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1. 发明申请

US20070059326A1 Escherichia coli-derived vaccine and therapy against botulism 审中-公开
标题翻译：大肠杆菌来源的疫苗和针对肉毒中毒的治疗
公开(公告)号：US20070059326A1
公开(公告)日：2007-03-15
申请号：US11289851
申请日：2005-11-30
申请人： Michael Baldwin , Marite Bradshaw , William Tepp , Eric Johnson , Joseph Barbieri , Christina Pier
发明人： Michael Baldwin , Marite Bradshaw , William Tepp , Eric Johnson , Joseph Barbieri , Christina Pier
IPC分类号： A61K39/08 , C07H21/04 , C12N15/74 , C12N1/21 , C07K14/33
CPC分类号： C12N9/52 , A61K39/0258 , A61K39/08 , A61K2039/523 , C12Y304/24069 , Y02A50/469 , Y02A50/474
摘要： A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
摘要翻译：公开了产生肉毒杆菌毒素C末端受体结合结构域（HCR）的方法。该方法包括以下步骤：（a）用包含编码HCR蛋白的DNA的表达载体转化大肠杆菌，（b）在培养基中降低温度诱导HCR蛋白的表达，和（c）通过提取纯化HCR蛋白质，其中提取物通过离心和过滤进行澄清，其中纯化的HCR蛋白质为至少10mg / L的培养基。

2. 发明申请

US20060258847A1 Method of preparing botulinum neurotoxin type A light chain 有权
标题翻译：制备肉毒杆菌神经毒素A型轻链的方法
公开(公告)号：US20060258847A1
公开(公告)日：2006-11-16
申请号：US11404289
申请日：2006-04-14
申请人： Eric Johnson , Marite Bradshaw , Michael Baldwin , Joseph Barbieri
发明人： Eric Johnson , Marite Bradshaw , Michael Baldwin , Joseph Barbieri
IPC分类号： C07K14/00 , C07K1/00 , C07K17/00
CPC分类号： C07K14/33
摘要： The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentially of amino acid residues 1 through 425 of the botulinum toxin light chain type A. A method of screening inhibitors is also provided, wherein the method comprises exposing a test inhibitor to the preparation of botulinum toxin light chain type A and evaluating the biological activity of the preparation. In another embodiment, a method of providing a catalytically active, soluble preparation of botulinum toxin light chain, type A is provided, wherein the method comprises obtaining an expression vector comprising a DNA sequence encoding amino acid residues 1-425 and expressing a polypeptide.
摘要翻译：本发明提供了A型或E型轻链型肉毒杆菌毒素的制备方法，其中所述制剂既具有催化活性，又具有可溶性。优选地，制剂基本上由A型肉毒毒素轻链的氨基酸残基1至425组成。还提供了筛选抑制剂的方法，其中所述方法包括将测试抑制剂暴露于A型轻链A型肉毒杆菌毒素的制备评估制剂的生物活性。在另一个实施方案中，提供了提供A型肉毒毒素轻链的催化活性可溶性制剂的方法，其中所述方法包括获得包含编码氨基酸残基1〜425的DNA序列并表达多肽的表达载体。

3. 发明授权

US10213288B2 Distal protection filter 有权
公开(公告)号：US10213288B2
公开(公告)日：2019-02-26
申请号：US13472417
申请日：2012-05-15
申请人： Eric Johnson , Gilbert Laroya , Paul Do
发明人： Eric Johnson , Gilbert Laroya , Paul Do
IPC分类号： A61F2/01 , A61B17/221 , A61B17/00 , A61M29/00
摘要： Embodiments of the invention relate generally to devices and methods for providing filtration of debris within a body lumen. More particularly, embodiments of the invention related to devices and methods for providing distal protection to a medical procedure by filtration of debris generated by the medical procedure using filters having a frame with a slidable crossover point.

