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1. 发明授权

US09533087B2 Apparatus for extracorporeal blood treatment 有权
标题翻译：体外血液治疗仪器
公开(公告)号：US09533087B2
公开(公告)日：2017-01-03
申请号：US13876368
申请日：2011-09-08
申请人： Mauro Suffritti , Michela Carpani
发明人： Mauro Suffritti , Michela Carpani
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , B01D61/22 , B01D61/32
CPC分类号： A61M1/341 , A61M1/1603 , A61M1/1615 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3639 , A61M2205/3331 , A61M2205/502 , A61M2205/52 , B01D61/22 , B01D61/32 , B01D2311/14
摘要： An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9; 9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (STMP1), determine a value of a control parameter (φ1) corresponding to the first increase, compare the value of the control parameter (φ1) with a reference value (φref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (STMP2) which is greater than the first increase (STMP1).
摘要翻译：一种用于体外血液处理的装置，包括具有通过半透膜（5）彼此分离的第一室（3）和第二室（4）的处理单元（2），连接在入口与第一腔室（3）和血液回流管线（7）连接在出口与第一腔室; 更换流体的输液管线（9; 9a，9b）和连接在第二室的出口处的排液管线（10）。跨膜压力的调节装置（20）在至少一条管线上有效，并且控制单元（15）构造成：通过设定第一增加（STMP1）来指示调节装置（20），确定调节装置对应于第一增加的控制参数（φ1），将控制参数（φ1）的值与参考值（φref）进行比较，并且如果控制参数的值大于参考值，则命令调节装置 20）通过设定大于第一增加量（STMP1）的第二增加量（STMP2）。

2. 发明申请

US20130299399A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 有权
标题翻译：用于提取血液治疗的装置
公开(公告)号：US20130299399A1
公开(公告)日：2013-11-14
申请号：US13876368
申请日：2011-09-08
申请人： Mauro Suffritti , Michela Carpani
发明人： Mauro Suffritti , Michela Carpani
IPC分类号： A61M1/36
CPC分类号： A61M1/341 , A61M1/1603 , A61M1/1615 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3639 , A61M2205/3331 , A61M2205/502 , A61M2205/52 , B01D61/22 , B01D61/32 , B01D2311/14
摘要： An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9; 9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (STMP1), determine a value of a control parameter (φ1) corresponding to the first increase, compare the value of the control parameter (φ1) with a reference value (φref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (STMP2) which is greater than the first increase (STMP1).
摘要翻译：一种用于体外血液处理的装置，包括具有通过半透膜（5）彼此分离的第一室（3）和第二室（4）的处理单元（2），连接在入口与第一腔室（3）和血液回流管线（7）连接在出口与第一腔室; 更换流体的输液管线（9; 9a，9b）和连接在第二室的出口处的排液管线（10）。跨膜压力的调节装置（20）在至少一条管线上有效，并且控制单元（15）构造成：通过设定第一增加（STMP1）来指示调节装置（20），确定调节装置对应于第一增加的控制参数（phi1），将控制参数（phi1）的值与参考值（phiref）进行比较，并且如果控制参数的值大于参考值，则命令调节装置 20）通过设定大于第一增加量（STMP1）的第二增加量（STMP2）。

3. 发明授权

US08529487B2 Method and apparatus for priming an extracorporeal blood circuit 有权
标题翻译：用于引发体外血液回路的方法和装置
公开(公告)号：US08529487B2
公开(公告)日：2013-09-10
申请号：US12595038
申请日：2007-04-12
申请人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
发明人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/3621 , A61M1/1627 , A61M1/1656 , A61M1/1662 , A61M1/1664 , A61M1/1682 , A61M1/1686 , A61M1/169 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/309 , A61M1/3465 , A61M1/3626 , A61M1/3629 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M2205/3331 , A61M2205/6018 , A61M2205/6072
摘要： A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.
摘要翻译：一种用于引发体外血液回路的方法和装置，其中动脉线（79）的患者端连接到第一排出口（61），静脉管路（87）的患者端连接到第二排出口（62）。两个排出口连接到将透析器（33）连接到排水管的用过的透析液管线上。动脉和静脉管线填充有引发液，而包含在动脉和静脉线中的空气部分地通过第一排出口排出，部分地通过第二排出口排出。两个止回阀（65,66）防止从使用过的透析液流向两个排放口流出。本发明降低了操作者准备启动配置的错误风险，以及在启动阶段期间体外电路污染的风险。

