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1. 发明申请

US20050196856A1 Polyelectrolyte-coated size-exclusion ion-exchange particles 审中-公开
标题翻译：聚电解质包被的尺寸排阻离子交换颗粒
公开(公告)号：US20050196856A1
公开(公告)日：2005-09-08
申请号：US11057936
申请日：2005-02-15
申请人： Michael Harrold , Aldrich Lau , Shiaw-Min Chen
发明人： Michael Harrold , Aldrich Lau , Shiaw-Min Chen
IPC分类号： B01D15/34 , B01J47/00 , B01J47/04 , C07H21/04 , C12M3/00 , C12P19/34 , C12Q1/68
CPC分类号： B01J20/28016 , B01D15/34 , B01J13/10 , B01J13/22 , B01J20/28009 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3221 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J47/018 , B01J47/04 , C12Q1/6869 , C12Q2565/631 , C12Q2565/125 , C12Q2563/113
摘要： A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.
摘要翻译：提供聚电解质涂覆的颗粒，使用该颗粒的装置，使用该颗粒分离PCR反应产物和/或DNA测序反应产物的方法，以及用于涂覆颗粒的组合物。

2. 发明申请

US20060160122A1 Polyelectrolyte-coated size-exclusion ion-exchange particles 审中-公开
标题翻译：聚电解质包被的尺寸排阻离子交换颗粒
公开(公告)号：US20060160122A1
公开(公告)日：2006-07-20
申请号：US11355872
申请日：2006-02-15
申请人： Michael Harrold , Aldrich Lau , Ben Johnson , Gilbert Amparo , Frank Mercer
发明人： Michael Harrold , Aldrich Lau , Ben Johnson , Gilbert Amparo , Frank Mercer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01D15/34 , B01J13/10 , B01J13/22 , B01J47/018 , B01J47/04 , C12Q1/6806 , C12Q2527/125 , C12Q2565/631 , C12Q2565/125 , C12Q2563/113
摘要： A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.
摘要翻译：提供聚电解质涂覆的颗粒，使用该颗粒的装置，使用该颗粒分离PCR反应产物和/或DNA测序反应产物的方法，以及用于涂覆颗粒的组合物。

3. 发明申请

US20050271553A1 Petal-array support for use with microplates 审中-公开
标题翻译：花瓣阵列支持与微孔板一起使用
公开(公告)号：US20050271553A1
公开(公告)日：2005-12-08
申请号：US11021039
申请日：2004-12-21
申请人： Paul Ramstad , Michael Harrold , Kevin Hennessy , Aldrich Lau
发明人： Paul Ramstad , Michael Harrold , Kevin Hennessy , Aldrich Lau
IPC分类号： B01J47/00 , B01L3/00 , B01L99/00 , B01L11/00
CPC分类号： B01L3/50853 , B01J20/3293 , B01J47/016 , B01L2200/0631 , B01L2300/046 , B01L2300/0829
摘要： Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.
摘要翻译：提供了包括可以设置一种或多种离子交换材料用于纯化样品的载体的装置。在各种实施例中，支撑件包括多个可变形构件，例如花瓣形净化构件，其提供用于离子交换材料和任选的生化物质，化学物质，盐或其它材料的结合位点。还提供了一种用于将净化构件插入和移除到多孔微板的相应孔中的装置和方法。

4. 发明申请

US20060223069A1 Products and methods for reducing dye artifacts 失效
标题翻译：用于减少染料伪影的产品和方法
公开(公告)号：US20060223069A1
公开(公告)日：2006-10-05
申请号：US11096731
申请日：2005-04-01
申请人： Michael Harrold , Kevin Hennessy , Aldrich Lau , Sean Desmond
发明人： Michael Harrold , Kevin Hennessy , Aldrich Lau , Sean Desmond
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12N15/1006 , C12N15/1017 , C12Q1/6848 , C12Q2527/149 , C12Q2523/308 , C12Q2521/101
摘要： The present invention provides products and methods of reducing dye artifacts from chain extension reactions.
摘要翻译：本发明提供了从延伸反应减少染料伪影的产物和方法。

5. 发明申请

US20060051583A1 Size-exclusion ion-exchange particles 审中-公开
标题翻译：尺寸排阻离子交换颗粒
公开(公告)号：US20060051583A1
公开(公告)日：2006-03-09
申请号：US11262036
申请日：2005-10-27
申请人： Aldrich Lau , Michael Harrold
发明人： Aldrich Lau , Michael Harrold
IPC分类号： B01D15/08 , B32B5/16
CPC分类号： B01J20/3293 , B01D15/34 , B01D15/361 , B01J47/018 , G01N1/405 , Y10T428/2991 , Y10T428/2998
摘要： A size-exclusion ion-exchange particle and a device using the particle are provided wherein the particle includes an ion-exchange core micro-encapsulated by a shell, and the shell includes a polymerization product of a reactive monomer. The shell can be an at least partially cross-linked polymer. The shell can be capable of excluding molecules of a size equal to or larger than a 10 nt ssDNA molecule or molecules of a size equal to or larger than a 100 nt ssDNA molecule, for example, and the core can be capable of ion-exchange. Methods of making size-exclusion ion-exchange particles are also provided, as are methods of purification using the particles.
摘要翻译：提供了尺寸排阻离子交换颗粒和使用该颗粒的装置，其中颗粒包括由壳微囊封装的离子交换核，壳包括反应性单体的聚合产物。壳可以是至少部分交联的聚合物。壳可以排除等于或大于10nt ssDNA分子的分子或等于或大于100nt ssDNA分子的分子的分子，并且核可以能够进行离子交换。还提供了制备尺寸排阻离子交换颗粒的方法，以及使用该颗粒的纯化方法。

