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1. 发明申请

US20070293564A1 Dimeric compounds and their use as anti-viral agents 审中-公开
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20070293564A1
公开(公告)日：2007-12-20
申请号：US11607872
申请日：2006-12-04
申请人： Michael Dowle , Betty Jin , Simon MacDonald , Andrew Mason , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Michael Dowle , Betty Jin , Simon MacDonald , Andrew Mason , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： C07D309/28
摘要： A method for the prevention of an orthomyxovirus or paramyxovirus infection comprising the step of administration to a subject in need thereof of an effective amount of a compound of formula (I)
摘要翻译：一种用于预防正粘病毒或副粘病毒感染的方法，包括向有需要的受试者施用有效量的式（I）化合物的步骤，

2. 发明申请

US20050038108A1 Dimeric compounds and their use as anti-viral agents 有权
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20050038108A1
公开(公告)日：2005-02-17
申请号：US10494243
申请日：2002-11-08
申请人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
发明人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
IPC分类号： A61K9/12 , A61K9/14 , A61K31/13 , A61K31/351 , A61K31/7052 , A61K45/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P43/00 , C07D309/28 , A61K31/34 , C07D45/02
CPC分类号： C07D309/28
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，SO2NH，NHCO或NHCONH; m为0或1; n为2-6的整数; q是0至3的整数; Y为氢或芳香族取代基，或其药学上可接受的衍生物; 其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

3. 发明申请

US20050054719A1 Dimeric compounds and their use as anti-viral agents 失效
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20050054719A1
公开(公告)日：2005-03-10
申请号：US10494260
申请日：2002-11-08
申请人： Betty Jin , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Betty Jin , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/13 , A61K31/351 , A61K31/7052 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/48 , A61P11/00 , A61P31/04 , A61P31/12 , A61P31/16 , C07D309/28 , C07K5/072 , C07D45/02 , A61K31/35
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (1); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C8 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（1）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X为CONH，NHCO或O; n为2-6的整数; 并且Y是C 2 -C 8烷基C 3-8环烷基，C 1 -C 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其用于预防或治疗病毒感染。

4. 发明申请

US20070225358A1 DIMERIC COMPOUNDS AND THIER USE AS ANTI-VIRAL AGENTS 失效
标题翻译：二元化合物，并被用作反病毒剂
公开(公告)号：US20070225358A1
公开(公告)日：2007-09-27
申请号：US11734394
申请日：2007-04-12
申请人： Betty JIN , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Betty JIN , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C9 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，NHCO或O; n为2-6的整数; 且Y为C 2 -C 9烷基C 3-8环烷基，C 1 -C 3烷基， 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

5. 发明申请

US20050085413A1 Dimeric pharmaceutical compounds and their use 审中-公开
标题翻译：二聚药物化合物及其用途
公开(公告)号：US20050085413A1
公开(公告)日：2005-04-21
申请号：US10494942
申请日：2002-11-08
申请人： Betty Jin , John Lambert , Roland Nearn , Van Nguyen , Simon Tucker , Wen-Yang Wu
发明人： Betty Jin , John Lambert , Roland Nearn , Van Nguyen , Simon Tucker , Wen-Yang Wu
IPC分类号： A61K47/48 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , C07D215/56 , C07D309/28 , C07H15/232 , C07H15/234 , C07H15/236 , C07H17/08 , A61K31/704 , A61K38/14 , C07H15/22 , C07K9/00
CPC分类号： C07H15/232 , A61K47/54 , A61K47/55 , C07D215/56 , C07D309/28 , C07H15/234
摘要： The invention relates to a compound of general formula (I): X-L-Y (I) in which X and Y are pharmaceutically active moieties which may be the same or different; and L is a linker which is an optionally substituted saturated or unsaturated straight chain, branched and/or cyclic hydrocarbon radical having a backbone of at least 11 atoms, or a pharmaceutically acceptable derivative or salt thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a microbial infection.
摘要翻译：本发明涉及通式（I）的化合物：<？in-line-formula description =“In-line formula”end =“lead”？> XLY（I）<？in-line-formula description =“In 其中X和Y是可以相同或不同的药学活性部分; 并且L是具有至少11个原子骨架的任选取代的饱和或不饱和的直链，支链和/或环状烃基或其药学上可接受的衍生物或盐的接头，其制备方法，含有它们的药物制剂或其用于预防或治疗微生物感染的用途。