4. 发明申请

US20110098625A1 HEMODIALYSIS OR HEMO(DIA)FILTRATION APPARATUS AND A METHOD FOR CONTROLLING A HEMODIALYSIS OR HEMO(DIA)FILTRATION APPARATUS 有权
标题翻译：血液透析或HEMO（DIA）过滤装置和控制HEMODIALYSIS或HEMO（DIA）过滤装置的方法
公开(公告)号：US20110098625A1
公开(公告)日：2011-04-28
申请号：US12994383
申请日：2008-05-26
申请人： Pietro Masala , Mauro Suffritti , Anders Wallenborg , Thomas Gebhart
发明人： Pietro Masala , Mauro Suffritti , Anders Wallenborg , Thomas Gebhart
IPC分类号： A61M1/34
CPC分类号： A61M1/3639 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M2205/3331 , G06F19/00
摘要： In a hemodiafiltration apparatus, a control and command unit (11) halts a replacement fluid supply pump (8) and contemporaneously modifies the control mode of a blood pump (1) passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor (12) arranged downstream of a hemodiafilter (3). The aim is to prevent risks due to excessive hemo-concentration in the blood circuit between the ultrafiltration zone and the infusion zone.
摘要翻译：在血液透析过滤装置中，控制和指令单元（11）停止替换流体供应泵（8），同时将基于泵速度的控制通过的血液泵（1）的控制模式同时修改为基于通过布置在血液透析滤器（3）下游的传感器（12）测量的血压。目的是防止超滤区和输液区血液循环过度血液浓度过高所引起的风险。

5. 发明授权

US09216248B2 Method and a device for monitoring a state of a blood line in a machine for extracorporeal blood treatment 有权
标题翻译：用于监测体外血液处理机器中血液线状态的方法和装置
公开(公告)号：US09216248B2
公开(公告)日：2015-12-22
申请号：US13643724
申请日：2011-04-22
申请人： Mauro Suffritti , Marco Lizzi
发明人： Mauro Suffritti , Marco Lizzi
IPC分类号： G08B21/00 , A61M1/36 , A61M1/16
CPC分类号： A61M1/3639 , A61M1/16
摘要： A method for monitoring a state of a blood line in a circuit for extracorporeal blood treatment, including the steps of: acquiring at least a first pressure value from a first sensor mounted at a first point of a circuit for extracorporeal blood treatment, comprising a blood line in which the blood is subjected to a pulsating thrust; acquiring at least a second pressure value from a second sensor mounted at a second point, distinct from the first point of the blood line of the circuit for extracorporeal blood treatment, and correlating at least a first value, correlated to the first pressure value, and at least a second value, correlated to the second pressure value, with at least a threshold value, in order to obtain a datum representing a state of the blood line.
摘要翻译：一种用于监测用于体外血液处理的回路中的血液线状态的方法，包括以下步骤：从安装在用于体外血液处理的回路的第一点的第一传感器获取至少第一压力值，所述第一传感器包括血液血液经受脉动推力的线; 从安装在不同于用于体外血液处理的电路的血液管线的第一点的第二点安装的第二传感器获取至少第二压力值，并且将与第一压力值相关的至少第一值和至少第二值与第二压力值相关联，具有至少一个阈值，以便获得表示血液线状态的基准。

