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1. 发明授权

US6071237A Device and method for assessing perfusion failure in a patient during endotracheal intubation 有权
标题翻译：在气管插管期间评估患者灌注失败的装置和方法
公开(公告)号：US6071237A
公开(公告)日：2000-06-06
申请号：US252633
申请日：1999-02-19
申请人： Max Harry Weil , Wanchun Tang , Jose Bisera
发明人： Max Harry Weil , Wanchun Tang , Jose Bisera
IPC分类号： A61B5/08 , A61B5/00 , A61B5/083 , A61M16/04
CPC分类号： A61B5/1459 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/6853 , A61M16/04 , A61M16/0443 , A61M2230/202
摘要： A device and method are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, wherein the patient requires mechanical ventilatory support. The invention involves measurement of PCO.sub.2 (partial pressure of carbon dioxide) within the lower respiratory tract of the patient, using a device that includes an endotracheal breathing tube for introducing air from an air supply pump into a patient's lungs, wherein a carbon dioxide sensor is provided as an integral part of that device, i.e., is physically connected to the endotracheal breathing tube in a manner that allows for PCO.sub.2 measurement along the sidewall of the patient's trachea.
摘要翻译：提供了一种用于评估患者血液循环的损伤的装置和方法，例如在灌注失败中的损伤，其中患者需要机械通气支持。本发明涉及使用包括用于将空气从空气供应泵引入患者肺部的气管内呼吸管的装置测量患者下呼吸道内的PCO2（二氧化碳分压），其中二氧化碳传感器是作为该装置的组成部分提供，即以允许沿着患者气管的侧壁进行PCO2测量的方式物理连接到气管内呼吸管。

2. 发明授权

US06258046B1 Method and device for assessing perfusion failure in a patient by measurement of blood flow 有权
标题翻译：通过测量血流量来评估患者灌注失败的方法和装置
公开(公告)号：US06258046B1
公开(公告)日：2001-07-10
申请号：US09285409
申请日：1999-04-02
申请人： Victor E. Kimball , Max Harry Weil , Wanchun Tang , Jose Bisera
发明人： Victor E. Kimball , Max Harry Weil , Wanchun Tang , Jose Bisera
IPC分类号： A61B500
CPC分类号： A61B5/14542 , A61B5/0071 , A61B5/0084 , A61B5/0261 , A61B5/14539 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/682 , A61B8/06 , A61B8/12
摘要： Methods and devices are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of blood flow in the gastrointestinal tract or upper respiratory/digestive tract of the patient. The method comprises introducing a blood-flow sensor into the gastrointestinal tract or the upper respiratory/digestive tract of a patient, placing the sensor adjacent a mucosal surface therein, and measuring blood flow in adjacent tissue to determine blood flow in that tissue. The method may also involve measurement of PCO2 and/or pH in combination with the blood flow determination. The invention affords rapid measurement and detection of perfusion failure.
摘要翻译：提供方法和装置，用于通过测量患者的胃肠道或上呼吸/消化道中的血流量来评估患者血液循环的损伤，例如灌注失败。该方法包括将血流传感器引入到患者的胃肠道或上呼吸/消化道中，将传感器放置在其中的粘膜表面附近，并测量相邻组织中的血流量以确定该组织中的血流。该方法还可以包括与血流测定结合的PCO2和/或pH的测量。本发明提供了快速测量和检测灌注失败。

3. 发明授权

US06369114B1 Administration of an &agr;2-adrenergic receptor agonist to enhance cardiopulmonary resuscitation 失效
标题翻译：施用α2-肾上腺素能受体激动剂以增强心肺复苏
公开(公告)号：US06369114B1
公开(公告)日：2002-04-09
申请号：US09451468
申请日：1999-11-30
申请人： Max Harry Weil , Wanchun Tang , Jose Bisera
发明人： Max Harry Weil , Wanchun Tang , Jose Bisera
IPC分类号： A01N4346
CPC分类号： A61K31/00 , A61K31/137 , A61K45/06 , Y10S514/821 , Y10S514/854
摘要： Methods, formulations and kits are described for resuscitating a patient suffering from cardiac arrest, for enhancing the efficacy of cardiopulmonary resuscitation, for treating post-resuscitation hypotension, and for reducing the incidence of ventricular arrhythmias and myocardial dysfunction in a patient following cardiopulmonary resuscitation. Prior methods and agents often cause inotropic or chronotropic effects, which can lead to undesirable post-resuscitation myocardial dysfunction. The invention comprises administering a therapeutically effective amount of an &agr;2-receptor agonist that does not cross the blood-brain barrier, such as &agr;-methylnorepinephrine, to enhance cardiopulmonary resuscitation.
摘要翻译：描述了用于复苏心脏停搏的患者的方法，制剂和试剂盒，用于增强心肺复苏的功效，用于治疗复苏后的低血压，以及降低心肺复苏术后患者的室性心律失常和心肌功能障碍的发生率。先前的方法和试剂通常会引起变力或变时效应，这可能导致不希望的复苏后心肌功能障碍。本发明包括施用治疗有效量的不穿过血脑屏障的α2受体激动剂，例如α-甲基去甲肾上腺素，以增强心肺复苏。