6. 发明申请

US20080026183A1 BIOCIDAL ROOFING GRANULES, ROOFING PRODUCTS INCLUDING SUCH GRANULES, AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：生物花岗岩，包括这种颗粒的屋面产品及其制备方法
公开(公告)号：US20080026183A1
公开(公告)日：2008-01-31
申请号：US11830580
申请日：2007-07-30
申请人： Sophie Vanpoulle , Van Nguyen , Alexandra Dekoninck
发明人： Sophie Vanpoulle , Van Nguyen , Alexandra Dekoninck
IPC分类号： B05D7/00 , E01F9/04
CPC分类号： A01N25/12 , A01N25/34 , C01P2006/12 , C01P2006/14 , C09C1/0081 , C09C3/006 , C09C3/063 , C09C3/08 , C09C3/12 , E04D13/002 , E04D2001/005 , Y10T428/24372 , Y10T428/2438 , Y10T428/24388 , A01N43/80
摘要： Biocidal roofing granules include a mineral core covered with an outer layer of mesoporous silica including photocatalytic nanoparticles of anatase titanium dioxide as a biocide and an optional organic biocide.
摘要翻译：杀菌屋面颗粒包括覆盖有介孔二氧化硅外层的矿物核心，包括作为杀生物剂的锐钛矿型二氧化钛的光催化纳米颗粒和任选的有机杀生物剂。

7. 发明授权

US06933294B2 Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：基于噻吩的三环化合物和包含它们的药物组合物
公开(公告)号：US06933294B2
公开(公告)日：2005-08-23
申请号：US10400387
申请日：2003-03-27
申请人： Makonen Belema , Amy Bunker , Van Nguyen , Francis Beaulieu , Carl Ouellet , Anne Marinier , Stephan Roy , Xuejie Yang , Yuping Qiu , Yunhui Zhang , Alain Martel , Christopher Zusi
发明人： Makonen Belema , Amy Bunker , Van Nguyen , Francis Beaulieu , Carl Ouellet , Anne Marinier , Stephan Roy , Xuejie Yang , Yuping Qiu , Yunhui Zhang , Alain Martel , Christopher Zusi
IPC分类号： C07D495/14 , A61K31/4985 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，水合物和前药可用作抗炎剂，其中R 1，R 2，和 R 3是氢，卤素，烷基或全氟烷基; R 4是任选取代的烷基或环烷基; X是一个连接子; A是芳基，杂芳基，杂环，环烷基或不存在; 并且R 7是在说明书中定义的A上的取代基。

8. 再颁专利

USRE35423E Method and apparatus for performing automated circuit board solder quality inspections 失效
标题翻译：执行自动化电路板焊料质量检查的方法和装置
公开(公告)号：USRE35423E
公开(公告)日：1997-01-14
申请号：US182841
申请日：1994-01-14
申请人： John Adams , Juan Amoroso, Jr. , Paul Axford , Phil Bowles , Mike Juha , Van Nguyen , Charles Preskitt , Ed Ross , Doug Thompson , Paul Turner
发明人： John Adams , Juan Amoroso, Jr. , Paul Axford , Phil Bowles , Mike Juha , Van Nguyen , Charles Preskitt , Ed Ross , Doug Thompson , Paul Turner
IPC分类号： H01L21/66 , G01N23/04 , G01N23/18 , G01R31/304 , G06T7/00 , H05K3/34 , G06F15/46
CPC分类号： G06T7/0006 , G01N23/18 , G01R31/304 , G06T2207/10121 , G06T2207/30141 , G06T2207/30152 , Y10S378/901
摘要： A method and apparatus for measuring structural characteristics of a manufactured circuit board containing solder joints by automated real-time digital X-ray radiographic inspection techniques. A circuit board under examination is automatically positioned by a digitally controlled multi-axis positioning system between an electronic X-ray source and an electronic X-ray imaging system, X-rays, in a beam of X-rays from the X-ray source, are directed towards the circuit board. The X-rays are absorbed, scattered and transmitted through the circuit board. The X-rays transmitted through the circuit board are directed upon the X-ray imaging system. The X-ray imaging system converts the transmitted X-rays into digital images which represent the radiographic density of the portion of the circuit board under examination. The digital images are stored within a digital image processor. A computer, under program control, performs calculational measurements on the digital images so as to measure the structural characteristics of the solder joints and components on the circuit board. The calculational measurements are compared to predetermined standards corresponding to acceptable quality standards programmed into the computer. In response to the comparison, the computer provides an accept/reject decision on the circuit board in addition to providing manufacturing process control information for correction of found defects.The questions raised in reexamination request No. 90/002,298, filed Mar. 15, 1991, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CRF 1.570(e).
摘要翻译：一种用于通过自动实时数字X射线照相检查技术测量制造的包含焊点的电路板的结构特性的方法和装置。正在检查的电路板通过数字控制的多轴定位系统在电子X射线源和电子X射线成像系统之间通过X射线从X射线源X射线自动定位，指向电路板。 X射线被吸收，散射并透过电路板。通过电路板传输的X射线被引导到X射线成像系统。 X射线成像系统将透射的X射线转换为表示正在检查的电路板的部分的放射照相密度的数字图像。数字图像存储在数字图像处理器中。计算机在程序控制下，对数字图像执行计算测量，以便测量电路板上焊点和部件的结构特性。将计算测量与对应于编入计算机的可接受的质量标准的预定标准进行比较。响应于比较，除了提供用于校正发现的缺陷的制造过程控制信息之外，计算机还在电路板上提供接受/拒绝决定。已经考虑了1991年3月15日提交的第90 / 002,298号复审请求中提出的问题，其结果反映在该重新颁发专利中，该专利构成了35U.S.C.所要求的复审证书。 307如CRF 1.570（e）所述。

