first group of embodiments, moveable article-mounts are underneath the platform, for example, by connection of a rail or other mounting portion of the article-mount to the underside and/or side edge of the platform. In a second group of embodiments, movable article-mounts are connected to the upper surface of the platform, and preferably include one or more paddles, posts, or other upright members. The above-platform article-mounts are preferably swivelable on an axis perpendicular to the upper surface of the platform. Latches and/or clamping features may secure the cargo item to or between the paddles, posts, or other upright members.
摘要翻译：用于越野车辆（例如ATV或雪地车）的负载承载器包括大致水平的平台和可移动的物品安装件，其可以可调节地固定在所述平台的下方和/或顶部的适当位置以接收各种货物。物品安装件可以接收和锚定诸如滑雪板，滑雪板和步枪壳的细长物体，优选地在大致平行于车辆长度的水平方向上。优选地，平台上表面的主要部分在单个基本水平的平面上，并且可用于多个所述物品安装件，而另一部分是凹进的，用于接收较小，较短或更规则形状的物体。在第一组实施例中，可移动物品安装件位于平台下方，例如通过将物品安装座的轨道或其他安装部分连接到平台的下侧和/或侧边缘。在第二组实施例中，可移动物品安装件连接到平台的上表面，并且优选地包括一个或多个桨叶，柱或其它直立构件。上述平台物品安装件优选地可在垂直于平台上表面的轴上旋转。闩锁和/或夹紧特征可将货物固定到桨叶，柱或其它直立构件之间或之间。

9. 发明申请

US20070067075A1 Quick automotive cosmetic repair 审中-公开
标题翻译：快速汽车化妆品修复
公开(公告)号：US20070067075A1
公开(公告)日：2007-03-22
申请号：US11353477
申请日：2006-02-14
申请人： Michael McMillan , Jonathan Purifoy , Keith Sena , Mario Soto
发明人： Michael McMillan , Jonathan Purifoy , Keith Sena , Mario Soto
IPC分类号： G01M17/00
CPC分类号： B60S5/00 , G01N21/88 , G01N2021/8854
摘要： This invention is directed to a method for quick repairing multiple cosmetic defects of a vehicle wherein the method comprises the steps of: (a) identifying said cosmetic defect of the vehicle; (b) regulating environmental elements within a controlled perimeter used for positioning the vehicle or an area around the cosmetic defect wherein the environmental elements comprise liquid, air, temperature, light, radiation, humidity, or a combination thereof; (c) acquiring repair data on the cosmetic defect of the vehicle within the controlled perimeter; (d) entering the repair data into a computing device; (e) retrieving one or more repair specification from a first database located in said computing device or located in a host computer in communication with said computing device; (f) estimating repair cost based on the repair specification; (g) obtaining an authorization to repair the cosmetic defect based on said repair cost and the repair specification; and (h) repairing the cosmetic defect based on the repair specification within 0.1 to 8 hours.
摘要翻译：本发明涉及一种用于快速修复车辆的多个美容缺陷的方法，其中所述方法包括以下步骤：（a）识别所述车辆的所述化妆品缺陷; （b）调节用于定位车辆的受控周界内的环境元素或围绕化妆品缺陷的区域，其中环境元素包括液体，空气，温度，光，辐射，湿度或其组合; （c）获取受控周界内车辆美容缺陷的修理数据; （d）将修理数据输入计算设备; （e）从位于所述计算设备中的位于与所述计算设备通信的主计算机中的第一数据库检索一个或多个修复规范; （f）根据修理规范估算维修成本; （g）根据所述维修成本和修理规范获得修理美容缺损的授权; 和（h）在0.1至8小时内根据修理规范修复化妆品缺陷。

10. 发明申请

US20090143830A1 MOLDABLE PASTE COMPOSITION 审中-公开
标题翻译：可塑性组合物
公开(公告)号：US20090143830A1
公开(公告)日：2009-06-04
申请号：US12235703
申请日：2008-09-23
申请人： Nicolas Bourgeois , Cameron M.L. Clokie , Uwe Tritthardt , Michael McMillan
发明人： Nicolas Bourgeois , Cameron M.L. Clokie , Uwe Tritthardt , Michael McMillan
IPC分类号： A61F5/00 , A61L27/50
CPC分类号： A61L27/46 , A61B2017/00933 , A61L27/50 , A61L2430/02 , C08G2650/58 , C08L71/02 , C08L2666/54
摘要： The invention concerns a novel moldable and/or flowable composition for application to a bone defect site to promote new bone growth at the site. The composition includes a therapeutic material and a carrier comprising means for achieving reverse phase characteristics. In one embodiment, the therapeutic material can be a resorbable alloplastic material and the carrier can be a poloxamer. In a specific embodiment, the resorbable alloplastic material is a biphasic material composed of hydroxyapatite and tricalcium phosphate (HA-TCP), and the carrier is poloxamer 407 (Pluronic® F127). The invention further includes methods for using the novel composition.
摘要翻译：本发明涉及一种新颖的可模制和/或可流动的组合物，用于应用于骨缺损部位以促进该部位的新骨生长。组合物包括治疗材料和载体，其包括用于实现反相特性的装置。在一个实施方案中，治疗材料可以是可再吸收的异体材料，并且载体可以是泊洛沙姆。在一个具体实施方案中，可再吸收的同种异体材料是由羟基磷灰石和磷酸三钙（HA-TCP）组成的双相材料，载体是泊洛沙姆407（Pluronic F127）。本发明还包括使用该组合物的方法。

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