4. 发明授权

US09265352B2 Heating and cooling sleeping system 有权
标题翻译：加热和冷却睡眠系统
公开(公告)号：US09265352B2
公开(公告)日：2016-02-23
申请号：US14685499
申请日：2015-04-13
申请人： Tim Oakhill , Craig McAndrews , Ken Bower , Craig Miller , Eric Johnson , Michael Schmidt , Lance Ellman
发明人： Tim Oakhill , Craig McAndrews , Ken Bower , Craig Miller , Eric Johnson , Michael Schmidt , Lance Ellman
IPC分类号： A47C21/04 , A47C27/15 , A47C20/04 , A47C27/08 , A47C27/18
CPC分类号： A47C21/044 , A47C20/04 , A47C21/048 , A47C27/081 , A47C27/085 , A47C27/14 , A47C27/15 , A47C27/18 , G05B19/042 , G05B2219/23258
摘要： A sleeping system is described in which comfort systems for a foam mattress assembly are mounted in a foundation assembly supporting the mattress assembly. The comfort systems include an air heating and cooling system, a firmness system and an elevation system. The foam mattress assembly includes a flexible encasement dish into which one or more foam layers are disposed. Blowers for the air system are mounted adjacent the foundation assembly top in direct fluid communication with apertures in the top, minimizing the air flow path from the blower exhaust to the mattress top to reduce air pressure loss and diminishment of the heated or cooled air.
摘要翻译：描述了一种睡眠系统，其中用于泡沫床垫组件的舒适系统安装在支撑床垫组件的基座组件中。舒适系统包括空气加热和冷却系统，坚固系统和升降系统。泡沫床垫组件包括柔性包装盘，其中设置有一个或多个泡沫层。用于空气系统的鼓风机安装在基础组件顶部附近，与顶部的孔直接流体连通，使从鼓风机排气到床垫顶部的空气流动路径最小化，以减少空气压力损失和加热或冷却的空气的减少。

5. 发明授权

US09091555B2 Map version control methods and apparatus for updating the use of network-maintained map data sets for mobile communication devices 有权
标题翻译：用于更新用于移动通信设备的网络维护地图数据集的使用的映射版本控制方法和装置
公开(公告)号：US09091555B2
公开(公告)日：2015-07-28
申请号：US13213797
申请日：2011-08-19
申请人： Jesse Joseph Boudreau , Eric Johnson , Gerhard Dietrich Klassen
发明人： Jesse Joseph Boudreau , Eric Johnson , Gerhard Dietrich Klassen
IPC分类号： G01C21/32 , H04W4/02
CPC分类号： G01C21/32 , H04W4/02
摘要： A method in a mobile device for use in receiving updates of network-maintained map data sets is described. The mobile device receives, through a wireless network, map data for rendering a map. The map data has a plurality of layers, where each of the plurality of layers includes a version number and a plurality of data entries associated therewith. Each of the plurality of data entries indicates a plurality of data points for rendering one or more artifacts or labels within an area of interest of the map. The mobile device stores the map data, and displays the area of interest from the plurality of layers of the stored map data. The mobile device then receives, through the wireless network, an indication of an alternative version of one of the layers of the stored map data. When the version number of the alternative version is greater than the version number of the stored version, the mobile device causes one or more requests for the alternative version of said layer for the area of interest to be sent through the wireless network. The mobile device also receives the alternative version of said layer for the area of interest through the wireless network in response to the one or more requests. The mobile device also then causes the map of the area of interest to be rendered in the display in accordance with the combined plurality of layers of the stored map data, but with use of the alternative version of said layer.
摘要翻译：描述了用于接收网络维护的地图数据集的更新的移动设备中的方法。移动设备通过无线网络接收用于渲染地图的数据。地图数据具有多个层，其中多个层中的每个层包括与其相关联的版本号和多个数据条目。多个数据条目中的每一个指示用于在地图的感兴趣区域内呈现一个或多个工件或标签的多个数据点。移动设备存储地图数据，并从存储的地图数据的多个层中显示感兴趣的区域。然后，移动设备通过无线网络接收存储的地图数据的层之一的替代版本的指示。当替代版本的版本号大于存储版本的版本号时，移动设备通过无线网络发送针对感兴趣区域的所述层的替代版本的一个或多个请求。响应于一个或多个请求，移动设备还通过无线网络接收针对感兴趣区域的所述层的替代版本。然后，移动设备还使得感兴趣区域的映射根据所存储的地图数据的组合的多个层次而在显示器中呈现，但是使用所述层的替代版本。

