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1. 发明申请

US20100215624A1 Pharmaceutical Compositions for Treating Rheumatoid Arthritis Comprising Semi-Mature Dendritic Cell 审中-公开
标题翻译：用于治疗包含半成熟树突状细胞的类风湿关节炎的药物组合物
公开(公告)号：US20100215624A1
公开(公告)日：2010-08-26
申请号：US12597259
申请日：2008-03-12
申请人： Mi-Sun Kang , Dae-Seog Lim , Ju-Ah Jeong , Hyun-Soo Lee , Yong-Soo Bae
发明人： Mi-Sun Kang , Dae-Seog Lim , Ju-Ah Jeong , Hyun-Soo Lee , Yong-Soo Bae
IPC分类号： A61K35/30 , C12N5/0784 , A61P29/00 , A61P19/00
CPC分类号： A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N5/064 , C12N2501/22 , C12N2501/25
摘要： The present invention relates to a pharmaceutical composition for treating rheumatoid arthritis, which comprises (a) a pharmaceutically effective amount of a semi-mature dendritic cell; and (b) a pharmaceutically acceptable carrier. The semi-mature dendritic cell of this invention has a safe and remarkably improved potential to treat or prevent rheumatoid arthritis through the activity of the suppression of auto-immune responses.
摘要翻译：本发明涉及一种用于治疗类风湿性关节炎的药物组合物，其包含（a）药学有效量的半成熟树突状细胞; 和（b）药学上可接受的载体。本发明的半成熟树突状细胞通过抑制自身免疫应答的活性具有安全和显着改善的治疗或预防类风湿性关节炎的潜力。

2. 发明申请

US20100235932A1 ANIMAL MODELS CARRYING TUMORS EXPRESSING HUMAN LIVER CANCER-SPECIFIC ANTIGEN AND METHOD FOR ANALYZING PREVENTION AND TREATMENT EFFICACY OF DENDRITIC CELLS-DERIVED IMMUNOTHERAPEUTICS USING THE ABOVE 审中-公开
标题翻译：携带肿瘤的动物模型表达人肝癌特异性抗原和分析预防和治疗使用上述细胞衍生的免疫球蛋白的效果的方法
公开(公告)号：US20100235932A1
公开(公告)日：2010-09-16
申请号：US12451508
申请日：2008-03-13
申请人： Yong-Soo Bae , Hyun-Soo Lee , Mi-Kyung Min , Cheol-Woong Jeong , Kyu-Ho Kang
发明人： Yong-Soo Bae , Hyun-Soo Lee , Mi-Kyung Min , Cheol-Woong Jeong , Kyu-Ho Kang
IPC分类号： A01K67/00 , C12N5/071
CPC分类号： G01N33/57438 , A61K35/12 , A61K39/0011 , A61K2039/5154 , A61K2039/6075 , C07K14/4748 , C12N2799/027
摘要： The present invention relates to a method for analyzing the prevention and treatment efficacy of a dendritic cell-derived immunotherapeutic for liver cancer using an animal model carrying tumors expressing a human liver cancer-specific antigen, which comprises the steps of: (a) (a1) administering to a normal animal other than human dendritic cells to be analyzed, or (a1) administering to a normal animal other than human a cancer cell line expressing the human liver cancer-specific antigen to induce cancer in the normal animal; (b) (b1) administering to the animal the cancer cell line expressing the human liver cancer-specific antigen to induce cancer in the animal when the step (a1) is performed in the step (a), or (b1) administering to the animal with cancer dendritic cells to be analyzed when the step (a1) is performed in the step (a); and (c) determining the prevention and treatment efficacy of the dendritic cells as immunotherapeutics for liver cancer by measuring the formation or growth of cancer cells originated from the cancer cell line in the animal.
摘要翻译：本发明涉及使用携带表达人肝癌特异性抗原的肿瘤的动物模型分析来自树突状细胞的免疫治疗用于肝癌的预防和治疗功效的方法，其包括以下步骤：（a）（a1））给予除了待分析的人树突状细胞以外的正常动物，或（a1）向正常动物中的表达人肝癌特异性抗原的癌细胞系的人以外的正常动物施用癌细胞系，（b）（b1）在步骤（a）中进行步骤（a1）时，（b1）向动物施用表达人肝癌特异性抗原的癌细胞系以在动物中诱导癌症，或（b1）当在步骤（a）中进行步骤（a1）时，分析具有癌症树突状细胞的动物; 和（c）通过测量来源于动物的癌细胞系的癌细胞的形成或生长来确定树突状细胞作为肝癌的免疫治疗剂的预防和治疗功效。