4. 发明授权

US6055447A Patient CO.sub.2 Measurement 失效
标题翻译：患者二氧化碳测量
公开(公告)号：US6055447A
公开(公告)日：2000-04-25
申请号：US99293
申请日：1998-06-18
申请人： Max Harry Weil , Wanchun Tang , Jose Bisera
发明人： Max Harry Weil , Wanchun Tang , Jose Bisera
IPC分类号： A61B5/00 , A61B5/026
CPC分类号： A61B5/14542 , A61B5/0261 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/682
摘要： A method and apparatus are provided for assessing impairment of blood circulation of a patient by measurement of PCO.sub.2 (partial pressure of carbon dioxide) in the upper digestive/respiratory tract of the patient. The method includes introducing a CO.sub.2 sensor into the mouth-nose area and against a mucosal surface. In one example, the sensor is placed under the tongue, in the manner of an oral thermometer, and sublingual (under the tongue) measurements of CO.sub.2 are taken. This allows for the triage of patients or victims in emergency of disaster settings. The measurement involves minimal invasion while avoiding false readings. For monitoring of more than about one or two minutes, holders are used to hold the CO.sub.2 sensor instrument stabily in the mouth or nose, and to isolate the mucosal area immediately around the CO.sub.2 sensor from air flow that could carry away CO.sub.2, while maintaining high humidity.
摘要翻译：提供了一种通过测量患者上消化道/呼吸道中PCO2（二氧化碳分压）来评估患者血液循环障碍的方法和装置。该方法包括将CO 2传感器引入口鼻部区域并抵靠粘膜表面。在一个示例中，传感器以口腔温度计的方式置于舌下，并且采用舌下（舌下）测量二氧化碳。这样可以在紧急情况下对患者或受害者进行分诊。测量涉及到最小的入侵，同时避免误读。为了监测超过约一到两分钟，保持器用于将CO2传感器仪器稳定地保持在嘴或鼻中，并将CO2传感器周围的粘膜区域与可能携带CO 2的空气流隔离，同时保持高度湿度。

5. 发明授权

US06216024B1 Method and device for assessing perfusion failure in a patient 有权
标题翻译：评估患者灌注失败的方法和装置
公开(公告)号：US06216024B1
公开(公告)日：2001-04-10
申请号：US09160224
申请日：1998-09-24
申请人： Max Harry Weil , Wanchun Tang , Jose Bisera
发明人： Max Harry Weil , Wanchun Tang , Jose Bisera
IPC分类号： A61B500
CPC分类号： A61B5/0261 , A61B5/14542 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/682
摘要： Methods and devices are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of pCO2 (partial pressure of carbon dioxide) in the upper digestive and/or respiratory tract of the patient. The method comprises introducing a carbon dioxide sensor into the upper digestive and/or respiratory tract of a patient, without passing the sensor down through or beyond the patient's epiglottis. Specifically, a carbon dioxide sensor is placed adjacent a mucosal surface within the upper digestive and/or respiratory tract, preferably within the patient's mouth or inside the patient's nose. By avoiding passage through the mouth into the throat and esophagus, discomfort is substantially avoided and the potential for injury minimized. Previously, the belief in the art was that increased partial pressure of carbon dioxide was a localized phenomenon during perfusion failure; however, applicants have now discovered that increases in tissue CO2 occur throughout the body during perfusion failure, and the method and device of the invention are premised on this discovery.
摘要翻译：提供了通过测量患者上消化道和/或呼吸道中pCO2（二氧化碳分压）来评估患者血液循环障碍（如灌注失败）的方法和装置。该方法包括将二氧化碳传感器引入患者的上消化道和/或呼吸道中，而不会使传感器向下穿过或超过患者的会厌。具体来说，将二氧化碳传感器放置在上消化道和/或呼吸道内的粘膜表面附近，优选在病人口内或患者鼻内。通过避免通过口腔进入喉咙和食道，基本上避免了不适，并减少了伤害的可能性。以前，对艺术的信念是，二氧化碳的分压增加是灌注失败期间的局部现象; 然而，申请人现在已经发现，在灌注失败期间，整个身体中发生组织CO 2的增加，并且本发明的方法和装置以该发现为前提。

