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1. 发明授权

US07648474B2 Method and device for detecting the detachment of the venous needle from a patient during dialysis 有权
标题翻译：用于在透析期间检测静脉针从患者脱离的方法和装置
公开(公告)号：US07648474B2
公开(公告)日：2010-01-19
申请号：US10481955
申请日：2002-06-24
申请人： Francesco Paolini , Carlo Alberto Lodi , Massimo Fava
发明人： Francesco Paolini , Carlo Alberto Lodi , Massimo Fava
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/367 , A61M5/16831 , A61M2039/1005 , A61M2205/13 , A61M2205/3331
摘要： A method of detecting the detachment of the venous needle from a patient during an extracorporeal blood treatment in a dialysis machine having an extracorporeal blood circuit provided with an arterial branch and a venous branch. The arterial pressure (Pa) is measured in the arterial branch and the venous pressure (Pv) is measured in the venous branch, and the determination is made of whether or not decreases of the arterial pressures (Pa) and venous pressures (Pv) are occurring during the dialysis treatment in normal conditions.
摘要翻译：在具有动脉分支和静脉分支的体外血液回路的透析机中检测静脉针在体外血液处理期间脱离的方法。在动脉分支中测量动脉压（Pa），并在静脉分支中测量静脉压（Pv），并且确定动脉压（Pa）和静脉压（Pv）的降低是否为在正常情况下透析治疗期间发生。

2. 发明授权

US06537240B2 Method for determining the recirculation of blood in a vascular access and a system for implementing same 有权
标题翻译：用于确定血管通路中血液再循环的方法和用于实施血管通路的系统
公开(公告)号：US06537240B2
公开(公告)日：2003-03-25
申请号：US09091349
申请日：1999-05-03
申请人： Giovanni Cavicchioli , Enrico Canini , Massimo Fava
发明人： Giovanni Cavicchioli , Enrico Canini , Massimo Fava
IPC分类号： A61M3700
CPC分类号： A61M1/3621 , A61M1/16 , A61M1/3609 , A61M1/3653 , A61M1/3655 , A61M1/3658 , A61M2202/0433 , A61M2205/3368 , A61M2205/52 , A61M2230/65
摘要： In an extracorporeal blood treatment system, non-treated blood may be withdrawn from a patient through an arterial line connected to a first compartment of a blood treatment apparatus. The blood treatment apparatus also includes a second compartment separated from the first component by a semi-permeable membrane. Treated blood may be returned to the patient through a venous line connected to the second compartment. In order to determine blood recirculation, i.e., a mixture of treated blood and non-treated blood in the arterial line, the ultrafiltration rate of plasma water through the semi permeable membrane of the treatment apparatus may be temporarily increased or decreased, and the resulting variation of the blood concentration, i.e., of the ratio of the volume of the plasma volume to the blood volume, is determined. The extent of the mixture of the treated blood and the non-treated blood in the arterial line may then be calculated as a function of the blood flow rate in the treatment apparatus, of the amplitude of the variation of the ultrafiltration rate, and of at least two values of the blood concentration, determined before and during the variation of the ultrafiltration flow rate, respectively.
摘要翻译：在体外血液处理系统中，未经处理的血液可以通过连接到血液处理设备的第一隔室的动脉管线从患者体内取出。血液处理装置还包括通过半透膜与第一部件分离的第二室。治疗的血液可以通过连接到第二隔室的静脉管线返回到患者。为了确定血液循环，即动脉管线中的处理血液和未处理血液的混合物，通过治疗装置的半透膜的血浆超滤速率可以暂时增加或减少，并且所得到的变化的血液浓度，即等离子体体积与血液体积的比率的比例。然后可以将处理的血液和未处理的血液在动脉线中的混合物的程度作为治疗装置中的血液流量的函数，超滤率的变化幅度和分别在超滤流量变化之前和期间测定血液浓度的至少两个值。

