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1. 发明授权

US08916380B2 Embryonic stem cell-like cells 有权
标题翻译：胚胎干细胞样细胞
公开(公告)号：US08916380B2
公开(公告)日：2014-12-23
申请号：US12377493
申请日：2006-12-20
申请人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
发明人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
IPC分类号： C12N5/07 , C12N5/02 , C12N5/10 , C12N5/074
CPC分类号： C12N5/0696 , C12N2501/235 , C12N2502/03 , C12N2502/04 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394
摘要： Disclosed is a method for preparing an embryonic stem cell (ESC)-like cell, which includes the steps of: (a) obtaining a first cell population from a mammalian tissue or body fluid, wherein the first cell population comprises adult stem cells; (b) obtaining a second somatic cell population from a mammalian tissue, wherein the mammalian tissue is different from the mammalian tissue in step (a) and the second cell population is different from the first cell population; (c) coculturing the first cell population and the second cell population in a medium for a period of time sufficient to form a colony from either the first cell population or the second cell population; and (d) subculturing a cell from the colony in a medium for a period time sufficient to prepare the ESC-like cell.
摘要翻译：公开了一种制备胚胎干细胞（ESC）样细胞的方法，其包括以下步骤：（a）从哺乳动物组织或体液获得第一细胞群，其中第一细胞群包含成体干细胞; （b）从哺乳动物组织获得第二体细胞群，其中所述哺乳动物组织在步骤（a）中不同于哺乳动物组织，而第二细胞群与第一细胞群不同; （c）在培养基中共培养第一细胞群体和第二细胞群体足以从第一细胞群体或第二细胞群体形成菌落的时间; 和（d）在培养基中将细胞从菌落中传代培养足以制备ESC样细胞的时间。

2. 发明申请

US20140057348A1 Novel Culture System for Ex Vivo Development 审中-公开
标题翻译：新型体外发育文化体系
公开(公告)号：US20140057348A1
公开(公告)日：2014-02-27
申请号：US14066510
申请日：2013-10-29
申请人： ADVANCED CELL TECHNOLOGY, INC.
发明人： Michael D. West , Karen B. Chapman , Irina V. Klimanskaya
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译：本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。

3. 发明申请

US20130309651A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
公开(公告)号：US20130309651A1
公开(公告)日：2013-11-21
申请号：US13844636
申请日：2013-03-15
申请人： INGURAN, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

4. 发明申请

US20130302887A1 COMPOSITIONS AND METHODS FOR GROWING HUMAN EMBRYONIC CELLS 审中-公开
标题翻译：用于生长人胚胎细胞的组合物和方法
公开(公告)号：US20130302887A1
公开(公告)日：2013-11-14
申请号：US13947884
申请日：2013-07-22
申请人： Michael Shamblott , Michael Cohen
发明人： Michael Shamblott , Michael Cohen
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2502/04 , C12N2533/54
摘要： Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.
摘要翻译：通过使用从人胚胎宝石（EG）细胞衍生物（例如胚状体衍生细胞）的培养基获得的分泌产物，提供用于衍生和培养人胚胎干（ES）细胞并维持其培养多能性的方法。底物包括诸如胶原I，纤连蛋白或超纤连蛋白的化合物，或通常人衍生的细胞外基质。

5. 发明申请

US20060031955A1 Novel culture systems for EX vivo development 有权
标题翻译：用于体外发育的新型文化系统
公开(公告)号：US20060031955A1
公开(公告)日：2006-02-09
申请号：US11211174
申请日：2005-08-24
申请人： Michael West , Karen Chapman , Irina Klimanskaya
发明人： Michael West , Karen Chapman , Irina Klimanskaya
IPC分类号： C12N5/06 , C12N5/08 , A01K67/027
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译：本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。

6. 发明申请

US20160257929A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
公开(公告)号：US20160257929A1
公开(公告)日：2016-09-08
申请号：US15157201
申请日：2016-05-17
申请人： Inguran, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： C12N5/075 , C12N5/071 , C12N5/076 , A01N1/02
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

7. 发明申请

US20140186944A1 USE OF CELLULAR EXTRACTS FOR OBTAINING PLURIPOTENT STEM CELLS 有权
标题翻译：使用细胞提取物获得多发性干细胞
公开(公告)号：US20140186944A1
公开(公告)日：2014-07-03
申请号：US14234192
申请日：2012-07-19
申请人： Marcel Mechali , Olivier Ganier
发明人： Marcel Mechali , Olivier Ganier
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N5/16 , C12N2502/04
摘要： The use of a composition including at least one permeabilized nucleus of a first cell, or at least one permeabilized first cell including the nucleus and an extract of female germinal cells, or eggs, of a multicellular organism, the eggs being blocked in the metaphase II of meiosis, the extract including EGTA, for carrying out a method for obtaining pluripotent stem cells, or tissues derived from the pluripotent stem cells, or of cloning, provided that the process is not for cloning human beings.
摘要翻译：使用组合物，其包含至少一个第一细胞的透化细胞核，或至少一个包含细胞核的透化第一细胞和多细胞生物的雌性生殖细胞或卵的提取物，卵在中期II中被阻断的减数分裂产物，包括EGTA的提取物，用于进行获得多能干细胞的方法，或衍生自多能干细胞的组织或克隆，条件是该方法不用于克隆人。