3. 发明申请

US20120328932A1 Rechargeable battery and method for manufacturing the same 有权
标题翻译：可充电电池及其制造方法
公开(公告)号：US20120328932A1
公开(公告)日：2012-12-27
申请号：US13317649
申请日：2011-10-25
申请人： Min-Hyung Guen , Hyun-Soo Lee , Yong-Chul Seo
发明人： Min-Hyung Guen , Hyun-Soo Lee , Yong-Chul Seo
IPC分类号： H01M2/02
CPC分类号： H01M2/024 , H01M2/043 , H01M2/06 , H01M2/08 , H01M2/1241 , H01M2/266 , H01M2/305 , H01M10/0413 , Y10T29/49108 , Y10T29/4911
摘要： A rechargeable battery includes an electrode assembly having electrodes on opposite sides of a separator, a case retaining the electrode assembly, a cap plate coupled with an opening of the case, electrode terminals extending through terminal holes of the cap plate, lead tabs connecting the electrode terminals to the electrode assembly, the electrode terminals being electrically connected to the lead tabs at connection parts, and insulators, the connection parts being embedded in the insulators.
摘要翻译：可再充电电池包括在隔板的相对侧上具有电极的电极组件，保持电极组件的壳体，与壳体的开口耦合的盖板，延伸穿过盖板的端子孔的电极端子，将电极端子到电极组件，电极端子电连接到连接部分处的引线片和绝缘体，连接部分嵌入绝缘体中。

4. 发明授权

US06713611B2 Method for removing endotoxin from the samples containing basic protein 失效
标题翻译：从含有碱性蛋白质的样品中去除内毒素的方法
公开(公告)号：US06713611B2
公开(公告)日：2004-03-30
申请号：US09948491
申请日：2001-09-06
申请人： Sang-Hyun Pyo , Heung-Bok Park , Jin-Eon So , Jin-Hyun Kim , Seung-Suh Hong , Hyun-Soo Lee
发明人： Sang-Hyun Pyo , Heung-Bok Park , Jin-Eon So , Jin-Hyun Kim , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C07K118
CPC分类号： C07K1/18
摘要： The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the surfactant to solution containing the basic protein obtained from the recombinant microorganism and mixing the resultant, of loading the resultant solution on the cation exchange column, washing the cation exchange column with solution which does not contain surfactant, and eluting the basic protein of interest from the cation exchange column.
摘要翻译：本发明涉及从含有碱性蛋白质的溶液中除去内毒素的方法。更具体地说，本发明的方法包括以下步骤：将表面活性剂加入含有由重组微生物获得的碱性蛋白质的溶液中，并将所得溶液混合，将所得溶液装载到阳离子交换柱上，用溶液洗涤阳离子交换柱其不含表面活性剂，并从阳离子交换柱洗脱出所需的碱性蛋白质。

5. 发明授权

US06531446B1 Peptides having biological activity 有权
标题翻译：具有生物活性的肽
公开(公告)号：US06531446B1
公开(公告)日：2003-03-11
申请号：US09600710
申请日：2000-11-02
申请人： Sun-Chang Kim , Chan-Bae Park , Jae-Hyun Lee , Seung-Suh Hong , Hyun-Soo Lee
发明人： Sun-Chang Kim , Chan-Bae Park , Jae-Hyun Lee , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C07K400
CPC分类号： C07K7/08 , A61K38/00 , C07K14/463
摘要： The present invention relates to peptides that are more potent than or equally potent as the conventional antimicrobial peptides and has strong antimicrobial activities at high salt concentration.
摘要翻译：本发明涉及比常规抗微生物肽更有效或同样有效的肽，并且在高盐浓度下具有很强的抗微生物活性。