3. 发明授权

US08529487B2 Method and apparatus for priming an extracorporeal blood circuit 有权
标题翻译：用于引发体外血液回路的方法和装置
公开(公告)号：US08529487B2
公开(公告)日：2013-09-10
申请号：US12595038
申请日：2007-04-12
申请人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
发明人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/3621 , A61M1/1627 , A61M1/1656 , A61M1/1662 , A61M1/1664 , A61M1/1682 , A61M1/1686 , A61M1/169 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/309 , A61M1/3465 , A61M1/3626 , A61M1/3629 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M2205/3331 , A61M2205/6018 , A61M2205/6072
摘要： A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.
摘要翻译：一种用于引发体外血液回路的方法和装置，其中动脉线（79）的患者端连接到第一排出口（61），静脉管路（87）的患者端连接到第二排出口（62）。两个排出口连接到将透析器（33）连接到排水管的用过的透析液管线上。动脉和静脉管线填充有引发液，而包含在动脉和静脉线中的空气部分地通过第一排出口排出，部分地通过第二排出口排出。两个止回阀（65,66）防止从使用过的透析液流向两个排放口流出。本发明降低了操作者准备启动配置的错误风险，以及在启动阶段期间体外电路污染的风险。

4. 发明申请

US20070112289A1 Apparatus and method of monitoring a vascular access of a patient subjected to an extracorporeal blood treatment 有权
标题翻译：监测经受体外血液处理的患者的血管通路的装置和方法
公开(公告)号：US20070112289A1
公开(公告)日：2007-05-17
申请号：US11641874
申请日：2006-12-20
申请人： Silvio Cavalcanti , Carlo Lodi , Massimo Fava
发明人： Silvio Cavalcanti , Carlo Lodi , Massimo Fava
IPC分类号： A61M37/00
CPC分类号： A61M1/3621 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3663
摘要： In the apparatus and method for monitoring a vascular access (6) of an extracorporeal circuit (5; 10) of a patient, a control and calculation unit (17) varies a flow rate of a blood pump (9) predisposed to cause blood to circulate in the extracorporeal circuit. The control and calculation unit receives-the pressure values in the blood withdrawal line (5) and the blood return line (10) from two pressure sensors (8, 12); the pressure values are a series of different values of the blood flow rate. The control and calculation unit processes the data gathered by means of a mathematical model which describes the variation of pressure in the vascular access as a function of the flow rate, in order to determine the blood flow rate in the vascular access. The invention detects the presence and location of a stenosis at the vascular access of a patient subjected to a hemodialysis treatment.
摘要翻译：在用于监测患者的体外循环（5; 10）的血管通路（6）的装置和方法中，控制和计算单元（17）改变预先使血液引起的血液泵（9）的流速在体外循环。控制和计算单元接收来自两个压力传感器（8,12）的抽血管线（5）和血液回流管线（10）中的压力值。压力值是一系列不同的血液流量值。控制和计算单元通过数学模型处理收集的数据，该数学模型描述作为流速的函数的血管通路中的压力变化，以便确定血管通路中的血流量。本发明检测经血液透析治疗的患者血管通路的狭窄的存在和位置。

5. 发明授权

US08480609B2 Apparatus for extracorporeal blood treatment 有权
公开(公告)号：US08480609B2
公开(公告)日：2013-07-09
申请号：US12514141
申请日：2006-11-15
申请人： Massimo Fava , Anna Puppini , Mauro Suffritti
发明人： Massimo Fava , Anna Puppini , Mauro Suffritti
IPC分类号： A61M37/00
CPC分类号： A61M1/1694 , A61M1/1658 , A61M2205/3331
摘要： An apparatus (1) for extracorporeal blood treatment comprising a blood treatment device (2) having a semipermeable membrane (5) which separates a blood chamber (3) from a fluid chamber (4). A used fluid line (7) connects the fluid chamber to a used fluid discharge. A first pump (8) controls the ultrafiltration through the semipermeable membrane. A second pump (9) arranged in the used fluid line downstream of the first pump keeps pressure between the first and the second pump at a constant predetermined value. The invention provides a protection system against any possible pressure change in the used fluid discharge in a hemodialysis or hemo(dia)filtration apparatus.

