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1. 发明授权

US08462333B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08462333B2
公开(公告)日：2013-06-11
申请号：US12905891
申请日：2010-10-15
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.
摘要翻译：用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中纳米手指以阵列排列在基板上。该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层，手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

2. 发明授权

US08404491B2 Luminescent chemical sensor integrated with at least one molecular trap 有权
标题翻译：与至少一个分子陷阱集成的发光化学传感器
公开(公告)号：US08404491B2
公开(公告)日：2013-03-26
申请号：US12916299
申请日：2010-10-29
申请人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
发明人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , B82Y15/00 , G01N21/648 , G01N21/658 , Y10T436/25
摘要： A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
摘要翻译：与至少一个分子阱集成的发光化学传感器。发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。分子阱包括捕获至少一种分析物分子的多个电极。金属纳米装置包括衬底和与衬底耦合的多个纳米器件。多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。还提供了使用方法和包括发光化学传感器的化学分析装置。

3. 发明申请

US20120013902A1 MULTI-WAVELENGTH RAMAN LIGHT DETECTION FOR DETECTING A SPECIES 有权
标题翻译：用于检测物种的多波长拉曼光检测
公开(公告)号：US20120013902A1
公开(公告)日：2012-01-19
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译：用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

4. 发明申请

US20110188033A1 MOLECULE DETECTION USING RAMAN LIGHT DETECTION 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US20110188033A1
公开(公告)日：2011-08-04
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

5. 发明授权

US08603606B2 Preventing adhesion between nanostructures 有权
标题翻译：防止纳米结构之间的粘附
公开(公告)号：US08603606B2
公开(公告)日：2013-12-10
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
IPC分类号： B32B3/00 , B05D7/00
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译：用于表面增强拉曼散射（SERS）的器件。该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。低摩擦膜是为了防止多个纳米结构之间的粘附。

6. 发明授权

US08279437B2 Multi-wavelength Raman light detection for detecting a species 有权
标题翻译：用于检测物种的多波长拉曼光检测
公开(公告)号：US08279437B2
公开(公告)日：2012-10-02
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译：用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

7. 发明申请

US20120107569A1 PREVENTING ADHESION BETWEEN NANOSTRUCTURES 有权
标题翻译：防止纳米结构之间的粘合
公开(公告)号：US20120107569A1
公开(公告)日：2012-05-03
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
IPC分类号： B32B3/30 , B05D3/06 , B05D3/02 , B05D1/36 , B05D3/00
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译：用于表面增强拉曼散射（SERS）的器件。该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。低摩擦膜是为了防止多个纳米结构之间的粘附。

8. 发明授权

US08416406B2 Sensing device and method producing a Raman signal 有权
标题翻译：产生拉曼信号的感测装置和方法
公开(公告)号：US08416406B2
公开(公告)日：2013-04-09
申请号：US12914655
申请日：2010-10-28
申请人： Michael Josef Stuke , Shih-Yuan Wang , Zhiyong Li
发明人： Michael Josef Stuke , Shih-Yuan Wang , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： B82Y15/00 , G01N21/65 , G01N21/658
摘要： A sensing device that produces a Raman signal includes micro-rods or nano-rods arranged on a substrate in a two-dimensional (2D) array, each of the rods having a length in a single row being substantially the same, with the rod length of each row being different from the rod length of each other row. Each row of rods has a respective resonant vibration frequency that varies from row to row. A source of vibration energy, operatively connected to the substrate, excites vibration in each of the rods such that a responding row resonates when an exciting frequency approaches the resonant vibration frequency of the responding row. A method includes exposing the 2D array to a light source and analyzing Raman scattering at each rod of the 2D array to render a Raman map.
摘要翻译：产生拉曼信号的感测装置包括以二维（2D）阵列布置在基底上的微棒或纳米棒，每根棒具有基本上相同的长度，其中棒长度每行的距离与每隔一行的杆长度不同。每排棒具有相应的谐振振动频率，其逐行变化。可操作地连接到基板的振动能量源激发每个杆中的振动，使得当激励频率接近响应行的谐振振动频率时，响应行谐振。一种方法包括将2D阵列暴露于光源并分析2D阵列的每个杆处的拉曼散射以呈现拉曼图。

9. 发明申请

US20120236298A1 TUNABLE APPARATUS FOR PERFORMING SERS 审中-公开
标题翻译：用于执行人员的装置
公开(公告)号：US20120236298A1
公开(公告)日：2012-09-20
申请号：US13048594
申请日：2011-03-15
申请人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
发明人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable substrate and a plurality of SERS-active nanoparticles disposed at a plurality of locations on the deformable substrate. The plurality of SERS-active nanoparticles are to enhance Raman scattered light emission from an analyte molecule located in close proximity to the SERS-active nanoparticles. In addition, the deformable substrate is to be deformed to vary distances between the SERS-active nanoparticles, in which varying distances between the SERS-active nanoparticles varies enhancement of an intensity of Raman scattered light emission from the analyte molecule.
摘要翻译：用于执行表面增强拉曼光谱（SERS）的可调谐装置包括可变形基板和设置在可变形基板上的多个位置处的多个SERS活性纳米颗粒。多个SERS活性纳米颗粒是增强来自位于紧邻SERS活性纳米颗粒的分析物分子的拉曼散射光发射。此外，可变形基底将变形以改变SERS活性纳米粒子之间的距离，其中SERS-活性纳米粒子之间的变化距离改变了来自分析物分子的拉曼散射光发射强度的增强。

10. 发明授权

US08665432B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08665432B2
公开(公告)日：2014-03-04
申请号：US12915148
申请日：2010-10-29
申请人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
发明人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
IPC分类号： G01N21/65
CPC分类号： G01J3/44 , G01N21/658
摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

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