9. 发明申请

US20070291552A1 Runtime flash device detection and configuration for flash data management software 有权
标题翻译：闪存数据管理软件的运行时闪存设备检测和配置
公开(公告)号：US20070291552A1
公开(公告)日：2007-12-20
申请号：US11895185
申请日：2007-08-23
申请人： Joseph Khatami , Van Nguyen , Wanmo Wong
发明人： Joseph Khatami , Van Nguyen , Wanmo Wong
IPC分类号： G11C11/34
CPC分类号： G11C16/20
摘要： A memory device driver is described that can support multiple differing memory devices, in particular, differing Flash memory devices, by being internally re-configurable to match the driving and management requirements of the particular memory device. This allows for a limited number of operating system versions to be produced and maintained for a given system by the manufacturer, reducing the possibility of misconfiguration of the system/device by the inadvertent updating or programming of the wrong operating system version by an end user or service personnel. The resulting driver routine and/or operating system is also typically smaller than operating systems/drivers that compile in or load multiple separate drivers into themselves. In one embodiment of the present invention, the software driver is automatically configures itself by querying the memory device for a device ID and/or manufacturer code or by detecting a specific characteristic of the memory device being driven.
摘要翻译：描述了可以通过在内部可重新配置以匹配特定存储器件的驱动和管理要求来支持多个不同存储器件，特别是不同闪存器件的存储器件驱动器。这允许制造商为给定的系统生产和维护有限数量的操作系统版本，从而减少由最终用户无意地更新或编程错误的操作系统版本的系统/设备的错误配置的可能性，或者服务人员。所产生的驱动程序例程和/或操作系统通常也小于在其中编译或加载多个单独驱动程序的操作系统/驱动程序。在本发明的一个实施例中，软件驱动程序通过向存储器件询问设备ID和/或制造商代码或者通过检测被驱动的存储器件的特定特性来自动配置自身。

10. 发明授权

US07277978B2 Runtime flash device detection and configuration for flash data management software 有权
公开(公告)号：US07277978B2
公开(公告)日：2007-10-02
申请号：US10663279
申请日：2003-09-16
申请人： Joseph Khatami , Van Nguyen , Wanmo Wong
发明人： Joseph Khatami , Van Nguyen , Wanmo Wong
IPC分类号： G06F12/00
CPC分类号： G11C16/20
摘要： A memory device driver is described that can support multiple differing memory devices, in particular, differing Flash memory devices, by being internally re-configurable to match the driving and management requirements of the particular memory device. This allows for a limited number of operating system versions to be produced and maintained for a given system by the manufacturer, reducing the possibility of misconfiguration of the system/device by the inadvertent updating or programming of the wrong operating system version by an end user or service personnel. The resulting driver routine and/or operating system is also typically smaller than operating systems/drivers that compile in or load multiple separate drivers into themselves. In one embodiment of the present invention, the software driver is automatically configures itself by querying the memory device for a device ID and/or manufacturer code or by detecting a specific characteristic of the memory device being driven.

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