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1. 发明授权

US09157550B2 Microfluidic systems and methods 有权
标题翻译：微流体系统和方法
公开(公告)号：US09157550B2
公开(公告)日：2015-10-13
申请号：US12652735
申请日：2010-01-05
申请人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
发明人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
IPC分类号： C12M1/34 , F16K99/00 , C12M3/06 , C12M3/00 , A61B17/425 , B01L3/00
CPC分类号： F16K99/0001 , A61B17/425 , B01L3/5085 , B01L2300/0829 , C12M21/06 , C12M23/16 , F16K99/0017 , F16K99/0028 , Y10T137/0318 , Y10T137/87249
摘要： Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel. A device for providing an amount of fluid for a fluidic system comprises a main reservoir, an aspiration well, tubing coupling the reservoirs, and a seal closing the main reservoir. Air tubing having a hydrophobic end extends into the at least one aspiration well.
摘要翻译：微流体系统和方法。用于体外受精的微流体装置包括衬底和设置在衬底中的多个微通道，包括布置在衬底上的多个微通道中的至少两个的入口，以与流体处理装置对准。用于测定多个细胞的另一个微流体系统包括底物和多个包含源通道，宿通道和细胞室的微流体通道。用于微流体系统的插入件包括构造成插入盘中的衬底和设置在衬底中的多个微孔。微流体通道包括基底和至少一个具有开放入口，开口的出口，通道和布置在通道的一部分上的基底中的开口的微通道。用于为流体系统提供一定量的流体的装置包括主储存器，抽吸井，联接储存器的管道和封闭主储存器的密封件。具有疏水端的空气管延伸到至少一个抽吸井中。

2. 发明申请

US20100234674A1 MICROFLUIDIC SYSTEMS AND METHODS 有权
标题翻译：微流体系统和方法
公开(公告)号：US20100234674A1
公开(公告)日：2010-09-16
申请号：US12652735
申请日：2010-01-05
申请人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
发明人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
IPC分类号： A61B17/43 , G03F7/20 , F16K11/20
CPC分类号： F16K99/0001 , A61B17/425 , B01L3/5085 , B01L2300/0829 , C12M21/06 , C12M23/16 , F16K99/0017 , F16K99/0028 , Y10T137/0318 , Y10T137/87249
摘要： Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel. A device for providing an amount of fluid for a fluidic system comprises a main reservoir, an aspiration well, tubing coupling the reservoirs, and a seal closing the main reservoir. Air tubing having a hydrophobic end extends into the at least one aspiration well.
摘要翻译：微流体系统和方法。用于体外受精的微流体装置包括衬底和设置在衬底中的多个微通道，其包括布置在衬底上的多个微通道中的至少两个的入口，以与流体处理装置对准。用于测定多个细胞的另一个微流体系统包括底物和多个包含源通道，宿通道和细胞室的微流体通道。用于微流体系统的插入件包括构造成插入盘中的衬底和设置在衬底中的多个微孔。微流体通道包括基底和至少一个具有开放入口，开口的出口，通道和布置在通道的一部分上的基底中的开口的微通道。用于为流体系统提供一定量的流体的装置包括主储存器，抽吸井，联接储存器的管道和封闭主储存器的密封件。具有疏水端的空气管延伸到至少一个抽吸井中。

3. 发明授权

US06695765B1 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation 有权
标题翻译：微流体通道胚胎和/或卵母细胞的处理，分析和生物学评估
公开(公告)号：US06695765B1
公开(公告)日：2004-02-24
申请号：US09570483
申请日：2000-05-12
申请人： David J. Beebe , Ian K. Glasgow , Matthew B. Wheeler , Henry Zeringue
发明人： David J. Beebe , Ian K. Glasgow , Matthew B. Wheeler , Henry Zeringue
IPC分类号： A61B1743
CPC分类号： B01L3/502761 , A61B17/435 , A61D19/04 , B01L3/502707 , B01L2200/143 , B01L2400/0457 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M29/10 , C12M41/00
摘要： Microfluidic embryo scaled channels for handling and positioning embryos provide the opportunity to evaluate and treat embryos in improved manners Fluid flow is used to move and position embryos within microfluidic channels and channel geometries may be used to place embryos at specific locations. Surface properties and compliance (deformation) properties of embryos are evaluated as a predictor of viability. The microfluidic channels provide the opportunity for fine controls of pressure to conduct various evaluations at forces slightly below which damage to embryos is known to occur.
摘要翻译：用于处理和定位胚胎的微流体胚胎标准化通道提供了以改进方式评估和治疗胚胎的机会。流体流动用于移动和定位微流体通道内的胚胎，并且通道几何形状可用于将胚胎放置在特定位置。胚胎的表面性质和顺应性（变形）性质被评估为生存力的预测因子。微流体通道提供精确控制压力的机会，在稍低于胚胎已知发生损伤的力下进行各种评估。