6. 发明申请

US20120265117A1 METHOD AND APPARATUS FOR PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT 有权
标题翻译：用于预处理血液循环的方法和装置
公开(公告)号：US20120265117A1
公开(公告)日：2012-10-18
申请号：US12595038
申请日：2007-04-12
申请人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
发明人： Massimo Fava , Mauro Suffritti , Alessandro Scaglione
IPC分类号： A61M1/16
CPC分类号： A61M1/3621 , A61M1/1627 , A61M1/1656 , A61M1/1662 , A61M1/1664 , A61M1/1682 , A61M1/1686 , A61M1/169 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/309 , A61M1/3465 , A61M1/3626 , A61M1/3629 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M2205/3331 , A61M2205/6018 , A61M2205/6072
摘要： A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.
摘要翻译：一种用于引发体外血液回路的方法和装置，其中动脉线（79）的患者端连接到第一排出口（61），静脉管路（87）的患者端连接到第二排出口（62）。两个排出口连接到将透析器（33）连接到排水管的用过的透析液管线上。动脉和静脉管线填充有引发液，而包含在动脉和静脉线中的空气部分地通过第一排出口排出，部分地通过第二排出口排出。两个止回阀（65,66）防止从使用过的透析液流向两个排放口流出。本发明降低了操作者准备启动配置的错误风险，以及在启动阶段期间体外电路污染的风险。

7. 发明申请

US20100181235A1 DEVICE FOR CONNECTING TO A LIQUID SOURCE 有权
标题翻译：用于连接液体源的装置
公开(公告)号：US20100181235A1
公开(公告)日：2010-07-22
申请号：US12601191
申请日：2007-05-25
申请人： Massimo Fava , Salvatore Rinaldi
发明人： Massimo Fava , Salvatore Rinaldi
IPC分类号： B01D61/32
CPC分类号： A61M1/1656 , A61M2205/84 , Y10T137/8342
摘要： A connecting device comprises a buffer chamber (2), a first connecting line (3) between a liquid source (4) and an inlet (5) of the buffer chamber, a second connecting line (9) between an outlet (10) of the buffer chamber and the medical treatment apparatus (11), two valves (7, 8) arranged in series on the first connecting line, a pump (12) on the second connecting line, two liquid level sensors (15, 16) operating in the buffer chamber, a vent valve (18) connected to the buffer chamber. The liquid source is a centralised distribution plant of dialysate, while the medical treatment apparatus is a dialysis apparatus. The invention prevents back-contamination of the centralised plant with disinfectant sourced from the dialysis apparatus.
摘要翻译：连接装置包括缓冲室（2），液体源（4）和缓冲室的入口（5）之间的第一连接管线（3），位于缓冲室的出口（10）之间的第二连接管线所述缓冲室和所述医疗处理装置（11），串联设置在所述第一连接线上的两个阀（7,8），在所述第二连接管线上的泵（12），两个液位传感器（15,16）缓冲室，连接到缓冲室的排气阀（18）。液体源是透析液的集中分配工厂，医疗设备是透析设备。本发明防止来自透析设备的消毒剂对集中式设备的背污染。

8. 发明授权

US07172570B2 Apparatus and method for monitoring a vascular access of a patient subjected to an extracorporeal blood treatment 有权
标题翻译：用于监测经受体外血液处理的患者的血管通路的装置和方法
公开(公告)号：US07172570B2
公开(公告)日：2007-02-06
申请号：US10765149
申请日：2004-01-28
申请人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
发明人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
IPC分类号： A61M37/00 , A61M1/36 , C02F1/44
CPC分类号： A61M1/3621 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3663
摘要： In the apparatus and method for monitoring a vascular access (6) of an extracorporeal circuit (5; 10) of a patient, a control and calculation unit (17) varies a flow rate of a blood pump (9) predisposed to cause blood to circulate in the extracorporeal circuit. The control and calculation unit receives the pressure values in the blood withdrawal line (5) and the blood return line (10) from two pressure sensors (8, 12); the pressure values are a series of different values of the blood flow rate. The control and calculation unit processes the data gathered by means of a mathematical model which describes the variation of pressure in the vascular access as a function of the flow rate, in order to determine the blood flow rate in the vascular access. The invention detects the presence and location of a stenosis at the vascular access of a patient subjected to a hemodialysis treatment.
摘要翻译：在用于监测患者的体外循环（5; 10）的血管通路（6）的装置和方法中，控制和计算单元（17）改变预先使血液引起的血液泵（9）的流速在体外循环。控制和计算单元从两个压力传感器（8,12）接收抽血管线（5）和血液回流管线（10）中的压力值; 压力值是一系列不同的血液流量值。控制和计算单元通过数学模型处理收集的数据，该数学模型描述作为流速的函数的血管通路中的压力变化，以便确定血管通路中的血流量。本发明检测经血液透析治疗的患者的血管通路的狭窄的存在和位置。

