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1. 发明授权

US5532411A Production of carboxylic acid halides and carboxylate salts 失效
标题翻译：制备羧酸卤化物和羧酸盐
公开(公告)号：US5532411A
公开(公告)日：1996-07-02
申请号：US233624
申请日：1994-04-26
申请人： Max Braun , Werner Rudolph , Stefan Palsherm , Kerstin Eichholz
发明人： Max Braun , Werner Rudolph , Stefan Palsherm , Kerstin Eichholz
IPC分类号： C07C51/41 , C07C51/60 , C07C53/18 , C07C67/14 , C07C51/58 , C07C69/02
CPC分类号： C07C67/14 , C07C51/60
摘要： A process for preparing carboxylic acid halides and carboxylate salts by reacting metal or "onium" halides with carboxylic anhydrides, which process is very suitable for working-up anhydrous, spent catalyst preparations. The resulting carboxylic acid halide or carboxylate salt can be used as an acylating reagent or alkylating reagent, and metal halide or "onium" halide liberated during this can be reacted anew with carboxylic anhydride and regenerated, thereby making it possible to effect a hydrolysis-free alkylation or acylation without forming salt-type waste products. If the mixture of carboxylic acid halide and carboxylate salt is allowed to react with an alcohol, preferably in situ, the resulting ester can be isolated without hydrolysis.
摘要翻译：通过使金属或“鎓”卤化物与羧酸酐反应来制备羧酸卤化物和羧酸盐的方法，该方法非常适用于加工无水的废催化剂制剂。所得羧酸卤化物或羧酸盐可用作酰化试剂或烷化试剂，并且在此期间释放的金属卤化物或“鎓”卤化物可与羧酸酐重新反应并再生，从而可以实现无水解烷基化或酰化而不形成盐类废物。如果允许羧酸卤化物和羧酸盐的混合物与醇反应，优选原位，所得到的酯可以在不水解的情况下分离。

2. 发明授权

US06723874B1 Method of producing acid fluorides from acid chlorides 失效
标题翻译：从酰氯生产酸性氟化物的方法
公开(公告)号：US06723874B1
公开(公告)日：2004-04-20
申请号：US09856909
申请日：2001-05-30
申请人： Max Braun , Matthias Rieland , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
发明人： Max Braun , Matthias Rieland , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
IPC分类号： C07C5158
CPC分类号： C01B17/4576 , C01B17/4561 , C07C51/58
摘要： Acid fluorides, for example carboxylic acid fluorides and sulfuryl fluoride are produced by reacting the corresponding acid chlorides with hydrogen fluoride adducts of ammonium fluoride or amine hydrofluorides (which act as a catalyst or as a fluorination agent). Consumed HF adducts may be regenerated with HF.
摘要翻译：酸性氟化物，例如羧酸氟化物和硫酰氟通过使相应的酰氯与氟化铵或胺氢氟酸（其充当催化剂或氟化剂）的氟化氢加合物反应来制备。消耗的HF加合物可以用HF再生。

3. 发明授权

US07282120B2 UV-activated chlorination process 失效
标题翻译：紫外线活化氯化法
公开(公告)号：US07282120B2
公开(公告)日：2007-10-16
申请号：US11008109
申请日：2004-12-10
申请人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
发明人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
IPC分类号： C07B63/00 , C07C17/00
CPC分类号： C07C17/10 , C07C17/04 , C07C17/395 , C07C19/01 , C07C19/12 , C07C19/08
摘要： A method of producing alkanes containing chlorine by addition of chlorine to C—C double bonds or C—C triple bonds or by exchange of hydrogen for chlorine by contacting the starting compound in the gas or liquid phase with elemental chlorine and irradiating the reaction mixture with UV light having a wavelength of λ≧280 nm. In this way pentachloroethane can be produced from trichloroethylene, CFC-113 from HCFC-123 or HFC-133a, CFC-112a from HCFC-142b, or HCFC-123 from HCFC-133a. The method also is suitable for separating photochlorinatable impurities from HFC-365-mfc to obtain purified HFC-365-mfc. Advantages include high yields and excellent selectivity.
摘要翻译：通过将氯气加入到CC双键或CC三键中，或通过使气相或液相中的起始化合物与元素氯接触并将反应混合物与具有 λ> 280nm波长。以这种方式，可以从三氯乙烯，来自HCFC-123的CFC-113或HFC-133a，来自HCFC-142b的CFC-112a或来自HCFC-133a的HCFC-123制备五氯乙烷。该方法也适用于从HFC-365-mfc分离光可氯化杂质，得到纯化的HFC-365-mfc。优点包括高产率和极好的选择性。