6. 发明申请

US20100010412A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 有权
标题翻译：用于提取血液治疗的装置
公开(公告)号：US20100010412A1
公开(公告)日：2010-01-14
申请号：US12514141
申请日：2006-11-15
申请人： Massimo Fava , Mauro Suffritti , Anna Puppini
发明人： Massimo Fava , Mauro Suffritti , Anna Puppini
IPC分类号： A61M1/16 , B01D61/32
CPC分类号： A61M1/1694 , A61M1/1658 , A61M2205/3331
摘要： An apparatus (1) for extracorporeal blood treatment comprising a blood treatment device (2) having a semipermeable membrane (5) which separates a blood chamber (3) from a fluid chamber (4). A used fluid line (7) connects the fluid chamber to a used fluid discharge. A first pump (8) controls the ultrafiltration through the semipermeable membrane. A second pump (9) arranged in the used fluid line downstream of the first pump keeps pressure between the first and the second pump at a constant predetermined value. The invention provides a protection system against any possible pressure change in the used fluid discharge in a hemodialysis or hemo(dia)filtration apparatus.
摘要翻译：一种用于体外血液处理的装置（1），包括具有将血液室（3）与流体室（4）分离的半透膜（5）的血液处理装置（2）。使用的流体管线（7）将流体室连接到使用的流体排放口。第一泵（8）通过半透膜控制超滤。布置在第一泵下游的使用流体管线中的第二泵（9）以恒定的预定值保持第一和第二泵之间的压力。本发明提供一种防止血液透析或血液透析过滤装置中所用流体排出物中任何可能的压力变化的保护系统。

7. 发明授权

US08881600B2 Apparatus and process for testing filters 有权
标题翻译：用于测试过滤器的装置和过程
公开(公告)号：US08881600B2
公开(公告)日：2014-11-11
申请号：US11993204
申请日：2005-07-01
申请人： Anna Puppini , Renato Pedrazzi , Mauro Suffritti
发明人： Anna Puppini , Renato Pedrazzi , Mauro Suffritti
IPC分类号： G01F1/00 , A61M1/34
CPC分类号： G01N15/0826 , A61M1/165 , A61M1/34 , A61M1/3403 , A61M1/3413 , A61M2205/3331 , A61M2205/705 , G01L13/00 , G01N2015/084
摘要： In a process for testing filters (4) and (13) of treatment fluid of a hemodiafiltration apparatus (1), each filter has a wet semipermeable membrane (5, 14) which separates a gas-filled first chamber (6 and 15) from a liquid-filled second chamber (7 and 16). The first chambers are pressurised by a pump (19) supplying air, while the second chambers are placed in depression by a drainage pump (17) of used dialysis fluid. A first closed system is formed which includes the first chambers and a second closed system is formed which includes the second chambers. Two pressure gauges (P1 and P2) monitor the pressure in the two closed systems for a predetermined time. The monitoring provides indications relating to the filter integrity.
摘要翻译：在用于测试血液透析过滤装置（1）的处理流体的过滤器（4）和（13）的过程中，每个过滤器具有湿气半透膜（5,14），其将充气的第一室（6和15）与充满液体的第二室（7和16）。第一腔室由供应空气的泵（19）加压，而第二腔室由所用透析液体的排水泵（17）放置在凹陷中。形成包括第一室的第一闭合系统，并且形成包括第二室的第二封闭系统。两个压力表（P1和P2）监测两个封闭系统中的压力达预定时间。监控提供了与过滤器完整性相关的指示。

8. 发明申请

US20130046226A1 METHOD AND A DEVICE FOR MONITORING A STATE OF A BLOOD LINE IN A MACHINE FOR EXTRACORPOREAL BLOOD TREATMENT 有权
标题翻译：用于监测机器血液状态的方法和装置，用于超声波血液处理
公开(公告)号：US20130046226A1
公开(公告)日：2013-02-21
申请号：US13643724
申请日：2011-04-22
申请人： Mauro Suffritti , Marco Lizzi
发明人： Mauro Suffritti , Marco Lizzi
IPC分类号： G01N33/49 , A61M1/14
CPC分类号： A61M1/3639 , A61M1/16
摘要： A method for monitoring a state of a blood line in a circuit for extracorporeal blood treatment, including the steps of: acquiring at least a first pressure value from a first sensor mounted at a first point of a circuit for extracorporeal blood treatment, comprising a blood line in which the blood is subjected to a pulsating thrust; acquiring at least a second pressure value from a second sensor mounted at a second point, distinct from the first point of the blood line of the circuit for extracorporeal blood treatment, and correlating at least a first value, correlated to the first pressure value, and at least a second value, correlated to the second pressure value, with at least a threshold value, in order to obtain a datum representing a state of the blood line.
摘要翻译：一种用于监测用于体外血液处理的回路中的血液线状态的方法，包括以下步骤：从安装在用于体外血液处理的回路的第一点的第一传感器获取至少第一压力值，所述第一传感器包括血液血液经受脉动推力的线; 从安装在不同于用于体外血液处理的电路的血液管线的第一点的第二点安装的第二传感器获取至少第二压力值，并且将与第一压力值相关的至少第一值和至少第二值与第二压力值相关联，具有至少一个阈值，以便获得表示血液线状态的基准。

