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    • 7. 发明授权
    • Generating gigapixel images
    • 生成千兆像素图像
    • US07961983B2
    • 2011-06-14
    • US11779871
    • 2007-07-18
    • Matthew UyttendaeleMichael Cohen
    • Matthew UyttendaeleMichael Cohen
    • G06K9/00G06K9/36G06K9/32
    • G06T3/4038
    • A gigapixel image is generated from a set of images in raw format depicting different portions of a panoramic scene that has up to a full spherical field of view. Radiometric alignment of the images creates a set of images in radiance format. Geometric alignment of the radiance format images creates a set of true poses for the images in radiance format. A gigapixel image depicting the entire scene is assembled from the set of radiance format images and radiance format true poses for the images. The set of images in raw format is captured using a conventional digital camera, equipped with a telephoto lens, attached to a motorized head. The head is programmed to pan and tilt the camera in prescribed increments to individually capture the images at a plurality of exposures and with a prescribed overlap between images depicting adjacent portions of the scene.
    • 从原始格式的一组图像生成一个千兆像素图,描绘具有全球面视野的全景场景的不同部分。 图像的放射线对准会以辐射格式创建一组图像。 辐射格式图像的几何对齐为辐射格式的图像创建一组真实姿势。 描绘整个场景的百万像素图像是由一组辐射格式图像和辐射格式组合而成的图像的真实姿势。 原始格式的图像集是使用配有远摄镜头的常规数码相机来捕捉的,该长焦镜头连接到电动头部。 头被编程为以规定的增量平移和倾斜相机,以单独地以多次曝光并且以描绘场景的相邻部分的图像之间的规定的重叠来捕获图像。
    • 8. 发明授权
    • Correlating packets
    • 关联数据包
    • US07729256B2
    • 2010-06-01
    • US11180879
    • 2005-07-13
    • Patrick J. MalloyMichael CohenAlain J. Cohen
    • Patrick J. MalloyMichael CohenAlain J. Cohen
    • G01R31/08G06F15/173
    • H04L63/0236H04L1/18H04L63/1416H04L2012/565
    • A system/method searches a traffic stream for a sequence of “matching” packets that exhibit a high degree of correlation or similarity to a sequence of “reference” packets. The correlation between matching and reference packets is based on a degree of correspondence between individual packets, as well as the sequence-order of the corresponding packets. A variation of the Needleman-Wunsch algorithm is preferably used to select corresponding packets in the traffic stream that provide a sequence-order that best matches the sequence-order of the reference packets, based on a measure of the correspondence for each match, and a penalty associated with each non-match. The algorithm is further modified to reduce the required search-space for finding corresponding packets in the traffic stream.
    • 系统/方法在业务流中搜索与“参考”分组的序列呈现高度相关性或相似性的“匹配”分组序列。 匹配和参考分组之间的相关性基于各个分组之间的对应程度以及相应分组的顺序。 Needleman-Wunsch算法的变体优选地用于基于每个匹配的对应度的度量来选择提供与参考分组的序列顺序最佳匹配的序列顺序的业务流中的相应分组,以及 与每个不匹配相关的罚款。 该算法被进一步修改以减少用于在流量流中找到相应分组的所需搜索空间。
    • 9. 发明授权
    • Selective serine/threonine kinase inhibitors
    • 选择性丝氨酸/苏氨酸激酶抑制剂
    • US07687506B2
    • 2010-03-30
    • US10552847
    • 2004-04-12
    • Jack TauntonMichael CohenKevan ShokatChao Zhang
    • Jack TauntonMichael CohenKevan ShokatChao Zhang
    • C07D487/04A61K31/52
    • C07D487/04
    • Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
    • 在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现 含有至少一个氮环原子的稠环,以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。 优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚,以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。 缺乏这种半胱氨酸残基的激酶可以被改造或修饰,使得它们能够被这样的化合物抑制,通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。