6. 发明授权

US06171257B2 Method and system for predicting the immediate success of a defibrillatory shock during cardiac arrest 有权
标题翻译：用于预测心脏骤停期间除颤器休克的直接成功的方法和系统
公开(公告)号：US06171257B2
公开(公告)日：2001-01-09
申请号：US09385537
申请日：1999-08-30
申请人： Max Harry Weil , Wanchun Tang , Joe Bisera
发明人： Max Harry Weil , Wanchun Tang , Joe Bisera
IPC分类号： A61B5046
CPC分类号： A61N1/39 , A61N1/36592 , A61N1/3925
摘要： A method and system (30, 50) for predicting the immediate success of a defibrillatory shock during cardiac arrest are shown. The sequencing of cardiopulmonary resuscitation is determined by an electronic computer (80) based on the probability of success as determined by a comparison of the amplitude spectrum area or the power spectrum area of an electrocardiogram sample and to empirical data. When the probability of successful resuscitation is 80% or greater, immediate defibrillation is implemented. When the probability of success is 20% or less, advanced cardiopulmonary resuscitation is implemented. When the probability of success remains greater than 20% but less than 80% for a period of four minutes, the patient is also defibrillated.
摘要翻译：示出了用于预测心脏骤停期间除颤器休克的直接成功的方法和系统（30,50）。基于通过心电图样本的振幅谱面积或功率谱面积的比较确定的成功概率与经验数据，由电子计算机（80）确定心肺复苏的顺序。当成功复苏的概率为80％以上时，立即进行除颤。当成功的概率在20％以下时，进行先进的心肺复苏。当成功的概率在四分钟的时间内保持大于20％但小于80％时，患者也被除颤。

7. 发明授权

US07570993B2 Enhanced CPR protector system 失效
公开(公告)号：US07570993B2
公开(公告)日：2009-08-04
申请号：US09953032
申请日：2001-09-12
申请人： Max Harry Weil , Wanchun Tang , Joe Bisera
发明人： Max Harry Weil , Wanchun Tang , Joe Bisera
IPC分类号： A61N1/39
CPC分类号： A61N1/046 , A61N1/0472 , A61N1/0484 , A61N1/14
摘要： Apparatus is provided for treatment of a victim to reverse cardiac arrest by chest compression and by electrical defibrillation through electrodes applied to the chest area of the victim. The apparatus includes a dielectric layer which is placed on the victim to electrically isolate the rescuer who is performing chest compressions. The protective sheet includes a layer of electrically conductive material sandwiched between two dielectric layers to electrically isolate the rescuer. The sandwiched conductive layer is connected to a location on the body of the victim that is spaced a plurality of inches from each of the electrodes.

8. 发明申请

US20080086057A1 Microcirculation imaging 有权
标题翻译：微循环成像
公开(公告)号：US20080086057A1
公开(公告)日：2008-04-10
申请号：US11524866
申请日：2006-09-21
申请人： Alain L. Fymat , Max Harry Weil , Wanchun Tang , Joe Bisera , Giuseppe Ristagno
发明人： Alain L. Fymat , Max Harry Weil , Wanchun Tang , Joe Bisera , Giuseppe Ristagno
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/02007 , A61B5/0261 , A61B5/412
摘要： A real time image is created of blood circulation deep (e.g. a plurality of millimeters) below the surface of living tissue to aid in evaluating a patient. A first beam (26) of circularly polarized light is directed forwardly (F) against an outer surface (14) of the tissue, the circularly polarized beam penetrating into a deep region (12) of the tissue. Along shallow depths (42), light of the first beam is scattered a minimum amount from tissue and a portion of such light that passes rearwardly and out of the tissue remains polarized. Along greater depths (12), light of the first beam is scattered much more and becomes depolarized, and a portion of that deep light travels rearwardly (R) and back illuminates the overlying tissue. Light emerging from the outer surface of the tissue and traveling rearwardly, which constitutes a second beam (36), is passed through a depolarizing filter (24) that passes primarily only unpolarized light, so light from a shallow depth is largely blocked. The unpolarized light of the filtered second beam is focused on a photodetector (48) that creates electrical signals representing a real time image. Light spots (54) on the image that move, represent spaces between blood platelets (52) that are moving through a capillary, and indicates the velocity of blood through the capillary.
摘要翻译：在生物体组织表面下方深层（例如，多个毫米）产生血液循环的实时图像，以帮助评估患者。圆偏振光的第一光束（26）向前（F）指向组织的外表面（14），圆偏振光束穿透组织的深部区域（12）。沿着浅深度（42），第一光束的光从组织中散射最小量，并且这些光向后通过并从组织出来的部分保持偏振。沿着更深的深度（12），第一光束的光被散射得更多并且变得去极化，并且该一部分深光向后行进（R）并且向后照射上覆的组织。构成第二光束（36）的从组织的外表面向后移动的光通过仅主要通过非偏振光的去极化滤光器（24），因此来自浅深度的光被大大阻挡。被滤波的第二光束的非偏振光聚焦在产生表示实时图像的电信号的光电检测器（48）上。移动的图像上的光点（54）表示在血细胞移动的血小板（52）之间的空间，并且指示通过毛细管的血液的速度。