6. 发明授权

US5871979A Method for mass production of taxol by semi-continuous culture with Taxus chinensis cell culture 失效
标题翻译：紫杉醇细胞培养半连续培养紫杉醇大量生产方法
公开(公告)号：US5871979A
公开(公告)日：1999-02-16
申请号：US652492
申请日：1996-05-28
申请人： Hyung-Kyoon Choi , Tom Lee Adams , Roy William Stahlhut , Sang-Ic Kim , Jeong-Hwan Yun , Bong-Kyu Song , Jin-Hyun Kim , Jun-Seog Song , Seung-Suh Hong , Hyun-Soo Lee
发明人： Hyung-Kyoon Choi , Tom Lee Adams , Roy William Stahlhut , Sang-Ic Kim , Jeong-Hwan Yun , Bong-Kyu Song , Jin-Hyun Kim , Jun-Seog Song , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C12P15/00 , C07D305/14 , C12P17/02 , C12R1/91
CPC分类号： C12P17/02
摘要： The present invention relates to a method for mass production of taxol by semi-continuous culture of Taxus genus plant with a high yield. According to the present invention, taxol can be prepared with a high yield, by employing semi-continuous culture of Taxus genus plant cell, which comprises: (i) inoculating Taxus genus plant cell on a medium containing 1 to 10% (w/v) sugar, and incubating it; and, (ii) transferring 1/10 to 1/2 volume of the culture obtained in the step (i) to a fresh medium and repeating the step (i), adding 1 to 10% (w/v) sugar to the remnant culture and incubating to the time of maximum production of taxol.
摘要翻译： PCT No.PCT / KR96 / 00060 Sec。 371日期：1996年5月28日 102（e）日期1996年5月28日PCT提交1996年4月27日PCT公布。公开号WO96 / 34110 PCT 日期：1996年10月31日本发明涉及一种高产量紫杉属半连续培养紫杉醇的大规模生产方法。根据本发明，通过采用紫杉属植物细胞的半连续培养，可以高产率制备紫杉醇，其包括：（i）将紫杉属植物细胞接种在含有1至10％（w / v））糖，并孵化; 将步骤（i）中获得的培养物的+ E，fra 1/10 + EE转化为+ E，将1/2 + EE体积转移到新鲜培养基中，并重复步骤（i），加入1 到10％（w / v）的糖到残留的培养物，并孵育到紫杉醇的最大生产时间。

7. 再颁专利

USRE48198E1 Loading space variable refrigeration system of refrigerator car 有权
公开(公告)号：USRE48198E1
公开(公告)日：2020-09-08
申请号：US16164435
申请日：2018-10-18
申请人： Hyun-Soo Lee , A-Gi Kim
发明人： Hyun-Soo Lee , A-Gi Kim
IPC分类号： B60P3/20 , B62D33/04
摘要： Disclosed is a loading space variable refrigeration system of a refrigerator vehicle, which can vary a loading space in a refrigeration trailer of a refrigerator vehicle according to volume of loads, thereby reducing fuel and oil costs for cool-air supply and can rapidly vary the loading space through simple operator manipulation. The refrigeration system includes a horizontal bulkhead moving in an upper space of the refrigeration trailer and defining the upper space and a vertical bulkhead moving in a rear space of the refrigeration trailer and defining the rear space, wherein an uncooling region is set in a cooling space of the refrigeration trailer by the horizontal and vertical bulkheads.

