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1. 发明授权

US11430279B2 Functionalized microfluidic device and method 有权
公开(公告)号：US11430279B2
公开(公告)日：2022-08-30
申请号：US13467599
申请日：2012-05-09
申请人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
发明人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
IPC分类号： B01L3/00 , G07C9/32 , B01L3/02 , G07C9/38
摘要： A microfluidic platform and method are provided. The microfluidic platform includes a base having an outer surface and a plurality of wells formed in the outer surface thereof for receiving fluid therein. The plurality of wells are in fluid communication with each other. A lid includes a plurality of channels having corresponding inputs and outputs. The lid is moveable between a first position wherein the lid is disengaged from the base and a second position wherein the inputs of each channel communicate with corresponding wells in the base. The fluid in each well is drawn into corresponding channels through the inputs thereof by capillary action.

2. 发明申请

US20130299041A1 Functionalized Microfluidic Device And Method 审中-公开
标题翻译：功能化微流控装置及方法
公开(公告)号：US20130299041A1
公开(公告)日：2013-11-14
申请号：US13467599
申请日：2012-05-09
申请人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
发明人： David J. Beebe , Erwin Berthler , Peter Cavnar , David John Guckenberger
IPC分类号： B65B3/04 , B01L3/00
CPC分类号： G07C9/00134 , B01L3/0255 , B01L3/0262 , B01L3/0293 , B01L3/50273 , B01L3/563 , B01L2200/16 , B01L2300/047 , B01L2300/0672 , B01L2300/0816 , B01L2400/024 , B01L2400/0406 , B01L2400/0481 , B01L2400/0683 , G07C9/00166 , G07C2209/08
摘要： A microfluidic platform and method are provided. The microfluidic platform includes a base having an outer surface and a plurality of wells formed in the outer surface thereof for receiving fluid therein. The plurality of wells are in fluid communication with each other. A lid includes a plurality of channels having corresponding inputs and outputs. The lid is moveable between a first position wherein the lid is disengaged from the base and a second position wherein the inputs of each channel communicate with corresponding wells in the base. The fluid in each well is drawn into corresponding channels through the inputs thereof by capillary action.
摘要翻译：提供微流体平台和方法。微流体平台包括具有外表面的基部和在其外表面中形成的用于在其中接收流体的多个阱。多个井彼此流体连通。盖包括具有相应输入和输出的多个通道。盖子可以在其中盖子与基座脱开的第一位置和第二位置之间移动，第二位置，每个通道的输入端与基座中的相应的孔连通。每个孔中的流体通过其通过毛细作用的输入被吸入相应的通道。

3. 发明申请

US20120152361A1 Inertia Enhanced Pumping Mechanism And Method 审中-公开
标题翻译：惯性增强泵送机理与方法
公开(公告)号：US20120152361A1
公开(公告)日：2012-06-21
申请号：US12973188
申请日：2010-12-20
申请人： Justin C. Williams , David J. Beebe , Pedro Resto , Erwin Berthler
发明人： Justin C. Williams , David J. Beebe , Pedro Resto , Erwin Berthler
IPC分类号： F15D1/00
CPC分类号： B01L3/50273 , B01L3/0268 , B01L2300/0816 , B01L2400/0406 , B01L2400/0475 , Y10T137/0318 , Y10T137/2076
摘要： A device and method are provided for pumping fluid through a channel of a microfluidic device. The channel has an input and an output. The channel is filled with fluid and droplets under pressure are sequentially directed at the input of the channel so as to cause fluid to flow in the channel towards the output.
摘要翻译：提供了一种用于泵送流体通过微流体装置的通道的装置和方法。通道有一个输入和一个输出。通道填充有流体，压力下的液滴依次指向通道的输入，以使流体在通道中流向输出。

4. 发明公开

US20230242856A1 Platform And Method For Testing Antibiotic Sensitivity Of A Polymicrobial Infection 审中-公开
公开(公告)号：US20230242856A1
公开(公告)日：2023-08-03
申请号：US18131620
申请日：2023-04-06
申请人： David J. Beebe , Layla J. Barkal , Jason Yu
发明人： David J. Beebe , Layla J. Barkal , Jason Yu
IPC分类号： C12M3/06 , C12M1/32 , C12Q1/18
CPC分类号： C12M23/16 , C12M23/12 , C12Q1/18
摘要： A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

5. 发明授权

US08728410B2 Device for and method of extracting a fraction from a biological sample 有权
$Device for and method of extracting a fraction from a biological sample$
标题翻译：从生物样品中提取级分的装置和方法
公开(公告)号：US08728410B2
公开(公告)日：2014-05-20
申请号：US13033351
申请日：2011-02-23
申请人： David J. Beebe , Scott M. Berry , Richard Burgess , Lindsay Strotman
发明人： David J. Beebe , Scott M. Berry , Richard Burgess , Lindsay Strotman
IPC分类号： B03C1/02
CPC分类号： B01D21/0009 , B01D2221/10 , B03C1/288 , B03C2201/18 , B03C2201/26 , C07K1/145 , C07K1/22 , C12N15/1006 , Y10T436/25375 , Y10T436/2575
摘要： A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.
摘要翻译：提供了一种用于促进从生物样品中提取级分的装置和方法。生物样品包括非期望的材料和分数结合的固相底物。该装置包括用于在其中接收生物样本的输入区和用于在其中接收隔离缓冲器的相门区。输出区在其中接收试剂。力可在邻近输入区的第一位置与邻近输出区的第二位置之间移动。力从输入区域通过相位闸区促进分数结合的固相基板进入输出区域。

