会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明授权
    • Method for purification of paclitaxel from paclitaxel-containing materials
    • 从含紫杉醇的材料中纯化紫杉醇的方法
    • US07259268B2
    • 2007-08-21
    • US11028487
    • 2004-12-30
    • Sang-Hyun PyoMoon-Suk KimJin-Suk ChoBong-Kyu SongHo-Joon Choi
    • Sang-Hyun PyoMoon-Suk KimJin-Suk ChoBong-Kyu SongHo-Joon Choi
    • C07D305/00C07D407/00C07D493/00
    • C07D305/14
    • This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield.
    • 本发明涉及从含紫杉醇的材料中纯化紫杉醇的方法。 该方法包括以下步骤:(a)用有机溶剂萃取含有紫杉醇的材料,得到提取物,浓缩提取物; (b)将浓缩物与不与水混合的有机溶剂加入以分离有机溶剂相,然后浓缩; (c)使浓缩物进行正相色谱以获得洗脱液; (d)将洗脱液溶解在丙酮或二氯甲烷中,然后加入戊烷或己烷以形成沉淀物; 和(e)使沉淀物进行高效液相色谱。 根据本发明的方法,可以容易地从具有高收率的紫杉属植物获得纯度超过99.5%的紫杉醇。
    • 10. 发明申请
    • Method for purification of paclitaxel from paclitaxel-containing materials
    • 从含紫杉醇的材料中纯化紫杉醇的方法
    • US20050154218A1
    • 2005-07-14
    • US11028487
    • 2004-12-30
    • Sang-Hyun PyoMoon-Suk KimJin-Suk ChoBong-Kyu SongHo-Joon Choi
    • Sang-Hyun PyoMoon-Suk KimJin-Suk ChoBong-Kyu SongHo-Joon Choi
    • C07D305/14C07D35/12
    • C07D305/14
    • This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield.
    • 本发明涉及从含紫杉醇的材料中纯化紫杉醇的方法。 该方法包括以下步骤:(a)用有机溶剂萃取含有紫杉醇的材料,得到提取物,浓缩提取物; (b)将浓缩物与不与水混合的有机溶剂加入以分离有机溶剂相,然后浓缩; (c)使浓缩物进行正相色谱以获得洗脱液; (d)将洗脱液溶解在丙酮或二氯甲烷中,然后加入戊烷或己烷以形成沉淀物; 和(e)使沉淀物进行高效液相色谱。 根据本发明的方法,可以容易地从具有高收率的紫杉属植物获得纯度超过99.5%的紫杉醇。