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1. 发明申请

US20110003741A1 NOVEL NEURTURIN CONJUGATES FOR PHARMACEUTICAL USE 有权
标题翻译：新型神经营养因子用于药物使用
公开(公告)号：US20110003741A1
公开(公告)日：2011-01-06
申请号：US12774235
申请日：2010-05-05
申请人： Matthias Austen , Marcus Geese , Rainer Mussmann , Friedrich Harder , Thomas Siegmund , Martin Schneider
发明人： Matthias Austen , Marcus Geese , Rainer Mussmann , Friedrich Harder , Thomas Siegmund , Martin Schneider
IPC分类号： A61K38/16 , C07K14/00 , A61P3/06 , A61P3/10 , A61P1/18 , A61P25/00
CPC分类号： C07K14/4756 , A61K9/0019 , A61K38/185 , A61K47/60
摘要： The present invention relates to neurturin protein products conjugated to polyols and to pharmaceutical compositions comprising neurturin conjugates as active ingredients, preferably PEGylated neurturin conjugates or variants thereof, having increased bioavailability.
摘要翻译：本发明涉及与多元醇缀合的neururin蛋白产物和包含neurturin偶联物作为活性成分的药物组合物，优选聚乙二醇化的neururin缀合物或其变体，具有增加的生物利用度。

2. 发明授权

US09029323B2 Neurturin conjugates for pharmaceutical use 有权
标题翻译：用于药物用途的Neurturin共轭物
公开(公告)号：US09029323B2
公开(公告)日：2015-05-12
申请号：US12774235
申请日：2010-05-05
申请人： Matthias Austen , Marcus Geese , Rainer Mussmann , Friedrich Harder , Thomas Siegmund , Martin Schneider
发明人： Matthias Austen , Marcus Geese , Rainer Mussmann , Friedrich Harder , Thomas Siegmund , Martin Schneider
IPC分类号： A61K38/18 , C07K14/475 , A61K47/48
CPC分类号： C07K14/4756 , A61K9/0019 , A61K38/185 , A61K47/60
摘要： The present invention relates to neurturin protein products conjugated to polyols and to pharmaceutical compositions comprising neurturin conjugates as active ingredients, preferably PEGylated neurturin conjugates or variants thereof, having increased bioavailability.
摘要翻译：本发明涉及与多元醇缀合的neururin蛋白产物和包含neurturin偶联物作为活性成分的药物组合物，优选聚乙二醇化的neururin缀合物或其变体，具有增加的生物利用度。

3. 发明申请

US20070110728A1 Method for preventing and treating diabetes using dg119 审中-公开
标题翻译：使用dg119预防和治疗糖尿病的方法
公开(公告)号：US20070110728A1
公开(公告)日：2007-05-17
申请号：US10580564
申请日：2004-11-29
申请人： Matthias Austen , Daria Onichtchouk , Thomas Siegmund , Kristin Aduroja , Bettina Rudolph , Friedrich Harder
发明人： Matthias Austen , Daria Onichtchouk , Thomas Siegmund , Kristin Aduroja , Bettina Rudolph , Friedrich Harder
IPC分类号： C12N5/08 , A61K38/17 , A61K35/39
CPC分类号： G01N33/507 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/058 , A01K2227/105 , A01K2227/40 , A01K2267/0362 , A61K35/12 , A61K38/1709 , C07K14/47 , C12N5/0676 , C12N15/8509 , C12N2506/02 , C12N2510/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
摘要： The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a DG119-1 product or a DG119-1 agonist and/or an antagonist To a DG 119-2 product.
摘要翻译：本发明一般涉及通过对DG 119-2产品施用DG119-1产物或DG119-1激动剂和/或拮抗剂来预防和/或治疗胰腺疾病，特别是与糖尿病有关的疾病的方法。