9. 发明申请

US20090151470A1 Apparatus and Process for Testing Filters 有权
标题翻译：用于测试过滤器的设备和过程
公开(公告)号：US20090151470A1
公开(公告)日：2009-06-18
申请号：US11993204
申请日：2005-07-01
申请人： Anna Puppini , Renato Pedrazzi , Mauro Suffritti
发明人： Anna Puppini , Renato Pedrazzi , Mauro Suffritti
IPC分类号： G01F1/00 , G01N1/14
CPC分类号： G01N15/0826 , A61M1/165 , A61M1/34 , A61M1/3403 , A61M1/3413 , A61M2205/3331 , A61M2205/705 , G01L13/00 , G01N2015/084
摘要： In a process for testing filters (4) and (13) of treatment fluid of a hemodiafiltration apparatus (1), each filter has a wet semipermeable membrane (5, 14) which separates a gas-filled first chamber (6 and 15) from a liquid-filled second chamber (7 and 16). The first chambers are pressurised by a pump (19) supplying air, while the second chambers are placed in depression by a drainage pump (17) of used dialysis fluid. A first closed system is formed which includes the first chambers and a second closed system is formed which includes the second chambers. Two pressure gauges (P1 and P2) monitor the pressure in the two closed systems for a predetermined time. The monitoring provides indications relating to the filter integrity.
摘要翻译：在用于测试血液透析过滤装置（1）的处理流体的过滤器（4）和（13）的过程中，每个过滤器具有湿气半透膜（5,14），其将充气的第一室（6和15）与充满液体的第二室（7和16）。第一腔室由供应空气的泵（19）加压，而第二腔室由所用透析液体的排水泵（17）放置在凹陷中。形成包括第一室的第一闭合系统，并且形成包括第二室的第二封闭系统。两个压力表（P1和P2）监测两个封闭系统中的压力达预定时间。监控提供了与过滤器完整性相关的指示。

10. 发明授权

US08647290B2 Hemodialysis or hemo(dia)filtration apparatus and a method for controlling a hemodialysis or hemo(dia)filtration apparatus 有权
标题翻译：血液透析或血液透析过滤装置和控制血液透析或血液透析过滤装置的方法
公开(公告)号：US08647290B2
公开(公告)日：2014-02-11
申请号：US12994383
申请日：2008-05-26
申请人： Pietro Masala , Mauro Suffritti , Anders Wallenborg , Thomas Gebhart
发明人： Pietro Masala , Mauro Suffritti , Anders Wallenborg , Thomas Gebhart
IPC分类号： A61M1/34 , A61M1/14 , A61M1/16 , A61M5/142
CPC分类号： A61M1/3639 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M2205/3331 , G06F19/00
摘要： In a hemodiafiltration apparatus, a control and command unit (11) halts a replacement fluid supply pump (8) and contemporaneously modifies the control mode of a blood pump (1) passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor (12) arranged downstream of a hemodiafilter (3). The aim is to prevent risks due to excessive hemoconcentration in the blood circuit between the ultrafiltration zone and the infusion zone.
摘要翻译：在血液透析过滤装置中，控制和指令单元（11）停止替换流体供应泵（8），同时将基于泵速度的控制通过的血液泵（1）的控制模式同时修改为基于通过布置在血液透析滤器（3）下游的传感器（12）测量的血压。目的是防止超滤区域和输注区域之间的血液循环过度血液浓缩引起的风险。

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