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1. 发明申请

US20080108113A1 Methods for the Enrichment of Trehalose Using Alumosilicates 审中-公开
标题翻译：使用硅铝酸盐富集海藻糖的方法
公开(公告)号：US20080108113A1
公开(公告)日：2008-05-08
申请号：US10593223
申请日：2005-03-18
申请人： Matthias Boy , Markus Pompejus , Daniela Klein , Martin Volkert , James Reuben Brown
发明人： Matthias Boy , Markus Pompejus , Daniela Klein , Martin Volkert , James Reuben Brown
IPC分类号： C12P19/12 , C07H1/06
CPC分类号： C07H3/04
摘要： The invention relates to a process for enriching trehalose from solutions, in which the enrichment is performed using an adsorbent, in which the adsorbent is an aluminosilicate. Preferably, the aluminosilicate is a zeolite. The invention further relates to the enrichment and purification of trehalose from fermentation broths, in particular as a coupled product of production by fermentation of other products of value.
摘要翻译：本发明涉及从溶液中富集海藻糖的方法，其中使用吸附剂进行富集，其中吸附剂是铝硅酸盐。优选地，硅铝酸盐是沸石。本发明还涉及从发酵液中富集和纯化海藻糖，特别是作为通过其他有价值产物的发酵生产的偶联产物。

2. 发明授权

US09109244B2 Fermentative production of fine chemicals 有权
公开(公告)号：US09109244B2
公开(公告)日：2015-08-18
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P25/00 , C12P7/46 , C12P13/12 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

3. 发明授权

US08741599B2 Fermentative production of organic compounds 失效
标题翻译：发酵生产有机化合物
公开(公告)号：US08741599B2
公开(公告)日：2014-06-03
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P19/14 , C12P19/02 , C12P13/04 , C12P13/08 , C12P13/00 , C12P7/66 , C12P1/00 , C12P19/38 , C12P7/14 , C12N1/00 , C12N1/20
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

4. 发明申请

US20090226571A1 Fermentative Production of Non-Volatile Microbial Metabolism Products in Solid Form 审中-公开
标题翻译：固体形式的非挥发性微生物代谢产物的发酵生产
公开(公告)号：US20090226571A1
公开(公告)日：2009-09-10
申请号：US11991515
申请日：2006-09-06
申请人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
发明人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
IPC分类号： A23K1/16 , C12P1/00 , C12P7/46 , C12P7/48 , C12P13/04 , C12P19/38 , C12P19/30 , C12P7/64 , C12P7/02 , C12P19/00 , C12P21/04 , C12P7/26 , C12P19/04 , C12P19/12 , C12P7/42 , C12P7/18 , C07C53/00 , C07C205/00 , C07H19/00 , C07C35/00 , C07H1/00 , C07K2/00 , C07C49/00 , C08B37/16 , C13K13/00 , C07C31/18 , D06M13/224 , D06M13/00 , A23L1/48 , D21H23/22
CPC分类号： C12P13/08 , A23K10/12 , A23L7/104 , C12P7/46 , C12P13/02 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/14
摘要： The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.
摘要翻译：本发明涉及一种通过糖基微生物发酵生产固体形式的至少一种非挥发性微生物代谢物的方法，其中使用含糖单体的含糖液体培养基生产所需代谢物的微生物菌株含量超过基于液体介质总重量的20重量％，随后大量除去发酵液的挥发性成分，所述含糖液体介质通过以下步骤制备：a1）从谷物中研磨选定的淀粉原料 ; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中为了液化目的，至少部分所述研磨料液体通过连续或分批加入水性液体。此外，本发明涉及通过本发明的方法获得的非挥发性微生物代谢物的固体制剂; 以及使用这种固体制剂作为人或动物营养的添加剂或补充剂或用于处理纺织品，皮革，纤维素，纸或表面的固体制剂。

5. 发明申请

US20090162892A1 Fermentative production of fine chemicals 有权
标题翻译：发酵精细化学品生产
公开(公告)号：US20090162892A1
公开(公告)日：2009-06-25
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/00 , C12P19/38 , C12P19/30 , C12P19/12 , C12P19/04 , C12P13/04 , C12P17/18 , C12P17/12 , C12P7/64 , C12P7/40 , C12P7/48 , C12P7/46 , C12P7/42 , C12P7/26 , C12P7/02
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.
摘要翻译：本发明涉及通过糖基微生物发酵生产具有至少3个碳原子或至少2个碳原子和至少1个氮原子的至少一种微生物代谢物的方法，包括：a）制备含糖液体介质，其单糖含量大于淀粉原料的20重量％以上，所述含糖液体介质还包含淀粉原料的非淀粉状固体成分; b）用于生产代谢物的含糖液体培养基的发酵; 和c）从所述发酵液中消耗或分离至少一种代谢物，其中产生所需代谢物的微生物菌株与所述含糖液体培养基一起培养，所述液体培养基通过以下步骤获得：a1）研磨所述淀粉原料; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中至少一些所述絮凝液通过连续或分批添加至所述水性液体而液化。

6. 发明申请

US20080299606A1 Fermentative Production of Organic Compounds 失效
标题翻译：有机化合物的发酵生产
公开(公告)号：US20080299606A1
公开(公告)日：2008-12-04
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/04 , C12P13/00 , C12P7/64 , C12P7/18 , C12P7/40 , C12P19/38 , C12P19/40 , C12P19/30
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