9. 发明授权

US06360125B1 CPR protector 有权
标题翻译： CPR保护器
公开(公告)号：US06360125B1
公开(公告)日：2002-03-19
申请号：US09217008
申请日：1998-12-21
申请人： Max Harry Weil , Wanchun Tang , Joe Bisera
发明人： Max Harry Weil , Wanchun Tang , Joe Bisera
IPC分类号： A61N139
CPC分类号： A61N1/39
摘要： Apparatus is provided for use during the treatment of a victim undergoing cardiac arrest, to facilitate treatment by chest compression as well as by shocks from an automatic defribrillator. The apparatus includes a sheet of dielectric material that covers much of the victim to electrically isolate a rescuer who is performing chest compressions, from the victim to whom electric shocks are being delivered. Defribrillator electrodes are mounted on the lower face of the sheet and are connected to the defribillator. The sheet extends down along the sides of the victim to isolate the rescuer, who is either standing or kneeling beside the victim to apply chest compressions.
摘要翻译：提供了在治疗受到心脏骤停的受害者的治疗期间使用的装置，以便于通过胸部按压治疗以及来自自动除颤器的冲击。该装置包括覆盖大部分受害者的电介质材料片，以将正在进行胸部按压的救护者从被传送电击的受害者电隔离。除颤电极安装在片材的下表面，并连接到除颤器。该片材沿着受害者的两侧向下延伸，以隔离救护人员，他们站立或跪在受害者旁边以应用胸部按压。

10. 发明授权

US07060041B1 Chest compressor 有权
标题翻译：胸部压缩机
公开(公告)号：US07060041B1
公开(公告)日：2006-06-13
申请号：US09678616
申请日：2000-10-04
申请人： Max Harry Weil , Joe Bisera , Clayton Young , Wanchun Tang
发明人： Max Harry Weil , Joe Bisera , Clayton Young , Wanchun Tang
IPC分类号： A61H31/00 , A61H7/00
CPC分类号： A61H31/006 , A61H1/008 , A61H31/00 , A61H2031/003 , A61H2201/1238 , A61H2201/5007
摘要： Apparatus for compressing the chest of a patient to stimulate blood circulation, includes a torso wrap (32) that has a back portion (40) lying at the back of the patient's chest and a front portion (42) lying at the front of the patient's chest, and includes a compressor assembly with an actuator (16) having a pressing member (12) that can apply a series of force pulses to the sternum of the patient to stimulate blood circulation. The actuator is energized by pressured fluid, with a controlled pressured fluid source (20) connected by an elongated flexible hose (24) to the actuator so the pressured fluid source and a control (22) can lie on the ground and only the actuator lies on the torso wrap. The actuator includes a cylinder (66) and a plurality of telescoping piston parts (64, 66) to provide a long stroke in an actuator of small height. A stabilizer (150) that limits tilt of the actuator from the vertical, includes a saucer-shaped member that presses against the front of the patient.
摘要翻译：用于压缩患者胸部以刺激血液循环的装置包括躯干包裹物（32），其具有位于患者胸部后部的后部（40）和位于患者胸部前方的前部（42）胸部，并且包括具有致动器（16）的压缩机组件，该致动器具有按压构件（12），所述按压构件能够向患者的胸骨施加一系列的力脉冲以刺激血液循环。致动器由加压流体通电，受控的压力流体源（20）通过细长的柔性软管（24）连接到致动器，使得加压流体源和控制器（22）可以位于地面上，并且只有致动器位于在躯干包裹上。致动器包括气缸（66）和多个伸缩式活塞部件（64,66），以在小高度的致动器中提供长行程。限制致动器从垂直方向倾斜的稳定器（150）包括压靠患者前方的碟形构件。

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