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1. 发明申请

US20060025853A1 Methods and systems for endovascular aneurysm treatment 有权
公开(公告)号：US20060025853A1
公开(公告)日：2006-02-02
申请号：US11187471
申请日：2005-07-22
申请人： Michael Evans , Thomas Howell , Gwendolyn Watanabe , Bhupendra Shah , James McKinley
发明人： Michael Evans , Thomas Howell , Gwendolyn Watanabe , Bhupendra Shah , James McKinley
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2002/075 , A61F2002/077 , A61F2230/0034 , A61F2250/0003
摘要： Aneurysms are treated by filling a double-walled filling structure with a curable medium. The structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. The filling structures are preferably used in pairs for providing flow into the iliac arteries when treating abdominal aortic aneurysm.

2. 发明申请

US20070162106A1 System and methods for endovascular aneurysm treatment 有权
标题翻译：血管内动脉瘤治疗的系统和方法
公开(公告)号：US20070162106A1
公开(公告)日：2007-07-12
申请号：US11482503
申请日：2006-07-07
申请人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
发明人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61B17/12118 , A61B17/12136 , A61B17/12195 , A61B2017/1205 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/95 , A61F2002/065 , A61F2002/067 , A61F2002/077 , A61F2220/005 , A61F2220/0058 , A61F2230/0034 , A61F2230/005 , A61F2250/0003 , A61M2025/0002
摘要： Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.
摘要翻译：实施例提供了使用填充有可固化介质的填充结构来治疗动脉瘤的方法和系统。方法的一个实施例包括将至少一个双壁填充结构定位在动脉瘤上并用填充介质填充结构，使得外壁符合动脉瘤的内部，并且内壁形成大致管状的内腔提供血流量。管腔在填充时和/或填充后用气囊或其他可扩张装置支撑。监测结构内的压力和/或在结构的外壁和动脉瘤壁之间的空间中的压力，并且响应于压力控制介质流入结构的流动。压力也可用于确定灌装终点。当腔保持气球支撑时，介质硬化。培养基硬化后，取出球囊。

3. 发明申请

US20070150041A1 Methods and systems for aneurysm treatment using filling structures 审中-公开
标题翻译：使用填充结构进行动脉瘤治疗的方法和系统
公开(公告)号：US20070150041A1
公开(公告)日：2007-06-28
申请号：US11444603
申请日：2006-05-31
申请人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
发明人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
IPC分类号： A61F2/06
CPC分类号： A61B17/12118 , A61B17/12136 , A61B2017/00893 , A61B2017/1205 , A61F2/07 , A61F2/90 , A61F2002/065 , A61F2002/077 , A61F2230/0078 , A61F2250/0067
摘要： Aneurysms are treated by placing a scaffold across an aneurysmal sac to provide a blood flow lumen therethrough. An aneurysmal space surrounding the scaffold is filled with one or more expandable structures which are simultaneously or sequentially expanded to fill the aneurysmal space and reduce the risk of endoluminal leaks and scaffold migration. The expandable structures are typically inflatable and delivered by delivery catheter, optionally with an inflation tube or structure attached to the expandable structure.
摘要翻译：通过将支架放置在动脉瘤囊上以提供通过其的血流腔来治疗动脉瘤。围绕支架的动脉瘤空间填充有一个或多个可扩张结构，其同时或依次扩张以填充动脉瘤空间并降低腔内泄漏和支架迁移的风险。可膨胀结构通常可充气并由输送导管递送，任选地具有连接到可膨胀结构的充气管或结构。