6. 发明授权

US08934645B2 Interaction of sound, silent and mute modes in an electronic device 有权
标题翻译：声音，静音和静音模式在电子设备中的相互作用
公开(公告)号：US08934645B2
公开(公告)日：2015-01-13
申请号：US12895464
申请日：2010-09-30
申请人： Patrick Coffman , Meriko Borogove , Jonathan Bennett , Gregory Chapman , Anthony Guetta , Deepak Iyer , Eric Johnson
发明人： Patrick Coffman , Meriko Borogove , Jonathan Bennett , Gregory Chapman , Anthony Guetta , Deepak Iyer , Eric Johnson
IPC分类号： H03G3/00 , G06F3/16
CPC分类号： G06F3/165 , G06F17/30743 , H04R29/00
摘要： This is directed to controlling the output of audio based on the mode of an electronic device. In particular, this is directed to an electronic device having a sound mode, silent mode, and mute mode controlling the output of audio along different audio output routes. In the sound mode, all audio can be output, while only registered or authorized audio can be output in the silent mode. In the mute mode, no audio can be output. The sound and silent modes can be enabled using an interface of the device (e.g., a switch having two possible states), while the mute mode can be enabled using an accessory coupled to the device. To disengage the mute mode, a user can provide a corresponding instruction using the accessory, or providing an instruction on the device related to volume control. For example, a user can change the device volume using an on-device interface, or toggle a sound/silent switch to a sound mode.
摘要翻译：这旨在基于电子设备的模式来控制音频的输出。特别地，这涉及具有声音模式，静音模式和静音模式的电子设备，其控制沿着不同音频输出路由的音频输出。在声音模式下，可以输出所有音频，只能以静音方式输出注册或授权音频。在静音模式下，不能输出音频。可以使用设备的接口（例如，具有两种可能状态的开关）来启用声音和静音模式，而可以使用耦合到该设备的附件来启用静音模式。为了解除静音模式，用户可以使用附件提供相应的指令，或者提供与音量控制相关的设备上的指令。例如，用户可以使用设备内接口来更改设备音量，或者将声音/静音开关切换到声音模式。

7. 发明授权

US08523335B2 System for venting gas at ink containers 有权
标题翻译：油墨容器排气系统
公开(公告)号：US08523335B2
公开(公告)日：2013-09-03
申请号：US13107982
申请日：2011-05-16
申请人： Eric Johnson , Jon Olson , Christopher Hibbard , Kent Benjamen Kwan , Geoffrey Philip Dyer , Edward Ellis Esdaile-Watts
发明人： Eric Johnson , Jon Olson , Christopher Hibbard , Kent Benjamen Kwan , Geoffrey Philip Dyer , Edward Ellis Esdaile-Watts
IPC分类号： B41J2/175
CPC分类号： B41J2/1752 , B41J2/16535 , B41J2/16541 , B41J2/16585 , B41J2/175 , B41J2/17553 , B41J2/17556 , B41J2/19
摘要： A system for venting gas at ink containers which supply inks to a multi-channel inkjet printhead is provided having a plurality of ink containers for supplying fluids to a printhead having a plurality of ink channels, and a gas vent assembly having a plurality of gas vents. Each ink container has an ink port connected to a corresponding one of the ink channels of the printhead and a gas port. Each gas vent is connected to a corresponding one of the gas ports of the ink containers. The gas vents of the gas vent assembly are in fluid communication with the external atmosphere.
摘要翻译：提供了一种用于将油墨供应给多通道喷墨打印头的油墨容器排气的系统，其具有用于向具有多个油墨通道的打印头供应流体的多个油墨容器，以及具有多个气体通风口的排气组件。每个墨水容器具有连接到打印头的相应一个墨水通道和气体端口的墨水口。每个气体通气口连接到墨水容器的相应一个气体端口。排气口组件的气体通风口与外部气氛流体连通。