6. 发明申请

US20140065654A1 Device For And Method Of Isolating A Fraction In A Biological Sample 有权
标题翻译：在生物样品中分离部分的装置和方法
公开(公告)号：US20140065654A1
公开(公告)日：2014-03-06
申请号：US13604192
申请日：2012-09-05
申请人： David J. Beebe , Scott M. Berry , David J. Guckenberger , Ben P. Casavant
发明人： David J. Beebe , Scott M. Berry , David J. Guckenberger , Ben P. Casavant
IPC分类号： G01N1/34 , C12Q1/02
CPC分类号： G01N1/34 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2200/0673 , B01L2300/087 , B01L2400/043 , G01N1/4077 , G01N35/0098
摘要： A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.
摘要翻译：提供了用于分离生物样品中的级分的装置和方法。该馏分与固相底物结合以限定分馏结合的固相底物。该装置包括用于在其中接收生物样品的输入区和用于在其中接收隔离流体的第二区。提供通常垂直于重力的力。该力可在邻近输入区的第一位置与邻近隔离区的第二位置之间移动。该力捕获分馏结合的固相底物，并且部分结合的固相基板响应于从第一位置移动到第二位置的力而从输入区移动到隔离区。

7. 发明授权

US08628517B2 Micro-fluidic device for drug delivery 有权
标题翻译：用于药物输送的微流体装置
公开(公告)号：US08628517B2
公开(公告)日：2014-01-14
申请号：US12821743
申请日：2010-06-23
申请人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
发明人： David J. Beebe , Michael J. MacDonald , David T. Eddington , Glennys A. Mensing
IPC分类号： A61K9/22
CPC分类号： A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
摘要： A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
摘要翻译：提供了用于将药物递送给个体的微流体装置。微流体装置包括限定用于在其中接收药物的储存器的主体。阀将储存器互连到可插入个人皮肤的输出针。压力源将药物从储存器推向针。所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件个人

8. 发明申请

US20110213133A1 Device For And Method Of Extracting A Fraction From A Biological Sample 有权
标题翻译：从生物样品中提取组分的装置和方法
公开(公告)号：US20110213133A1
公开(公告)日：2011-09-01
申请号：US12713950
申请日：2010-02-26
申请人： David J. Beebe , Scott M. Barry
发明人： David J. Beebe , Scott M. Barry
IPC分类号： C07K1/14 , C07H21/00 , G01N1/34
CPC分类号： C07K1/145 , C07K1/22
摘要： A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.
摘要翻译：提供了一种用于促进从生物样品中提取级分的装置和方法。生物样品包括非期望的材料和分数结合的固相底物。该装置包括用于在其中接收生物样本的输入区和用于在其中接收隔离缓冲器的相门区。输出区在其中接收试剂。力可在邻近输入区的第一位置与邻近输出区的第二位置之间移动。力从输入区域通过相位闸区促进分数结合的固相基板进入输出区域。

9. 发明申请

US20100030198A1 DRUG DELIVERY PLATFORM UTILIZING HYDROGEL PUMPING MECHANISM 有权
标题翻译：药物输送平台利用水压泵机构
公开(公告)号：US20100030198A1
公开(公告)日：2010-02-04
申请号：US12184613
申请日：2008-08-01
申请人： David J. Beebe , Benjamin J. Moga , Tony Escarcega , Kent Chase
发明人： David J. Beebe , Benjamin J. Moga , Tony Escarcega , Kent Chase
IPC分类号： A61K9/22
CPC分类号： A61M37/00 , A61M5/14248 , A61M5/145 , A61M5/148 , A61M2005/14252 , A61M2005/14513
摘要： A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual.
摘要翻译：提供药物递送平台用于将受控的药物输注输送给个体。药物递送平台包括用于在其中接收药物的储存器和可与贮存器接合的压力源。压力源可在第一配置和第二配置之间移动，其中压力源对储存器施加压力以从其中推动药物。提供用于将药物传输到个体中的输出导管。致动机构可操作地连接到压力源和输出导管。致动机构可在非致动位置和致动位置之间移动，其中压力源从第一构型移动到第二构型，并且其中输出导管的输入与药物连通，输出管道的输出端可接收在个人

10. 发明授权

US07554743B2 Variable-focus lens assembly 有权
标题翻译：变焦镜头组件
公开(公告)号：US07554743B2
公开(公告)日：2009-06-30
申请号：US11442927
申请日：2006-05-30
申请人： Hongrui Jiang , Abhishek K. Agarwal , Liang Dong , David J. Beebe
发明人： Hongrui Jiang , Abhishek K. Agarwal , Liang Dong , David J. Beebe
IPC分类号： G02B1/06
CPC分类号： G02B3/14 , G02B3/0006
摘要： A variable-focus lens assembly is provided. The lens assembly includes a microfluidic device that defines a chamber for receiving a fluid therein. A slip having an aperture therethrough is disposed in the chamber. A first fluid is disposed on the first side of the slip and a second fluid is disposed on the second side of the slip. A lens is formed from the interface of the first and second fluids. The outer periphery is pinned to the slip about the aperture. A turning structure fabricated from a hydrogel material engages the slip and tunes the focal length of the lens in response to a predetermined stimulus.
摘要翻译：提供了可变焦距透镜组件。透镜组件包括限定用于在其中接收流体的室的微流体装置。具有通孔的滑动件设置在腔室中。第一流体设置在滑动件的第一侧上，并且第二流体设置在滑动件的第二侧上。透镜由第一和第二流体的界面形成。外周围被钉住在孔周围的滑块上。由水凝胶材料制成的转动结构与滑动接合并响应于预定的刺激调谐透镜的焦距。

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