4. 发明申请

US20060212112A1 Graft systems having filling structures supported by scaffolds and methods for their use 有权
标题翻译：具有由支架支撑的填充结构的移植系统及其使用方法
公开(公告)号：US20060212112A1
公开(公告)日：2006-09-21
申请号：US11413460
申请日：2006-04-28
申请人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
发明人： Michael Evans , Gwendolyn Watanabe , Amy Lee , Steven Herbowy
IPC分类号： A61F2/06
CPC分类号： A61F2/844 , A61F2/07 , A61F2/90 , A61F2/95 , A61F2002/065 , A61F2002/077 , A61F2230/0034 , A61F2250/0003 , A61F2250/0069
摘要： Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.
摘要翻译：通过在动脉瘤内填充至少一个具有可固化培养基的双壁填充结构来治疗动脉瘤。填充结构可以在气囊展开机构上传送，以形成和打开通过其中的管状流明。将脚手架放置在管状内腔中，以帮助保持形状，将填充结构锚定在适当位置，并且提供进入和离开管状内腔的改善的血流过渡。

5. 发明授权

US07517352B2 Devices for percutaneous remote endarterectomy 有权
标题翻译：用于经皮远端内膜切除术的装置
公开(公告)号：US07517352B2
公开(公告)日：2009-04-14
申请号：US09820084
申请日：2001-03-27
申请人： Michael Evans , Denise Demarais , Gwendolyn Watanabe , Stephen Leeflang
发明人： Michael Evans , Denise Demarais , Gwendolyn Watanabe , Stephen Leeflang
IPC分类号： A61M29/00
CPC分类号： A61B17/3207 , A61B17/22 , A61B17/221 , A61B17/32002 , A61B17/320725 , A61B17/32075 , A61B17/320783 , A61B2017/00287 , A61B2017/00362 , A61B2017/320004 , A61B2017/320044 , A61B2017/320741 , A61M25/1002 , A61M25/1027 , A61M29/02 , A61M2025/1015 , A61M2025/1088 , A61M2025/109
摘要： The present invention provides devices, systems, methods and kits for the percutaneous removal of unwanted tissue or obstructive matter from body cavities or lumens, particularly from the vasculature. Blood vessels, including the coronary, peripheral and neurovascular circulation, which are narrowed or blocked by atheromatous material or plaque are often treated with traditional endarterectomy procedures. The present invention allows the benefits of such a procedure with an intraluminal approach, particularly a percutaneous approach. Generally, the present invention provides a set of catheters or tools which are percutaneously introduceable to the site of the blockage or occlusion. The tools dissect or cut through the innermost tissue layer of the lumen to an underlying tissue layer. The innermost tissue layer is then stripped away from the underlying layer with the occlusive material thereattached. The detached tissue layer and occlusive material is then removed from the lumen; this may include additional cutting, maceration and removal through mechanical aspiration. In any case, the resulting lumen is free of obstruction.
摘要翻译：本发明提供用于经皮去除不想要的组织或阻塞物质的装置，系统，方法和试剂盒，所述装置，系统，方法和试剂盒用于从体腔或腔，特别是脉管系统中去除。通常使用传统的内膜切除手术治疗包括动脉粥样硬化材料或斑块变窄或阻塞的冠状动脉，周围和神经血管循环的血管。本发明允许使用腔内方法，特别是经皮方法的这种手术的益处。通常，本发明提供一组导管或工具，其经皮可引入阻塞部位或闭塞部位。该工具将内腔的最内层组织切割或切割到下面的组织层。然后将最内侧的组织层从附近的闭塞材料剥离下来的层。然后从管腔移除脱离的组织层和封闭材料; 这可能包括通过机械抽吸进行额外的切割，浸渍和去除。在任何情况下，所得到的内腔没有阻塞。

