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1. 发明授权

US06266550B1 Catheter apparatus for treating arterial occlusions 有权
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US06266550B1
公开(公告)日：2001-07-24
申请号：US09483173
申请日：2000-01-13
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B1732
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2090/3784 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

2. 发明授权

US6157852A Catheter apparatus for treating arterial occlusions 失效
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US6157852A
公开(公告)日：2000-12-05
申请号：US8033
申请日：1998-01-16
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61B19/00 , A61M25/01 , A61M29/02 , A61B5/00
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M2025/1097 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

3. 发明授权

US6081738A Method and apparatus for the guided bypass of coronary occlusions 失效
标题翻译：冠状动脉闭塞引导旁路的方法和装置
公开(公告)号：US6081738A
公开(公告)日：2000-06-27
申请号：US7434
申请日：1998-01-15
申请人： Tomoaki Hinohara , Matthew R. Selmon , James W. Vetter , Charles F. Milo
发明人： Tomoaki Hinohara , Matthew R. Selmon , James W. Vetter , Charles F. Milo
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61B19/00 , A61M25/01 , A61M29/02 , A61B5/05
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M2025/1097 , A61M25/0147
摘要： Described herein is a catheter method and apparatus for the guided intraluminal bypass of a coronary occlusion. A method is described employing an intraluminally operable catheter shaft including an optionally steerable working element, combined with an extraluminally operable locator including an imaging device, to selectively direct the working element to create a fluid path from the artery proximal to the occlusion into the vein and further from the vein back into the artery distal to the occlusion, to perfuse myocardium distal to the occlusion. Methods are described for creating a fluid path from the artery proximal to the occlusion into an adjacent vein and thereafter either stent grafting the fluid path to the vein, directing arterial blood distally within the vein, or stenting the fluid path and occluding the vein proximal thereto, in either case arterializing the venous system distal to the stent or stent graft. A catheter shaft is described for creating and perfusing the fluid path. Conical, guide wire and tissue-penetrating working elements are described. A scanning acoustic transducer and flexible imaging tube, and suction devices for anchoring are described for the locator. A signal-emitting working element and signal-detecting locator cooperating therewith are described.
摘要翻译：本文描述了用于冠状动脉闭塞引导的腔内旁路的导管方法和装置。描述了一种采用可腔内操作的导管轴的方法，该导管轴包括可选择的可操纵的工作元件，与包括成像装置的外部可操作的定位器组合，以选择性地引导工作元件以创建从靠近闭塞到静脉的动脉的流体路径，进一步从静脉回到动脉远端闭塞，将心肌远端灌注到闭塞。描述了用于创建从靠近闭塞的动脉到相邻静脉的流体路径的方法，之后任一支架将流体路径移植到静脉，将动脉血液定向在静脉内远端，或支架化流体路径并闭塞其附近的静脉在任何一种情况下动脉化远端支架或支架植入物的静脉系统。描述了用于创建和灌注流体路径的导管轴。描述了锥形，导丝和组织穿透工作元件。描述了扫描声换能器和柔性成像管，以及用于锚定的抽吸装置。描述与之配合的信号发射工作元件和信号检测定位器。

4. 发明授权

US06241667B1 Catheter apparatus for guided transvascular treatment of arterial occlusions 失效
标题翻译：用于导管经血管内治疗动脉闭塞的导管器
公开(公告)号：US06241667B1
公开(公告)日：2001-06-05
申请号：US09008198
申请日：1998-01-15
申请人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
发明人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
IPC分类号： A61B1700
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M25/0147 , A61M2025/1097
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter having an occlusion-crossing working element, with an extraluminally operable locator for imaging the progress of the working element through the occlusion. Suction coupling means are described for removably anchoring the locator to a surface proximate the heart. A method for treating arterial occlusions is described in which the distal end of the catheter shaft exits a lumen of the locator, penetrates the arterial wall distal to the occlusion, crosses the occlusion retrograde and passes into a separately introduced standard intravascular catheter, whereupon the distal end of the shaft may be manipulated from the proximal end of the standard catheter. The proximal end of the shaft is then released from external attachments and drawn into the artery to perform treatment or guiding functions. Spatial interrelationships are observed real-time via the locator. Conical, abrasive, blunt-dissecting, sharp-pointed and guide-wire type working elements, steerable and non-steering, are described. Acoustic transducers and a flexible imaging tube are described for the locator. A signal-emitting working element and cooperating signal-receiving locator are described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可内窥术操作的导管与可外部操作的定位器，用于通过闭塞成像工作元件的进展。吸入联接装置被描述为用于可移除地将定位器锚定到靠近心脏的表面。描述了治疗动脉闭塞的方法，其中导管轴的远端离开定位器的内腔，穿过远端阻塞的动脉壁，逆行阻塞并进入单独引入的标准血管内导管，于是远端可以从标准导管的近端操纵轴的端部。然后将轴的近端从外部附件释放并拉入动脉以执行治疗或引导功能。通过定位器实时观察空间相互关系。描述了锥形，磨料，钝性解剖，尖锐和导丝式工作元件，可转向和非转向。描述了定位器的声学换能器和柔性成像管。描述信号发射工作元件和配合信号接收定位器。

5. 发明授权

US06217549B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06217549B1
公开(公告)日：2001-04-17
申请号：US09149875
申请日：1998-09-08
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22069 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

6. 发明授权

US06800085B2 Methods and apparatus for treating vascular occlusions 有权
公开(公告)号：US06800085B2
公开(公告)日：2004-10-05
申请号：US09835043
申请日：2001-04-13
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.

7. 发明授权

US06221049B1 Methods and apparatus for crossing vascular occlusions 有权
公开(公告)号：US06221049B1
公开(公告)日：2001-04-24
申请号：US09427966
申请日：1999-10-27
申请人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
发明人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
IPC分类号： A61M5178
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/018 , A61M2025/0197
摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other interventional and diagnostic catheters for performing procedures such as stenting.

8. 发明授权

US06746462B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06746462B1
公开(公告)日：2004-06-08
申请号：US09538850
申请日：2000-03-28
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61B1722
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22069 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

9. 发明授权

US06638247B1 Method and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06638247B1
公开(公告)日：2003-10-28
申请号：US09538441
申请日：2000-03-29
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

10. 发明授权

US06508825B1 Apparatus for treating vascular occlusions 有权
标题翻译：用于治疗血管闭塞的装置
公开(公告)号：US06508825B1
公开(公告)日：2003-01-21
申请号：US09149874
申请日：1998-09-08
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be, provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件，用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

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