4. 发明授权

US08237382B2 LED module and method for operating at least one LED 失效
标题翻译：用于操作至少一个LED的LED模块和方法
公开(公告)号：US08237382B2
公开(公告)日：2012-08-07
申请号：US12526251
申请日：2007-02-13
申请人： Thomas Siegmund , Adrian Zingalik
发明人： Thomas Siegmund , Adrian Zingalik
IPC分类号： H05B41/16 , H05B41/24
CPC分类号： H05B33/0815 , H05B33/0809 , Y02B20/346
摘要： An LED module (10) for operating at least one LED (18) comprising an input (E1, E2) adapted for coupling to a DC voltage source (UE); an output (A1, A2) adapted for coupling to the at least one LED (18); a filter device (14); and a DC-DC converter (16); wherein the filter device (14) and the DC-DC converter (16) are coupled in series between the input (E1, E2) and the output (A1, A2), and wherein the output (DCA1, DCA2) of the DC-DC converter (16) is coupled to the output (A1, A2) of the LED module (10); wherein the LED module further comprises an electronic switch (Q1), which is configured to couple the DC-DC converter (16) to the input (E1, E2) of the LED module (10) and to decouple it therefrom.
摘要翻译：一种用于操作至少一个LED（18）的LED模块（10），包括适于耦合到DC电压源（UE）的输入端（E1，E2）; 适于耦合到所述至少一个LED（18）的输出（A1，A2）; 过滤装置（14）; 和DC-DC转换器（16）; 其中所述滤波器装置（14）和所述DC-DC转换器（16）串联耦合在所述输入端（E1，E2）和所述输出端（A1，A2）之间，并且其中所述DC- DC转换器（16）耦合到LED模块（10）的输出（A1，A2）; 其中所述LED模块还包括电子开关（Q1），其被配置为将所述DC-DC转换器（16）耦合到所述LED模块（10）的输入端（E1，E2）并将其从其分离。

5. 发明申请

US20050266203A1 Manufacture of thick preform composites via multiple pre-shaped fabric mat layers 失效
标题翻译：通过多个预成型织物垫层制造厚预成型复合材料
公开(公告)号：US20050266203A1
公开(公告)日：2005-12-01
申请号：US10852992
申请日：2004-05-25
申请人： Mark La Forest , Nabil Gharbieh , Raymond Cipra , Alan Fatz , Thomas Siegmund
发明人： Mark La Forest , Nabil Gharbieh , Raymond Cipra , Alan Fatz , Thomas Siegmund
IPC分类号： B29B11/16 , B29C70/30 , B29C70/38 , B32B3/02 , D04H1/00 , D04H13/00 , F16D69/02
CPC分类号： B29B11/16 , B29C70/305 , B29L2031/7482 , D04H1/593 , D04H1/60 , D04H1/76 , F16D69/023 , F16D2069/008 , Y10T428/213
摘要： A preform for a carbon-carbon composite part (55) comprising multiple layers of fibrous mats (51, 52, 53) wherein each of the fibrous mats (51, 52, 53) comprises a random carbon-containing fibrous matrix (11) within which is distributed a polymeric binder and wherein adjacent mat layers (51, 52, 53) are bound together by additional polymer binder, stitching and interlocking tabs. The preform of the present invention may be an aircraft landing system brake disc. Also, a method of manufacturing a thick multi-layer composite preform. The method includes the steps of: providing an optionally reconfigurable tool including a perforated screen through which a vacuum can be drawn; delivering chopped fibers (b), such as pitch fibers, polyacrylonitrile fibers, or mixtures thereof, to said tool while drawing vacuum therethrough, to form a fibrous object; delivering binder (c), for instance in the form of a spray, to said fibrous object; melting or curing said binder (d), for instance by the application of heat or ultraviolet light, to make a fibrous mat (51, 52, 53); assembling, preferably in the substantial absence of cutting or other mechanical modification, a plurality of said fibrous mats (51, 52, 53) and additional binder into the shape of a preform (e); and heat-pressing the resulting mat assembly (f) into a finished thick preform (55).
摘要翻译：一种用于碳 - 碳复合材料部件（55）的预成型件，其包括多层纤维垫（51,52,53），其中每个纤维垫（51,52,53）包括含有无规碳的纤维基质（11）其分布有聚合物粘合剂，并且其中相邻的垫层（51,52,53）通过另外的聚合物粘合剂，缝合和互锁接头结合在一起。本发明的预成型件可以是飞机着陆系统制动盘。另外，制造厚的多层复合预型体的方法。该方法包括以下步骤：提供可选地可重新配置的工具，其包括穿孔筛网，通过该筛孔可抽出真空; 将所述短纤维（b），例如沥青纤维，聚丙烯腈纤维或其混合物输送到所述工具，同时抽真空从而形成纤维物体; 将粘合剂（c）（例如以喷雾的形式）递送到所述纤维物体; 熔融或固化所述粘合剂（d），例如通过施加热或紫外线来制备纤维垫（51,52,53）; 多个所述纤维垫（51,52,53）和预成型件（e）形状的另外的粘合剂组合，优选地基本不存在切割或其它机械改性。并将所得的垫组件（f）热压成成品的厚预成型件（55）。