4. 发明授权

US06193647B1 Microfluidic embryo and/or oocyte handling device and method 失效
标题翻译：微流体胚和/或卵母细胞处理装置及方法
公开(公告)号：US06193647B1
公开(公告)日：2001-02-27
申请号：US09289137
申请日：1999-04-08
申请人： David J. Beebe , Ian K. Glasgow , Matthew B. Wheeler
发明人： David J. Beebe , Ian K. Glasgow , Matthew B. Wheeler
IPC分类号： A61B1743
CPC分类号： B01L3/502761 , A61B17/435 , A61D19/04 , B01L3/502707 , B01L2200/143 , B01L2400/0457 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M29/10 , C12M41/00
摘要： A microfluidic embryo handling device and method in which biological rotating of embryos is simulated. Fluid flow is used to move and position embryos without assistance of electrical stimulus or other means which may produce undesired heating of biological medium used as the fluid for transporting and position. Continuous or pulsed flow is maintained around an embryo or embryos in the device. The device provides an excellent simulation of biological conditions and may be used for culturing, sorting, testing, evaluating, fertilizing and other similar typical handling operations. An embryo may be parked at a desired location to carry out such a typical operation, while the microfluidic handling device maintains fluid flow around the embryo.
摘要翻译：一种微流体胚胎处理装置和方法，其中模拟胚胎的生物旋转。流体流动用于移动和定位胚胎，而无需电刺激或其他可能产生用作运输和定位的流体的生物介质的不期望的加热的手段。在装置中的胚胎或胚胎周围保持连续或脉冲流动。该设备提供了良好的生物条件模拟，可用于培养，分选，测试，评估，施肥和其他类似的典型处理操作。胚胎可以停放在期望的位置以执行这种典型的操作，而微流体处理装置保持围绕胚胎的流体流动。

5. 发明申请

US20100254830A1 Magnetically driven micro-pumping method using external rotating stirrer 审中-公开
标题翻译：使用外部旋转搅拌器的磁驱微泵法
公开(公告)号：US20100254830A1
公开(公告)日：2010-10-07
申请号：US11545189
申请日：2006-10-10
申请人： David J. Beebe , Ivar Meyvantsson , Dongshin Kim
发明人： David J. Beebe , Ivar Meyvantsson , Dongshin Kim
IPC分类号： F04B17/00
CPC分类号： F04B19/006
摘要： A device and method for conducting peristaltic pumping of a fluid in a body is provided. The body includes a channel having an input and an output and being partially defined by a flexible layer. A plurality of contacts are spaced along the layer and the channel is filled with the fluid. The plurality of spaced contacts is magnetically coupled to a magnetic field in sequence so as to translate peristaltic motion to the layer thereby pumping the fluid through the channel.
摘要翻译：提供了一种用于在体内进行流体的蠕动泵送的装置和方法。身体包括具有输入和输出并且由柔性层局部限定的通道。多个触点沿着该层间隔开，并且通道充满流体。多个间隔开的触点依次磁耦合到磁场，以便将蠕动运动转移到该层，从而将流体泵送通过通道。

6. 发明授权

US07562562B2 Method and device for detecting a material 有权
标题翻译：用于检测材料的方法和装置
公开(公告)号：US07562562B2
公开(公告)日：2009-07-21
申请号：US11745855
申请日：2007-05-08
申请人： David J. Beebe , Dongshin Kim
发明人： David J. Beebe , Dongshin Kim
IPC分类号： G01N33/48 , G01N3/08
CPC分类号： G01N19/00 , G01N19/10 , G01N33/48
摘要： A method and device is provided for detecting a predetermined material. The device includes a first inner layer having first and second surfaces and a volume responsive to a first predetermined stimuli. A second inner layer has first and second surfaces. An adhesive bonds at least a portion of the first surface of the first inner layer to the first surface of the second inner layer with a bonding force. A change in the volume of the first layer generates an elastic force on the adhesive material. As a result, the first inner layer delaminates from the second inner layer in response to the elastic force overcoming the bonding force.
摘要翻译：提供了用于检测预定材料的方法和装置。该装置包括具有第一和第二表面的第一内层和响应于第一预定刺激的体积。第二内层具有第一和第二表面。粘合剂通过结合力将第一内层的第一表面的至少一部分粘合到第二内层的第一表面。第一层的体积变化在粘合剂材料上产生弹性力。结果，第一内层响应于克服接合力的弹力而从第二内层分层。