6. 发明授权

US09492263B2 Retrieval apparatus and methods for use 有权
标题翻译：检索仪器和使用方法
公开(公告)号：US09492263B2
公开(公告)日：2016-11-15
申请号：US12746920
申请日：2008-12-10
申请人： Jeffrey A. Krolik , James H. Dreher , Gwendolyn Watanabe
发明人： Jeffrey A. Krolik , James H. Dreher , Gwendolyn Watanabe
IPC分类号： A61M29/00 , A61F2/01 , A61B17/221 , A61B17/22
CPC分类号： A61B17/221 , A61B2017/00862 , A61B2017/22035 , A61B2017/22038 , A61B2017/2212 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0069 , A61M1/3655
摘要： An apparatus for capturing material within a body lumen includes a shaft carrying an expandable basket device on a distal end thereof. The basket device includes a distal basket carried and a proximal basket carried on the shaft such that the proximal basket is proximal to and spaced apart from the distal basket. Each basket includes an open end communicating with an interior of the respective basket and oriented towards one another. In one embodiment, a tubular middle portion extends between the baskets. In another embodiment, the distal basket includes an actuator coupled to the distal basket open end such that movement of the baskets towards one another causes the actuator to direct the distal basket open end inwardly to allow the open end to be received within the proximal basket to facilitate removal of the apparatus after capturing material within the baskets.
摘要翻译：用于在体腔内捕获材料的装置包括在其远端承载可膨胀篮装置的轴。篮子装置包括承载的远侧篮子和承载在轴上的近侧篮，使得近侧篮子靠近并与远侧篮子间隔开。每个篮子包括与相应篮子的内部相通并且朝向彼此定向的开放端。在一个实施例中，管状中间部分在篮子之间延伸。在另一个实施例中，远侧筐包括联接到远侧筐开口端的致动器，使得篮子朝向彼此的移动导致致动器将远侧筐开放端向内引导，以允许开放端被容纳在近侧筐内便于在筐内捕获材料之后移除设备。

7. 发明申请

US20160271372A9 DUAL PURPOSE BALLOON CATHETERS 有权
标题翻译：双目气球导管
公开(公告)号：US20160271372A9
公开(公告)日：2016-09-22
申请号：US13644022
申请日：2012-10-03
申请人： Gwendolyn Watanabe , Jeffrey A. Krolik
发明人： Gwendolyn Watanabe , Jeffrey A. Krolik
IPC分类号： A61M25/10 , A61M29/02
CPC分类号： A61M25/10 , A61M25/007 , A61M25/1011 , A61M25/10181 , A61M25/104 , A61M29/02 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61M2025/1093
摘要： Enhanced dual purpose systems enable dilating of at least a lesion within a blood vessel and providing an anti-proliferative medicament in a non-attached form directly into the lumen of the vessel. Likewise provided is the ability to stop blood flow to prevent wash-out of the medicament during dwell time within the body lumen, and the ability to remove the medicament after the dwell time of the device to prevent unwanted exposure of the same within the body.
摘要翻译：增强的双重目的系统使得能够扩张血管内的至少一个病变，并将非附着形式的抗增殖药物直接提供到血管的内腔中。类似地，提供了在体内停留时间期间停止血液流动以防止药物洗出的能力，以及在该装置的停留时间之后去除药物以防止其在体内不期望的暴露的能力。

8. 发明授权

US09101382B2 Apparatus and methods for treating obstructions within body lumens 有权
公开(公告)号：US09101382B2
公开(公告)日：2015-08-11
申请号：US13216208
申请日：2011-08-23
申请人： Jeffrey A. Krolik , Juan Domingo , Gwendolyn Watanabe , Ray Betelia , Lucas Fernandez
发明人： Jeffrey A. Krolik , Juan Domingo , Gwendolyn Watanabe , Ray Betelia , Lucas Fernandez
IPC分类号： A61M25/10 , A61B17/22 , A61M25/00 , A61B17/221 , A61F2/958 , A61M29/02 , A61B17/3205 , A61B17/3207
CPC分类号： A61B17/22032 , A61B5/6853 , A61B17/221 , A61B17/32056 , A61B17/3207 , A61B17/320725 , A61B2017/22034 , A61B2017/22061 , A61B2017/22082 , A61B2017/22084 , A61B2017/2212 , A61B2017/2215 , A61F2/958 , A61M5/007 , A61M25/0075 , A61M25/0097 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M25/10185 , A61M29/02 , A61M2025/0008 , A61M2025/105 , A61M2025/1068 , A61M2025/1077 , A61M2025/1084 , A61M2025/1086 , A61M2025/109
摘要： Apparatus and methods are provided for delivering fluid into a body lumen during a medical procedure. A distal end of an apparatus may be introduced into a body lumen, and a valve on the distal end may be opened to deliver fluid through a first lumen into the body lumen, e.g., contrast and/or other diagnostic or therapeutic agents. The valve may be closed, and a procedure may be performed within the body lumen, e.g., using a treatment element carried on the distal end. For example, the treatment element may include a balloon that may be inflated when fluid is delivered through the first lumen with the valve closed. Optionally, a prosthesis, energy source, drug platform, and the like may be carried by the balloon for treating the body lumen. In various embodiments, the valve may be located proximal or distal to the treatment element.