8. 发明授权

US08457302B1 Access-controlled data storage medium 有权
标题翻译：访问控制的数据存储介质
公开(公告)号：US08457302B1
公开(公告)日：2013-06-04
申请号：US09700656
申请日：1999-05-17
申请人： Harald Vater , Hermann Drexler , Eric Johnson
发明人： Harald Vater , Hermann Drexler , Eric Johnson
IPC分类号： H04L9/00 , H04L9/28 , H04K1/00 , G06F12/14
CPC分类号： H04L9/003 , G06F21/755 , G06F21/77 , G06K19/07363 , G06Q20/341 , G07F7/082 , G07F7/1008 , H04L2209/08
摘要： The invention relates to a data carrier (1) having a semiconductor chip (5). In order to prevent an attacker from determining secret data of the chip (5) from intercepted signal patterns of the chip (5), security-relevant operations are performed only with commands or command strings of the operating program whose use does not permit the processed data to be inferred from the signal patterns.
摘要翻译：本发明涉及一种具有半导体芯片（5）的数据载体（1）。为了防止攻击者从芯片（5）的截取的信号模式中确定芯片（5）的秘密数据，只有使用不允许处理的操作程序的命令或命令字符串执行与安全相关的操作从信号模式推断的数据。

9. 发明授权

US08424611B2 Downhole safety valve having flapper and protected opening procedure 有权
标题翻译：井下安全阀具有挡板和保护开启程序
公开(公告)号：US08424611B2
公开(公告)日：2013-04-23
申请号：US12548853
申请日：2009-08-27
申请人： Roddie R. Smith , Michael J. Foster , Eric Johnson
发明人： Roddie R. Smith , Michael J. Foster , Eric Johnson
IPC分类号： E21B34/14
CPC分类号： E21B34/14 , E21B41/0021 , E21B2034/005
摘要： A downhole valve has a closure device (e.g., one or more flappers) for closing off the valve. A no-go actuation mechanism protects the flappers from damage. When the flappers are closed, the mechanism prevents a tool from passing into the valve and causing damage to the flappers. Yet, the mechanism may open the valve's flappers when the tool string is forced into the valve. When the valve has successfully opened, then the mechanism moves out of the way of the toolstring so it can pass through the valve. For the mechanically operated valves, operators use a shifting profile in the valve only in the upward direction to return the valve to the closed position. For hydraulic actuated valves, hydraulic pressure may be used or exhausted, depending on the design, to allow the flappers to go closed. Once the flappers have closed, the no-go mechanism is once again realized.
摘要翻译：井下阀具有用于关闭阀的闭合装置（例如，一个或多个挡板）。不起动致动机构保护挡板免受损坏。当盖板关闭时，该机构防止工具进入阀门并导致刮板损坏。然而，当工具串被迫进入阀门时，该机构可以打开阀的挡板。当阀门成功打开时，机构就会移动到工具串的方式，使其能够通过阀门。对于机械操作的阀门，操作人员仅在向上的方向上使用阀门中的换档曲线，使阀门返回关闭位置。对于液压致动阀，可以根据设计使用或排出液压，以允许挡板关闭。一旦挡板关闭，再次实现了脱扣机构。

10. 发明授权

US08290440B2 High performance mobility network with autoconfiguration 有权
标题翻译：具有自动配置功能的高性能移动网络
公开(公告)号：US08290440B2
公开(公告)日：2012-10-16
申请号：US12496398
申请日：2009-07-01
申请人： Chris Williams , Eric Johnson , Dave Park , Marcel Chenier , Stephen Rayment , Roland A. Smith
发明人： Chris Williams , Eric Johnson , Dave Park , Marcel Chenier , Stephen Rayment , Roland A. Smith
IPC分类号： H04B1/00 , H04B15/00
CPC分类号： H04W72/02 , H01Q1/246 , H01Q21/205 , H04W16/28 , H04W24/02 , H04W84/18 , H04W88/02 , H04W88/08
摘要： A high performance wireless mesh architecture which has been optimized for mobile end points is described. The mesh architecture is intended for Navy applications, where the wireless mesh network extends between mobile ships and includes ship-to-shore links, but it is equally applicable to other mobile elements on, in, or under land, air, sea, or space.
摘要翻译：描述了针对移动端点进行了优化的高性能无线网状结构。网格架构适用于海军应用，其中无线网状网络在移动船之间延伸并且包括船对岸链路，但它同样适用于陆上，空中，海上或空间内的其他移动元件。

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