6. 发明授权

US07352079B2 Electronic ballast for a lamp 失效
标题翻译：电子镇流器灯
公开(公告)号：US07352079B2
公开(公告)日：2008-04-01
申请号：US11402901
申请日：2006-04-13
申请人： Markus Heckmann , Alfons Lechner , Thomas Siegmund
发明人： Markus Heckmann , Alfons Lechner , Thomas Siegmund
IPC分类号： H02J3/02
CPC分类号： H05B41/282 , Y02B20/183
摘要： An electronic ballast for a lamp has a DC voltage connection; a switching unit having a supply voltage with the DC voltage connection being coupled thereto, and a first capacitor coupled between the supply voltage connection and a reference potential; an AC voltage connection, at which a voltage can be made available which has at least one AC component. The series circuit includes a first nonreactive resistor and a first diode, as a second nonreactive resistor coupled between the AC voltage connection and the supply voltage connection, a connection point between the first diode and the second nonreactive resistor, and a second capacitor coupled between the connection point and the reference potential. The first capacitor and the second nonreactive resistor are dimensioned such that the average voltage drop across the second nonreactive resistor is greater than or equal to the average voltage drop across the first capacitor.
摘要翻译：灯的电子镇流器具有直流电压连接; 具有与所述直流电压连接耦合的电源电压的开关单元和耦合在所述电源电压连接和参考电位之间的第一电容器; AC电压连接，在该AC电压连接处可以获得具有至少一个AC分量的电压。串联电路包括第一非反应电阻器和第一二极管，作为耦合在AC电压连接和电源电压连接之间的第二非反应电阻器，第一二极管和第二非反应电阻器之间的连接点，以及耦合在第二非反应电阻器连接点和参考电位。第一电容器和第二非反应电阻器的尺寸使得第二非反应电阻器两端的平均电压降大于或等于第一电容器两端的平均电压降。

7. 发明授权

US07309963B2 Smoothing circuit for improving EMC 失效
标题翻译：平滑电路，用于提高EMC
公开(公告)号：US07309963B2
公开(公告)日：2007-12-18
申请号：US11455796
申请日：2006-06-20
申请人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
发明人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
IPC分类号： H05B41/36
CPC分类号： H05B41/2827 , H05B41/2851 , H05B41/2855
摘要： The present invention relates to an electronic ballast for discharge lamps, for example low-pressure discharge lamps, having a converter having a switching element and a two-part lamp inductor which is connected upstream and downstream of the discharge lamp. An electronic ballast according to the invention has a smoothing circuit which reduces voltage jumps caused by switching operations in the converter at the lamp terminals.
摘要翻译：本发明涉及一种用于放电灯的电子镇流器，例如低压放电灯，具有连接在放电灯的上游和下游的开关元件和两部分灯电感器的转换器。根据本发明的电子镇流器具有平滑电路，其减少在灯端子处的转换器中的开关操作引起的电压跳变。

8. 发明申请

US20060284572A1 Smoothing circuit for improving EMC 失效
标题翻译：平滑电路，用于提高EMC
公开(公告)号：US20060284572A1
公开(公告)日：2006-12-21
申请号：US11455796
申请日：2006-06-20
申请人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
发明人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
IPC分类号： H05B41/36
CPC分类号： H05B41/2827 , H05B41/2851 , H05B41/2855
摘要： The present invention relates to an electronic ballast for discharge lamps, for example low-pressure discharge lamps, having a converter having a switching element and a two-part lamp inductor which is connected upstream and downstream of the discharge lamp. An electronic ballast according to the invention has a smoothing circuit which reduces voltage jumps caused by switching operations in the converter at the lamp terminals.
摘要翻译：本发明涉及一种用于放电灯的电子镇流器，例如低压放电灯，具有连接在放电灯的上游和下游的开关元件和两部分灯电感器的转换器。根据本发明的电子镇流器具有平滑电路，其减少在灯端子处的转换器中的开关操作引起的电压跳变。