9. 发明授权

US07749184B2 Apparatus and method of monitoring a vascular access of a patient subjected to an extracorporeal blood treatment 有权
标题翻译：监测经受体外血液处理的患者的血管通路的装置和方法
公开(公告)号：US07749184B2
公开(公告)日：2010-07-06
申请号：US11641874
申请日：2006-12-20
申请人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
发明人： Silvio Cavalcanti , Carlo Alberto Lodi , Massimo Fava
IPC分类号： A61M37/00 , A61M1/36 , C02F1/44
CPC分类号： A61M1/3621 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3663
摘要： In the apparatus and method for monitoring a vascular access (6) of an extracorporeal circuit (5; 10) of a patient, a control and calculation unit (17) varies a flow rate of a blood pump (9) predisposed to cause blood to circulate in the extracorporeal circuit. The control and calculation unit receives the pressure values in the blood withdrawal line (5) and the blood return line (10) from two pressure sensors (8, 12); the pressure values are a series of different values of the blood flow rate. The control and calculation unit processes the data gathered by means of a mathematical model which describes the variation of pressure in the vascular access as a function of the flow rate, in order to determine the blood flow rate in the vascular access. The invention detects the presence and location of a stenosis at the vascular access of a patient subjected to a hemodialysis treatment.
摘要翻译：在用于监测患者的体外循环（5; 10）的血管通路（6）的装置和方法中，控制和计算单元（17）改变预先使血液引起的血液泵（9）的流速在体外循环。控制和计算单元从两个压力传感器（8,12）接收抽血管线（5）和血液回流管线（10）中的压力值; 压力值是一系列不同的血液流量值。控制和计算单元通过数学模型处理收集的数据，该数学模型描述作为流速的函数的血管通路中的压力变化，以便确定血管通路中的血流量。本发明检测经血液透析治疗的患者的血管通路的狭窄的存在和位置。

10. 发明授权

US08425767B2 Device for connecting to a liquid source 有权
标题翻译：用于连接液体源的装置
公开(公告)号：US08425767B2
公开(公告)日：2013-04-23
申请号：US12601191
申请日：2007-05-25
申请人： Massimo Fava , Salvatore Rinaldi
发明人： Massimo Fava , Salvatore Rinaldi
IPC分类号： B01D61/32 , A61M1/00
CPC分类号： A61M1/1656 , A61M2205/84 , Y10T137/8342
摘要： A connecting device comprises a buffer chamber (2), a first connecting line (3) between a liquid source (4) and an inlet (5) of the buffer chamber, a second connecting line (9) between an outlet (10) of the buffer chamber and the medical treatment apparatus (11), two valves (7, 8) arranged in series on the first connecting line, a pump (12) on the second connecting line, two liquid level sensors (15, 16) operating in the buffer chamber, a vent valve (18) connected to the buffer chamber. The liquid source is a centralized distribution plant of dialysate, while the medical treatment apparatus is a dialysis apparatus. The invention prevents back-contamination of the centralized plant with disinfectant sourced from the dialysis apparatus.
摘要翻译：连接装置包括缓冲室（2），液体源（4）和缓冲室的入口（5）之间的第一连接管线（3），位于缓冲室的出口（10）之间的第二连接管线所述缓冲室和所述医疗处理装置（11），串联设置在所述第一连接线上的两个阀（7,8），在所述第二连接管线上的泵（12），两个液位传感器（15,16）缓冲室，连接到缓冲室的排气阀（18）。液体源是透析液的集中分配工厂，医疗设备是透析设备。本发明防止来自透析设备的消毒剂对集中式设备的背污染。

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