4. 发明申请

US20050101811A1 UV-activated chlorination process 失效
标题翻译：紫外线活化氯化法
公开(公告)号：US20050101811A1
公开(公告)日：2005-05-12
申请号：US11008109
申请日：2004-12-10
申请人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
发明人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
IPC分类号： C07C17/04 , C07C17/10 , C07C17/395 , C07C19/043 , C07C19/08 , C07C19/12 , C07C17/00
CPC分类号： C07C17/10 , C07C17/04 , C07C17/395 , C07C19/01 , C07C19/12 , C07C19/08
摘要： A method of producing alkanes containing chlorine by addition of chlorine to C—C double bonds or C—C triple bonds or by exchange of hydrogen for chlorine by contacting the starting compound in the gas or liquid phase with elemental chlorine and irradiating the reaction mixture with UV light having a wavelength of λ>280 nm. In this way pentachloroethane can be produced from trichloroethylene, CFC-113 from HCFC-123 or HFC-133a, CFC-112a from HCFC-142b, or HCFC-123 from HCFC-133a. The method also is suitable for separating photochlorinatable impurities from HFC-365-mfc to obtain purified HFC-365-mfc. Advantages include high yields and excellent selectivity.
摘要翻译：通过将氯气加入到CC双键或CC三键中，或通过使气相或液相中的起始化合物与元素氯接触并将反应混合物与具有波长> 280nm。以这种方式，可以从三氯乙烯，来自HCFC-123的CFC-113或HFC-133a，来自HCFC-142b的CFC-112a或来自HCFC-133a的HCFC-123制备五氯乙烷。该方法也适用于从HFC-365-mfc分离光可氯化杂质，得到纯化的HFC-365-mfc。优点包括高产率和极好的选择性。

5. 发明授权

US06252105B1 Synthesis of low-fluoride organic compounds 失效
标题翻译：低氟有机化合物的合成
公开(公告)号：US06252105B1
公开(公告)日：2001-06-26
申请号：US09348072
申请日：1999-07-06
申请人： Max Braun , Johannes Eicher , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
发明人： Max Braun , Johannes Eicher , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
IPC分类号： C07C6963
CPC分类号： C07C67/56 , C07C51/47 , C07C51/64 , C07C53/18 , C07C67/14 , C07C67/58 , C07C53/48 , C07C59/195 , C07C69/63 , C07C69/72
摘要： Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of “onium” salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.
摘要翻译：有机化合物，例如含氟有机化合物如氟化羧酸或氟化羧酸氯化物可含有少量羧酸氟化物，氟化氢或水解性氟化物，其在氟化有机化合物衍生物的制备过程中，例如通过酯化反应，可产生腐蚀性氟化物或氟化氢。本发明是一种合成和/或纯化优选氟化有机化合物如羧酸，羧酸氯化物及其衍生物如酯的方法，起始于含有酸性氟化物或可水解氟化物的相应的羧酸氯化物和催化剂下的醇羧酸的“鎓”盐的作用，以获得具有低氟含量的产物。或者，使用无机氧化物吸附剂。该方法特别适用于三氟乙酸，氯二氟乙酸，三氟乙酰乙酸和/或二氟乙酰乙酸的酯的合成。

6. 发明授权

US5894075A Catalytic mixtures composed of titanium and tin and uses thereof 失效
标题翻译：由钛和锡组成的催化混合物及其用途
公开(公告)号：US5894075A
公开(公告)日：1999-04-13
申请号：US773495
申请日：1996-12-23
申请人： Max Braun , Werner Rudolph , Stefan Palsherm
发明人： Max Braun , Werner Rudolph , Stefan Palsherm
IPC分类号： B01J27/08 , C07B61/00 , C07C17/08 , C07C17/087 , C07C17/20 , C07C17/21 , C07C19/08 , C07C19/10
CPC分类号： B01J27/08 , C07C17/08 , C07C17/087 , C07C17/206 , C07C17/21
摘要： The addition of hydrogen fluoride to unsaturated C--C groups and the chlorine-fluorine exchange on perhalogenated carbon atoms can be advantageously catalyzed by a catalyst mixture which comprises at least partially fluorinated titanium halide in combination with tin (IV) halide.
摘要翻译：可以有利地通过催化剂混合物催化向不饱和C-C基团加入氟化氢和全卤代碳原子上的氯 - 氟交换，所述催化剂混合物包含至少部分氟化的卤化钛与卤化锡（IV）。