9. 发明申请

US20120197193A1 APPARATUS AND METHODS FOR TREATING OBSTRUCTIONS WITHIN BODY LUMENS 有权
标题翻译：用于在体内治疗梗阻的装置和方法
公开(公告)号：US20120197193A1
公开(公告)日：2012-08-02
申请号：US13444739
申请日：2012-04-11
申请人： Jeffrey A. Krolik , Juan Domingo , Gwendolyn Watanabe , Ray Betelia , Lucas Fernandez
发明人： Jeffrey A. Krolik , Juan Domingo , Gwendolyn Watanabe , Ray Betelia , Lucas Fernandez
IPC分类号： A61M25/10
CPC分类号： A61B17/22032 , A61B5/6853 , A61B17/221 , A61B17/32056 , A61B17/3207 , A61B17/320725 , A61B2017/22034 , A61B2017/22061 , A61B2017/22082 , A61B2017/22084 , A61B2017/2212 , A61B2017/2215 , A61F2/958 , A61M5/007 , A61M25/0075 , A61M25/0097 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M25/10185 , A61M29/02 , A61M2025/0008 , A61M2025/105 , A61M2025/1068 , A61M2025/1077 , A61M2025/1084 , A61M2025/1086 , A61M2025/109
摘要： Apparatus and methods are provided for delivering fluid into a body lumen during a medical procedure. A distal end of an apparatus may be introduced into a body lumen, and a valve on the distal end may be opened to deliver fluid through a first lumen into the body lumen, e.g., contrast and/or other diagnostic or therapeutic agents. The valve may be closed, and a procedure may be performed within the body lumen, e.g., using a treatment element carried on the distal end. For example, the treatment element may include a balloon that may be inflated when fluid is delivered through the first lumen with the valve closed. Optionally, a prosthesis, energy source, drug platform, and the like may be carried by the balloon for treating the body lumen. In various embodiments, the valve may be located proximal or distal to the treatment element.
摘要翻译：提供了设备和方法，用于在医疗过程中将流体输送到体腔中。装置的远端可以被引入体腔，并且可以打开远端上的阀，以将流体通过第一腔输送到体腔，例如造影剂和/或其它诊断或治疗剂。可以关闭阀，并且可以在体腔内执行程序，例如使用在远端承载的治疗元件。例如，治疗元件可以包括当阀关闭时流体通过第一内腔输送时可膨胀的球囊。任选地，假体，能量源，药物平台等可以由球囊承载以用于处理体腔。在各种实施例中，阀可以位于治疗元件的近侧或远侧。

10. 发明授权

US09737690B2 Dual purpose balloon catheters 有权
公开(公告)号：US09737690B2
公开(公告)日：2017-08-22
申请号：US13644022
申请日：2012-10-03
申请人： Gwendolyn Watanabe , Jeffrey A. Krolik
发明人： Gwendolyn Watanabe , Jeffrey A. Krolik
IPC分类号： A61M25/10 , A61M29/02 , A61M25/00
CPC分类号： A61M25/10 , A61M25/007 , A61M25/1011 , A61M25/10181 , A61M25/104 , A61M29/02 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61M2025/1093
摘要： Enhanced dual purpose systems enable dilating of at least a lesion within a blood vessel and providing an anti-proliferative medicament in a non-attached form directly into the lumen of the vessel. Likewise provided is the ability to stop blood flow to prevent wash-out of the medicament during dwell time within the body lumen, and the ability to remove the medicament after the dwell time of the device to prevent unwanted exposure of the same within the body.

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