8. 发明申请

US20110256622A1 Novel Culture Systems for Ex Vivo Development 有权
标题翻译：用于体外发育的新型文化系统
公开(公告)号：US20110256622A1
公开(公告)日：2011-10-20
申请号：US13172027
申请日：2011-06-29
申请人： Michael D. West , Karen B. Chapman , Irina V. Klimanskaya
发明人： Michael D. West , Karen B. Chapman , Irina V. Klimanskaya
IPC分类号： C12N5/073 , C12N5/0735 , C12N5/02
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译：本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。

9. 发明申请

US20100330043A1 GPR125 AS A MARKER FOR STEM AND PROGENITOR CELLS AND METHODS USE THEREOF 审中-公开
标题翻译： GPR125作为干细胞和祖细胞的标记物及其使用方法
公开(公告)号：US20100330043A1
公开(公告)日：2010-12-30
申请号：US12446730
申请日：2007-10-23
申请人： Shahin Rafii , Sergey V. Shmelkov , Marco Seandel , Sai H. Chavala
发明人： Shahin Rafii , Sergey V. Shmelkov , Marco Seandel , Sai H. Chavala
IPC分类号： A61K35/12 , C12N5/074 , G01N33/53 , A61P35/00
CPC分类号： C12N5/061 , A61K35/12 , C12N5/0623 , C12N5/068 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/998 , C12N2502/02 , C12N2502/04 , G01N33/56966 , G01N33/57492
摘要： The present invention relates to GPR1 25 as a marker of stem and progenitor cells, including multipotent adult spermatogonial-derived stem cells (MASCs), spermatogonial stem and progenitor cells, skin stem or progenitor cells, intestinal stem or progenitor cells, neural stem or progenitor cells, and cancer stem cells. The invention provides, inter alia, methods for enriching or isolating GPR125-positive stem or progenitor cells, methods for detecting GPR125-positive stem or progenitor cells, methods for culturing GPR125-positive stem or progenitor cells, purified GPR125-positive stem or progenitor cells, therapeutic compositions containing purified GPR125-positive stem or progenitor cells, methods for targeting therapeutic agents to GPR125-positive stem and progenitor cells, and methods of treatment comprising administering GPR125-positive stem and progenitor cells, or differentiated cells derived therefrom, to subjects in need thereof. The present invention also provides methods of detecting cancer cells based on GPR1 25 expression, and methods of targeting therapeutic agents to cancer cells to GPR125-positive cancer cells.
摘要翻译：本发明涉及GPR125作为干细胞和祖细胞的标志物，包括多能成人精原细胞来源的干细胞（MASC），精原干细胞和祖细胞，皮肤干细胞或祖细胞，肠干或祖细胞，神经干或祖细胞细胞和癌症干细胞。本发明尤其提供了富集或分离GPR125阳性干细胞或祖细胞的方法，用于检测GPR125阳性干细胞或祖细胞的方法，培养GPR125阳性干细胞或祖细胞，纯化的GPR125阳性干细胞或祖细胞含有纯化的GPR125阳性干细胞或祖细胞的治疗组合物，用于将治疗剂靶向GPR125阳性干细胞和祖细胞的方法，以及治疗方法，包括将GPR125阳性干细胞和祖细胞或其衍生的分化细胞给予受试者需要。本发明还提供了基于GPR125表达检测癌细胞的方法，以及将治疗剂靶向癌细胞至GPR125阳性癌细胞的方法。

10. 发明申请

US20080267930A1 Biological Materials and Uses Thereof 审中-公开
标题翻译：生物材料及其用途
公开(公告)号：US20080267930A1
公开(公告)日：2008-10-30
申请号：US11996434
申请日：2006-07-21
申请人： Andrew Johnson , Keith Campbell , Ramiro Alberio
发明人： Andrew Johnson , Keith Campbell , Ramiro Alberio
IPC分类号： A61K35/12 , C12N15/06 , C12N5/22 , A61P43/00 , C12N1/00
CPC分类号： C12N5/16 , A61K35/60 , A61K35/65 , C07K14/4702 , C12N5/0696 , C12N15/8773 , C12N2501/605 , C12N2502/04 , C12N2506/00 , C12N2517/10
摘要： A method of producing a reprogrammed cell or reprogrammed cell nucleus, comprising exposing a differentiated cell, or the nucleus of a differentiated cell to a cell or cell extract thereof derived from an oocyte, egg, ovary or early embryo of a cold blooded vertebrate, wherein the cold blooded vertebrate has one or more of the following properties: (i) a primitive vertebrate body plan including laterally projecting ribs and/or spinal projections; (ii) germ cells which do not contain germ plasm; and/or (iii) the oocyte, egg, ovary or early embryo cell or cell from which the cell extract is derived, expresses a highly conserved form of Oct-4 and/or nanog. There is also provided uses of the reprogrammed cells.
摘要翻译：一种生产重编程细胞或重编程细胞核的方法，包括将分化的细胞或分化细胞的核暴露于衍生自冷血脊椎动物的卵母细胞，卵，卵巢或早期胚胎的细胞或细胞提取物中，其中冷血脊椎动物具有以下一个或多个性质：（i）包括横向突出的肋和/或脊柱突起的原始脊椎动物体平面图; （ii）不含生殖细胞的生殖细胞; 和/或（iii）来自细胞提取物的卵母细胞，卵，卵巢或早期胚胎细胞或细胞，表达高度保守形式的Oct-4和/或纳米。还提供了重编程细胞的用途。

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