7. 发明申请

US20120116128A1 Process For The Manufacture Of Halogenated Precursors Of Alkenones In The Presence Of A Solvent 有权
标题翻译：烯烃酮在溶剂存在下制备卤代前体的方法
公开(公告)号：US20120116128A1
公开(公告)日：2012-05-10
申请号：US12999714
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claassen
发明人： Max Braun , Stefan Palsherm , Uta Claassen
IPC分类号： C07C45/70 , C07C45/65
CPC分类号： C07C45/455 , C07C45/41 , C07C45/65 , C07C49/255 , C07C49/175
摘要： A process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium comprising an alkenone or a halogenated precursor of the alkenone, and a process for preparing an alkenone, which comprises (a) reacting a carboxylic acid halide with a vinyl ether by introducing vinyl ether into a liquid reaction medium containing carboxylic acid halide to form a halogenated precursor of the alkenone and (b) eliminating hydrogen halide from said precursor to form the alkenone.
摘要翻译：一种制备烯酮的卤化前体的方法，其包括在包含烯酮的烯酮或卤代前体的液体反应介质中使羧酸卤化物与乙烯基醚反应，以及制备烯酮的方法，其包含（a ）通过将乙烯基醚引入到含有羧酸卤化物的液体反应介质中以形成烯酮的卤化前体，和（b）从所述前体中除去卤化氢以形成烯酮，使羧酸卤化物与乙烯基醚反应。

8. 发明授权

US06521199B2 Regeneration of onium fluoride-HF adducts 失效
公开(公告)号：US06521199B2
公开(公告)日：2003-02-18
申请号：US10086635
申请日：2002-03-04
申请人： Max Braun , Stefan Palsherm
发明人： Max Braun , Stefan Palsherm
IPC分类号： C01B719
CPC分类号： C01B17/4576 , C01B7/191 , C07B39/00 , C07C17/206 , C07C41/22 , C07C51/58 , C07C211/07
摘要： Hydrogen fluoride adducts and ammonium fluorides are used for fluorinating acid chlorides and halocarbon compounds such as chloroalkanes or chloronated ethers. The used adducts can be regenerated and then reused in the fluorination reactions.

9. 发明申请

US20120101305A1 Process For The Manufacture Of Halogenated Precursors Of Alkenones Under Specific Conditions 有权
标题翻译：在特定条件下制备烯酮的卤化前体的方法
公开(公告)号：US20120101305A1
公开(公告)日：2012-04-26
申请号：US12999730
申请日：2010-07-05
申请人： Max Braun , Stefan Palsherm , Uta Claasen
发明人： Max Braun , Stefan Palsherm , Uta Claasen
IPC分类号： C07C45/70 , C07C45/65
CPC分类号： C07C45/65 , C07C45/41 , C07C49/175 , C07C49/255
摘要： A process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium under turbulent conditions and a process for preparing an alkenone, by eliminating hydrogen halide from said precursor to form the alkenone.
摘要翻译：一种制备烯酮的卤化前体的方法，其包括在湍流条件下在液体反应介质中使羧酸卤化物与乙烯基醚反应，以及通过从所述前体中除去卤化氢以形成烯酮，制备烯酮的方法。

10. 发明授权

US08957254B2 Process for chemical synthesis from an alkenone made from a halogenated precursor 有权
标题翻译：由卤化前体制成的烯酮进行化学合成的方法
公开(公告)号：US08957254B2
公开(公告)日：2015-02-17
申请号：US14046171
申请日：2013-10-04
申请人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
发明人： Max Braun , Stefan Palsherm , Uta Claassen , Alain Lambert
IPC分类号： C07C45/41 , C07D211/02 , C07D213/64 , C07D401/00 , C07C45/65
CPC分类号： C07C45/41 , C07C45/65 , C07C49/175 , C07C49/255
摘要： Process for synthesizing a chemical, in particular an agriculturally or pharmaceutically active compound, including: a first step comprising reacting a carboxylic acid halide with a vinyl ether to prepare a halogenated precursor of an alkenone; a second step comprising eliminating hydrogen halide from such precursor to form an alkenone, preferably by thermolysis under specific conditions; and a third step which uses the formed alkenone as a building block to synthesize the chemical. First step may be done in a liquid reaction medium comprising an alkenone or a halogenated alkenone precursor, or in a liquid reaction medium in turbulent state, specifically by creation of gas bubbles of the carboxylic acid halide herein. Second step may include a flash thermolysis, vacuum thermolysis, thermolysis under stripping with inert gas, and/or a thermolysis at a temperature from >90° C. to 120° C. Third step preferably comprises reacting the alkenone with a nitrogen-containing compound.
摘要翻译：用于合成化学品，特别是农业或药学活性化合物的方法，包括：第一步，包括使羧酸卤化物与乙烯基醚反应以制备烯酮的卤化前体; 第二步，包括从这种前体消除卤化氢以形成烯酮，优选通过在特定条件下的热解; 和使用形成的烯酮作为结构单元合成化学品的第三步骤。第一步可以在包含烯酮或卤代烯酮前体的液体反应介质中或在湍流状态的液体反应介质中，特别是通过产生本文中的羧酸卤化物的气泡进行。第二步骤可以包括闪蒸热解，真空热解，用惰性气体汽提时的热解，和/或在> 90℃至120℃的温度下的热解。第三步优选包括使烯酮与含氮化合物。

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