7. 发明授权

US09249448B2 Malodour standards and inhibitors 有权
标题翻译： Malodour标准和抑制剂
公开(公告)号：US09249448B2
公开(公告)日：2016-02-02
申请号：US13994289
申请日：2011-12-19
申请人： Markus Pompejus
发明人： Markus Pompejus
IPC分类号： C12Q1/25 , C12N9/84 , A61K8/36 , A61Q15/00
CPC分类号： C12Q1/25 , A61K8/36 , A61K8/64 , A61Q15/00 , C12N9/84
摘要： The invention pertains to the field of reaction systems generating malodor, particularly from constituents of human sweat. Specifically, the invention pertains to proteins for generating malodors, substrates for generating such malodor, inhibitors of such malodor generation and test and screening systems for measuring their malodor inhibition efficacy and finding substances previously not known to inhibit malodor generation. Thus, the invention also pertains to the field of deodorants.
摘要翻译：本发明涉及产生恶臭的反应系统领域，特别是人汗的成分。具体地，本发明涉及用于产生恶臭的蛋白质，用于产生这种恶臭的底物，这种恶臭产生的抑制剂以及测量和筛选系统，用于测量其恶臭抑制功效并发现先前不知道抑制恶臭产生的物质。因此，本发明也涉及除臭剂领域。

8. 发明申请

US20130344010A1 Oral Health Improving Compositions 审中-公开
标题翻译：口腔健康改善组合
公开(公告)号：US20130344010A1
公开(公告)日：2013-12-26
申请号：US13981194
申请日：2012-01-12
申请人： Markus Pompejus
发明人： Markus Pompejus
IPC分类号： A61K8/99 , A61Q11/00
CPC分类号： A61K8/99 , A23K10/16 , A23K10/18 , A23K50/42 , A23L33/135 , A61K35/74 , A61P1/02 , A61Q11/00
摘要： The present invention is concerned with microorganisms or fragments thereof as sensorically neutral oral care agents, particularly for prevention of dental calculus, as anti-caries agents and/or anti-oral malodor agents. The invention is furthermore concerned with compositions comprising microorganisms or fragments thereof for reducing mutans Streptococci. Such compositions can be used in oral care compositions, e.g. for caries prophylaxis, or for prophylaxis of dental calculus or oral malodor. They may also or instead be used for prevention or treatment of oral malodor. As the microorganisms and fragments thereof according to the present invention have a very low, unobtrusive smell and taste, they are particularly suited as sensorically neutral agents for preventment of dental calculus, caries, oral biofilm formation and/or for prevention or treatment of oral malodor. The microorganisms and fragments thereof, and also compositions comprising such microorganisms and fragments, can thus advantageously be used in food and feed compositions, particularly in pet foods. Furthermore, the invention is concerned with methods of preparing such microorganisms, fragments, compositions, foods and feeds.
摘要翻译：本发明涉及作为感觉中性口腔护理剂的微生物或其片段，特别是用于预防牙结石，作为抗龋剂和/或抗口腔恶臭剂。本发明还涉及包含用于降低变形链球菌的微生物或其片段的组合物。这样的组合物可以用于口腔护理组合物，例如用于龋齿预防，或预防牙结石或口腔恶臭。他们也可以或替代地用于预防或治疗口臭。由于根据本发明的微生物及其碎片具有非常低的，不显眼的气味和味道，所以它们特别适用于用于预防牙结石，龋齿，口腔生物膜形成和/或预防或治疗口腔恶臭的感觉中性剂。微生物及其片段以及包含这些微生物和碎片的组合物因此可有利地用于食品和饲料组合物中，特别是在宠物食品中。此外，本发明涉及制备这种微生物，碎片，组合物，食品和饲料的方法。

9. 发明申请

US20130315851A1 Malodour Standards And Inhibitors 有权
标题翻译： Malodour标准和抑制剂
公开(公告)号：US20130315851A1
公开(公告)日：2013-11-28
申请号：US13994289
申请日：2011-12-19
申请人： Markus Pompejus
发明人： Markus Pompejus
IPC分类号： C12Q1/25 , A61K8/36 , A61Q15/00
CPC分类号： C12Q1/25 , A61K8/36 , A61K8/64 , A61Q15/00 , C12N9/84
摘要： The invention pertains to the field of reaction systems generating malodour, particularly from constituents of human sweat. Specifically, the invention pertains to proteins for generating malodours, substrates for generating such malodour, inhibitors of such malodour generation and test and screening systems for measuring their malodour inhibition efficacy and finding substances previously not known to inhibit malodour generation. Thus, the invention also pertains to the field of deodorants.
摘要翻译：本发明涉及产生恶臭的反应系统领域，特别是人汗的成分。具体地，本发明涉及用于产生恶臭的蛋白质，用于产生这种恶臭的底物，这种恶臭产生的抑制剂以及用于测量其恶臭抑制功效的测试和筛选系统，并且发现先前不知道抑制恶臭产生的物质。因此，本发明也涉及除臭剂领域。

10. 发明授权

US08389251B2 Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis 有权
标题翻译：使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法
公开(公告)号：US08389251B2
公开(公告)日：2013-03-05
申请号：US13018119
申请日：2011-01-31
申请人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
发明人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
IPC分类号： C12P13/12 , C12N15/74
CPC分类号： C07K14/34
摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
摘要翻译：描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。

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