7. 发明申请

US20080276718A1 METHOD AND DEVICE FOR DETECTING A MATERIAL 有权
标题翻译：用于检测材料的方法和装置
公开(公告)号：US20080276718A1
公开(公告)日：2008-11-13
申请号：US11745855
申请日：2007-05-08
申请人： David J. Beebe , Dongshin Kim
发明人： David J. Beebe , Dongshin Kim
IPC分类号： G01N3/08
CPC分类号： G01N19/00 , G01N19/10 , G01N33/48
摘要： A method and device is provided for detecting a predetermined material. The device includes a first inner layer having first and second surfaces and a volume responsive to a first predetermined stimuli. A second inner layer has first and second surfaces. An adhesive bonds at least a portion of the first surface of the first inner layer to the first surface of the second inner layer with a bonding force. A change in the volume of the first layer generates an elastic force on the adhesive material. As a result, the first inner layer delaminates from the second inner layer in response to the elastic force overcoming the bonding force.
摘要翻译：提供了用于检测预定材料的方法和装置。该装置包括具有第一和第二表面的第一内层和响应于第一预定刺激的体积。第二内层具有第一和第二表面。粘合剂通过结合力将第一内层的第一表面的至少一部分粘合到第二内层的第一表面。第一层的体积变化在粘合剂材料上产生弹性力。结果，第一内层响应于克服接合力的弹力而从第二内层分层。

8. 发明公开

US20230242856A1 Platform And Method For Testing Antibiotic Sensitivity Of A Polymicrobial Infection 审中-公开
公开(公告)号：US20230242856A1
公开(公告)日：2023-08-03
申请号：US18131620
申请日：2023-04-06
申请人： David J. Beebe , Layla J. Barkal , Jason Yu
发明人： David J. Beebe , Layla J. Barkal , Jason Yu
IPC分类号： C12M3/06 , C12M1/32 , C12Q1/18
CPC分类号： C12M23/16 , C12M23/12 , C12Q1/18
摘要： A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

9. 发明授权

US11430279B2 Functionalized microfluidic device and method 有权
公开(公告)号：US11430279B2
公开(公告)日：2022-08-30
申请号：US13467599
申请日：2012-05-09
申请人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
发明人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
IPC分类号： B01L3/00 , G07C9/32 , B01L3/02 , G07C9/38
摘要： A microfluidic platform and method are provided. The microfluidic platform includes a base having an outer surface and a plurality of wells formed in the outer surface thereof for receiving fluid therein. The plurality of wells are in fluid communication with each other. A lid includes a plurality of channels having corresponding inputs and outputs. The lid is moveable between a first position wherein the lid is disengaged from the base and a second position wherein the inputs of each channel communicate with corresponding wells in the base. The fluid in each well is drawn into corresponding channels through the inputs thereof by capillary action.

10. 发明授权

US08728410B2 Device for and method of extracting a fraction from a biological sample 有权
$Device for and method of extracting a fraction from a biological sample$
标题翻译：从生物样品中提取级分的装置和方法
公开(公告)号：US08728410B2
公开(公告)日：2014-05-20
申请号：US13033351
申请日：2011-02-23
申请人： David J. Beebe , Scott M. Berry , Richard Burgess , Lindsay Strotman
发明人： David J. Beebe , Scott M. Berry , Richard Burgess , Lindsay Strotman
IPC分类号： B03C1/02
CPC分类号： B01D21/0009 , B01D2221/10 , B03C1/288 , B03C2201/18 , B03C2201/26 , C07K1/145 , C07K1/22 , C12N15/1006 , Y10T436/25375 , Y10T436/2575
摘要： A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.
摘要翻译：提供了一种用于促进从生物样品中提取级分的装置和方法。生物样品包括非期望的材料和分数结合的固相底物。该装置包括用于在其中接收生物样本的输入区和用于在其中接收隔离缓冲器的相门区。输出区在其中接收试剂。力可在邻近输入区的第一位置与邻近输出区的第二位置之间移动。力从输入区域通过相位闸区促进分数结合的固相基板进入输出区域。

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