9. 发明申请

US20050266220A1 Manufacture of functionally graded carbon-carbon composites 失效
标题翻译：功能梯度碳 - 碳复合材料的制造
公开(公告)号：US20050266220A1
公开(公告)日：2005-12-01
申请号：US10852933
申请日：2004-05-25
申请人： Mark La Forest , Charles Parker , Frank Dillon , Thomas Siegmund , Raymond Cipra , Alan Fatz , Peter Braunisch , Tobey Cordell
发明人： Mark La Forest , Charles Parker , Frank Dillon , Thomas Siegmund , Raymond Cipra , Alan Fatz , Peter Braunisch , Tobey Cordell
IPC分类号： B32B18/00 , C04B35/00 , C04B35/83 , D04H1/00 , D04H1/72 , D04H3/00 , F16D69/02
CPC分类号： B32B18/00 , B32B2315/02 , C04B35/83 , C04B2235/48 , C04B2235/614 , C04B2237/385 , C04B2237/584 , C04B2237/62 , D04H1/72 , F16D69/023 , Y10T428/249924
摘要： Annular brake disc preform (15), wherein 40 to 80 layers of reinforcement fibers of at least two different lengths (11, 19) ranging from 10-60 mm are distributed in a planar gradient throughout the body of the preform, with the reinforcement fibers located near the exterior planes of the disc being predominately shorter fibers (11) and with the reinforcement fibers located in the central planes of the disc being predominately longer fibers (19). Also, process of making carbon-carbon composite preforms by: providing chopped pitch or PAN fibers (11, 19) of at least two different lengths; directing a robotic spraying apparatus to spray the chopped fibers into an annular mold (5) in 40 to 80 concentric iterations of chopped fiber deposition to provide a matrix of fibers in the mold; depositing a curable binder into the mold to intermix the binder with the fiber matrix; compressing the fiber matrix and curable binder within the mold; curing the binder to form a preform matrix; filling the preform matrix with pitch to form a pitch matrix; and subjecting the pitch matrix to chemical vapor deposition to form a carbon-carbon composite preform (15).
摘要翻译：环形制动盘预成型件（15），其中具有10-60mm的至少两个不同长度（11,19）的40至80层增强纤维以预制件的整个主体分布在平面梯度中，其中增强纤维位于盘的外部平面附近的主要是较短的纤维（11）并且位于盘的中心平面中的增强纤维主要是较长的纤维（19）。另外，通过以下方式制造碳 - 碳复合预型件的方法：提供至少两个不同长度的短切沥青或PAN纤维（11,19）; 引导机器人喷涂设备以短时间纤维沉积的40至80次同心迭代将切碎的纤维喷射到环形模具（5）中以在模具中提供纤维矩阵; 将可固化粘合剂沉积到模具中以使粘合剂与纤维基质混合; 在模具内压缩纤维基质和可固化粘合剂; 固化粘合剂以形成预成型体基体; 用间距填充预成型体基体以形成间距矩阵; 并对沥青基体进行化学气相沉积以形成碳 - 碳复合预制件（15）。

10. 发明授权

US08134297B2 Ballast for a discharge lamp with adaptive preheating 失效
标题翻译：用于具有自适应预热功能的放电灯的镇流器
公开(公告)号：US08134297B2
公开(公告)日：2012-03-13
申请号：US11990080
申请日：2006-08-30
申请人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
发明人： Olaf Busse , Markus Heckmann , Reinhard Lecheler , Alfons Lechner , Siegfried Mayer , Thomas Pollischansky , Bernd Rudolph , Bernhard Schemmel , Kay Schmidtmann , Harald Schmitt , Thomas Siegmund , Arwed Storm , Horst Werni
IPC分类号： H05J17/28
CPC分类号： H05B41/295
摘要： The present invention relates to an electronic ballast for discharge lamps (LA) which have preheatable electrodes (E1, E2). The electronic ballast has a measuring apparatus (M), which is designed to measure, during the preheating process, a variable, which is correlated with the electrode temperature increased by the preheating, of at least one of the electrodes (E1, E2) of a connected discharge lamp (LA), and a control apparatus (C), which is designed to match the electrode temperature, during the preheating process, in response to the measurement by adjusting an operational parameter of the electronic ballast. Furthermore, the electronic ballast is designed to detect cross discharges or a sufficient operating temperature of one of the electrodes (E1, E2) and possibly to ignite the discharge.
摘要翻译：本发明涉及一种具有可预热电极（E1，E2）的放电灯（LA）的电子镇流器。电子镇流器具有测量装置（M），该测量装置（M）被设计成在预热过程期间测量与由预热增加的电极温度相关的变量，所述变量与至少一个电极（E1，E2）连接的放电灯（LA）和控制装置（C），其被设计为在预热过程期间响应于通过调节电子镇流器的操作参数的测量来匹配电极温度。此外，电子镇流器被设计成检测一个电极（E1，E2）的交叉放电或足够的工作温度，并且可能点燃放电。

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