6. 发明申请

US20050181378A1 Polyelectrolyte-coated size-exclusion ion-exchange particles 审中-公开
公开(公告)号：US20050181378A1
公开(公告)日：2005-08-18
申请号：US10780963
申请日：2004-02-18
申请人： Michael Harrold , Aldrich Lau
发明人： Michael Harrold , Aldrich Lau
IPC分类号： B01D15/34 , B01J47/00 , B01J47/04 , C07H21/04 , C12M3/00 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/101 , B01D15/34 , B01J20/3293 , B01J43/00 , B01J47/018 , B01J47/04 , Y10T428/29
摘要： A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.

7. 发明申请

US20070095667A1 Optoelectronic Separation of Biomolecules 审中-公开
标题翻译：光电子分离生物分子
公开(公告)号：US20070095667A1
公开(公告)日：2007-05-03
申请号：US11426222
申请日：2006-06-23
申请人： Aldrich Lau
发明人： Aldrich Lau
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： B03C5/026 , B03C5/005 , B03C5/028 , C07K1/26 , G01N27/305
摘要： The present teachings relate to systems and methods for separation of substances such as cells, nucleic acids, and carbon nanotubes. The substances are combined with a separation medium in a liquid sample cavity, for example a microchannel, and transit through the separation by optically activated dielectrophoretic forces. The substances are advantageously labeled and visualized using a microscope and camera.
摘要翻译：本教导涉及用于分离诸如细胞，核酸和碳纳米管的物质的系统和方法。这些物质与液体样品腔（例如微通道）中的分离介质组合，并通过光学活化的介电电泳力穿过分离。使用显微镜和照相机有利地将物质标记和可视化。

8. 发明授权

US08147770B2 Microfluidic device including a dissolvable structure for flow control 有权
标题翻译：微流体装置包括用于流量控制的可溶解结构
公开(公告)号：US08147770B2
公开(公告)日：2012-04-03
申请号：US12954519
申请日：2010-11-24
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
IPC分类号： B01D11/04 , B01L3/00 , B01L3/02 , G01N1/10
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

9. 发明申请

US20070175768A1 MICROFLUIDIC SYSTEMS INCLUDING POROUS POLYMER ELECTRODES 审中-公开
标题翻译：包含多孔聚合物电极的微流体系统
公开(公告)号：US20070175768A1
公开(公告)日：2007-08-02
申请号：US11558343
申请日：2006-11-09
申请人： Aldrich Lau , Konrad Faulstich , Kristian Scaboo
发明人： Aldrich Lau , Konrad Faulstich , Kristian Scaboo
IPC分类号： C12Q1/00 , G01N27/26 , G01N33/487 , G01F1/64
CPC分类号： G01N27/44704 , B01L3/5023 , B01L3/502707 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2400/0418 , B01L2400/0421
摘要： Microfluidic devices that incorporate a porous polymer electrode assemblies, including microfluidic device useful for detection of nucleic acids, as well as methods of using the microfluidic devices.
摘要翻译：包含多孔聚合物电极组件的微流体装置，包括可用于检测核酸的微流体装置，以及使用微流体装置的方法。

10. 发明申请

US20070114128A1 Porous polymer electrodes 审中-公开
标题翻译：多孔聚合物电极
公开(公告)号：US20070114128A1
公开(公告)日：2007-05-24
申请号：US11479175
申请日：2006-06-30
申请人： Aldrich Lau , Konrad Faulstich , Kristian Scaboo
发明人： Aldrich Lau , Konrad Faulstich , Kristian Scaboo
IPC分类号： C25C7/02 , C25B11/03
CPC分类号： G01N27/3335
摘要： Porous polymer electrode assemblies are useful in the detection or quantification of a variety of analytes. By preparing a porous monolith, and applying a conductive polymer to the monolith, a porous matrix is prepared that combines favorable conductive properties, by virtue of the presence of the conductive polymer, with the porous character of the underlying monolith. The resulting porous electrode can be used for qualitative or quantitative analysis, and the capture and/or release of selected charged materials, such as nucleic acids. The pores of the electrode matrix may also be filled with nonconductive material, yielding electrodes having a plurality of discrete conductive surfaces.
摘要翻译：多孔聚合物电极组件可用于检测或定量各种分析物。通过制备多孔整料并将导电聚合物施加到整料上，制备出多孔基质，其通过导电聚合物的存在与下面的整料的多孔特征结合有利的导电性能。所得的多孔电极可用于定性或定量分析，以及所选择的带电材料（例如核酸）的捕获和/或释放。电极基体的孔也可以用非导电材料填充，产生具有多个离散导电表面的电极。

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