8. 发明申请

US20110128748A1 METHOD OF CONTROLLING ADAPTIVE HEADLAMP 审中-公开
标题翻译：控制自适应头灯的方法
公开(公告)号：US20110128748A1
公开(公告)日：2011-06-02
申请号：US12835379
申请日：2010-07-13
申请人： Sung Uk Choi , Hun Soo Kim , Hee Jun Jeong , Se Wook Oh , Hyun-Soo Lee
发明人： Sung Uk Choi , Hun Soo Kim , Hee Jun Jeong , Se Wook Oh , Hyun-Soo Lee
IPC分类号： B60Q1/04
CPC分类号： B60Q1/076 , B60Q2200/38
摘要： A method of controlling an adaptive head lamp including a control unit for detecting a driving signal of a vehicle to control an actuator which controls the head lamp in a horizontal or vertical direction in accordance with a control signal of the control unit, may include steps of, a) verifying whether an ignition of the vehicle is turned on or off, b) after the ignition of the vehicle is verified, driving the actuator to move the head lamp to a rightmost or leftmost position in the horizontal direction, or a lowermost or uppermost position in the vertical direction, c) driving the actuator by a predetermined number of pulses previously set in a micro stepping manner in a direction opposite to a driving direction of the headlamp at the step b), and d) setting a position of the head lamp determined at the step c) as an initial position.
摘要翻译：一种控制自适应头灯的方法，包括：控制单元，用于根据控制单元的控制信号，检测车辆的驱动信号，以控制在水平或垂直方向上控制头灯的致动器，可以包括以下步骤：，a）验证车辆的点火是否被打开或关闭，b）在确认车辆点火之后，驱动致动器将前灯沿水平方向或最下方或最下方移动到最右侧或最左侧位置， c）在步骤b）中，以与步进方向相反的方向以微步进方式预先设定的预定数量的脉冲驱动致动器，以及d）设定位置在步骤c）中确定的头灯作为初始位置。

9. 发明授权

US06376658B1 Proteins related to encapsulation and genes encoding the same 有权
标题翻译：与封装相关的蛋白质和编码相同的基因
公开(公告)号：US06376658B1
公开(公告)日：2002-04-23
申请号：US09521780
申请日：2000-03-09
申请人： Bok Luel Lee , Mi Young Cho , Chong Jin Park , Seung-Suh Hong , Hyun-Soo Lee
发明人： Bok Luel Lee , Mi Young Cho , Chong Jin Park , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C07H2104
CPC分类号： C07K14/43563 , A61K38/00 , A61K39/00 , Y02A50/412
摘要： The present invention relates to a protein related to encapsulation in immune reaction and a gene encoding the same.
摘要翻译：本发明涉及与免疫反应中的包封有关的蛋白质及其编码基因。

10. 发明授权

US06248572B1 Production of taxol from taxus plant cell culture adding silver nitrate 有权
标题翻译：从紫杉醇植物细胞培养物中加入硝酸银生产紫杉醇
公开(公告)号：US06248572B1
公开(公告)日：2001-06-19
申请号：US09218406
申请日：1998-12-22
申请人： Hyung-Kyoon Choi , Tom Lee Adams , Roy William Stahlhut , Sang-Ic Kim , Jeong-Hwan Yun , Bong-Kyu Song , Jin-Hyun Kim , Jun-Seog Song , Seung-Suh Hong , Hyun-Soo Lee , Ho-Joon Choi
发明人： Hyung-Kyoon Choi , Tom Lee Adams , Roy William Stahlhut , Sang-Ic Kim , Jeong-Hwan Yun , Bong-Kyu Song , Jin-Hyun Kim , Jun-Seog Song , Seung-Suh Hong , Hyun-Soo Lee , Ho-Joon Choi
IPC分类号： C12P1702
CPC分类号： C12P17/02
摘要： The present invention provides a method for mass production of taxol which comprises adding sugar into a culture medium containing sugar in the course of semicontinuous culture of Taxus genus plant cell, and a universal method for mass production of taxol which comprises culturing Taxus genus plant cell in a culture medium containing sugar and AgNO3 as well. In accordance with the present invention, large amount of taxol can be produced with a high yield, simply by manipulating the culture condition of Taxus genus plant cell culture.
摘要翻译：本发明提供一种紫杉醇的批量生产方法，其包括在紫杉属植物细胞的半连续培养过程中向含有糖的培养基中加入糖，以及大量生产紫杉醇的通用方法，其包括将紫杉属植物细胞培养还含有糖和AgNO3的培养基。根据本发明，通过操纵紫杉属植物细胞培养物的培养条件，可以高产量生产大量紫杉醇。

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